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Decreased Corticomedullary Ratio

MedGen UID:
1788152
•Concept ID:
C5447230
•
Finding

Definition

Decrease in the size of the cortex relative to the medulla. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased Corticomedullary Ratio

Professional guidelines

PubMed

Fetal kidneys: additional sonographic criteria of normal development.
Devriendt A, Cassart M, Massez A, Donner C, Avni FE
Prenat Diagn 2013 Dec;33(13):1248-52. Epub 2013 Oct 7 doi: 10.1002/pd.4240. PMID: 24105773

Recent clinical studies

Etiology

The effects of semaglutide, empagliflozin and their combination on the kidney sodium signal from magnetic resonance imaging: A prespecified, secondary analysis from a randomized, clinical trial.
Gullaksen S, Vernstrøm L, Sørensen SS, Ringgaard S, Laustsen C, Birn H, Funck KL, Poulsen PL, Laugesen E
J Diabetes Complications 2024 Feb;38(2):108673. Epub 2024 Jan 5 doi: 10.1016/j.jdiacomp.2023.108673. PMID: 38219335
Fetal growth restriction followed by very preterm birth is associated with smaller kidneys but preserved kidney function in adolescence.
Liefke J, Heijl C, Steding-Ehrenborg K, Morsing E, Arheden H, Ley D, Hedström E
Pediatr Nephrol 2023 Jun;38(6):1855-1866. Epub 2022 Nov 21 doi: 10.1007/s00467-022-05785-x. PMID: 36409369Free PMC Article
Fetal kidneys: additional sonographic criteria of normal development.
Devriendt A, Cassart M, Massez A, Donner C, Avni FE
Prenat Diagn 2013 Dec;33(13):1248-52. Epub 2013 Oct 7 doi: 10.1002/pd.4240. PMID: 24105773
Corticomedullary strain ratio: a quantitative marker for assessment of renal allograft cortical fibrosis.
Gao J, Min R, Hamilton J, Weitzel W, Chen J, Juluru K, Rubin JM
J Ultrasound Med 2013 Oct;32(10):1769-75. doi: 10.7863/ultra.32.10.1769. PMID: 24065258
Noninvasive evaluation of renal oxygenation in diabetic nephropathy by BOLD-MRI.
Yin WJ, Liu F, Li XM, Yang L, Zhao S, Huang ZX, Huang YQ, Liu RB
Eur J Radiol 2012 Jul;81(7):1426-31. Epub 2011 Apr 5 doi: 10.1016/j.ejrad.2011.03.045. PMID: 21470811

Diagnosis

Utilization of the corticomedullary difference in magnetic resonance imaging-derived apparent diffusion coefficient for noninvasive assessment of chronic kidney disease in type 2 diabetes.
Duan S, Geng L, Lu F, Chen C, Jiang L, Chen S, Zhang C, Huang Z, Zeng M, Sun B, Zhang B, Mao H, Xing C, Zhang Y, Yuan Y
Diabetes Metab Syndr 2024 Feb;18(2):102963. Epub 2024 Feb 12 doi: 10.1016/j.dsx.2024.102963. PMID: 38373384
Corticomedullary strain ratio: a quantitative marker for assessment of renal allograft cortical fibrosis.
Gao J, Min R, Hamilton J, Weitzel W, Chen J, Juluru K, Rubin JM
J Ultrasound Med 2013 Oct;32(10):1769-75. doi: 10.7863/ultra.32.10.1769. PMID: 24065258
Indicators of acute rejection on Tc-99m DTPA renal scintigraphy.
Aktaş A, Aras M, Colak T, Gençoğlu A, Moray G
Transplant Proc 2006 Mar;38(2):443-8. doi: 10.1016/j.transproceed.2006.01.004. PMID: 16549143
Sporadic unilateral adrenomedullary hyperplasia with hypertension cured by adrenalectomy.
Dralle H, Schröder S, Gratz KF, Grote R, Padberg B, Hesch RD
World J Surg 1990 May-Jun;14(3):308-15; discussion 316. doi: 10.1007/BF01658512. PMID: 2368434

Therapy

The effects of semaglutide, empagliflozin and their combination on the kidney sodium signal from magnetic resonance imaging: A prespecified, secondary analysis from a randomized, clinical trial.
Gullaksen S, Vernstrøm L, Sørensen SS, Ringgaard S, Laustsen C, Birn H, Funck KL, Poulsen PL, Laugesen E
J Diabetes Complications 2024 Feb;38(2):108673. Epub 2024 Jan 5 doi: 10.1016/j.jdiacomp.2023.108673. PMID: 38219335
Renal transplant recipients receiving loop diuretic therapy have increased urinary tract infection rate and altered medullary macrophage polarization marker expression.
Casper J, Schmitz J, Bräsen JH, Khalifa A, Schmidt BMW, Einecke G, Haller H, von Vietinghoff S
Kidney Int 2018 Nov;94(5):993-1001. Epub 2018 Sep 28 doi: 10.1016/j.kint.2018.06.029. PMID: 30274681
Corticomedullary strain ratio: a quantitative marker for assessment of renal allograft cortical fibrosis.
Gao J, Min R, Hamilton J, Weitzel W, Chen J, Juluru K, Rubin JM
J Ultrasound Med 2013 Oct;32(10):1769-75. doi: 10.7863/ultra.32.10.1769. PMID: 24065258
Regulated oxygen sensing by protein hydroxylation in renal erythropoietin-producing cells.
Wenger RH, Hoogewijs D
Am J Physiol Renal Physiol 2010 Jun;298(6):F1287-96. Epub 2010 Mar 10 doi: 10.1152/ajprenal.00736.2009. PMID: 20219824

Prognosis

Utilization of the corticomedullary difference in magnetic resonance imaging-derived apparent diffusion coefficient for noninvasive assessment of chronic kidney disease in type 2 diabetes.
Duan S, Geng L, Lu F, Chen C, Jiang L, Chen S, Zhang C, Huang Z, Zeng M, Sun B, Zhang B, Mao H, Xing C, Zhang Y, Yuan Y
Diabetes Metab Syndr 2024 Feb;18(2):102963. Epub 2024 Feb 12 doi: 10.1016/j.dsx.2024.102963. PMID: 38373384
Fetal growth restriction followed by very preterm birth is associated with smaller kidneys but preserved kidney function in adolescence.
Liefke J, Heijl C, Steding-Ehrenborg K, Morsing E, Arheden H, Ley D, Hedström E
Pediatr Nephrol 2023 Jun;38(6):1855-1866. Epub 2022 Nov 21 doi: 10.1007/s00467-022-05785-x. PMID: 36409369Free PMC Article
Noninvasive evaluation of renal oxygenation in diabetic nephropathy by BOLD-MRI.
Yin WJ, Liu F, Li XM, Yang L, Zhao S, Huang ZX, Huang YQ, Liu RB
Eur J Radiol 2012 Jul;81(7):1426-31. Epub 2011 Apr 5 doi: 10.1016/j.ejrad.2011.03.045. PMID: 21470811
A multiunit model of solute and water removal by inner medullary vasa recta.
Edwards A, Pallone TL
Am J Physiol 1998 Apr;274(4):H1202-10. doi: 10.1152/ajpheart.1998.274.4.H1202. PMID: 9575923
Sporadic unilateral adrenomedullary hyperplasia with hypertension cured by adrenalectomy.
Dralle H, Schröder S, Gratz KF, Grote R, Padberg B, Hesch RD
World J Surg 1990 May-Jun;14(3):308-15; discussion 316. doi: 10.1007/BF01658512. PMID: 2368434

Clinical prediction guides

Utilization of the corticomedullary difference in magnetic resonance imaging-derived apparent diffusion coefficient for noninvasive assessment of chronic kidney disease in type 2 diabetes.
Duan S, Geng L, Lu F, Chen C, Jiang L, Chen S, Zhang C, Huang Z, Zeng M, Sun B, Zhang B, Mao H, Xing C, Zhang Y, Yuan Y
Diabetes Metab Syndr 2024 Feb;18(2):102963. Epub 2024 Feb 12 doi: 10.1016/j.dsx.2024.102963. PMID: 38373384
Measurement of renal cortical thickness using noncontrast-enhanced steady-state free precession MRI with spatially selective inversion recovery pulse: Association with renal function.
Noda Y, Ito K, Kanki A, Tamada T, Yamamoto A, Kazuya Y, Higaki A
J Magn Reson Imaging 2015 Jun;41(6):1615-21. Epub 2014 Jul 28 doi: 10.1002/jmri.24719. PMID: 25066504
Corticomedullary strain ratio: a quantitative marker for assessment of renal allograft cortical fibrosis.
Gao J, Min R, Hamilton J, Weitzel W, Chen J, Juluru K, Rubin JM
J Ultrasound Med 2013 Oct;32(10):1769-75. doi: 10.7863/ultra.32.10.1769. PMID: 24065258
Indicators of acute rejection on Tc-99m DTPA renal scintigraphy.
Aktaş A, Aras M, Colak T, Gençoğlu A, Moray G
Transplant Proc 2006 Mar;38(2):443-8. doi: 10.1016/j.transproceed.2006.01.004. PMID: 16549143
A multiunit model of solute and water removal by inner medullary vasa recta.
Edwards A, Pallone TL
Am J Physiol 1998 Apr;274(4):H1202-10. doi: 10.1152/ajpheart.1998.274.4.H1202. PMID: 9575923

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