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High-grade vesicoureteral reflux

MedGen UID:
1785293
•Concept ID:
C5539785
•
Disease or Syndrome
HPO: HP:0033734

Definition

Vesicoureteral reflux with dilation of the renal calyces (Grade III - V). [from HPO]

Professional guidelines

PubMed

Management of antenatal hydronephrosis.
Yalçınkaya F, Özçakar ZB
Pediatr Nephrol 2020 Dec;35(12):2231-2239. Epub 2019 Dec 6 doi: 10.1007/s00467-019-04420-6. PMID: 31811536
Updated Italian recommendations for the diagnosis, treatment and follow-up of the first febrile urinary tract infection in young children.
Ammenti A, Alberici I, Brugnara M, Chimenz R, Guarino S, La Manna A, La Scola C, Maringhini S, Marra G, Materassi M, Morello W, Nicolini G, Pennesi M, Pisanello L, Pugliese F, Scozzola F, Sica F, Toffolo A, Montini G; Italian Society of Pediatric Nephrology
Acta Paediatr 2020 Feb;109(2):236-247. Epub 2019 Oct 6 doi: 10.1111/apa.14988. PMID: 31454101Free PMC Article
Evaluation of prenatal hydronephrosis: novel criteria for predicting vesicoureteral reflux on ultrasonography.
Lee NG, Rushton HG, Peters CA, Groves DS, Pohl HG
J Urol 2014 Sep;192(3):914-8. Epub 2014 Apr 1 doi: 10.1016/j.juro.2014.03.100. PMID: 24704010

Recent clinical studies

Etiology

Model for predicting high-grade vesicoureteral reflux in young children presenting with febrile urinary tract infection.
Klubdaeng A, Chaiyapak T, Sumboonnanonda A, Piyaphanee N
J Pediatr Urol 2022 Aug;18(4):518-524. Epub 2022 Jun 11 doi: 10.1016/j.jpurol.2022.06.006. PMID: 35760670
High-grade vesicoureteral reflux in infants: Our experience with endoscopic subureteric injections.
Al Hindi S, Mubarak M, Al Aradi H
Urologia 2022 Feb;89(1):120-125. Epub 2020 Oct 16 doi: 10.1177/0391560320966187. PMID: 33063631
Sex effects in pyelonephritis.
Albracht CD, Hreha TN, Hunstad DA
Pediatr Nephrol 2021 Mar;36(3):507-515. Epub 2020 Feb 10 doi: 10.1007/s00467-020-04492-9. PMID: 32040629Free PMC Article
Updated Italian recommendations for the diagnosis, treatment and follow-up of the first febrile urinary tract infection in young children.
Ammenti A, Alberici I, Brugnara M, Chimenz R, Guarino S, La Manna A, La Scola C, Maringhini S, Marra G, Materassi M, Morello W, Nicolini G, Pennesi M, Pisanello L, Pugliese F, Scozzola F, Sica F, Toffolo A, Montini G; Italian Society of Pediatric Nephrology
Acta Paediatr 2020 Feb;109(2):236-247. Epub 2019 Oct 6 doi: 10.1111/apa.14988. PMID: 31454101Free PMC Article
The Swedish infant high-grade reflux trial: UTI and renal damage.
Nordenström J, Sjöström S, Sillén U, Sixt R, Brandström P
J Pediatr Urol 2017 Apr;13(2):146-154. Epub 2017 Feb 2 doi: 10.1016/j.jpurol.2016.12.023. PMID: 28215835

Diagnosis

Model for predicting high-grade vesicoureteral reflux in young children presenting with febrile urinary tract infection.
Klubdaeng A, Chaiyapak T, Sumboonnanonda A, Piyaphanee N
J Pediatr Urol 2022 Aug;18(4):518-524. Epub 2022 Jun 11 doi: 10.1016/j.jpurol.2022.06.006. PMID: 35760670
High-grade vesicoureteral reflux in infants: Our experience with endoscopic subureteric injections.
Al Hindi S, Mubarak M, Al Aradi H
Urologia 2022 Feb;89(1):120-125. Epub 2020 Oct 16 doi: 10.1177/0391560320966187. PMID: 33063631
Management of antenatal hydronephrosis.
Yalçınkaya F, Özçakar ZB
Pediatr Nephrol 2020 Dec;35(12):2231-2239. Epub 2019 Dec 6 doi: 10.1007/s00467-019-04420-6. PMID: 31811536
Updated Italian recommendations for the diagnosis, treatment and follow-up of the first febrile urinary tract infection in young children.
Ammenti A, Alberici I, Brugnara M, Chimenz R, Guarino S, La Manna A, La Scola C, Maringhini S, Marra G, Materassi M, Morello W, Nicolini G, Pennesi M, Pisanello L, Pugliese F, Scozzola F, Sica F, Toffolo A, Montini G; Italian Society of Pediatric Nephrology
Acta Paediatr 2020 Feb;109(2):236-247. Epub 2019 Oct 6 doi: 10.1111/apa.14988. PMID: 31454101Free PMC Article
The Swedish infant high-grade reflux trial: UTI and renal damage.
Nordenström J, Sjöström S, Sillén U, Sixt R, Brandström P
J Pediatr Urol 2017 Apr;13(2):146-154. Epub 2017 Feb 2 doi: 10.1016/j.jpurol.2016.12.023. PMID: 28215835

Therapy

Model for predicting high-grade vesicoureteral reflux in young children presenting with febrile urinary tract infection.
Klubdaeng A, Chaiyapak T, Sumboonnanonda A, Piyaphanee N
J Pediatr Urol 2022 Aug;18(4):518-524. Epub 2022 Jun 11 doi: 10.1016/j.jpurol.2022.06.006. PMID: 35760670
The Swedish infant high-grade reflux trial: UTI and renal damage.
Nordenström J, Sjöström S, Sillén U, Sixt R, Brandström P
J Pediatr Urol 2017 Apr;13(2):146-154. Epub 2017 Feb 2 doi: 10.1016/j.jpurol.2016.12.023. PMID: 28215835
The Swedish Infant High-grade Reflux Trial - Bladder function.
Nordenström J, Sillen U, Holmdahl G, Linnér T, Stokland E, Sjöström S
J Pediatr Urol 2017 Apr;13(2):139-145. Epub 2016 Nov 30 doi: 10.1016/j.jpurol.2016.10.022. PMID: 27989639
The Swedish infant high-grade reflux trial: Study presentation and vesicoureteral reflux outcome.
Nordenström J, Holmdahl G, Brandström P, Sixt R, Stokland E, Sillén U, Sjöström S
J Pediatr Urol 2017 Apr;13(2):130-138. Epub 2016 Oct 24 doi: 10.1016/j.jpurol.2016.08.026. PMID: 27889221
Urinary Tract Infections in Infants and Children.
Schlager TA
Microbiol Spectr 2016 Oct;4(5) doi: 10.1128/microbiolspec.UTI-0022-2016. PMID: 28087926

Prognosis

Model for predicting high-grade vesicoureteral reflux in young children presenting with febrile urinary tract infection.
Klubdaeng A, Chaiyapak T, Sumboonnanonda A, Piyaphanee N
J Pediatr Urol 2022 Aug;18(4):518-524. Epub 2022 Jun 11 doi: 10.1016/j.jpurol.2022.06.006. PMID: 35760670
Updated Italian recommendations for the diagnosis, treatment and follow-up of the first febrile urinary tract infection in young children.
Ammenti A, Alberici I, Brugnara M, Chimenz R, Guarino S, La Manna A, La Scola C, Maringhini S, Marra G, Materassi M, Morello W, Nicolini G, Pennesi M, Pisanello L, Pugliese F, Scozzola F, Sica F, Toffolo A, Montini G; Italian Society of Pediatric Nephrology
Acta Paediatr 2020 Feb;109(2):236-247. Epub 2019 Oct 6 doi: 10.1111/apa.14988. PMID: 31454101Free PMC Article
The Swedish infant high-grade reflux trial: UTI and renal damage.
Nordenström J, Sjöström S, Sillén U, Sixt R, Brandström P
J Pediatr Urol 2017 Apr;13(2):146-154. Epub 2017 Feb 2 doi: 10.1016/j.jpurol.2016.12.023. PMID: 28215835
The Swedish Infant High-grade Reflux Trial - Bladder function.
Nordenström J, Sillen U, Holmdahl G, Linnér T, Stokland E, Sjöström S
J Pediatr Urol 2017 Apr;13(2):139-145. Epub 2016 Nov 30 doi: 10.1016/j.jpurol.2016.10.022. PMID: 27989639
Renal ultrasound and DMSA screening for high-grade vesicoureteral reflux.
Wongbencharat K, Tongpenyai Y, Na-Rungsri K
Pediatr Int 2016 Mar;58(3):214-218. Epub 2016 Feb 15 doi: 10.1111/ped.12803. PMID: 26275163

Clinical prediction guides

Model for predicting high-grade vesicoureteral reflux in young children presenting with febrile urinary tract infection.
Klubdaeng A, Chaiyapak T, Sumboonnanonda A, Piyaphanee N
J Pediatr Urol 2022 Aug;18(4):518-524. Epub 2022 Jun 11 doi: 10.1016/j.jpurol.2022.06.006. PMID: 35760670
High-grade vesicoureteral reflux in infants: Our experience with endoscopic subureteric injections.
Al Hindi S, Mubarak M, Al Aradi H
Urologia 2022 Feb;89(1):120-125. Epub 2020 Oct 16 doi: 10.1177/0391560320966187. PMID: 33063631
The Swedish infant high-grade reflux trial: UTI and renal damage.
Nordenström J, Sjöström S, Sillén U, Sixt R, Brandström P
J Pediatr Urol 2017 Apr;13(2):146-154. Epub 2017 Feb 2 doi: 10.1016/j.jpurol.2016.12.023. PMID: 28215835
The Swedish Infant High-grade Reflux Trial - Bladder function.
Nordenström J, Sillen U, Holmdahl G, Linnér T, Stokland E, Sjöström S
J Pediatr Urol 2017 Apr;13(2):139-145. Epub 2016 Nov 30 doi: 10.1016/j.jpurol.2016.10.022. PMID: 27989639
Renal ultrasound and DMSA screening for high-grade vesicoureteral reflux.
Wongbencharat K, Tongpenyai Y, Na-Rungsri K
Pediatr Int 2016 Mar;58(3):214-218. Epub 2016 Feb 15 doi: 10.1111/ped.12803. PMID: 26275163

Recent systematic reviews

Effectiveness and risks of endoscopic management compared to vesicoureteral reimplantation in patients with high-grade vesicoureteral reflux: systematic review and network meta-analysis.
Mina-Riascos SH, Fernández N, García-Perdomo HA
Eur J Pediatr 2021 May;180(5):1383-1391. Epub 2021 Jan 20 doi: 10.1007/s00431-021-03948-w. PMID: 33474581

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