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Metastatic Glioblastoma

MedGen UID:: 1762790
•Concept ID:: C5418922
•: Neoplastic Process

Definition

Glioblastoma that has spread from its original site of growth to another anatomic site. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVMetastatic Glioblastoma

Pathological process
- Disease
  - Neoplasm
    - Malignant neoplastic disease
      - Anaplastic cancer
        Glioblastoma multiforme
        Metastatic Glioblastoma
        Advanced Glioblastoma
        Locally Advanced Glioblastoma

Professional guidelines

PubMed

The evolving role of reirradiation in the management of recurrent brain tumors.

De Pietro R, Zaccaro L, Marampon F, Tini P, De Felice F, Minniti G
J Neurooncol 2023 Sep;164(2):271-286. Epub 2023 Aug 25 doi: 10.1007/s11060-023-04407-2. PMID: 37624529 Free PMC Article

Biomarkers for immunotherapy for treatment of glioblastoma.

Lynes JP, Nwankwo AK, Sur HP, Sanchez VE, Sarpong KA, Ariyo OI, Dominah GA, Nduom EK
J Immunother Cancer 2020 May;8(1) doi: 10.1136/jitc-2019-000348. PMID: 32474411 Free PMC Article

Bevacizumab (Avastin®) in cancer treatment: A review of 15 years of clinical experience and future outlook.

Garcia J, Hurwitz HI, Sandler AB, Miles D, Coleman RL, Deurloo R, Chinot OL
Cancer Treat Rev 2020 Jun;86:102017. Epub 2020 Mar 26 doi: 10.1016/j.ctrv.2020.102017. PMID: 32335505

See all (149)

Recent clinical studies

Etiology

Extracranial metastasis of brain glioblastoma outside CNS: Pathogenesis revisited.

Kurdi M, Baeesa S, Okal F, Bamaga AK, Faizo E, Fathaddin AA, Alkhotani A, Karami MM, Bahakeem B
Cancer Rep (Hoboken) 2023 Dec;6(12):e1905. Epub 2023 Oct 9 doi: 10.1002/cnr2.1905. PMID: 37814403 Free PMC Article

Evaluation of prognostic integrin α2β1 PET tracer and concurrent targeting delivery using focused ultrasound for brain glioma detection.

Chung YH, Hsu PH, Huang CW, Hsieh WC, Huang FT, Chang WC, Chiu H, Hsu ST, Yen TC
Mol Pharm 2014 Nov 3;11(11):3904-14. Epub 2014 Aug 25 doi: 10.1021/mp500296n. PMID: 25153169

Extraneural metastatic glioblastoma after interstitial brachytherapy.

Houston SC, Crocker IR, Brat DJ, Olson JJ
Int J Radiat Oncol Biol Phys 2000 Oct 1;48(3):831-6. doi: 10.1016/s0360-3016(00)00662-3. PMID: 11020581

See all (3)

Diagnosis

Extracranial metastasis of brain glioblastoma outside CNS: Pathogenesis revisited.

Primary and metastatic glioblastoma of the spine in the pediatric population: a systematic review.

Yang R, Isaacs AM, Cadieux M, Hirmer TJ, CreveCoeur TS, Lapointe AP, Opoku-Darko M, Premji Z, Riva-Cambrin J, Gallagher CN
Childs Nerv Syst 2021 Jun;37(6):1849-1858. Epub 2021 Mar 6 doi: 10.1007/s00381-021-05098-8. PMID: 33675391

Solitary vertebral metastatic glioblastoma in the absence of primary brain tumor relapse: a case report and literature review.

Li ZG, Zheng MY, Zhao Q, Liu K, Du JX, Zhang SW
BMC Med Imaging 2020 Jul 31;20(1):89. doi: 10.1186/s12880-020-00488-x. PMID: 32736607 Free PMC Article

Genetic and histologic spatiotemporal evolution of recurrent, multifocal, multicentric and metastatic glioblastoma.

Georgescu MM, Olar A
Acta Neuropathol Commun 2020 Feb 3;8(1):10. doi: 10.1186/s40478-020-0889-x. PMID: 32014051 Free PMC Article

Widely metastatic glioblastoma with BRCA1 and ARID1A mutations: a case report.

Umphlett M, Shea S, Tome-Garcia J, Zhang Y, Hormigo A, Fowkes M, Tsankova NM, Yong RL
BMC Cancer 2020 Jan 20;20(1):47. doi: 10.1186/s12885-020-6540-1. PMID: 31959133 Free PMC Article

See all (20)

Therapy

Solitary vertebral metastatic glioblastoma in the absence of primary brain tumor relapse: a case report and literature review.

Li ZG, Zheng MY, Zhao Q, Liu K, Du JX, Zhang SW
BMC Med Imaging 2020 Jul 31;20(1):89. doi: 10.1186/s12880-020-00488-x. PMID: 32736607 Free PMC Article

Widely metastatic glioblastoma with BRCA1 and ARID1A mutations: a case report.

Umphlett M, Shea S, Tome-Garcia J, Zhang Y, Hormigo A, Fowkes M, Tsankova NM, Yong RL
BMC Cancer 2020 Jan 20;20(1):47. doi: 10.1186/s12885-020-6540-1. PMID: 31959133 Free PMC Article

Cytological diagnosis of metastatic glioblastoma in the pleural effusion of a lung transplant patient.

Nauen DW, Li QK
Diagn Cytopathol 2014 Jul;42(7):619-23. Epub 2013 Apr 3 doi: 10.1002/dc.22993. PMID: 23554289

Radiotherapy and bevacizumab for intramedullary and leptomenigeal metastatic glioblastoma: a case report and review of the literature.

Fiorentino A, Caivano R, Chiumento C, Cozzolino M, Fusco V
Int J Neurosci 2012 Nov;122(11):691-4. Epub 2012 Aug 8 doi: 10.3109/00207454.2012.704456. PMID: 22720749

Extraneural metastatic glioblastoma after interstitial brachytherapy.

Houston SC, Crocker IR, Brat DJ, Olson JJ
Int J Radiat Oncol Biol Phys 2000 Oct 1;48(3):831-6. doi: 10.1016/s0360-3016(00)00662-3. PMID: 11020581

See all (7)

Prognosis

Extracranial metastasis of brain glioblastoma outside CNS: Pathogenesis revisited.

Management of Glioblastoma Metastatic to the Vertebral Spine.

Hersh AM, Lubelski D, Theodore N
World Neurosurg 2022 May;161:52-53. Epub 2022 Jan 26 doi: 10.1016/j.wneu.2022.01.074. PMID: 35091107

Primary and metastatic glioblastoma of the spine in the pediatric population: a systematic review.

Solitary vertebral metastatic glioblastoma in the absence of primary brain tumor relapse: a case report and literature review.

Li ZG, Zheng MY, Zhao Q, Liu K, Du JX, Zhang SW
BMC Med Imaging 2020 Jul 31;20(1):89. doi: 10.1186/s12880-020-00488-x. PMID: 32736607 Free PMC Article

Subcutaneous tissue metastasis from glioblastoma multiforme: A case report and review of the literature.

Frade Porto N, Delgado Fernández J, García Pallero MLÁ, Penanes Cuesta JR, Pulido Rivas P, Gil Simoes R
Neurocirugia (Astur : Engl Ed) 2019 May-Jun;30(3):149-154. Epub 2018 May 16 doi: 10.1016/j.neucir.2018.03.005. PMID: 29778285

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Clinical prediction guides

Concurrence of chromosome 6 chromothripsis and glioblastoma metastasis.

Rennert RC, Hoshide RR, Signorelli JW, Amaro D, Sack JA, Brennan CW, Chen CC
J Neurosurg 2017 May;126(5):1472-1478. Epub 2016 Jul 22 doi: 10.3171/2016.4.JNS153052. PMID: 27447440

Malignant melanoma mimicking giant cell variant of glioblastoma multiforme: a case report and review of literature.

Arcega R, Yong WH, Xu H
Int J Clin Exp Pathol 2015;8(5):5929-33. Epub 2015 May 1 PMID: 26191321 Free PMC Article

Systemic metastasis in glioblastoma may represent the emergence of neoplastic subclones.

Park CC, Hartmann C, Folkerth R, Loeffler JS, Wen PY, Fine HA, Black PM, Shafman T, Louis DN
J Neuropathol Exp Neurol 2000 Dec;59(12):1044-50. doi: 10.1093/jnen/59.12.1044. PMID: 11138924

High levels of gelatinase-B and active gelatinase-A in metastatic glioblastoma.

Forsyth PA, Laing TD, Gibson AW, Rewcastle NB, Brasher P, Sutherland G, Johnston RN, Edwards DR
J Neurooncol 1998 Jan;36(1):21-9. doi: 10.1023/a:1005879027267. PMID: 9525822

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Recent systematic reviews

Bone metastasis from glioblastoma: a systematic review.

Strong MJ, Koduri S, Allison JA, Pesavento CM, Ogunsola S, Ogunsola O, Yee TJ, Khalsa SSS, Saadeh YS, Joseph JR, Kashlan ON, Park P, Oppenlander ME, Szerlip NJ
J Neurooncol 2022 Jul;158(3):379-392. Epub 2022 May 17 doi: 10.1007/s11060-022-04025-4. PMID: 35578056

Primary and metastatic glioblastoma of the spine in the pediatric population: a systematic review.

See all (2)

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Metastatic Glioblastoma

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Practice guidelines

Recent activity