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Abnormal amygdala morphology

MedGen UID:
1779036
•Concept ID:
C5539752
•
Anatomical Abnormality
Synonym: Abnormal morphology of the amygdala
 
HPO: HP:0033668

Definition

A structural anomaly of the amygdala. [from HPO]

Professional guidelines

PubMed

Spine synapse remodeling in the pathophysiology and treatment of depression.
Duman CH, Duman RS
Neurosci Lett 2015 Aug 5;601:20-9. Epub 2015 Jan 9 doi: 10.1016/j.neulet.2015.01.022. PMID: 25582786Free PMC Article
Can pharmacological and psychological treatment change brain structure and function in PTSD? A systematic review.
Thomaes K, Dorrepaal E, Draijer N, Jansma EP, Veltman DJ, van Balkom AJ
J Psychiatr Res 2014 Mar;50:1-15. Epub 2013 Nov 12 doi: 10.1016/j.jpsychires.2013.11.002. PMID: 24321592
Remodeling of axo-spinous synapses in the pathophysiology and treatment of depression.
Licznerski P, Duman RS
Neuroscience 2013 Oct 22;251:33-50. Epub 2012 Oct 2 doi: 10.1016/j.neuroscience.2012.09.057. PMID: 23036622Free PMC Article

Recent clinical studies

Etiology

Abnormal development pattern of the amygdala and hippocampus from childhood to adulthood with autism.
Xu Q, Zuo C, Liao S, Long Y, Wang Y
J Clin Neurosci 2020 Aug;78:327-332. Epub 2020 Apr 13 doi: 10.1016/j.jocn.2020.03.049. PMID: 32593622
Stress-Induced Metabolic Disorder in Peripheral CD4(+) T Cells Leads to Anxiety-like Behavior.
Fan KQ, Li YY, Wang HL, Mao XT, Guo JX, Wang F, Huang LJ, Li YN, Ma XY, Gao ZJ, Chen W, Qian DD, Xue WJ, Cao Q, Zhang L, Shen L, Zhang L, Tong C, Zhong JY, Lu W, Lu L, Ren KM, Zhong G, Wang Y, Tang M, Feng XH, Chai RJ, Jin J
Cell 2019 Oct 31;179(4):864-879.e19. doi: 10.1016/j.cell.2019.10.001. PMID: 31675497
The Amygdala in Schizophrenia and Bipolar Disorder: A Synthesis of Structural MRI, Diffusion Tensor Imaging, and Resting-State Functional Connectivity Findings.
Ho NF, Li Hui Chong P, Lee DR, Chew QH, Chen G, Sim K
Harv Rev Psychiatry 2019 May/Jun;27(3):150-164. doi: 10.1097/HRP.0000000000000207. PMID: 31082993
Abnormal metabolite concentrations and amygdala volume in patients with recent-onset posttraumatic stress disorder.
Su X, Xia C, Wang W, Sun H, Tan Q, Zhang S, Li L, Kemp GJ, Yue Q, Gong Q
J Affect Disord 2018 Dec 1;241:539-545. Epub 2018 Aug 11 doi: 10.1016/j.jad.2018.08.018. PMID: 30153637
The neuroanatomy of autism - a developmental perspective.
Donovan AP, Basson MA
J Anat 2017 Jan;230(1):4-15. Epub 2016 Sep 12 doi: 10.1111/joa.12542. PMID: 27620360Free PMC Article

Diagnosis

PTSD-related neuroimaging abnormalities in brain function, structure, and biochemistry.
Harnett NG, Goodman AM, Knight DC
Exp Neurol 2020 Aug;330:113331. Epub 2020 Apr 25 doi: 10.1016/j.expneurol.2020.113331. PMID: 32343956
Aging and Alzheimer's disease pathology.
Sengoku R
Neuropathology 2020 Feb;40(1):22-29. Epub 2019 Dec 21 doi: 10.1111/neup.12626. PMID: 31863504
Autism spectrum disorder: neuropathology and animal models.
Varghese M, Keshav N, Jacot-Descombes S, Warda T, Wicinski B, Dickstein DL, Harony-Nicolas H, De Rubeis S, Drapeau E, Buxbaum JD, Hof PR
Acta Neuropathol 2017 Oct;134(4):537-566. Epub 2017 Jun 5 doi: 10.1007/s00401-017-1736-4. PMID: 28584888Free PMC Article
The neuroanatomy of autism - a developmental perspective.
Donovan AP, Basson MA
J Anat 2017 Jan;230(1):4-15. Epub 2016 Sep 12 doi: 10.1111/joa.12542. PMID: 27620360Free PMC Article
Reward and aversion in a heterogeneous midbrain dopamine system.
Lammel S, Lim BK, Malenka RC
Neuropharmacology 2014 Jan;76 Pt B(0 0):351-9. Epub 2013 Apr 8 doi: 10.1016/j.neuropharm.2013.03.019. PMID: 23578393Free PMC Article

Therapy

The Role of the Thalamus in Post-Traumatic Stress Disorder.
Yoshii T
Int J Mol Sci 2021 Feb 9;22(4) doi: 10.3390/ijms22041730. PMID: 33572198Free PMC Article
Exercise effects on depression: Possible neural mechanisms.
Gujral S, Aizenstein H, Reynolds CF 3rd, Butters MA, Erickson KI
Gen Hosp Psychiatry 2017 Nov;49:2-10. doi: 10.1016/j.genhosppsych.2017.04.012. PMID: 29122145Free PMC Article
Spine synapse remodeling in the pathophysiology and treatment of depression.
Duman CH, Duman RS
Neurosci Lett 2015 Aug 5;601:20-9. Epub 2015 Jan 9 doi: 10.1016/j.neulet.2015.01.022. PMID: 25582786Free PMC Article
Neuropsychological mechanism underlying antidepressant effect: a systematic meta-analysis.
Ma Y
Mol Psychiatry 2015 Mar;20(3):311-9. Epub 2014 Mar 25 doi: 10.1038/mp.2014.24. PMID: 24662929
Open questions in current models of antidepressant action.
Tanti A, Belzung C
Br J Pharmacol 2010 Mar;159(6):1187-200. Epub 2010 Feb 2 doi: 10.1111/j.1476-5381.2009.00585.x. PMID: 20132212Free PMC Article

Prognosis

Impact of Stress on Brain Morphology: Insights into Structural Biomarkers of Stress-related Disorders.
Cardoner N, Andero R, Cano M, Marin-Blasco I, Porta-Casteràs D, Serra-Blasco M, Via E, Vicent-Gil M, Portella MJ
Curr Neuropharmacol 2024;22(5):935-962. doi: 10.2174/1570159X21666230703091435. PMID: 37403395Free PMC Article
Abnormal corneal nerve morphology and brain volume in patients with schizophrenia.
Ponirakis G, Ghandi R, Ahmed A, Gad H, Petropoulos IN, Khan A, Elsotouhy A, Vattoth S, Alshawwaf MKM, Khoodoruth MAS, Ramadan M, Bhagat A, Currie J, Mahfoud Z, Al Hamad H, Own A, M Haddad P, Alabdulla M, Malik RA, Woodruff PW
Sci Rep 2022 Feb 3;12(1):1870. doi: 10.1038/s41598-022-05609-w. PMID: 35115592Free PMC Article
PTSD-related neuroimaging abnormalities in brain function, structure, and biochemistry.
Harnett NG, Goodman AM, Knight DC
Exp Neurol 2020 Aug;330:113331. Epub 2020 Apr 25 doi: 10.1016/j.expneurol.2020.113331. PMID: 32343956
Aging and Alzheimer's disease pathology.
Sengoku R
Neuropathology 2020 Feb;40(1):22-29. Epub 2019 Dec 21 doi: 10.1111/neup.12626. PMID: 31863504
Toward a neurobiology of delusions.
Corlett PR, Taylor JR, Wang XJ, Fletcher PC, Krystal JH
Prog Neurobiol 2010 Nov;92(3):345-69. Epub 2010 Jun 15 doi: 10.1016/j.pneurobio.2010.06.007. PMID: 20558235Free PMC Article

Clinical prediction guides

Motor neuron pathology in CANVAS due to RFC1 expansions.
Huin V, Coarelli G, Guemy C, Boluda S, Debs R, Mochel F, Stojkovic T, Grabli D, Maisonobe T, Gaymard B, Lenglet T, Tard C, Davion JB, Sablonnière B, Monin ML, Ewenczyk C, Viala K, Charles P, Le Ber I, Reilly MM, Houlden H, Cortese A, Seilhean D, Brice A, Durr A
Brain 2022 Jun 30;145(6):2121-2132. doi: 10.1093/brain/awab449. PMID: 34927205
Aging and Alzheimer's disease pathology.
Sengoku R
Neuropathology 2020 Feb;40(1):22-29. Epub 2019 Dec 21 doi: 10.1111/neup.12626. PMID: 31863504
Exercise effects on depression: Possible neural mechanisms.
Gujral S, Aizenstein H, Reynolds CF 3rd, Butters MA, Erickson KI
Gen Hosp Psychiatry 2017 Nov;49:2-10. doi: 10.1016/j.genhosppsych.2017.04.012. PMID: 29122145Free PMC Article
The neuroanatomy of autism - a developmental perspective.
Donovan AP, Basson MA
J Anat 2017 Jan;230(1):4-15. Epub 2016 Sep 12 doi: 10.1111/joa.12542. PMID: 27620360Free PMC Article
Reward and aversion in a heterogeneous midbrain dopamine system.
Lammel S, Lim BK, Malenka RC
Neuropharmacology 2014 Jan;76 Pt B(0 0):351-9. Epub 2013 Apr 8 doi: 10.1016/j.neuropharm.2013.03.019. PMID: 23578393Free PMC Article

Recent systematic reviews

Does pediatric post-traumatic stress disorder alter the brain? Systematic review and meta-analysis of structural and functional magnetic resonance imaging studies.
Milani AC, Hoffmann EV, Fossaluza V, Jackowski AP, Mello MF
Psychiatry Clin Neurosci 2017 Mar;71(3):154-169. Epub 2017 Jan 6 doi: 10.1111/pcn.12473. PMID: 27778421
A Systematic Review and Meta-analysis of Neuroimaging in Oppositional Defiant Disorder (ODD) and Conduct Disorder (CD) Taking Attention-Deficit Hyperactivity Disorder (ADHD) Into Account.
Noordermeer SD, Luman M, Oosterlaan J
Neuropsychol Rev 2016 Mar;26(1):44-72. Epub 2016 Feb 5 doi: 10.1007/s11065-015-9315-8. PMID: 26846227Free PMC Article
Biomarkers and staging of bipolar disorder: a systematic review.
Roda Â, Chendo I, Kunz M
Trends Psychiatry Psychother 2015 Jan-Mar;37(1):3-11. Epub 2014 Dec 9 doi: 10.1590/2237-6089-2014-0002. PMID: 25860561
Can pharmacological and psychological treatment change brain structure and function in PTSD? A systematic review.
Thomaes K, Dorrepaal E, Draijer N, Jansma EP, Veltman DJ, van Balkom AJ
J Psychiatr Res 2014 Mar;50:1-15. Epub 2013 Nov 12 doi: 10.1016/j.jpsychires.2013.11.002. PMID: 24321592
Magnetic resonance imaging studies in bipolar disorder and schizophrenia: meta-analysis.
Arnone D, Cavanagh J, Gerber D, Lawrie SM, Ebmeier KP, McIntosh AM
Br J Psychiatry 2009 Sep;195(3):194-201. doi: 10.1192/bjp.bp.108.059717. PMID: 19721106

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