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Non-Neoplastic Lacrimal System Disorder

MedGen UID:
1784225
•Concept ID:
C5446379
•
Disease or Syndrome
Synonym: Non-Neoplastic Lacrimal Apparatus Disorder

Definition

A non-neoplastic disorder that affects the lacrimal gland and/or the lacrimal drainage system. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNon-Neoplastic Lacrimal System Disorder

Professional guidelines

PubMed

The investigation and management of non-neoplastic diseases affecting the salivary glands.
Diamant H
J Laryngol Otol 1974 Aug;88(8):705-16. doi: 10.1017/s0022215100079287. PMID: 4421406

Recent clinical studies

Etiology

Study of microRNAs (miRNAs) that are predicted to target the autoantigens Ro/SSA and La/SSB in primary Sjögren's Syndrome.
Gourzi VC, Kapsogeorgou EK, Kyriakidis NC, Tzioufas AG
Clin Exp Immunol 2015 Oct;182(1):14-22. Epub 2015 Jul 21 doi: 10.1111/cei.12664. PMID: 26201309Free PMC Article
Lacrimal gland lesions in Denmark between 1974 and 2007.
von Holstein SL, Therkildsen MH, Prause JU, Stenman G, Siersma VD, Heegaard S
Acta Ophthalmol 2013 Jun;91(4):349-54. Epub 2012 Apr 4 doi: 10.1111/j.1755-3768.2012.02403.x. PMID: 22471375
Diagnostic and interventional sialendoscopy: a preliminary experience.
Bowen MA, Tauzin M, Kluka EA, Nuss DW, DiLeo M, McWhorter AJ, Schaitkin B, Walvekar RR
Laryngoscope 2011 Feb;121(2):299-303. Epub 2011 Jan 14 doi: 10.1002/lary.21390. PMID: 21271577

Diagnosis

IgG4-Related Skin Disease Presenting as a Pseudolymphoma in a White Adolescent Girl.
Shakeri A, Kindley KJ, Noland MM, Gru AA
Am J Dermatopathol 2019 Sep;41(9):675-679. doi: 10.1097/DAD.0000000000001401. PMID: 30839348
Clinical significance of routine lacrimal sac biopsy during dacryocystorhinostomy: A comprehensive review of literature.
Koturović Z, Knežević M, Rašić DM
Bosn J Basic Med Sci 2017 Feb 21;17(1):1-8. doi: 10.17305/bjbms.2016.1424. PMID: 27754826Free PMC Article
Tumours of the lacrimal gland. Epidemiological, clinical and genetic characteristics.
von Holstein SL
Acta Ophthalmol 2013 Nov;91 Thesis 6:1-28. doi: 10.1111/aos.12271. PMID: 24893972
Lacrimal gland lesions in Denmark between 1974 and 2007.
von Holstein SL, Therkildsen MH, Prause JU, Stenman G, Siersma VD, Heegaard S
Acta Ophthalmol 2013 Jun;91(4):349-54. Epub 2012 Apr 4 doi: 10.1111/j.1755-3768.2012.02403.x. PMID: 22471375
Parotid space: anatomic imaging.
Kanekar SG, Mannion K, Zacharia T, Showalter M
Otolaryngol Clin North Am 2012 Dec;45(6):1253-72. doi: 10.1016/j.otc.2012.08.011. PMID: 23153748

Therapy

Diagnostic and interventional sialendoscopy: a preliminary experience.
Bowen MA, Tauzin M, Kluka EA, Nuss DW, DiLeo M, McWhorter AJ, Schaitkin B, Walvekar RR
Laryngoscope 2011 Feb;121(2):299-303. Epub 2011 Jan 14 doi: 10.1002/lary.21390. PMID: 21271577

Prognosis

Study of microRNAs (miRNAs) that are predicted to target the autoantigens Ro/SSA and La/SSB in primary Sjögren's Syndrome.
Gourzi VC, Kapsogeorgou EK, Kyriakidis NC, Tzioufas AG
Clin Exp Immunol 2015 Oct;182(1):14-22. Epub 2015 Jul 21 doi: 10.1111/cei.12664. PMID: 26201309Free PMC Article
Tumours of the lacrimal gland. Epidemiological, clinical and genetic characteristics.
von Holstein SL
Acta Ophthalmol 2013 Nov;91 Thesis 6:1-28. doi: 10.1111/aos.12271. PMID: 24893972
Lacrimal gland lesions in Denmark between 1974 and 2007.
von Holstein SL, Therkildsen MH, Prause JU, Stenman G, Siersma VD, Heegaard S
Acta Ophthalmol 2013 Jun;91(4):349-54. Epub 2012 Apr 4 doi: 10.1111/j.1755-3768.2012.02403.x. PMID: 22471375

Clinical prediction guides

Repertoire Analysis of B-Cells Located in Striated Ducts of Salivary Glands of Patients With Sjögren's Syndrome.
Visser A, Verstappen GM, van der Vegt B, Vissink A, Bende RJ, Bootsma H, Bos NA, Kroese FGM
Front Immunol 2020;11:1486. Epub 2020 Jul 14 doi: 10.3389/fimmu.2020.01486. PMID: 32760405Free PMC Article
Cell-autonomous epithelial activation of AIM2 (absent in melanoma-2) inflammasome by cytoplasmic DNA accumulations in primary Sjögren's syndrome.
Vakrakou AG, Svolaki IP, Evangelou K, Gorgoulis VG, Manoussakis MN
J Autoimmun 2020 Mar;108:102381. Epub 2020 Jan 7 doi: 10.1016/j.jaut.2019.102381. PMID: 31919014
The role of intrinsic epithelial activation in the pathogenesis of Sjögren's syndrome.
Manoussakis MN, Kapsogeorgou EK
J Autoimmun 2010 Nov;35(3):219-24. Epub 2010 Aug 4 doi: 10.1016/j.jaut.2010.06.011. PMID: 20685080
Induction of TNF-alpha-converting enzyme-ectodomain shedding by pathogenic autoantibodies.
Sisto M, Lisi S, Lofrumento DD, Frassanito MA, Cucci L, D'Amore S, Mitolo V, D'Amore M
Int Immunol 2009 Dec;21(12):1341-9. Epub 2009 Oct 23 doi: 10.1093/intimm/dxp103. PMID: 19854762
Immunoreactivity of neoplastic and non-neoplastic monocytoid B lymphocytes for DBA.44 and other antibodies.
Ohsawa M, Kanno H, Machii T, Aozasa K
J Clin Pathol 1994 Oct;47(10):928-32. doi: 10.1136/jcp.47.10.928. PMID: 7962607Free PMC Article

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