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Abnormal circulating sex hormone concentration

MedGen UID:
1779099
•Concept ID:
C5539818
•
Finding
Synonyms: Abnormal circulating gonadal steroid concentration; Abnormal circulating gonadocorticoid concentration; Abnormal circulating sex steroid concentration
 
HPO: HP:0033799

Definition

Any deviation from the normal concentration of a sex hormone in the blood circulation [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal circulating sex hormone concentration

Professional guidelines

PubMed

MANAGEMENT OF ENDOCRINE DISEASE Hyperandrogenic states in women: pitfalls in laboratory diagnosis.
Pugeat M, Plotton I, de la Perrière AB, Raverot G, Déchaud H, Raverot V
Eur J Endocrinol 2018 Apr;178(4):R141-R154. Epub 2018 Feb 16 doi: 10.1530/EJE-17-0776. PMID: 29453202
Turner syndrome and clinical treatment.
Hjerrild BE, Mortensen KH, Gravholt CH
Br Med Bull 2008;86:77-93. Epub 2008 Apr 9 doi: 10.1093/bmb/ldn015. PMID: 18400842
Clinical utility of sex hormone-binding globulin measurement.
Pugeat M, Crave JC, Tourniaire J, Forest MG
Horm Res 1996;45(3-5):148-55. doi: 10.1159/000184778. PMID: 8964574

Recent clinical studies

Etiology

PCOS during the menopausal transition and after menopause: a systematic review and meta-analysis.
Millán-de-Meer M, Luque-Ramírez M, Nattero-Chávez L, Escobar-Morreale HF
Hum Reprod Update 2023 Nov 2;29(6):741-772. doi: 10.1093/humupd/dmad015. PMID: 37353908
Impact of sex hormones dysregulation and adiposity on the outcome of postmenopausal breast cancer patients.
Coradini D, Oriana S
Clin Obes 2021 Feb;11(1):e12423. Epub 2020 Nov 1 doi: 10.1111/cob.12423. PMID: 33135396
The role of sulfated steroid hormones in reproductive processes.
Geyer J, Bakhaus K, Bernhardt R, Blaschka C, Dezhkam Y, Fietz D, Grosser G, Hartmann K, Hartmann MF, Neunzig J, Papadopoulos D, Sánchez-Guijo A, Scheiner-Bobis G, Schuler G, Shihan M, Wrenzycki C, Wudy SA, Bergmann M
J Steroid Biochem Mol Biol 2017 Sep;172:207-221. Epub 2016 Jul 5 doi: 10.1016/j.jsbmb.2016.07.002. PMID: 27392637
Premature adrenarche: etiology, clinical findings, and consequences.
Voutilainen R, Jääskeläinen J
J Steroid Biochem Mol Biol 2015 Jan;145:226-36. Epub 2014 Jun 9 doi: 10.1016/j.jsbmb.2014.06.004. PMID: 24923732
Turner syndrome and clinical treatment.
Hjerrild BE, Mortensen KH, Gravholt CH
Br Med Bull 2008;86:77-93. Epub 2008 Apr 9 doi: 10.1093/bmb/ldn015. PMID: 18400842

Diagnosis

PCOS during the menopausal transition and after menopause: a systematic review and meta-analysis.
Millán-de-Meer M, Luque-Ramírez M, Nattero-Chávez L, Escobar-Morreale HF
Hum Reprod Update 2023 Nov 2;29(6):741-772. doi: 10.1093/humupd/dmad015. PMID: 37353908
Hyperparathyroidism in Patients With X-Linked Hypophosphatemia.
Lecoq AL, Chaumet-Riffaud P, Blanchard A, Dupeux M, Rothenbuhler A, Lambert B, Durand E, Boros E, Briot K, Silve C, Francou B, Piketty M, Chanson P, Brailly-Tabard S, Linglart A, Kamenický P
J Bone Miner Res 2020 Jul;35(7):1263-1273. Epub 2020 Mar 27 doi: 10.1002/jbmr.3992. PMID: 32101626
Androgens in Menopausal Women: Not Only Polycystic Ovary Syndrome.
Kostakis EK, Gkioni LN, Macut D, Mastorakos G
Front Horm Res 2019;53:135-161. Epub 2019 Sep 9 doi: 10.1159/000494909. PMID: 31499509
MANAGEMENT OF ENDOCRINE DISEASE Hyperandrogenic states in women: pitfalls in laboratory diagnosis.
Pugeat M, Plotton I, de la Perrière AB, Raverot G, Déchaud H, Raverot V
Eur J Endocrinol 2018 Apr;178(4):R141-R154. Epub 2018 Feb 16 doi: 10.1530/EJE-17-0776. PMID: 29453202
Effects of DHEA on metabolic and endocrine functions of adipose tissue.
Karbowska J, Kochan Z
Horm Mol Biol Clin Investig 2013 Aug;14(2):65-74. doi: 10.1515/hmbci-2013-0009. PMID: 25436721

Therapy

PCOS during the menopausal transition and after menopause: a systematic review and meta-analysis.
Millán-de-Meer M, Luque-Ramírez M, Nattero-Chávez L, Escobar-Morreale HF
Hum Reprod Update 2023 Nov 2;29(6):741-772. doi: 10.1093/humupd/dmad015. PMID: 37353908
Metabolic Effects of Oxytocin.
McCormack SE, Blevins JE, Lawson EA
Endocr Rev 2020 Apr 1;41(2):121-45. doi: 10.1210/endrev/bnz012. PMID: 31803919Free PMC Article
Turner syndrome and clinical treatment.
Hjerrild BE, Mortensen KH, Gravholt CH
Br Med Bull 2008;86:77-93. Epub 2008 Apr 9 doi: 10.1093/bmb/ldn015. PMID: 18400842
Testosterone hormone replacement therapy: state-of-the-art and emerging technologies.
Leichtnam ML, Rolland H, Wüthrich P, Guy RH
Pharm Res 2006 Jun;23(6):1117-32. Epub 2006 Jun 9 doi: 10.1007/s11095-006-0072-5. PMID: 16755346
The pharmacology of letrozole.
Haynes BP, Dowsett M, Miller WR, Dixon JM, Bhatnagar AS
J Steroid Biochem Mol Biol 2003 Oct;87(1):35-45. doi: 10.1016/s0960-0760(03)00384-4. PMID: 14630089

Prognosis

PCOS during the menopausal transition and after menopause: a systematic review and meta-analysis.
Millán-de-Meer M, Luque-Ramírez M, Nattero-Chávez L, Escobar-Morreale HF
Hum Reprod Update 2023 Nov 2;29(6):741-772. doi: 10.1093/humupd/dmad015. PMID: 37353908
PCOS Features and Steroid Profiles Among Young Adult Women with a History of Premature Adrenarche.
Tennilä J, Jääskeläinen J, Utriainen P, Voutilainen R, Häkkinen M, Auriola S, Morin-Papunen L, Liimatta J
J Clin Endocrinol Metab 2021 Aug 18;106(9):e3335-e3345. doi: 10.1210/clinem/dgab385. PMID: 34060603Free PMC Article
Circulating hormones and breast cancer risk in premenopausal women: a randomized trial of low-dose tamoxifen and fenretinide.
Johansson H, Bonanni B, Gandini S, Guerrieri-Gonzaga A, Cazzaniga M, Serrano D, Macis D, Puccio A, Sandri MT, Gulisano M, Formelli F, Decensi A
Breast Cancer Res Treat 2013 Dec;142(3):569-78. Epub 2013 Nov 17 doi: 10.1007/s10549-013-2768-7. PMID: 24241787
Association between circulating fibroblast growth factor 23, α-Klotho, and the left ventricular ejection fraction and left ventricular mass in cardiology inpatients.
Shibata K, Fujita S, Morita H, Okamoto Y, Sohmiya K, Hoshiga M, Ishizaka N
PLoS One 2013;8(9):e73184. Epub 2013 Sep 9 doi: 10.1371/journal.pone.0073184. PMID: 24039882Free PMC Article
Bile acids and progesterone metabolites in intrahepatic cholestasis of pregnancy.
Reyes H, Sjövall J
Ann Med 2000 Mar;32(2):94-106. doi: 10.3109/07853890009011758. PMID: 10766400

Clinical prediction guides

Oxidative stress promotes hyperandrogenism by reducing sex hormone-binding globulin in polycystic ovary syndrome.
Sun Y, Li S, Liu H, Bai H, Hu K, Zhang R, Liu Q, Fan P
Fertil Steril 2021 Dec;116(6):1641-1650. Epub 2021 Aug 22 doi: 10.1016/j.fertnstert.2021.07.1203. PMID: 34433519
Hyperparathyroidism in Patients With X-Linked Hypophosphatemia.
Lecoq AL, Chaumet-Riffaud P, Blanchard A, Dupeux M, Rothenbuhler A, Lambert B, Durand E, Boros E, Briot K, Silve C, Francou B, Piketty M, Chanson P, Brailly-Tabard S, Linglart A, Kamenický P
J Bone Miner Res 2020 Jul;35(7):1263-1273. Epub 2020 Mar 27 doi: 10.1002/jbmr.3992. PMID: 32101626
Metabolic Effects of Oxytocin.
McCormack SE, Blevins JE, Lawson EA
Endocr Rev 2020 Apr 1;41(2):121-45. doi: 10.1210/endrev/bnz012. PMID: 31803919Free PMC Article
Bile acids and progesterone metabolites in intrahepatic cholestasis of pregnancy.
Reyes H, Sjövall J
Ann Med 2000 Mar;32(2):94-106. doi: 10.3109/07853890009011758. PMID: 10766400
Clinical utility of sex hormone-binding globulin measurement.
Pugeat M, Crave JC, Tourniaire J, Forest MG
Horm Res 1996;45(3-5):148-55. doi: 10.1159/000184778. PMID: 8964574

Recent systematic reviews

Association between female circulating heavy metal concentration and abortion: a systematic review and meta-analysis.
Ren M, Wang L, Wen L, Chen J, Quan S, Shi X
Front Endocrinol (Lausanne) 2023;14:1216507. Epub 2023 Aug 29 doi: 10.3389/fendo.2023.1216507. PMID: 37711903Free PMC Article
PCOS during the menopausal transition and after menopause: a systematic review and meta-analysis.
Millán-de-Meer M, Luque-Ramírez M, Nattero-Chávez L, Escobar-Morreale HF
Hum Reprod Update 2023 Nov 2;29(6):741-772. doi: 10.1093/humupd/dmad015. PMID: 37353908

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