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Mesonephric Differentiation

MedGen UID:
1792048
•Concept ID:
C5555607
•
Finding

Definition

A morphologic finding indicating the presence of a cellular infiltrate exhibiting tubular, ductal, papillary, sieve-like, and solid patterns. Eosinophilic, colloid-like material may be present in the tubules. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMesonephric Differentiation

Professional guidelines

PubMed

The presentation and management of complex female genital malformations.
Acién P, Acién M
Hum Reprod Update 2016 Jan-Feb;22(1):48-69. Epub 2015 Nov 3 doi: 10.1093/humupd/dmv048. PMID: 26537987
Best practice in diagnostic immunohistochemistry: prostate carcinoma and its mimics in needle core biopsies.
Paner GP, Luthringer DJ, Amin MB
Arch Pathol Lab Med 2008 Sep;132(9):1388-96. doi: 10.5858/2008-132-1388-BPIDIP. PMID: 18788849
Endocervical adenocarcinoma and its variants: their morphology and differential diagnosis.
Young RH, Clement PB
Histopathology 2002 Sep;41(3):185-207. doi: 10.1046/j.1365-2559.2002.01462.x. PMID: 12207781

Recent clinical studies

Etiology

Mesonephric-like adenocarcinoma harbours characteristic copy number variations and a distinct DNA methylation signature closely related to mesonephric adenocarcinoma of the cervix.
Kommoss FK, Lee CH, Tessier-Cloutier B, Gilks CB, Stewart CJ, von Deimling A, Köbel M
J Pathol 2024 Jan;262(1):4-9. Epub 2023 Oct 18 doi: 10.1002/path.6217. PMID: 37850576
Coexistence of endometrial mesonephric-like adenocarcinoma and endometrioid carcinoma suggests a Müllerian duct lineage: a case report.
Yano M, Shintani D, Katoh T, Hamada M, Ito K, Kozawa E, Hasegawa K, Yasuda M
Diagn Pathol 2019 Jun 7;14(1):54. doi: 10.1186/s13000-019-0830-4. PMID: 31174566Free PMC Article

Diagnosis

Coexistence of endometrial mesonephric-like adenocarcinoma and endometrioid carcinoma suggests a Müllerian duct lineage: a case report.
Yano M, Shintani D, Katoh T, Hamada M, Ito K, Kozawa E, Hasegawa K, Yasuda M
Diagn Pathol 2019 Jun 7;14(1):54. doi: 10.1186/s13000-019-0830-4. PMID: 31174566Free PMC Article
Mesonephric adenocarcinoma of the uterine corpus with intracystic growth completely confined to the myometrium: a case report and literature review.
Ando H, Watanabe Y, Ogawa M, Tamura H, Deguchi T, Ikeda K, Fujitani M, Shioji M, Tsujie T, Doi R, Wakimoto A, Adachi S
Diagn Pathol 2017 Aug 25;12(1):63. doi: 10.1186/s13000-017-0655-y. PMID: 28841919Free PMC Article
Mesonephric adenocarcinoma of the uterine corpus: CD10 expression as evidence of mesonephric differentiation.
Ordi J, Nogales FF, Palacin A, Márquez M, Pahisa J, Vanrell JA, Cardesa A
Am J Surg Pathol 2001 Dec;25(12):1540-5. doi: 10.1097/00000478-200112000-00011. PMID: 11717545

Therapy

Coexistence of endometrial mesonephric-like adenocarcinoma and endometrioid carcinoma suggests a Müllerian duct lineage: a case report.
Yano M, Shintani D, Katoh T, Hamada M, Ito K, Kozawa E, Hasegawa K, Yasuda M
Diagn Pathol 2019 Jun 7;14(1):54. doi: 10.1186/s13000-019-0830-4. PMID: 31174566Free PMC Article

Prognosis

Cervical pathology.
Herrington CS
Curr Opin Obstet Gynecol 1997 Feb;9(1):57-62. PMID: 9090484

Clinical prediction guides

Cystic dysplasia of the epididymis: a disorder of mesonephric differentiation associated with renal maldevelopment.
Nistal M, González-Peramato P, Sousa G, García-Cabezas MA, Rodríguez JI, Cajaiba MM
Virchows Arch 2010 Jun;456(6):695-702. Epub 2010 Apr 2 doi: 10.1007/s00428-010-0906-8. PMID: 20361206
Progression of epididymal maldevelopment into hamartoma-like neoplasia in VHL disease.
Mehta GU, Shively SB, Duong H, Tran MG, Moncrief TJ, Smith JH, Li J, Edwards NA, Lonser RR, Zhuang Z, Merrill MJ, Raffeld M, Maxwell PH, Oldfield EH, Vortmeyer AO
Neoplasia 2008 Oct;10(10):1146-53. doi: 10.1593/neo.08476. PMID: 18813354Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

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