U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Advanced Nasopharyngeal Carcinoma

MedGen UID:
1778755
Concept ID:
C5446568
Neoplastic Process

Definition

Nasopharyngeal carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Term Hierarchy

Professional guidelines

PubMed

Wang S, Chen S, Zhong Q, Liu Y
J Cancer Res Clin Oncol 2023 May;149(5):2071-2079. Epub 2022 Jul 25 doi: 10.1007/s00432-022-04214-8. PMID: 35876949
Zhong L, Dong D, Fang X, Zhang F, Zhang N, Zhang L, Fang M, Jiang W, Liang S, Li C, Liu Y, Zhao X, Cao R, Shan H, Hu Z, Ma J, Tang L, Tian J
EBioMedicine 2021 Aug;70:103522. Epub 2021 Aug 11 doi: 10.1016/j.ebiom.2021.103522. PMID: 34391094Free PMC Article
Lee VH, Lam KO, Chang AT, Lam TC, Chiang CL, So TH, Choi CW, Lee AW
J Oncol Pract 2018 Oct;14(10):594-602. doi: 10.1200/JOP.18.00219. PMID: 30312564

Recent clinical studies

Etiology

Li WZ, Lv X, Hu D, Lv SH, Liu GY, Liang H, Ye YF, Yang W, Zhang HX, Yuan TZ, Wang DS, Lu N, Ke LR, Tang WB, Tong LH, Chen ZJ, Liu T, Cao KJ, Mo HY, Guo L, Zhao C, Chen MY, Chen QY, Huang PY, Sun R, Qiu F, Luo DH, Wang L, Hua YJ, Tang LQ, Qian CN, Mai HQ, Guo X, Xiang YQ, Xia WX
JAMA Oncol 2022 May 1;8(5):706-714. doi: 10.1001/jamaoncol.2022.0122. PMID: 35323856Free PMC Article
Zhong L, Dong D, Fang X, Zhang F, Zhang N, Zhang L, Fang M, Jiang W, Liang S, Li C, Liu Y, Zhao X, Cao R, Shan H, Hu Z, Ma J, Tang L, Tian J
EBioMedicine 2021 Aug;70:103522. Epub 2021 Aug 11 doi: 10.1016/j.ebiom.2021.103522. PMID: 34391094Free PMC Article
Mai HQ, Chen QY, Chen D, Hu C, Yang K, Wen J, Li J, Shi YR, Jin F, Xu R, Pan J, Qu S, Li P, Hu C, Liu YC, Jiang Y, He X, Wang HM, Lim WT, Liao W, He X, Chen X, Liu Z, Yuan X, Li Q, Lin X, Jing S, Chen Y, Lu Y, Hsieh CY, Yang MH, Yen CJ, Samol J, Feng H, Yao S, Keegan P, Xu RH
Nat Med 2021 Sep;27(9):1536-1543. Epub 2021 Aug 2 doi: 10.1038/s41591-021-01444-0. PMID: 34341578
Chen YP, Liu X, Zhou Q, Yang KY, Jin F, Zhu XD, Shi M, Hu GQ, Hu WH, Sun Y, Wu HF, Wu H, Lin Q, Wang H, Tian Y, Zhang N, Wang XC, Shen LF, Liu ZZ, Huang J, Luo XL, Li L, Zang J, Mei Q, Zheng BM, Yue D, Xu J, Wu SG, Shi YX, Mao YP, Chen L, Li WF, Zhou GQ, Sun R, Guo R, Zhang Y, Xu C, Lv JW, Guo Y, Feng HX, Tang LL, Xie FY, Sun Y, Ma J
Lancet 2021 Jul 24;398(10297):303-313. Epub 2021 Jun 7 doi: 10.1016/S0140-6736(21)01123-5. PMID: 34111416
Zhang Y, Chen L, Hu GQ, Zhang N, Zhu XD, Yang KY, Jin F, Shi M, Chen YP, Hu WH, Cheng ZB, Wang SY, Tian Y, Wang XC, Sun Y, Li JG, Li WF, Li YH, Tang LL, Mao YP, Zhou GQ, Sun R, Liu X, Guo R, Long GX, Liang SQ, Li L, Huang J, Long JH, Zang J, Liu QD, Zou L, Su QF, Zheng BM, Xiao Y, Guo Y, Han F, Mo HY, Lv JW, Du XJ, Xu C, Liu N, Li YQ, Chua MLK, Xie FY, Sun Y, Ma J
N Engl J Med 2019 Sep 19;381(12):1124-1135. Epub 2019 May 31 doi: 10.1056/NEJMoa1905287. PMID: 31150573

Diagnosis

Juarez-Vignon Whaley JJ, Afkhami M, Sampath S, Amini A, Bell D, Villaflor VM
Curr Treat Options Oncol 2023 Jul;24(7):845-866. Epub 2023 May 5 doi: 10.1007/s11864-023-01083-2. PMID: 37145382Free PMC Article
Zhong L, Dong D, Fang X, Zhang F, Zhang N, Zhang L, Fang M, Jiang W, Liang S, Li C, Liu Y, Zhao X, Cao R, Shan H, Hu Z, Ma J, Tang L, Tian J
EBioMedicine 2021 Aug;70:103522. Epub 2021 Aug 11 doi: 10.1016/j.ebiom.2021.103522. PMID: 34391094Free PMC Article
Lee VH, Lam KO, Chang AT, Lam TC, Chiang CL, So TH, Choi CW, Lee AW
J Oncol Pract 2018 Oct;14(10):594-602. doi: 10.1200/JOP.18.00219. PMID: 30312564
Tang XR, Li YQ, Liang SB, Jiang W, Liu F, Ge WX, Tang LL, Mao YP, He QM, Yang XJ, Zhang Y, Wen X, Zhang J, Wang YQ, Zhang PP, Sun Y, Yun JP, Zeng J, Li L, Liu LZ, Liu N, Ma J
Lancet Oncol 2018 Mar;19(3):382-393. Epub 2018 Feb 7 doi: 10.1016/S1470-2045(18)30080-9. PMID: 29428165
Chan KCA, Woo JKS, King A, Zee BCY, Lam WKJ, Chan SL, Chu SWI, Mak C, Tse IOL, Leung SYM, Chan G, Hui EP, Ma BBY, Chiu RWK, Leung SF, van Hasselt AC, Chan ATC, Lo YMD
N Engl J Med 2017 Aug 10;377(6):513-522. doi: 10.1056/NEJMoa1701717. PMID: 28792880

Therapy

Li WZ, Lv X, Hu D, Lv SH, Liu GY, Liang H, Ye YF, Yang W, Zhang HX, Yuan TZ, Wang DS, Lu N, Ke LR, Tang WB, Tong LH, Chen ZJ, Liu T, Cao KJ, Mo HY, Guo L, Zhao C, Chen MY, Chen QY, Huang PY, Sun R, Qiu F, Luo DH, Wang L, Hua YJ, Tang LQ, Qian CN, Mai HQ, Guo X, Xiang YQ, Xia WX
JAMA Oncol 2022 May 1;8(5):706-714. doi: 10.1001/jamaoncol.2022.0122. PMID: 35323856Free PMC Article
Hong S, Zhang Y, Yu G, Peng P, Peng J, Jia J, Wu X, Huang Y, Yang Y, Lin Q, Xi X, Xu M, Chen D, Lu X, Wang R, Cao X, Chen X, Lin Z, Xiong J, Lin Q, Xie C, Li Z, Pan J, Li J, Wu S, Lian Y, Yang Q, Zhao C, Fang W, Zhang L
J Clin Oncol 2021 Oct 10;39(29):3273-3282. Epub 2021 Aug 11 doi: 10.1200/JCO.21.00396. PMID: 34379443Free PMC Article
Mai HQ, Chen QY, Chen D, Hu C, Yang K, Wen J, Li J, Shi YR, Jin F, Xu R, Pan J, Qu S, Li P, Hu C, Liu YC, Jiang Y, He X, Wang HM, Lim WT, Liao W, He X, Chen X, Liu Z, Yuan X, Li Q, Lin X, Jing S, Chen Y, Lu Y, Hsieh CY, Yang MH, Yen CJ, Samol J, Feng H, Yao S, Keegan P, Xu RH
Nat Med 2021 Sep;27(9):1536-1543. Epub 2021 Aug 2 doi: 10.1038/s41591-021-01444-0. PMID: 34341578
Chen YP, Liu X, Zhou Q, Yang KY, Jin F, Zhu XD, Shi M, Hu GQ, Hu WH, Sun Y, Wu HF, Wu H, Lin Q, Wang H, Tian Y, Zhang N, Wang XC, Shen LF, Liu ZZ, Huang J, Luo XL, Li L, Zang J, Mei Q, Zheng BM, Yue D, Xu J, Wu SG, Shi YX, Mao YP, Chen L, Li WF, Zhou GQ, Sun R, Guo R, Zhang Y, Xu C, Lv JW, Guo Y, Feng HX, Tang LL, Xie FY, Sun Y, Ma J
Lancet 2021 Jul 24;398(10297):303-313. Epub 2021 Jun 7 doi: 10.1016/S0140-6736(21)01123-5. PMID: 34111416
Zhang Y, Chen L, Hu GQ, Zhang N, Zhu XD, Yang KY, Jin F, Shi M, Chen YP, Hu WH, Cheng ZB, Wang SY, Tian Y, Wang XC, Sun Y, Li JG, Li WF, Li YH, Tang LL, Mao YP, Zhou GQ, Sun R, Liu X, Guo R, Long GX, Liang SQ, Li L, Huang J, Long JH, Zang J, Liu QD, Zou L, Su QF, Zheng BM, Xiao Y, Guo Y, Han F, Mo HY, Lv JW, Du XJ, Xu C, Liu N, Li YQ, Chua MLK, Xie FY, Sun Y, Ma J
N Engl J Med 2019 Sep 19;381(12):1124-1135. Epub 2019 May 31 doi: 10.1056/NEJMoa1905287. PMID: 31150573

Prognosis

Chen B, Jiang W, Huang Y, Zhang J, Yu P, Wu L, Peng H
Oncogene 2022 Apr;41(15):2239-2253. Epub 2022 Feb 26 doi: 10.1038/s41388-022-02250-9. PMID: 35217794
Zhong L, Dong D, Fang X, Zhang F, Zhang N, Zhang L, Fang M, Jiang W, Liang S, Li C, Liu Y, Zhao X, Cao R, Shan H, Hu Z, Ma J, Tang L, Tian J
EBioMedicine 2021 Aug;70:103522. Epub 2021 Aug 11 doi: 10.1016/j.ebiom.2021.103522. PMID: 34391094Free PMC Article
Jiang Y, Qu S, Pan X, Huang S, Zhu X
Sci Rep 2020 Jan 21;10(1):861. doi: 10.1038/s41598-020-57968-x. PMID: 31965045Free PMC Article
Tang XR, Li YQ, Liang SB, Jiang W, Liu F, Ge WX, Tang LL, Mao YP, He QM, Yang XJ, Zhang Y, Wen X, Zhang J, Wang YQ, Zhang PP, Sun Y, Yun JP, Zeng J, Li L, Liu LZ, Liu N, Ma J
Lancet Oncol 2018 Mar;19(3):382-393. Epub 2018 Feb 7 doi: 10.1016/S1470-2045(18)30080-9. PMID: 29428165
Liang ZG, Chen ZT, Li L, Qu S, Zhu XD
Asian Pac J Cancer Prev 2015;16(12):4825-32. doi: 10.7314/apjcp.2015.16.12.4825. PMID: 26163598

Clinical prediction guides

Zhong L, Dong D, Fang X, Zhang F, Zhang N, Zhang L, Fang M, Jiang W, Liang S, Li C, Liu Y, Zhao X, Cao R, Shan H, Hu Z, Ma J, Tang L, Tian J
EBioMedicine 2021 Aug;70:103522. Epub 2021 Aug 11 doi: 10.1016/j.ebiom.2021.103522. PMID: 34391094Free PMC Article
Mai HQ, Chen QY, Chen D, Hu C, Yang K, Wen J, Li J, Shi YR, Jin F, Xu R, Pan J, Qu S, Li P, Hu C, Liu YC, Jiang Y, He X, Wang HM, Lim WT, Liao W, He X, Chen X, Liu Z, Yuan X, Li Q, Lin X, Jing S, Chen Y, Lu Y, Hsieh CY, Yang MH, Yen CJ, Samol J, Feng H, Yao S, Keegan P, Xu RH
Nat Med 2021 Sep;27(9):1536-1543. Epub 2021 Aug 2 doi: 10.1038/s41591-021-01444-0. PMID: 34341578
Chen YP, Liu X, Zhou Q, Yang KY, Jin F, Zhu XD, Shi M, Hu GQ, Hu WH, Sun Y, Wu HF, Wu H, Lin Q, Wang H, Tian Y, Zhang N, Wang XC, Shen LF, Liu ZZ, Huang J, Luo XL, Li L, Zang J, Mei Q, Zheng BM, Yue D, Xu J, Wu SG, Shi YX, Mao YP, Chen L, Li WF, Zhou GQ, Sun R, Guo R, Zhang Y, Xu C, Lv JW, Guo Y, Feng HX, Tang LL, Xie FY, Sun Y, Ma J
Lancet 2021 Jul 24;398(10297):303-313. Epub 2021 Jun 7 doi: 10.1016/S0140-6736(21)01123-5. PMID: 34111416
Peng L, Liu JQ, Chen YP, Ma J
Br J Radiol 2019 Oct;92(1102):20181031. Epub 2019 May 24 doi: 10.1259/bjr.20181031. PMID: 31112398Free PMC Article
Tang XR, Li YQ, Liang SB, Jiang W, Liu F, Ge WX, Tang LL, Mao YP, He QM, Yang XJ, Zhang Y, Wen X, Zhang J, Wang YQ, Zhang PP, Sun Y, Yun JP, Zeng J, Li L, Liu LZ, Liu N, Ma J
Lancet Oncol 2018 Mar;19(3):382-393. Epub 2018 Feb 7 doi: 10.1016/S1470-2045(18)30080-9. PMID: 29428165

Recent systematic reviews

Guven DC, Stephen B, Sahin TK, Cakir IY, Aksoy S
Laryngoscope 2024 Jan;134(1):7-17. Epub 2023 May 25 doi: 10.1002/lary.30754. PMID: 37227161
Wu Q, Li S, Liu J, Zhong Y
Eur Arch Otorhinolaryngol 2022 Nov;279(11):5057-5069. Epub 2022 Jun 29 doi: 10.1007/s00405-022-07435-2. PMID: 35767064
Li Z, Li C, Yang D, Song J, Liu T, Zhou Z, Zhou L, Kang M
BMC Cancer 2022 Jun 6;22(1):616. doi: 10.1186/s12885-022-09712-z. PMID: 35668431Free PMC Article
Mané M, Benkhaled S, Dragan T, Paesmans M, Beauvois S, Lalami Y, Szturz P, Gaye PM, Vermorken JB, Van Gestel D
Oncologist 2021 Jan;26(1):e130-e141. Epub 2020 Oct 1 doi: 10.1002/ONCO.13520. PMID: 32924198Free PMC Article
Yan M, Kumachev A, Siu LL, Chan KK
Eur J Cancer 2015 Aug;51(12):1570-9. Epub 2015 Jun 1 doi: 10.1016/j.ejca.2015.04.027. PMID: 26044925

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...