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Thrombotic Disorder

MedGen UID:: 1790555
•Concept ID:: C5552685
•: Disease or Syndrome

Definition

A disorder in which there is pathological development of blood clots within the cardiovascular system. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVThrombotic Disorder

Pathological Conditions, Signs and Symptoms
- Pathological process
  - Disease
    - Disorder by Site
      - Disorder of cardiovascular system
        Thrombotic Disorder
        Thrombophilia
        Disseminated intravascular coagulation
        Acute disseminated intravascular coagulation
        Chronic disseminated intravascular coagulation
        Disseminated intravascular coagulation in newborn
        Hereditary antithrombin deficiency
        Hereditary thrombophilia
        Hereditary thrombophilia due to congenital histidine-rich (poly-L) glycoprotein deficiency
        Hereditary thrombophilia due to congenital protein C deficiency
        Hereditary thrombophilia due to congenital protein S deficiency
        Protein S deficiency disease
        Reduced protein C activity
        Resistance to activated protein C
        Thrombotic thrombocytopenic purpura
        Acquired thrombotic thrombocytopenic purpura
        Upshaw-Schulman syndrome
        Thrombotic microangiopathy
        Hemolytic-uremic syndrome
        Atypical hemolytic-uremic syndrome
        Atypical hemolytic-uremic syndrome with DGKE deficiency
        Cobalamin C disease
        D-minus hemolytic uremic syndrome (D-HUS)
        D-plus hemolytic uremic syndrome (D+HUS)
        Diarrhea-associated hemolytic uremic syndrome
        Infection-related hemolytic uremic syndrome
        Systemic lupus erythematosus
        Bullous systemic lupus erythematosus
        Central nervous system lupus
        Childhood-Onset Systemic Lupus Erythematosus
        Lupus Encephalitis
        Lupus nephritis
        Rash of systemic lupus erythematosus
        Systemic lupus erythematosus, susceptibility to, 1
        Systemic lupus erythematosus, susceptibility to, 2
        Systemic lupus erythematosus, susceptibility to, 3
        Systemic lupus erythematosus, susceptibility to, 4
        Systemic lupus erythematosus, susceptibility to, 5
        Systemic lupus erythematosus, susceptibility to, 6
        Systemic lupus erythematosus, susceptibility to, 7
        Systemic lupus erythematosus, susceptibility to, 8
        Systemic lupus erythematosus, susceptibility to, 9
        Systemic lupus erythematosus, susceptibility to, 10
        Systemic lupus erythematosus, susceptibility to, 11
        Systemic lupus erythematosus, susceptibility to, 12
        Systemic lupus erythematosus, susceptibility to, 13
        Systemic lupus erythematosus, susceptibility to, 14
        Thrombocytopenic purpura
        Autoimmune thrombocytopenic purpura
        Transplant-Associated Thrombotic Microangiopathy

Professional guidelines

PubMed

Antithrombotic treatment for retinal vein occlusion: a systematic review and meta-analysis.

Valeriani E, Paciullo F, Porfidia A, Pignatelli P, Candeloro M, Di Nisio M, Donadini MP, Mastroianni CM, Pola R, Gresele P, Ageno W
J Thromb Haemost 2023 Feb;21(2):284-293. Epub 2022 Dec 22 doi: 10.1016/j.jtha.2022.10.003. PMID: 36700511

Advances in the diagnosis and treatment of disseminated intravascular coagulation in haematological malignancies.

Ikezoe T
Int J Hematol 2021 Jan;113(1):34-44. Epub 2020 Sep 9 doi: 10.1007/s12185-020-02992-w. PMID: 32902759

The evaluation and management of neonatal coagulation disorders.

Saxonhouse MA, Manco-Johnson MJ
Semin Perinatol 2009 Feb;33(1):52-65. doi: 10.1053/j.semperi.2008.10.007. PMID: 19167582

See all (9)

Recent clinical studies

Etiology

Anticoagulation in Patients with Liver Cirrhosis: Friend or Foe?

Protopapas AA, Savopoulos C, Skoura L, Goulis I
Dig Dis Sci 2023 Jun;68(6):2237-2246. Epub 2023 Mar 24 doi: 10.1007/s10620-023-07858-9. PMID: 36961672 Free PMC Article

Evaluation of safety, pharmacokinetics, and pharmacodynamics of apixaban in pediatric subjects at risk of venous or arterial thrombotic disorder.

Merali SJ, Byon W, Patel YT, Elsrougy A, Marchisin D, Perera V, Chen W, He B, Murthy B
CPT Pharmacometrics Syst Pharmacol 2023 Apr;12(4):500-512. Epub 2023 Mar 5 doi: 10.1002/psp4.12935. PMID: 36861188 Free PMC Article

Advances in the diagnosis and treatment of disseminated intravascular coagulation in haematological malignancies.

Ikezoe T
Int J Hematol 2021 Jan;113(1):34-44. Epub 2020 Sep 9 doi: 10.1007/s12185-020-02992-w. PMID: 32902759

Risk Factors for Cerebral Venous Thrombosis.

Silvis SM, Middeldorp S, Zuurbier SM, Cannegieter SC, Coutinho JM
Semin Thromb Hemost 2016 Sep;42(6):622-31. Epub 2016 Jun 6 doi: 10.1055/s-0036-1584132. PMID: 27272966

The evaluation and management of neonatal coagulation disorders.

Saxonhouse MA, Manco-Johnson MJ
Semin Perinatol 2009 Feb;33(1):52-65. doi: 10.1053/j.semperi.2008.10.007. PMID: 19167582

See all (44)

Diagnosis

Advances in the diagnosis and treatment of disseminated intravascular coagulation in haematological malignancies.

Ikezoe T
Int J Hematol 2021 Jan;113(1):34-44. Epub 2020 Sep 9 doi: 10.1007/s12185-020-02992-w. PMID: 32902759

Cancer and Cerebrovascular Disease.

Adams HP Jr
Curr Neurol Neurosci Rep 2019 Aug 23;19(10):73. doi: 10.1007/s11910-019-0985-0. PMID: 31440841

Risk Factors for Cerebral Venous Thrombosis.

Silvis SM, Middeldorp S, Zuurbier SM, Cannegieter SC, Coutinho JM
Semin Thromb Hemost 2016 Sep;42(6):622-31. Epub 2016 Jun 6 doi: 10.1055/s-0036-1584132. PMID: 27272966

The evaluation and management of neonatal coagulation disorders.

Saxonhouse MA, Manco-Johnson MJ
Semin Perinatol 2009 Feb;33(1):52-65. doi: 10.1053/j.semperi.2008.10.007. PMID: 19167582

Catastrophic antiphospholipid syndrome.

Merrill JT, Asherson RA
Nat Clin Pract Rheumatol 2006 Feb;2(2):81-9. doi: 10.1038/ncprheum0069. PMID: 16932661

See all (48)

Therapy

Targeted ADAMTS-13 replacement therapy for thrombotic thrombocytopenic purpura.

Moroniti JJ, Vrbensky JR, Nazy I, Arnold DM
J Thromb Haemost 2024 Apr;22(4):896-904. Epub 2023 Dec 22 doi: 10.1016/j.jtha.2023.11.030. PMID: 38142844

Anticoagulation in Patients with Liver Cirrhosis: Friend or Foe?

Protopapas AA, Savopoulos C, Skoura L, Goulis I
Dig Dis Sci 2023 Jun;68(6):2237-2246. Epub 2023 Mar 24 doi: 10.1007/s10620-023-07858-9. PMID: 36961672 Free PMC Article

Antithrombotic treatment for retinal vein occlusion: a systematic review and meta-analysis.

Modulation of ultralarge immune complexes in heparin-induced thrombocytopenia.

Cai Z, Bdeir K, Yarovoi SV, Rauova L, Arepally GM, Khandelwal S, Rollin J, Gruel Y, Zaitsev S, Poncz M, Greene MI, Cines DB
J Thromb Haemost 2023 Mar;21(3):652-666. Epub 2022 Dec 22 doi: 10.1016/j.jtha.2022.11.043. PMID: 36696211

Risk Factors for Cerebral Venous Thrombosis.

Silvis SM, Middeldorp S, Zuurbier SM, Cannegieter SC, Coutinho JM
Semin Thromb Hemost 2016 Sep;42(6):622-31. Epub 2016 Jun 6 doi: 10.1055/s-0036-1584132. PMID: 27272966

See all (44)

Prognosis

Anticoagulation in Patients with Liver Cirrhosis: Friend or Foe?

Protopapas AA, Savopoulos C, Skoura L, Goulis I
Dig Dis Sci 2023 Jun;68(6):2237-2246. Epub 2023 Mar 24 doi: 10.1007/s10620-023-07858-9. PMID: 36961672 Free PMC Article

Advances in the diagnosis and treatment of disseminated intravascular coagulation in haematological malignancies.

Ikezoe T
Int J Hematol 2021 Jan;113(1):34-44. Epub 2020 Sep 9 doi: 10.1007/s12185-020-02992-w. PMID: 32902759

Clinical outcomes in a cohort of patients with heparin-induced thrombocytopenia.

Kuter DJ, Konkle BA, Hamza TH, Uhl L, Assmann SF, Kiss JE, Kaufman RM, Key NS, Sachais BS, Hess JR, Ness P, McCrae KR, Leissinger C, Strauss RG, McFarland JG, Neufeld E, Bussel JB, Ortel TL
Am J Hematol 2017 Aug;92(8):730-738. Epub 2017 Apr 26 doi: 10.1002/ajh.24759. PMID: 28388835

Global public awareness of venous thromboembolism.

Wendelboe AM, McCumber M, Hylek EM, Buller H, Weitz JI, Raskob G; ISTH Steering Committee for World Thrombosis Day
J Thromb Haemost 2015 Aug;13(8):1365-71. Epub 2015 Jul 14 doi: 10.1111/jth.13031. PMID: 26084415

Catastrophic antiphospholipid syndrome.

Merrill JT, Asherson RA
Nat Clin Pract Rheumatol 2006 Feb;2(2):81-9. doi: 10.1038/ncprheum0069. PMID: 16932661

See all (17)

Clinical prediction guides

Antithrombotic treatment for retinal vein occlusion: a systematic review and meta-analysis.

Clinical outcomes in a cohort of patients with heparin-induced thrombocytopenia.

Purpura Fulminans in Toxic Epidermal Necrolysis: Case Report and Review.

Jones E, Stair-Buchmann M, Kotliar S, Haith L
J Burn Care Res 2015 Nov-Dec;36(6):e274-82. doi: 10.1097/BCR.0000000000000195. PMID: 25412057

Incidence and clinical course of thrombus formation on atrial septal defect and patient foramen ovale closure devices in 1,000 consecutive patients.

Krumsdorf U, Ostermayer S, Billinger K, Trepels T, Zadan E, Horvath K, Sievert H
J Am Coll Cardiol 2004 Jan 21;43(2):302-9. doi: 10.1016/j.jacc.2003.10.030. PMID: 14736453

Natural anticoagulants and the liver.

Castelino DJ, Salem HH
J Gastroenterol Hepatol 1997 Jan;12(1):77-83. doi: 10.1111/j.1440-1746.1997.tb00351.x. PMID: 9076629

See all (18)