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Neuroinflammatory Diseases

MedGen UID:
1787585
•Concept ID:
C5544451
•
Disease or Syndrome
Synonyms: Disease, Neuroinflammatory; Disorder, Neuroinflammatory; Neuroinflammatory Disease; Neuroinflammatory Disorder; Neuroinflammatory Disorders

Definition

Diseases characterized by inflammation of the nervous tissue. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeuroinflammatory Diseases

Professional guidelines

PubMed

PPAR agonists for the treatment of neuroinflammatory diseases.
Titus C, Hoque MT, Bendayan R
Trends Pharmacol Sci 2024 Jan;45(1):9-23. Epub 2023 Dec 7 doi: 10.1016/j.tips.2023.11.004. PMID: 38065777
Anti-inflammatory role of gold nanoparticles in the prevention and treatment of Alzheimer's disease.
Aili M, Zhou K, Zhan J, Zheng H, Luo F
J Mater Chem B 2023 Sep 20;11(36):8605-8621. doi: 10.1039/d3tb01023f. PMID: 37615596
Nutritional modulation of the intestinal microbiota; future opportunities for the prevention and treatment of neuroimmune and neuroinflammatory disease.
Lombardi VC, De Meirleir KL, Subramanian K, Nourani SM, Dagda RK, Delaney SL, Palotás A
J Nutr Biochem 2018 Nov;61:1-16. Epub 2018 Apr 19 doi: 10.1016/j.jnutbio.2018.04.004. PMID: 29886183Free PMC Article

Recent clinical studies

Etiology

The effects of microglia-associated neuroinflammation on Alzheimer's disease.
Wang C, Zong S, Cui X, Wang X, Wu S, Wang L, Liu Y, Lu Z
Front Immunol 2023;14:1117172. Epub 2023 Feb 22 doi: 10.3389/fimmu.2023.1117172. PMID: 36911732Free PMC Article
Innate immune dysfunction and neuroinflammation in autism spectrum disorder (ASD).
Hughes HK, R J Moreno, Ashwood P
Brain Behav Immun 2023 Feb;108:245-254. Epub 2022 Dec 6 doi: 10.1016/j.bbi.2022.12.001. PMID: 36494048
Glucagon-like peptide-1 (GLP-1) receptor agonists and neuroinflammation: Implications for neurodegenerative disease treatment.
Kopp KO, Glotfelty EJ, Li Y, Greig NH
Pharmacol Res 2022 Dec;186:106550. Epub 2022 Nov 11 doi: 10.1016/j.phrs.2022.106550. PMID: 36372278Free PMC Article
Gut microbiota regulate Alzheimer's disease pathologies and cognitive disorders via PUFA-associated neuroinflammation.
Chen C, Liao J, Xia Y, Liu X, Jones R, Haran J, McCormick B, Sampson TR, Alam A, Ye K
Gut 2022 Nov;71(11):2233-2252. Epub 2022 Jan 11 doi: 10.1136/gutjnl-2021-326269. PMID: 35017199Free PMC Article
Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?
Leng F, Edison P
Nat Rev Neurol 2021 Mar;17(3):157-172. Epub 2020 Dec 14 doi: 10.1038/s41582-020-00435-y. PMID: 33318676

Diagnosis

The effects of microglia-associated neuroinflammation on Alzheimer's disease.
Wang C, Zong S, Cui X, Wang X, Wu S, Wang L, Liu Y, Lu Z
Front Immunol 2023;14:1117172. Epub 2023 Feb 22 doi: 10.3389/fimmu.2023.1117172. PMID: 36911732Free PMC Article
Celiac Disease and Neurological Manifestations: From Gluten to Neuroinflammation.
Giuffrè M, Gazzin S, Zoratti C, Llido JP, Lanza G, Tiribelli C, Moretti R
Int J Mol Sci 2022 Dec 8;23(24) doi: 10.3390/ijms232415564. PMID: 36555205Free PMC Article
Glial Cell-Mediated Neuroinflammation in Alzheimer's Disease.
Al-Ghraiybah NF, Wang J, Alkhalifa AE, Roberts AB, Raj R, Yang E, Kaddoumi A
Int J Mol Sci 2022 Sep 12;23(18) doi: 10.3390/ijms231810572. PMID: 36142483Free PMC Article
Biomarker of Neuroinflammation in Parkinson's Disease.
Liu TW, Chen CM, Chang KH
Int J Mol Sci 2022 Apr 8;23(8) doi: 10.3390/ijms23084148. PMID: 35456966Free PMC Article
Neuroinflammation, Stroke, Blood-Brain Barrier Dysfunction, and Imaging Modalities.
Candelario-Jalil E, Dijkhuizen RM, Magnus T
Stroke 2022 May;53(5):1473-1486. Epub 2022 Apr 7 doi: 10.1161/STROKEAHA.122.036946. PMID: 35387495Free PMC Article

Therapy

Role of neuroinflammation in neurodegeneration development.
Zhang W, Xiao D, Mao Q, Xia H
Signal Transduct Target Ther 2023 Jul 12;8(1):267. doi: 10.1038/s41392-023-01486-5. PMID: 37433768Free PMC Article
Glucagon-like peptide-1 (GLP-1) receptor agonists and neuroinflammation: Implications for neurodegenerative disease treatment.
Kopp KO, Glotfelty EJ, Li Y, Greig NH
Pharmacol Res 2022 Dec;186:106550. Epub 2022 Nov 11 doi: 10.1016/j.phrs.2022.106550. PMID: 36372278Free PMC Article
The role of the gut microbiota in multiple sclerosis.
Correale J, Hohlfeld R, Baranzini SE
Nat Rev Neurol 2022 Sep;18(9):544-558. Epub 2022 Aug 5 doi: 10.1038/s41582-022-00697-8. PMID: 35931825
An Overview of Oxidative Stress, Neuroinflammation, and Neurodegenerative Diseases.
Teleanu DM, Niculescu AG, Lungu II, Radu CI, Vladâcenco O, Roza E, Costăchescu B, Grumezescu AM, Teleanu RI
Int J Mol Sci 2022 May 25;23(11) doi: 10.3390/ijms23115938. PMID: 35682615Free PMC Article
NAD(+) supplementation reduces neuroinflammation and cell senescence in a transgenic mouse model of Alzheimer's disease via cGAS-STING.
Hou Y, Wei Y, Lautrup S, Yang B, Wang Y, Cordonnier S, Mattson MP, Croteau DL, Bohr VA
Proc Natl Acad Sci U S A 2021 Sep 14;118(37) doi: 10.1073/pnas.2011226118. PMID: 34497121Free PMC Article

Prognosis

Amyloid-related imaging abnormalities (ARIA): radiological, biological and clinical characteristics.
Hampel H, Elhage A, Cho M, Apostolova LG, Nicoll JAR, Atri A
Brain 2023 Nov 2;146(11):4414-4424. doi: 10.1093/brain/awad188. PMID: 37280110Free PMC Article
Role of cGAS-Sting Signaling in Alzheimer's Disease.
Govindarajulu M, Ramesh S, Beasley M, Lynn G, Wallace C, Labeau S, Pathak S, Nadar R, Moore T, Dhanasekaran M
Int J Mol Sci 2023 May 2;24(9) doi: 10.3390/ijms24098151. PMID: 37175853Free PMC Article
The role of the gut microbiota in multiple sclerosis.
Correale J, Hohlfeld R, Baranzini SE
Nat Rev Neurol 2022 Sep;18(9):544-558. Epub 2022 Aug 5 doi: 10.1038/s41582-022-00697-8. PMID: 35931825
PET Imaging of Neuroinflammation in Alzheimer's Disease.
Zhou R, Ji B, Kong Y, Qin L, Ren W, Guan Y, Ni R
Front Immunol 2021;12:739130. Epub 2021 Sep 16 doi: 10.3389/fimmu.2021.739130. PMID: 34603323Free PMC Article
Current state of Alzheimer's fluid biomarkers.
Molinuevo JL, Ayton S, Batrla R, Bednar MM, Bittner T, Cummings J, Fagan AM, Hampel H, Mielke MM, Mikulskis A, O'Bryant S, Scheltens P, Sevigny J, Shaw LM, Soares HD, Tong G, Trojanowski JQ, Zetterberg H, Blennow K
Acta Neuropathol 2018 Dec;136(6):821-853. Epub 2018 Nov 28 doi: 10.1007/s00401-018-1932-x. PMID: 30488277Free PMC Article

Clinical prediction guides

Amyloid-related imaging abnormalities (ARIA): radiological, biological and clinical characteristics.
Hampel H, Elhage A, Cho M, Apostolova LG, Nicoll JAR, Atri A
Brain 2023 Nov 2;146(11):4414-4424. doi: 10.1093/brain/awad188. PMID: 37280110Free PMC Article
APOE mediated neuroinflammation and neurodegeneration in Alzheimer's disease.
Parhizkar S, Holtzman DM
Semin Immunol 2022 Jan;59:101594. Epub 2022 Feb 26 doi: 10.1016/j.smim.2022.101594. PMID: 35232622Free PMC Article
NAD(+) supplementation reduces neuroinflammation and cell senescence in a transgenic mouse model of Alzheimer's disease via cGAS-STING.
Hou Y, Wei Y, Lautrup S, Yang B, Wang Y, Cordonnier S, Mattson MP, Croteau DL, Bohr VA
Proc Natl Acad Sci U S A 2021 Sep 14;118(37) doi: 10.1073/pnas.2011226118. PMID: 34497121Free PMC Article
MCP-1: Function, regulation, and involvement in disease.
Singh S, Anshita D, Ravichandiran V
Int Immunopharmacol 2021 Dec;101(Pt B):107598. Epub 2021 May 20 doi: 10.1016/j.intimp.2021.107598. PMID: 34233864Free PMC Article
Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?
Leng F, Edison P
Nat Rev Neurol 2021 Mar;17(3):157-172. Epub 2020 Dec 14 doi: 10.1038/s41582-020-00435-y. PMID: 33318676

Recent systematic reviews

Implications of gut and oral microbiota in neuroinflammatory responses in Alzheimer's disease.
Bello-Corral L, Alves-Gomes L, Fernández-Fernández JA, Fernández-García D, Casado-Verdejo I, Sánchez-Valdeón L
Life Sci 2023 Nov 15;333:122132. Epub 2023 Oct 2 doi: 10.1016/j.lfs.2023.122132. PMID: 37793482
Neuroinflammation in Parkinson's Disease: From Gene to Clinic: A Systematic Review.
Castillo-Rangel C, Marin G, Hernández-Contreras KA, Vichi-Ramírez MM, Zarate-Calderon C, Torres-Pineda O, Diaz-Chiguer DL, De la Mora González D, Gómez Apo E, Teco-Cortes JA, Santos-Paez FM, Coello-Torres MLÁ, Baldoncini M, Reyes Soto G, Aranda-Abreu GE, García LI
Int J Mol Sci 2023 Mar 17;24(6) doi: 10.3390/ijms24065792. PMID: 36982866Free PMC Article
A systematic review of the research progress of non-coding RNA in neuroinflammation and immune regulation in cerebral infarction/ischemia-reperfusion injury.
Yang K, Zeng L, Ge A, Wang S, Zeng J, Yuan X, Mei Z, Wang G, Ge J
Front Immunol 2022;13:930171. Epub 2022 Oct 7 doi: 10.3389/fimmu.2022.930171. PMID: 36275741Free PMC Article
The Amyloid-β Pathway in Alzheimer's Disease.
Hampel H, Hardy J, Blennow K, Chen C, Perry G, Kim SH, Villemagne VL, Aisen P, Vendruscolo M, Iwatsubo T, Masters CL, Cho M, Lannfelt L, Cummings JL, Vergallo A
Mol Psychiatry 2021 Oct;26(10):5481-5503. Epub 2021 Aug 30 doi: 10.1038/s41380-021-01249-0. PMID: 34456336Free PMC Article
Schizophrenia and Dental Health: A Systematic Review.
Comparelli A, Stampatore L, Costacurta M, Pompili M
J Nerv Ment Dis 2021 Sep 1;209(9):684-690. doi: 10.1097/NMD.0000000000001371. PMID: 34448736

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