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Advanced Carcinoma Of Unknown Primary

MedGen UID:
1754526
Concept ID:
C5418905
Neoplastic Process

Definition

A carcinoma of unknown primary that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdvanced Carcinoma Of Unknown Primary

Professional guidelines

PubMed

Mann H, Seligman K, Colwell N, Burr A, Glazer TA
Otolaryngol Clin North Am 2023 Apr;56(2):305-312. doi: 10.1016/j.otc.2022.11.001. PMID: 37030943
Provencio M, Ortega AL, Coves-Sarto J, Calvo V, Marsé-Fabregat R, Dómine M, Guirado M, Carcereny E, Fernández N, Álvarez R, Blanco R, León-Mateos L, Sánchez-Torres JM, Sullivan IG, Cobo M, Sánchez-Hernández A, Massuti B, Sierra-Rodero B, Mártinez-Toledo C, Serna-Blasco R, Romero A, Cruz-Bermúdez A
JAMA Oncol 2023 Mar 1;9(3):344-353. doi: 10.1001/jamaoncol.2022.5959. PMID: 36520426Free PMC Article
Chaudhari VA, Khobragade K, Bhandare M, Shrikhande SV
Chin Clin Oncol 2018 Oct;7(5):51. doi: 10.21037/cco.2018.08.08. PMID: 30395718

Recent clinical studies

Etiology

Choueiri TK, Powles T, Albiges L, Burotto M, Szczylik C, Zurawski B, Yanez Ruiz E, Maruzzo M, Suarez Zaizar A, Fein LE, Schutz FA, Heng DYC, Wang F, Mataveli F, Chang YL, van Kooten Losio M, Suarez C, Motzer RJ; COSMIC-313 Investigators
N Engl J Med 2023 May 11;388(19):1767-1778. doi: 10.1056/NEJMoa2212851. PMID: 37163623Free PMC Article
Kiyota N, Tahara M, Mizusawa J, Kodaira T, Fujii H, Yamazaki T, Mitani H, Iwae S, Fujimoto Y, Onozawa Y, Hanai N, Ogawa T, Hara H, Monden N, Shimura E, Minami S, Fujii T, Tanaka K, Homma A, Yoshimoto S, Oridate N, Omori K, Ueda T, Okami K, Ota I, Shiga K, Sugasawa M, Asakage T, Saito Y, Murono S, Nishimura Y, Nakamura K, Hayashi R; Head and Neck Cancer Study Group of the Japan Clinical Oncology Group (JCOG-HNCSG)
J Clin Oncol 2022 Jun 20;40(18):1980-1990. Epub 2022 Mar 1 doi: 10.1200/JCO.21.01293. PMID: 35230884Free PMC Article
Wu YL, Tsuboi M, He J, John T, Grohe C, Majem M, Goldman JW, Laktionov K, Kim SW, Kato T, Vu HV, Lu S, Lee KY, Akewanlop C, Yu CJ, de Marinis F, Bonanno L, Domine M, Shepherd FA, Zeng L, Hodge R, Atasoy A, Rukazenkov Y, Herbst RS; ADAURA Investigators
N Engl J Med 2020 Oct 29;383(18):1711-1723. Epub 2020 Sep 19 doi: 10.1056/NEJMoa2027071. PMID: 32955177
Bakst RL, Glastonbury CM, Parvathaneni U, Katabi N, Hu KS, Yom SS
Int J Radiat Oncol Biol Phys 2019 Apr 1;103(5):1109-1124. Epub 2018 Dec 15 doi: 10.1016/j.ijrobp.2018.12.009. PMID: 30562546
Huang SH, O'Sullivan B
Curr Treat Options Oncol 2017 Jul;18(7):40. doi: 10.1007/s11864-017-0484-y. PMID: 28555375

Diagnosis

Chu T, Meng Y, Wu P, Li Z, Wen H, Ren F, Zou D, Lu H, Wu L, Zhou S, Chen Y, Li J, Xu M, Wu X, Xiong X, Wang Z, He M, Zhang Y, Lin S, Cao C, Ding W, Chen Y, Zhi W, Peng T, Wei Y, Liu B, Xu Y, Ma D, Wang J, Sun C, Wu P
Lancet Oncol 2023 Jun;24(6):701-708. doi: 10.1016/S1470-2045(23)00185-7. PMID: 37269846
Petit C, Lacas B, Pignon JP, Le QT, Grégoire V, Grau C, Hackshaw A, Zackrisson B, Parmar MKB, Lee JW, Ghi MG, Sanguineti G, Temam S, Cheugoua-Zanetsie M, O'Sullivan B, Posner MR, Vokes EE, Cruz Hernandez JJ, Szutkowski Z, Lartigau E, Budach V, Suwiński R, Poulsen M, Kumar S, Ghosh Laskar S, Mazeron JJ, Jeremic B, Simes J, Zhong LP, Overgaard J, Fortpied C, Torres-Saavedra P, Bourhis J, Aupérin A, Blanchard P; MACH-NC and MARCH Collaborative Groups
Lancet Oncol 2021 May;22(5):727-736. Epub 2021 Apr 13 doi: 10.1016/S1470-2045(21)00076-0. PMID: 33862002
Ambrosini V, Kunikowska J, Baudin E, Bodei L, Bouvier C, Capdevila J, Cremonesi M, de Herder WW, Dromain C, Falconi M, Fani M, Fanti S, Hicks RJ, Kabasakal L, Kaltsas G, Lewington V, Minozzi S, Cinquini M, Öberg K, Oyen WJG, O'Toole D, Pavel M, Ruszniewski P, Scarpa A, Strosberg J, Sundin A, Taïeb D, Virgolini I, Wild D, Herrmann K, Yao J
Eur J Cancer 2021 Mar;146:56-73. Epub 2021 Feb 12 doi: 10.1016/j.ejca.2021.01.008. PMID: 33588146Free PMC Article
Ofri A, Moore K
Breast 2020 Dec;54:211-215. Epub 2020 Oct 27 doi: 10.1016/j.breast.2020.10.012. PMID: 33130487Free PMC Article
Huang SH, O'Sullivan B
Curr Treat Options Oncol 2017 Jul;18(7):40. doi: 10.1007/s11864-017-0484-y. PMID: 28555375

Therapy

Choueiri TK, Powles T, Albiges L, Burotto M, Szczylik C, Zurawski B, Yanez Ruiz E, Maruzzo M, Suarez Zaizar A, Fein LE, Schutz FA, Heng DYC, Wang F, Mataveli F, Chang YL, van Kooten Losio M, Suarez C, Motzer RJ; COSMIC-313 Investigators
N Engl J Med 2023 May 11;388(19):1767-1778. doi: 10.1056/NEJMoa2212851. PMID: 37163623Free PMC Article
Wu YL, Tsuboi M, He J, John T, Grohe C, Majem M, Goldman JW, Laktionov K, Kim SW, Kato T, Vu HV, Lu S, Lee KY, Akewanlop C, Yu CJ, de Marinis F, Bonanno L, Domine M, Shepherd FA, Zeng L, Hodge R, Atasoy A, Rukazenkov Y, Herbst RS; ADAURA Investigators
N Engl J Med 2020 Oct 29;383(18):1711-1723. Epub 2020 Sep 19 doi: 10.1056/NEJMoa2027071. PMID: 32955177
Drilon A, Oxnard GR, Tan DSW, Loong HHF, Johnson M, Gainor J, McCoach CE, Gautschi O, Besse B, Cho BC, Peled N, Weiss J, Kim YJ, Ohe Y, Nishio M, Park K, Patel J, Seto T, Sakamoto T, Rosen E, Shah MH, Barlesi F, Cassier PA, Bazhenova L, De Braud F, Garralda E, Velcheti V, Satouchi M, Ohashi K, Pennell NA, Reckamp KL, Dy GK, Wolf J, Solomon B, Falchook G, Ebata K, Nguyen M, Nair B, Zhu EY, Yang L, Huang X, Olek E, Rothenberg SM, Goto K, Subbiah V
N Engl J Med 2020 Aug 27;383(9):813-824. doi: 10.1056/NEJMoa2005653. PMID: 32846060Free PMC Article
Kelley RK, Bridgewater J, Gores GJ, Zhu AX
J Hepatol 2020 Feb;72(2):353-363. doi: 10.1016/j.jhep.2019.10.009. PMID: 31954497
Mok TS, Wu Y-L, Ahn M-J, Garassino MC, Kim HR, Ramalingam SS, Shepherd FA, He Y, Akamatsu H, Theelen WS, Lee CK, Sebastian M, Templeton A, Mann H, Marotti M, Ghiorghiu S, Papadimitrakopoulou VA; AURA3 Investigators
N Engl J Med 2017 Feb 16;376(7):629-640. Epub 2016 Dec 6 doi: 10.1056/NEJMoa1612674. PMID: 27959700Free PMC Article

Prognosis

Chu T, Meng Y, Wu P, Li Z, Wen H, Ren F, Zou D, Lu H, Wu L, Zhou S, Chen Y, Li J, Xu M, Wu X, Xiong X, Wang Z, He M, Zhang Y, Lin S, Cao C, Ding W, Chen Y, Zhi W, Peng T, Wei Y, Liu B, Xu Y, Ma D, Wang J, Sun C, Wu P
Lancet Oncol 2023 Jun;24(6):701-708. doi: 10.1016/S1470-2045(23)00185-7. PMID: 37269846
Choueiri TK, Powles T, Albiges L, Burotto M, Szczylik C, Zurawski B, Yanez Ruiz E, Maruzzo M, Suarez Zaizar A, Fein LE, Schutz FA, Heng DYC, Wang F, Mataveli F, Chang YL, van Kooten Losio M, Suarez C, Motzer RJ; COSMIC-313 Investigators
N Engl J Med 2023 May 11;388(19):1767-1778. doi: 10.1056/NEJMoa2212851. PMID: 37163623Free PMC Article
Kelley RK, Bridgewater J, Gores GJ, Zhu AX
J Hepatol 2020 Feb;72(2):353-363. doi: 10.1016/j.jhep.2019.10.009. PMID: 31954497
Bakst RL, Glastonbury CM, Parvathaneni U, Katabi N, Hu KS, Yom SS
Int J Radiat Oncol Biol Phys 2019 Apr 1;103(5):1109-1124. Epub 2018 Dec 15 doi: 10.1016/j.ijrobp.2018.12.009. PMID: 30562546
Huang SH, O'Sullivan B
Curr Treat Options Oncol 2017 Jul;18(7):40. doi: 10.1007/s11864-017-0484-y. PMID: 28555375

Clinical prediction guides

Chu T, Meng Y, Wu P, Li Z, Wen H, Ren F, Zou D, Lu H, Wu L, Zhou S, Chen Y, Li J, Xu M, Wu X, Xiong X, Wang Z, He M, Zhang Y, Lin S, Cao C, Ding W, Chen Y, Zhi W, Peng T, Wei Y, Liu B, Xu Y, Ma D, Wang J, Sun C, Wu P
Lancet Oncol 2023 Jun;24(6):701-708. doi: 10.1016/S1470-2045(23)00185-7. PMID: 37269846
Petit C, Lacas B, Pignon JP, Le QT, Grégoire V, Grau C, Hackshaw A, Zackrisson B, Parmar MKB, Lee JW, Ghi MG, Sanguineti G, Temam S, Cheugoua-Zanetsie M, O'Sullivan B, Posner MR, Vokes EE, Cruz Hernandez JJ, Szutkowski Z, Lartigau E, Budach V, Suwiński R, Poulsen M, Kumar S, Ghosh Laskar S, Mazeron JJ, Jeremic B, Simes J, Zhong LP, Overgaard J, Fortpied C, Torres-Saavedra P, Bourhis J, Aupérin A, Blanchard P; MACH-NC and MARCH Collaborative Groups
Lancet Oncol 2021 May;22(5):727-736. Epub 2021 Apr 13 doi: 10.1016/S1470-2045(21)00076-0. PMID: 33862002
Sequist LV, Han JY, Ahn MJ, Cho BC, Yu H, Kim SW, Yang JC, Lee JS, Su WC, Kowalski D, Orlov S, Cantarini M, Verheijen RB, Mellemgaard A, Ottesen L, Frewer P, Ou X, Oxnard G
Lancet Oncol 2020 Mar;21(3):373-386. Epub 2020 Feb 3 doi: 10.1016/S1470-2045(19)30785-5. PMID: 32027846
Haratani K, Hayashi H, Chiba Y, Kudo K, Yonesaka K, Kato R, Kaneda H, Hasegawa Y, Tanaka K, Takeda M, Nakagawa K
JAMA Oncol 2018 Mar 1;4(3):374-378. doi: 10.1001/jamaoncol.2017.2925. PMID: 28975219Free PMC Article
Huang SH, O'Sullivan B
Curr Treat Options Oncol 2017 Jul;18(7):40. doi: 10.1007/s11864-017-0484-y. PMID: 28555375

Recent systematic reviews

Chen AM
Radiother Oncol 2023 Dec;189:109952. Epub 2023 Oct 14 doi: 10.1016/j.radonc.2023.109952. PMID: 37844736
Rowell NP
Br J Radiol 2023 Aug;96(1148):20220660. Epub 2023 Jun 29 doi: 10.1259/bjr.20220660. PMID: 37335288Free PMC Article
Cameron LB, Hitchen N, Chandran E, Morris T, Manser R, Solomon BJ, Jordan V
Cochrane Database Syst Rev 2022 Jan 7;1(1):CD013453. doi: 10.1002/14651858.CD013453.pub2. PMID: 34994987Free PMC Article
Ferrara R, Imbimbo M, Malouf R, Paget-Bailly S, Calais F, Marchal C, Westeel V
Cochrane Database Syst Rev 2021 Apr 30;4(4):CD013257. doi: 10.1002/14651858.CD013257.pub3. PMID: 33930176Free PMC Article
Ferrara R, Imbimbo M, Malouf R, Paget-Bailly S, Calais F, Marchal C, Westeel V
Cochrane Database Syst Rev 2020 Dec 14;12(12):CD013257. doi: 10.1002/14651858.CD013257.pub2. PMID: 33316104Free PMC Article

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