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Unresectable Large Cell Neuroendocrine Carcinoma

MedGen UID:
1766894
•Concept ID:
C5419871
•
Neoplastic Process

Definition

Large cell neuroendocrine carcinoma that is not amenable to surgical resection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUnresectable Large Cell Neuroendocrine Carcinoma

Professional guidelines

PubMed

Management of Localized Small- and Large-Cell Pancreatic Neuroendocrine Carcinoma in the National Cancer Database.
Sugawara T, Rodriguez Franco S, Franklin O, Kirsch MJ, Colborn KL, Del Chiaro M, Schulick RD
J Am Coll Surg 2023 Sep 1;237(3):515-524. Epub 2023 May 5 doi: 10.1097/XCS.0000000000000735. PMID: 37146214
Neuroendocrine Tumors of the Lung: Current Challenges and Advances in the Diagnosis and Management of Well-Differentiated Disease.
Hendifar AE, Marchevsky AM, Tuli R
J Thorac Oncol 2017 Mar;12(3):425-436. Epub 2016 Nov 24 doi: 10.1016/j.jtho.2016.11.2222. PMID: 27890494
Advances in the Diagnosis and Management of Well-Differentiated and Intermediate-Differentiated Neuroendocrine Tumors of the Lung.
Wolin EM
Chest 2017 May;151(5):1141-1146. Epub 2016 Jun 29 doi: 10.1016/j.chest.2016.06.018. PMID: 27373769

Recent clinical studies

Etiology

Management of Localized Small- and Large-Cell Pancreatic Neuroendocrine Carcinoma in the National Cancer Database.
Sugawara T, Rodriguez Franco S, Franklin O, Kirsch MJ, Colborn KL, Del Chiaro M, Schulick RD
J Am Coll Surg 2023 Sep 1;237(3):515-524. Epub 2023 May 5 doi: 10.1097/XCS.0000000000000735. PMID: 37146214
Neuroendocrine Tumors of the Lung: Current Challenges and Advances in the Diagnosis and Management of Well-Differentiated Disease.
Hendifar AE, Marchevsky AM, Tuli R
J Thorac Oncol 2017 Mar;12(3):425-436. Epub 2016 Nov 24 doi: 10.1016/j.jtho.2016.11.2222. PMID: 27890494
Advances in the Diagnosis and Management of Well-Differentiated and Intermediate-Differentiated Neuroendocrine Tumors of the Lung.
Wolin EM
Chest 2017 May;151(5):1141-1146. Epub 2016 Jun 29 doi: 10.1016/j.chest.2016.06.018. PMID: 27373769
Clinical features of unresectable high-grade lung neuroendocrine carcinoma diagnosed using biopsy specimens.
Shimada Y, Niho S, Ishii G, Hishida T, Yoshida J, Nishimura M, Yoh K, Goto K, Ohmatsu H, Ohe Y, Nagai K
Lung Cancer 2012 Mar;75(3):368-73. Epub 2011 Sep 13 doi: 10.1016/j.lungcan.2011.08.012. PMID: 21920624
Primary carcinoid tumors of the lung: a role for radiotherapy.
Mackley HB, Videtic GM
Oncology (Williston Park) 2006 Nov;20(12):1537-43; discussion 1544-5, 1549. PMID: 17153907

Diagnosis

Adult pancreatoblastoma: Current concepts in pathology.
Omiyale AO
World J Gastroenterol 2021 Jul 14;27(26):4172-4181. doi: 10.3748/wjg.v27.i26.4172. PMID: 34326617Free PMC Article
Biliary tract large cell neuroendocrine carcinoma: current evidence.
Raiker R, Chauhan A, Hasanein H, Burkeen G, Horn M, Veedu J, Vela C, Arnold S, Kolesar J, Anthony L, Evers BM, Cavnar M
Orphanet J Rare Dis 2019 Nov 21;14(1):266. doi: 10.1186/s13023-019-1230-2. PMID: 31752927Free PMC Article
Neuroendocrine Tumors of the Lung: Current Challenges and Advances in the Diagnosis and Management of Well-Differentiated Disease.
Hendifar AE, Marchevsky AM, Tuli R
J Thorac Oncol 2017 Mar;12(3):425-436. Epub 2016 Nov 24 doi: 10.1016/j.jtho.2016.11.2222. PMID: 27890494
Advances in the Diagnosis and Management of Well-Differentiated and Intermediate-Differentiated Neuroendocrine Tumors of the Lung.
Wolin EM
Chest 2017 May;151(5):1141-1146. Epub 2016 Jun 29 doi: 10.1016/j.chest.2016.06.018. PMID: 27373769
The spectrum of neuroendocrine tumors: histologic classification, unique features and areas of overlap.
Klimstra DS, Beltran H, Lilenbaum R, Bergsland E
Am Soc Clin Oncol Educ Book 2015:92-103. doi: 10.14694/EdBook_AM.2015.35.92. PMID: 25993147

Therapy

Avelumab in unresectable/metastatic, progressive, grade 2-3 neuroendocrine neoplasms (NENs): Combined results from NET-001 and NET-002 trials.
Chan DL, Rodriguez-Freixinos V, Doherty M, Wasson K, Iscoe N, Raskin W, Hallet J, Myrehaug S, Law C, Thawer A, Nguyen K, Singh S
Eur J Cancer 2022 Jul;169:74-81. Epub 2022 May 2 doi: 10.1016/j.ejca.2022.03.029. PMID: 35504244
Neuroendocrine Tumors of the Lung: Current Challenges and Advances in the Diagnosis and Management of Well-Differentiated Disease.
Hendifar AE, Marchevsky AM, Tuli R
J Thorac Oncol 2017 Mar;12(3):425-436. Epub 2016 Nov 24 doi: 10.1016/j.jtho.2016.11.2222. PMID: 27890494
Advances in the Diagnosis and Management of Well-Differentiated and Intermediate-Differentiated Neuroendocrine Tumors of the Lung.
Wolin EM
Chest 2017 May;151(5):1141-1146. Epub 2016 Jun 29 doi: 10.1016/j.chest.2016.06.018. PMID: 27373769
Challenges in the Diagnosis and Management of Well-Differentiated Neuroendocrine Tumors of the Lung (Typical and Atypical Carcinoid): Current Status and Future Considerations.
Wolin EM
Oncologist 2015 Oct;20(10):1123-31. Epub 2015 Aug 25 doi: 10.1634/theoncologist.2015-0198. PMID: 26306904Free PMC Article
Clinical features of unresectable high-grade lung neuroendocrine carcinoma diagnosed using biopsy specimens.
Shimada Y, Niho S, Ishii G, Hishida T, Yoshida J, Nishimura M, Yoh K, Goto K, Ohmatsu H, Ohe Y, Nagai K
Lung Cancer 2012 Mar;75(3):368-73. Epub 2011 Sep 13 doi: 10.1016/j.lungcan.2011.08.012. PMID: 21920624

Prognosis

Biliary tract large cell neuroendocrine carcinoma: current evidence.
Raiker R, Chauhan A, Hasanein H, Burkeen G, Horn M, Veedu J, Vela C, Arnold S, Kolesar J, Anthony L, Evers BM, Cavnar M
Orphanet J Rare Dis 2019 Nov 21;14(1):266. doi: 10.1186/s13023-019-1230-2. PMID: 31752927Free PMC Article
Neuroendocrine Tumors of the Lung: Current Challenges and Advances in the Diagnosis and Management of Well-Differentiated Disease.
Hendifar AE, Marchevsky AM, Tuli R
J Thorac Oncol 2017 Mar;12(3):425-436. Epub 2016 Nov 24 doi: 10.1016/j.jtho.2016.11.2222. PMID: 27890494
Advances in the Diagnosis and Management of Well-Differentiated and Intermediate-Differentiated Neuroendocrine Tumors of the Lung.
Wolin EM
Chest 2017 May;151(5):1141-1146. Epub 2016 Jun 29 doi: 10.1016/j.chest.2016.06.018. PMID: 27373769
The spectrum of neuroendocrine tumors: histologic classification, unique features and areas of overlap.
Klimstra DS, Beltran H, Lilenbaum R, Bergsland E
Am Soc Clin Oncol Educ Book 2015:92-103. doi: 10.14694/EdBook_AM.2015.35.92. PMID: 25993147
Clinical features of unresectable high-grade lung neuroendocrine carcinoma diagnosed using biopsy specimens.
Shimada Y, Niho S, Ishii G, Hishida T, Yoshida J, Nishimura M, Yoh K, Goto K, Ohmatsu H, Ohe Y, Nagai K
Lung Cancer 2012 Mar;75(3):368-73. Epub 2011 Sep 13 doi: 10.1016/j.lungcan.2011.08.012. PMID: 21920624

Clinical prediction guides

Avelumab in unresectable/metastatic, progressive, grade 2-3 neuroendocrine neoplasms (NENs): Combined results from NET-001 and NET-002 trials.
Chan DL, Rodriguez-Freixinos V, Doherty M, Wasson K, Iscoe N, Raskin W, Hallet J, Myrehaug S, Law C, Thawer A, Nguyen K, Singh S
Eur J Cancer 2022 Jul;169:74-81. Epub 2022 May 2 doi: 10.1016/j.ejca.2022.03.029. PMID: 35504244
Association Between Programmed Death-Ligand 1 Expression and Clinicopathological Characteristics, Structural Recurrence, and Biochemical Recurrence/Persistent Disease in Medullary Thyroid Carcinoma.
Shi X, Yu PC, Lei BW, Li CW, Zhang Y, Tan LC, Shi RL, Wang J, Ma B, Xu WB, Wang X, Hu JQ, Huang NS, Wei WJ, Wang Y, Chen TZ, Wang YL, Ji QH
Thyroid 2019 Sep;29(9):1269-1278. Epub 2019 Aug 19 doi: 10.1089/thy.2019.0079. PMID: 31328653
Survival outcomes and incidence of brain recurrence in high-grade neuroendocrine carcinomas of the lung: Implications for clinical practice.
Metro G, Ricciuti B, Chiari R, Baretti M, Falcinelli L, Giannarelli D, Sidoni A, Mountzios G, Crinò L, Bellezza G, Rebonato A, Ferolla P, Toschi L
Lung Cancer 2016 May;95:82-7. Epub 2016 Mar 15 doi: 10.1016/j.lungcan.2016.03.006. PMID: 27040856

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