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Advanced Adenocarcinoma of Unknown Primary

MedGen UID:
1771720
Concept ID:
C5418904
Neoplastic Process

Definition

An adenocarcinoma of unknown primary that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdvanced Adenocarcinoma of Unknown Primary

Professional guidelines

PubMed

Ota I, Kitahara T
Auris Nasus Larynx 2021 Feb;48(1):23-31. Epub 2020 Sep 1 doi: 10.1016/j.anl.2020.08.014. PMID: 32888761
Qian XH, Yan YC, Gao BQ, Wang WL
World J Gastroenterol 2020 Oct 28;26(40):6195-6206. doi: 10.3748/wjg.v26.i40.6195. PMID: 33177793Free PMC Article
Chaudhari VA, Khobragade K, Bhandare M, Shrikhande SV
Chin Clin Oncol 2018 Oct;7(5):51. doi: 10.21037/cco.2018.08.08. PMID: 30395718

Recent clinical studies

Etiology

Gao X, Xu N, Li Z, Shen L, Ji K, Zheng Z, Liu D, Lou H, Bai L, Liu T, Li Y, Li Y, Fan Q, Feng M, Zhong H, Huang Y, Lou G, Wang J, Lin X, Chen Y, An R, Li C, Zhou Q, Huang X, Guo Z, Wang S, Li G, Fei J, Zhu L, Zhu H, Li X, Li F, Liao S, Min Q, Tang L, Shan F, Gong J, Gao Y, Zhou J, Lu Z, Li X, Li J, Ren H, Liu X, Yang H, Li W, Song W, Wang ZM, Li B, Xia M, Wu X, Ji J
Lancet Oncol 2023 Oct;24(10):1134-1146. doi: 10.1016/S1470-2045(23)00411-4. PMID: 37797632
Choueiri TK, Powles T, Albiges L, Burotto M, Szczylik C, Zurawski B, Yanez Ruiz E, Maruzzo M, Suarez Zaizar A, Fein LE, Schutz FA, Heng DYC, Wang F, Mataveli F, Chang YL, van Kooten Losio M, Suarez C, Motzer RJ; COSMIC-313 Investigators
N Engl J Med 2023 May 11;388(19):1767-1778. doi: 10.1056/NEJMoa2212851. PMID: 37163623Free PMC Article
Cameron LB, Hitchen N, Chandran E, Morris T, Manser R, Solomon BJ, Jordan V
Cochrane Database Syst Rev 2022 Jan 7;1(1):CD013453. doi: 10.1002/14651858.CD013453.pub2. PMID: 34994987Free PMC Article
Bakst RL, Glastonbury CM, Parvathaneni U, Katabi N, Hu KS, Yom SS
Int J Radiat Oncol Biol Phys 2019 Apr 1;103(5):1109-1124. Epub 2018 Dec 15 doi: 10.1016/j.ijrobp.2018.12.009. PMID: 30562546
Solomon BJ, Mok T, Kim DW, Wu YL, Nakagawa K, Mekhail T, Felip E, Cappuzzo F, Paolini J, Usari T, Iyer S, Reisman A, Wilner KD, Tursi J, Blackhall F; PROFILE 1014 Investigators
N Engl J Med 2014 Dec 4;371(23):2167-77. doi: 10.1056/NEJMoa1408440. PMID: 25470694

Diagnosis

Krstić MN, Mijač D, Tomašević RS, Lukić S, Stojković Lalošević M, Krstić JM, Milosavljević T
Dig Dis 2022;40(2):206-214. Epub 2021 May 10 doi: 10.1159/000517110. PMID: 33971644
Ota I, Kitahara T
Auris Nasus Larynx 2021 Feb;48(1):23-31. Epub 2020 Sep 1 doi: 10.1016/j.anl.2020.08.014. PMID: 32888761
Qian XH, Yan YC, Gao BQ, Wang WL
World J Gastroenterol 2020 Oct 28;26(40):6195-6206. doi: 10.3748/wjg.v26.i40.6195. PMID: 33177793Free PMC Article
Chaudhari VA, Khobragade K, Bhandare M, Shrikhande SV
Chin Clin Oncol 2018 Oct;7(5):51. doi: 10.21037/cco.2018.08.08. PMID: 30395718
De Vries B, Weersma RK
Minerva Gastroenterol Dietol 2016 Mar;62(1):49-62. Epub 2015 Oct 7 PMID: 26446685

Therapy

Gao X, Xu N, Li Z, Shen L, Ji K, Zheng Z, Liu D, Lou H, Bai L, Liu T, Li Y, Li Y, Fan Q, Feng M, Zhong H, Huang Y, Lou G, Wang J, Lin X, Chen Y, An R, Li C, Zhou Q, Huang X, Guo Z, Wang S, Li G, Fei J, Zhu L, Zhu H, Li X, Li F, Liao S, Min Q, Tang L, Shan F, Gong J, Gao Y, Zhou J, Lu Z, Li X, Li J, Ren H, Liu X, Yang H, Li W, Song W, Wang ZM, Li B, Xia M, Wu X, Ji J
Lancet Oncol 2023 Oct;24(10):1134-1146. doi: 10.1016/S1470-2045(23)00411-4. PMID: 37797632
Choueiri TK, Powles T, Albiges L, Burotto M, Szczylik C, Zurawski B, Yanez Ruiz E, Maruzzo M, Suarez Zaizar A, Fein LE, Schutz FA, Heng DYC, Wang F, Mataveli F, Chang YL, van Kooten Losio M, Suarez C, Motzer RJ; COSMIC-313 Investigators
N Engl J Med 2023 May 11;388(19):1767-1778. doi: 10.1056/NEJMoa2212851. PMID: 37163623Free PMC Article
Cameron LB, Hitchen N, Chandran E, Morris T, Manser R, Solomon BJ, Jordan V
Cochrane Database Syst Rev 2022 Jan 7;1(1):CD013453. doi: 10.1002/14651858.CD013453.pub2. PMID: 34994987Free PMC Article
Kelley RK, Bridgewater J, Gores GJ, Zhu AX
J Hepatol 2020 Feb;72(2):353-363. doi: 10.1016/j.jhep.2019.10.009. PMID: 31954497
Solomon BJ, Mok T, Kim DW, Wu YL, Nakagawa K, Mekhail T, Felip E, Cappuzzo F, Paolini J, Usari T, Iyer S, Reisman A, Wilner KD, Tursi J, Blackhall F; PROFILE 1014 Investigators
N Engl J Med 2014 Dec 4;371(23):2167-77. doi: 10.1056/NEJMoa1408440. PMID: 25470694

Prognosis

Choueiri TK, Powles T, Albiges L, Burotto M, Szczylik C, Zurawski B, Yanez Ruiz E, Maruzzo M, Suarez Zaizar A, Fein LE, Schutz FA, Heng DYC, Wang F, Mataveli F, Chang YL, van Kooten Losio M, Suarez C, Motzer RJ; COSMIC-313 Investigators
N Engl J Med 2023 May 11;388(19):1767-1778. doi: 10.1056/NEJMoa2212851. PMID: 37163623Free PMC Article
Liu Y, Xu Q, Deng F, Zheng Z, Luo J, Wang P, Zhou J, Lu X, Zhang L, Chen Z, Zhang Q, Chen Q, Zuo D
J Exp Clin Cancer Res 2023 Feb 1;42(1):38. doi: 10.1186/s13046-023-02609-0. PMID: 36721234Free PMC Article
Jones RH, Casbard A, Carucci M, Cox C, Butler R, Alchami F, Madden TA, Bale C, Bezecny P, Joffe J, Moon S, Twelves C, Venkitaraman R, Waters S, Foxley A, Howell SJ
Lancet Oncol 2020 Mar;21(3):345-357. Epub 2020 Feb 5 doi: 10.1016/S1470-2045(19)30817-4. PMID: 32035020Free PMC Article
Kelley RK, Bridgewater J, Gores GJ, Zhu AX
J Hepatol 2020 Feb;72(2):353-363. doi: 10.1016/j.jhep.2019.10.009. PMID: 31954497
Bakst RL, Glastonbury CM, Parvathaneni U, Katabi N, Hu KS, Yom SS
Int J Radiat Oncol Biol Phys 2019 Apr 1;103(5):1109-1124. Epub 2018 Dec 15 doi: 10.1016/j.ijrobp.2018.12.009. PMID: 30562546

Clinical prediction guides

Verschoor YL, van de Haar J, van den Berg JG, van Sandick JW, Kodach LL, van Dieren JM, Balduzzi S, Grootscholten C, IJsselsteijn ME, Veenhof AAFA, Hartemink KJ, Vollebergh MA, Jurdi A, Sharma S, Spickard E, Owers EC, Bartels-Rutten A, den Hartog P, de Miranda NFCC, van Leerdam ME, Haanen JBAG, Schumacher TN, Voest EE, Chalabi M
Nat Med 2024 Feb;30(2):519-530. Epub 2024 Jan 8 doi: 10.1038/s41591-023-02758-x. PMID: 38191613Free PMC Article
Barnault R, Verzeroli C, Fournier C, Michelet M, Redavid AR, Chicherova I, Plissonnier ML, Adrait A, Khomich O, Chapus F, Richaud M, Hervieu M, Reiterer V, Centonze FG, Lucifora J, Bartosch B, Rivoire M, Farhan H, Couté Y, Mirakaj V, Decaens T, Mehlen P, Gibert B, Zoulim F, Parent R
Hepatology 2022 Nov;76(5):1345-1359. Epub 2022 Apr 1 doi: 10.1002/hep.32446. PMID: 35253915
Krstić MN, Mijač D, Tomašević RS, Lukić S, Stojković Lalošević M, Krstić JM, Milosavljević T
Dig Dis 2022;40(2):206-214. Epub 2021 May 10 doi: 10.1159/000517110. PMID: 33971644
Chaudhari VA, Khobragade K, Bhandare M, Shrikhande SV
Chin Clin Oncol 2018 Oct;7(5):51. doi: 10.21037/cco.2018.08.08. PMID: 30395718
De Vries B, Weersma RK
Minerva Gastroenterol Dietol 2016 Mar;62(1):49-62. Epub 2015 Oct 7 PMID: 26446685

Recent systematic reviews

Rowell NP
Br J Radiol 2023 Aug;96(1148):20220660. Epub 2023 Jun 29 doi: 10.1259/bjr.20220660. PMID: 37335288Free PMC Article
Cameron LB, Hitchen N, Chandran E, Morris T, Manser R, Solomon BJ, Jordan V
Cochrane Database Syst Rev 2022 Jan 7;1(1):CD013453. doi: 10.1002/14651858.CD013453.pub2. PMID: 34994987Free PMC Article
Girardi DM, Silva ACB, Rêgo JFM, Coudry RA, Riechelmann RP
Cancer Treat Rev 2017 May;56:28-35. Epub 2017 Apr 17 doi: 10.1016/j.ctrv.2017.04.002. PMID: 28456055

Supplemental Content

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