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Increased risk of AML

MedGen UID:
1759111
•Concept ID:
C5435576
•
Finding

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased risk of AML

Professional guidelines

PubMed

Lenalidomide treatment of Japanese patients with myelodysplastic syndromes with 5q deletion: a post-marketing surveillance study.
Uno S, Motegi Y, Minehata K, Aoki Y
Int J Hematol 2023 Oct;118(4):432-442. Epub 2023 Jul 26 doi: 10.1007/s12185-023-03634-7. PMID: 37493867Free PMC Article
Risk for the development of treatment-related acute myelocytic leukemia and myelodysplastic syndrome among patients with breast cancer: review of the literature and the National Surgical Adjuvant Breast and Bowel Project experience.
Smith RE
Clin Breast Cancer 2003 Oct;4(4):273-9. doi: 10.3816/cbc.2003.n.032. PMID: 14651772
Risk of acute myelogenous leukaemia and myelodysplasia following cancer treatment.
van Leeuwen FE
Baillieres Clin Haematol 1996 Mar;9(1):57-85. doi: 10.1016/s0950-3536(96)80037-0. PMID: 8730551

Recent clinical studies

Etiology

An inflammatory state remodels the immune microenvironment and improves risk stratification in acute myeloid leukemia.
Lasry A, Nadorp B, Fornerod M, Nicolet D, Wu H, Walker CJ, Sun Z, Witkowski MT, Tikhonova AN, Guillamot-Ruano M, Cayanan G, Yeaton A, Robbins G, Obeng EA, Tsirigos A, Stone RM, Byrd JC, Pounds S, Carroll WL, Gruber TA, Eisfeld AK, Aifantis I
Nat Cancer 2023 Jan;4(1):27-42. Epub 2022 Dec 29 doi: 10.1038/s43018-022-00480-0. PMID: 36581735Free PMC Article
Comparison and validation of the 2022 European LeukemiaNet guidelines in acute myeloid leukemia.
Lachowiez CA, Long N, Saultz J, Gandhi A, Newell LF, Hayes-Lattin B, Maziarz RT, Leonard J, Bottomly D, McWeeney S, Dunlap J, Press R, Meyers G, Swords R, Cook RJ, Tyner JW, Druker BJ, Traer E
Blood Adv 2023 May 9;7(9):1899-1909. doi: 10.1182/bloodadvances.2022009010. PMID: 36441905Free PMC Article
Updates in infection risk and management in acute leukemia.
Logan C, Koura D, Taplitz R
Hematology Am Soc Hematol Educ Program 2020 Dec 4;2020(1):135-139. doi: 10.1182/hematology.2020000098. PMID: 33275701Free PMC Article
Myelodysplastic syndromes: 2021 update on diagnosis, risk stratification and management.
Garcia-Manero G, Chien KS, Montalban-Bravo G
Am J Hematol 2020 Nov;95(11):1399-1420. doi: 10.1002/ajh.25950. PMID: 32744763
Hematopoietic stem cell transplantation for acute myeloid leukemia.
Takami A
Int J Hematol 2018 May;107(5):513-518. Epub 2018 Jan 27 doi: 10.1007/s12185-018-2412-8. PMID: 29374826

Diagnosis

Prognostic Value of FLT3-Internal Tandem Duplication Residual Disease in Acute Myeloid Leukemia.
Grob T, Sanders MA, Vonk CM, Kavelaars FG, Rijken M, Hanekamp DW, Gradowska PL, Cloos J, Fløisand Y, van Marwijk Kooy M, Manz MG, Ossenkoppele GJ, Tick LW, Havelange V, Löwenberg B, Jongen-Lavrencic M, Valk PJM
J Clin Oncol 2023 Feb 1;41(4):756-765. Epub 2022 Oct 31 doi: 10.1200/JCO.22.00715. PMID: 36315929Free PMC Article
Myelodysplastic syndromes.
Li H, Hu F, Gale RP, Sekeres MA, Liang Y
Nat Rev Dis Primers 2022 Nov 17;8(1):74. doi: 10.1038/s41572-022-00402-5. PMID: 36396662
Diagnosis and Treatment of Myelodysplastic Syndromes: A Review.
Sekeres MA, Taylor J
JAMA 2022 Sep 6;328(9):872-880. doi: 10.1001/jama.2022.14578. PMID: 36066514
Myelodysplastic syndromes: 2021 update on diagnosis, risk stratification and management.
Garcia-Manero G, Chien KS, Montalban-Bravo G
Am J Hematol 2020 Nov;95(11):1399-1420. doi: 10.1002/ajh.25950. PMID: 32744763
How I investigate acute myeloid leukemia.
Narayanan D, Weinberg OK
Int J Lab Hematol 2020 Feb;42(1):3-15. Epub 2019 Dec 10 doi: 10.1111/ijlh.13135. PMID: 31820579

Therapy

Management of Down Syndrome-Associated Leukemias: A Review.
Verma A, Lupo PJ, Shah NN, Hitzler J, Rabin KR
JAMA Oncol 2023 Sep 1;9(9):1283-1290. doi: 10.1001/jamaoncol.2023.2163. PMID: 37440251
Myelodysplastic syndromes: 2023 update on diagnosis, risk-stratification, and management.
Garcia-Manero G
Am J Hematol 2023 Aug;98(8):1307-1325. Epub 2023 Jun 8 doi: 10.1002/ajh.26984. PMID: 37288607
Updates in infection risk and management in acute leukemia.
Logan C, Koura D, Taplitz R
Hematology Am Soc Hematol Educ Program 2020 Dec 4;2020(1):135-139. doi: 10.1182/hematology.2020000098. PMID: 33275701Free PMC Article
Myelodysplastic syndromes: 2021 update on diagnosis, risk stratification and management.
Garcia-Manero G, Chien KS, Montalban-Bravo G
Am J Hematol 2020 Nov;95(11):1399-1420. doi: 10.1002/ajh.25950. PMID: 32744763
Hematopoietic stem cell transplantation for acute myeloid leukemia.
Takami A
Int J Hematol 2018 May;107(5):513-518. Epub 2018 Jan 27 doi: 10.1007/s12185-018-2412-8. PMID: 29374826

Prognosis

Comparison and validation of the 2022 European LeukemiaNet guidelines in acute myeloid leukemia.
Lachowiez CA, Long N, Saultz J, Gandhi A, Newell LF, Hayes-Lattin B, Maziarz RT, Leonard J, Bottomly D, McWeeney S, Dunlap J, Press R, Meyers G, Swords R, Cook RJ, Tyner JW, Druker BJ, Traer E
Blood Adv 2023 May 9;7(9):1899-1909. doi: 10.1182/bloodadvances.2022009010. PMID: 36441905Free PMC Article
Myelodysplastic syndromes: 2021 update on diagnosis, risk stratification and management.
Garcia-Manero G, Chien KS, Montalban-Bravo G
Am J Hematol 2020 Nov;95(11):1399-1420. doi: 10.1002/ajh.25950. PMID: 32744763
The global burden and attributable risk factor analysis of acute myeloid leukemia in 195 countries and territories from 1990 to 2017: estimates based on the global burden of disease study 2017.
Yi M, Li A, Zhou L, Chu Q, Song Y, Wu K
J Hematol Oncol 2020 Jun 8;13(1):72. doi: 10.1186/s13045-020-00908-z. PMID: 32513227Free PMC Article
Prediction of acute myeloid leukaemia risk in healthy individuals.
Abelson S, Collord G, Ng SWK, Weissbrod O, Mendelson Cohen N, Niemeyer E, Barda N, Zuzarte PC, Heisler L, Sundaravadanam Y, Luben R, Hayat S, Wang TT, Zhao Z, Cirlan I, Pugh TJ, Soave D, Ng K, Latimer C, Hardy C, Raine K, Jones D, Hoult D, Britten A, McPherson JD, Johansson M, Mbabaali F, Eagles J, Miller JK, Pasternack D, Timms L, Krzyzanowski P, Awadalla P, Costa R, Segal E, Bratman SV, Beer P, Behjati S, Martincorena I, Wang JCY, Bowles KM, Quirós JR, Karakatsani A, La Vecchia C, Trichopoulou A, Salamanca-Fernández E, Huerta JM, Barricarte A, Travis RC, Tumino R, Masala G, Boeing H, Panico S, Kaaks R, Krämer A, Sieri S, Riboli E, Vineis P, Foll M, McKay J, Polidoro S, Sala N, Khaw KT, Vermeulen R, Campbell PJ, Papaemmanuil E, Minden MD, Tanay A, Balicer RD, Wareham NJ, Gerstung M, Dick JE, Brennan P, Vassiliou GS, Shlush LI
Nature 2018 Jul;559(7714):400-404. Epub 2018 Jul 9 doi: 10.1038/s41586-018-0317-6. PMID: 29988082Free PMC Article
Glyphosate Use and Cancer Incidence in the Agricultural Health Study.
Andreotti G, Koutros S, Hofmann JN, Sandler DP, Lubin JH, Lynch CF, Lerro CC, De Roos AJ, Parks CG, Alavanja MC, Silverman DT, Beane Freeman LE
J Natl Cancer Inst 2018 May 1;110(5):509-516. doi: 10.1093/jnci/djx233. PMID: 29136183Free PMC Article

Clinical prediction guides

Myelodysplastic syndromes: 2023 update on diagnosis, risk-stratification, and management.
Garcia-Manero G
Am J Hematol 2023 Aug;98(8):1307-1325. Epub 2023 Jun 8 doi: 10.1002/ajh.26984. PMID: 37288607
An inflammatory state remodels the immune microenvironment and improves risk stratification in acute myeloid leukemia.
Lasry A, Nadorp B, Fornerod M, Nicolet D, Wu H, Walker CJ, Sun Z, Witkowski MT, Tikhonova AN, Guillamot-Ruano M, Cayanan G, Yeaton A, Robbins G, Obeng EA, Tsirigos A, Stone RM, Byrd JC, Pounds S, Carroll WL, Gruber TA, Eisfeld AK, Aifantis I
Nat Cancer 2023 Jan;4(1):27-42. Epub 2022 Dec 29 doi: 10.1038/s43018-022-00480-0. PMID: 36581735Free PMC Article
Myelodysplastic syndromes.
Li H, Hu F, Gale RP, Sekeres MA, Liang Y
Nat Rev Dis Primers 2022 Nov 17;8(1):74. doi: 10.1038/s41572-022-00402-5. PMID: 36396662
Diagnosis and Treatment of Myelodysplastic Syndromes: A Review.
Sekeres MA, Taylor J
JAMA 2022 Sep 6;328(9):872-880. doi: 10.1001/jama.2022.14578. PMID: 36066514
Myelodysplastic syndromes: 2021 update on diagnosis, risk stratification and management.
Garcia-Manero G, Chien KS, Montalban-Bravo G
Am J Hematol 2020 Nov;95(11):1399-1420. doi: 10.1002/ajh.25950. PMID: 32744763

Recent systematic reviews

Prognosis of older patients with newly diagnosed AML undergoing antileukemic therapy: A systematic review.
Hao Q, Foroutan F, Han MA, Devji T, Nampo FK, Mukherjee S, Alibhai SMH, Rosko A, Sekeres MA, Guyatt GH, Brignardello-Petersen R
PLoS One 2022;17(12):e0278578. Epub 2022 Dec 5 doi: 10.1371/journal.pone.0278578. PMID: 36469519Free PMC Article
Increased circulating vascular endothelial growth factor in acute myeloid leukemia patients: a systematic review and meta-analysis.
Song M, Wang H, Ye Q
Syst Rev 2020 May 6;9(1):103. doi: 10.1186/s13643-020-01368-9. PMID: 32375879Free PMC Article
A systematic review on the use of exercise interventions for individuals with myeloid leukemia.
Smith-Turchyn J, Richardson J
Support Care Cancer 2015 Aug;23(8):2435-46. Epub 2015 May 7 doi: 10.1007/s00520-015-2752-3. PMID: 25947256
Exposure to benzene at work and the risk of leukemia: a systematic review and meta-analysis.
Khalade A, Jaakkola MS, Pukkala E, Jaakkola JJ
Environ Health 2010 Jun 28;9:31. doi: 10.1186/1476-069X-9-31. PMID: 20584305Free PMC Article
A systematic review of myeloid leukemias and occupational pesticide exposure.
Van Maele-Fabry G, Duhayon S, Lison D
Cancer Causes Control 2007 Jun;18(5):457-78. Epub 2007 Apr 18 doi: 10.1007/s10552-007-0122-2. PMID: 17443416

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