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Advanced Thyroid Gland Anaplastic Carcinoma

MedGen UID:
1750004
Concept ID:
C5420153
Neoplastic Process

Definition

Thyroid gland anaplastic carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdvanced Thyroid Gland Anaplastic Carcinoma

Professional guidelines

PubMed

Bible KC, Kebebew E, Brierley J, Brito JP, Cabanillas ME, Clark TJ Jr, Di Cristofano A, Foote R, Giordano T, Kasperbauer J, Newbold K, Nikiforov YE, Randolph G, Rosenthal MS, Sawka AM, Shah M, Shaha A, Smallridge R, Wong-Clark CK
Thyroid 2021 Mar;31(3):337-386. doi: 10.1089/thy.2020.0944. PMID: 33728999Free PMC Article
Alobuia W, Gillis A, Kebebew E
Curr Treat Options Oncol 2020 Aug 7;21(10):78. doi: 10.1007/s11864-020-00776-2. PMID: 32767129
Araque KA, Gubbi S, Klubo-Gwiezdzinska J
Horm Metab Res 2020 Aug;52(8):562-577. Epub 2020 Feb 10 doi: 10.1055/a-1089-7870. PMID: 32040962Free PMC Article

Recent clinical studies

Etiology

Boucai L, Zafereo M, Cabanillas ME
JAMA 2024 Feb 6;331(5):425-435. doi: 10.1001/jama.2023.26348. PMID: 38319329
Fallahi P, Ferrari SM, Galdiero MR, Varricchi G, Elia G, Ragusa F, Paparo SR, Benvenga S, Antonelli A
Semin Cancer Biol 2022 Feb;79:180-196. Epub 2020 Nov 26 doi: 10.1016/j.semcancer.2020.11.013. PMID: 33249201
Capdevila J, Wirth LJ, Ernst T, Ponce Aix S, Lin CC, Ramlau R, Butler MO, Delord JP, Gelderblom H, Ascierto PA, Fasolo A, Führer D, Hütter-Krönke ML, Forde PM, Wrona A, Santoro A, Sadow PM, Szpakowski S, Wu H, Bostel G, Faris J, Cameron S, Varga A, Taylor M
J Clin Oncol 2020 Aug 10;38(23):2620-2627. Epub 2020 May 4 doi: 10.1200/JCO.19.02727. PMID: 32364844Free PMC Article
Prete A, Borges de Souza P, Censi S, Muzza M, Nucci N, Sponziello M
Front Endocrinol (Lausanne) 2020;11:102. Epub 2020 Mar 13 doi: 10.3389/fendo.2020.00102. PMID: 32231639Free PMC Article
Araque KA, Gubbi S, Klubo-Gwiezdzinska J
Horm Metab Res 2020 Aug;52(8):562-577. Epub 2020 Feb 10 doi: 10.1055/a-1089-7870. PMID: 32040962Free PMC Article

Diagnosis

Boucai L, Zafereo M, Cabanillas ME
JAMA 2024 Feb 6;331(5):425-435. doi: 10.1001/jama.2023.26348. PMID: 38319329
Maniakas A, Zafereo M, Cabanillas ME
Endocrinol Metab Clin North Am 2022 Jun;51(2):391-401. Epub 2022 May 4 doi: 10.1016/j.ecl.2021.11.020. PMID: 35662448
Bible KC, Kebebew E, Brierley J, Brito JP, Cabanillas ME, Clark TJ Jr, Di Cristofano A, Foote R, Giordano T, Kasperbauer J, Newbold K, Nikiforov YE, Randolph G, Rosenthal MS, Sawka AM, Shah M, Shaha A, Smallridge R, Wong-Clark CK
Thyroid 2021 Mar;31(3):337-386. doi: 10.1089/thy.2020.0944. PMID: 33728999Free PMC Article
Prete A, Borges de Souza P, Censi S, Muzza M, Nucci N, Sponziello M
Front Endocrinol (Lausanne) 2020;11:102. Epub 2020 Mar 13 doi: 10.3389/fendo.2020.00102. PMID: 32231639Free PMC Article
Araque KA, Gubbi S, Klubo-Gwiezdzinska J
Horm Metab Res 2020 Aug;52(8):562-577. Epub 2020 Feb 10 doi: 10.1055/a-1089-7870. PMID: 32040962Free PMC Article

Therapy

Subbiah V, Kreitman RJ, Wainberg ZA, Gazzah A, Lassen U, Stein A, Wen PY, Dietrich S, de Jonge MJA, Blay JY, Italiano A, Yonemori K, Cho DC, de Vos FYFL, Moreau P, Fernandez EE, Schellens JHM, Zielinski CC, Redhu S, Boran A, Passos VQ, Ilankumaran P, Bang YJ
Nat Med 2023 May;29(5):1103-1112. Epub 2023 Apr 14 doi: 10.1038/s41591-023-02321-8. PMID: 37059834Free PMC Article
Maniakas A, Zafereo M, Cabanillas ME
Endocrinol Metab Clin North Am 2022 Jun;51(2):391-401. Epub 2022 May 4 doi: 10.1016/j.ecl.2021.11.020. PMID: 35662448
Fallahi P, Ferrari SM, Galdiero MR, Varricchi G, Elia G, Ragusa F, Paparo SR, Benvenga S, Antonelli A
Semin Cancer Biol 2022 Feb;79:180-196. Epub 2020 Nov 26 doi: 10.1016/j.semcancer.2020.11.013. PMID: 33249201
Capdevila J, Wirth LJ, Ernst T, Ponce Aix S, Lin CC, Ramlau R, Butler MO, Delord JP, Gelderblom H, Ascierto PA, Fasolo A, Führer D, Hütter-Krönke ML, Forde PM, Wrona A, Santoro A, Sadow PM, Szpakowski S, Wu H, Bostel G, Faris J, Cameron S, Varga A, Taylor M
J Clin Oncol 2020 Aug 10;38(23):2620-2627. Epub 2020 May 4 doi: 10.1200/JCO.19.02727. PMID: 32364844Free PMC Article
Araque KA, Gubbi S, Klubo-Gwiezdzinska J
Horm Metab Res 2020 Aug;52(8):562-577. Epub 2020 Feb 10 doi: 10.1055/a-1089-7870. PMID: 32040962Free PMC Article

Prognosis

Bible KC, Kebebew E, Brierley J, Brito JP, Cabanillas ME, Clark TJ Jr, Di Cristofano A, Foote R, Giordano T, Kasperbauer J, Newbold K, Nikiforov YE, Randolph G, Rosenthal MS, Sawka AM, Shah M, Shaha A, Smallridge R, Wong-Clark CK
Thyroid 2021 Mar;31(3):337-386. doi: 10.1089/thy.2020.0944. PMID: 33728999Free PMC Article
Capdevila J, Wirth LJ, Ernst T, Ponce Aix S, Lin CC, Ramlau R, Butler MO, Delord JP, Gelderblom H, Ascierto PA, Fasolo A, Führer D, Hütter-Krönke ML, Forde PM, Wrona A, Santoro A, Sadow PM, Szpakowski S, Wu H, Bostel G, Faris J, Cameron S, Varga A, Taylor M
J Clin Oncol 2020 Aug 10;38(23):2620-2627. Epub 2020 May 4 doi: 10.1200/JCO.19.02727. PMID: 32364844Free PMC Article
Prete A, Borges de Souza P, Censi S, Muzza M, Nucci N, Sponziello M
Front Endocrinol (Lausanne) 2020;11:102. Epub 2020 Mar 13 doi: 10.3389/fendo.2020.00102. PMID: 32231639Free PMC Article
Araque KA, Gubbi S, Klubo-Gwiezdzinska J
Horm Metab Res 2020 Aug;52(8):562-577. Epub 2020 Feb 10 doi: 10.1055/a-1089-7870. PMID: 32040962Free PMC Article
Pozdeyev N, Gay LM, Sokol ES, Hartmaier R, Deaver KE, Davis S, French JD, Borre PV, LaBarbera DV, Tan AC, Schweppe RE, Fishbein L, Ross JS, Haugen BR, Bowles DW
Clin Cancer Res 2018 Jul 1;24(13):3059-3068. Epub 2018 Apr 3 doi: 10.1158/1078-0432.CCR-18-0373. PMID: 29615459Free PMC Article

Clinical prediction guides

Boucai L, Zafereo M, Cabanillas ME
JAMA 2024 Feb 6;331(5):425-435. doi: 10.1001/jama.2023.26348. PMID: 38319329
Capdevila J, Wirth LJ, Ernst T, Ponce Aix S, Lin CC, Ramlau R, Butler MO, Delord JP, Gelderblom H, Ascierto PA, Fasolo A, Führer D, Hütter-Krönke ML, Forde PM, Wrona A, Santoro A, Sadow PM, Szpakowski S, Wu H, Bostel G, Faris J, Cameron S, Varga A, Taylor M
J Clin Oncol 2020 Aug 10;38(23):2620-2627. Epub 2020 May 4 doi: 10.1200/JCO.19.02727. PMID: 32364844Free PMC Article
Ibrahimpasic T, Ghossein R, Shah JP, Ganly I
Thyroid 2019 Mar;29(3):311-321. doi: 10.1089/thy.2018.0509. PMID: 30747050Free PMC Article
Giordano TJ
Annu Rev Pathol 2018 Jan 24;13:141-162. Epub 2017 Oct 30 doi: 10.1146/annurev-pathol-121808-102139. PMID: 29083981
Landa I, Ibrahimpasic T, Boucai L, Sinha R, Knauf JA, Shah RH, Dogan S, Ricarte-Filho JC, Krishnamoorthy GP, Xu B, Schultz N, Berger MF, Sander C, Taylor BS, Ghossein R, Ganly I, Fagin JA
J Clin Invest 2016 Mar 1;126(3):1052-66. Epub 2016 Feb 15 doi: 10.1172/JCI85271. PMID: 26878173Free PMC Article

Recent systematic reviews

Coca-Pelaz A, Rodrigo JP, Agaimy A, Williams MD, Saba NF, Nuyts S, Randolph GW, López F, Vander Poorten V, Kowalski LP, Civantos FJ, Zafereo ME, Mäkitie AA, Cohen O, Nixon IJ, Rinaldo A, Ferlito A
Virchows Arch 2024 May;484(5):733-742. Epub 2024 Feb 24 doi: 10.1007/s00428-024-03752-5. PMID: 38400843
Bible KC, Kebebew E, Brierley J, Brito JP, Cabanillas ME, Clark TJ Jr, Di Cristofano A, Foote R, Giordano T, Kasperbauer J, Newbold K, Nikiforov YE, Randolph G, Rosenthal MS, Sawka AM, Shah M, Shaha A, Smallridge R, Wong-Clark CK
Thyroid 2021 Mar;31(3):337-386. doi: 10.1089/thy.2020.0944. PMID: 33728999Free PMC Article
Kwon J, Kim BH, Jung HW, Besic N, Sugitani I, Wu HG
Eur J Cancer 2016 May;59:34-45. Epub 2016 Mar 23 doi: 10.1016/j.ejca.2016.02.015. PMID: 27014798
Lee YS, Kim Y, Jeon S, Bae JS, Jung SL, Jung CK
Int J Clin Exp Pathol 2015;8(7):7988-97. Epub 2015 Jul 1 PMID: 26339365Free PMC Article
Bernet V, Smallridge R
Expert Opin Emerg Drugs 2014 Jun;19(2):225-41. Epub 2014 Mar 3 doi: 10.1517/14728214.2014.894017. PMID: 24588376

Supplemental Content

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