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Advanced HER2-Low Breast Carcinoma

MedGen UID:
1792207
Concept ID:
C5555766
Neoplastic Process
Synonyms: Advanced HER2 Low Breast Adenocarcinoma; Advanced HER2 Low Breast Carcinoma; Advanced HER2-Low Breast Adenocarcinoma

Definition

HER2-low breast adenocarcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdvanced HER2-Low Breast Carcinoma

Professional guidelines

PubMed

Tarantino P, Viale G, Press MF, Hu X, Penault-Llorca F, Bardia A, Batistatou A, Burstein HJ, Carey LA, Cortes J, Denkert C, Diéras V, Jacot W, Koutras AK, Lebeau A, Loibl S, Modi S, Mosele MF, Provenzano E, Pruneri G, Reis-Filho JS, Rojo F, Salgado R, Schmid P, Schnitt SJ, Tolaney SM, Trapani D, Vincent-Salomon A, Wolff AC, Pentheroudakis G, André F, Curigliano G
Ann Oncol 2023 Aug;34(8):645-659. Epub 2023 Jun 1 doi: 10.1016/j.annonc.2023.05.008. PMID: 37269905
Wu Y, Zhong R, Ma F
Crit Rev Oncol Hematol 2023 Jan;181:103883. Epub 2022 Nov 23 doi: 10.1016/j.critrevonc.2022.103883. PMID: 36427769
Aoki M, Iwasa S, Boku N
Gastric Cancer 2021 May;24(3):567-576. Epub 2021 Mar 1 doi: 10.1007/s10120-021-01164-x. PMID: 33646464

Recent clinical studies

Etiology

Tarantino P, Viale G, Press MF, Hu X, Penault-Llorca F, Bardia A, Batistatou A, Burstein HJ, Carey LA, Cortes J, Denkert C, Diéras V, Jacot W, Koutras AK, Lebeau A, Loibl S, Modi S, Mosele MF, Provenzano E, Pruneri G, Reis-Filho JS, Rojo F, Salgado R, Schmid P, Schnitt SJ, Tolaney SM, Trapani D, Vincent-Salomon A, Wolff AC, Pentheroudakis G, André F, Curigliano G
Ann Oncol 2023 Aug;34(8):645-659. Epub 2023 Jun 1 doi: 10.1016/j.annonc.2023.05.008. PMID: 37269905
Modi S, Jacot W, Yamashita T, Sohn J, Vidal M, Tokunaga E, Tsurutani J, Ueno NT, Prat A, Chae YS, Lee KS, Niikura N, Park YH, Xu B, Wang X, Gil-Gil M, Li W, Pierga JY, Im SA, Moore HCF, Rugo HS, Yerushalmi R, Zagouri F, Gombos A, Kim SB, Liu Q, Luo T, Saura C, Schmid P, Sun T, Gambhire D, Yung L, Wang Y, Singh J, Vitazka P, Meinhardt G, Harbeck N, Cameron DA; DESTINY-Breast04 Trial Investigators
N Engl J Med 2022 Jul 7;387(1):9-20. Epub 2022 Jun 5 doi: 10.1056/NEJMoa2203690. PMID: 35665782Free PMC Article
Najjar S, Allison KH
Virchows Arch 2022 Jan;480(1):163-176. Epub 2022 Jan 14 doi: 10.1007/s00428-022-03267-x. PMID: 35029776
Lee J, Park YH
Future Oncol 2022 Jan;18(1):7-19. Epub 2021 Nov 26 doi: 10.2217/fon-2021-0550. PMID: 34823373
Zhang H, Katerji H, Turner BM, Hicks DG
Am J Clin Pathol 2022 Mar 3;157(3):328-336. doi: 10.1093/ajcp/aqab117. PMID: 34519765

Diagnosis

Peng Y, Wang L, Peng L, Liu Q, Yi L, Luo X, Li S, Qin S, Wan X, Tan C, Chen G
Clin Ther 2023 Oct;45(10):965-972. Epub 2023 Aug 1 doi: 10.1016/j.clinthera.2023.07.014. PMID: 37537015
Tarantino P, Viale G, Press MF, Hu X, Penault-Llorca F, Bardia A, Batistatou A, Burstein HJ, Carey LA, Cortes J, Denkert C, Diéras V, Jacot W, Koutras AK, Lebeau A, Loibl S, Modi S, Mosele MF, Provenzano E, Pruneri G, Reis-Filho JS, Rojo F, Salgado R, Schmid P, Schnitt SJ, Tolaney SM, Trapani D, Vincent-Salomon A, Wolff AC, Pentheroudakis G, André F, Curigliano G
Ann Oncol 2023 Aug;34(8):645-659. Epub 2023 Jun 1 doi: 10.1016/j.annonc.2023.05.008. PMID: 37269905
Wu Y, Zhong R, Ma F
Crit Rev Oncol Hematol 2023 Jan;181:103883. Epub 2022 Nov 23 doi: 10.1016/j.critrevonc.2022.103883. PMID: 36427769
Najjar S, Allison KH
Virchows Arch 2022 Jan;480(1):163-176. Epub 2022 Jan 14 doi: 10.1007/s00428-022-03267-x. PMID: 35029776
Yao M, Fu P
Chin Clin Oncol 2018 Jun;7(3):27. doi: 10.21037/cco.2018.05.04. PMID: 30056729

Therapy

Tarantino P, Viale G, Press MF, Hu X, Penault-Llorca F, Bardia A, Batistatou A, Burstein HJ, Carey LA, Cortes J, Denkert C, Diéras V, Jacot W, Koutras AK, Lebeau A, Loibl S, Modi S, Mosele MF, Provenzano E, Pruneri G, Reis-Filho JS, Rojo F, Salgado R, Schmid P, Schnitt SJ, Tolaney SM, Trapani D, Vincent-Salomon A, Wolff AC, Pentheroudakis G, André F, Curigliano G
Ann Oncol 2023 Aug;34(8):645-659. Epub 2023 Jun 1 doi: 10.1016/j.annonc.2023.05.008. PMID: 37269905
Schlam I, Tolaney SM, Tarantino P
Breast 2023 Feb;67:116-123. Epub 2023 Jan 12 doi: 10.1016/j.breast.2023.01.005. PMID: 36669993Free PMC Article
Zhang H, Karakas C, Tyburski H, Turner BM, Peng Y, Wang X, Katerji H, Schiffhauer L, Hicks DG
Semin Diagn Pathol 2022 Sep;39(5):305-312. Epub 2022 Jul 9 doi: 10.1053/j.semdp.2022.07.003. PMID: 35872032
Modi S, Jacot W, Yamashita T, Sohn J, Vidal M, Tokunaga E, Tsurutani J, Ueno NT, Prat A, Chae YS, Lee KS, Niikura N, Park YH, Xu B, Wang X, Gil-Gil M, Li W, Pierga JY, Im SA, Moore HCF, Rugo HS, Yerushalmi R, Zagouri F, Gombos A, Kim SB, Liu Q, Luo T, Saura C, Schmid P, Sun T, Gambhire D, Yung L, Wang Y, Singh J, Vitazka P, Meinhardt G, Harbeck N, Cameron DA; DESTINY-Breast04 Trial Investigators
N Engl J Med 2022 Jul 7;387(1):9-20. Epub 2022 Jun 5 doi: 10.1056/NEJMoa2203690. PMID: 35665782Free PMC Article
Deeks ED
Drugs 2021 Nov;81(16):1929-1935. doi: 10.1007/s40265-021-01614-x. PMID: 34661865

Prognosis

Wu Y, Zhong R, Ma F
Crit Rev Oncol Hematol 2023 Jan;181:103883. Epub 2022 Nov 23 doi: 10.1016/j.critrevonc.2022.103883. PMID: 36427769
Schettini F, Venturini S, Giuliano M, Lambertini M, Pinato DJ, Onesti CE, De Placido P, Harbeck N, Lüftner D, Denys H, Van Dam P, Arpino G, Zaman K, Mustacchi G, Gligorov J, Awada A, Campone M, Wildiers H, Gennari A, Tjan-Heijnen V, Bartsch R, Cortes J, Paris I, Martín M, De Placido S, Del Mastro L, Jerusalem G, Curigliano G, Prat A, Generali D
Cancer Treat Rev 2022 Dec;111:102468. Epub 2022 Sep 28 doi: 10.1016/j.ctrv.2022.102468. PMID: 36202026
Tarantino P, Gandini S, Nicolò E, Trillo P, Giugliano F, Zagami P, Vivanet G, Bellerba F, Trapani D, Marra A, Esposito A, Criscitiello C, Viale G, Curigliano G
Eur J Cancer 2022 Mar;163:35-43. Epub 2022 Jan 13 doi: 10.1016/j.ejca.2021.12.022. PMID: 35032815
Najjar S, Allison KH
Virchows Arch 2022 Jan;480(1):163-176. Epub 2022 Jan 14 doi: 10.1007/s00428-022-03267-x. PMID: 35029776
Rinnerthaler G, Gampenrieder SP, Greil R
Int J Mol Sci 2019 Mar 5;20(5) doi: 10.3390/ijms20051115. PMID: 30841523Free PMC Article

Clinical prediction guides

Zhang H, Karakas C, Tyburski H, Turner BM, Peng Y, Wang X, Katerji H, Schiffhauer L, Hicks DG
Semin Diagn Pathol 2022 Sep;39(5):305-312. Epub 2022 Jul 9 doi: 10.1053/j.semdp.2022.07.003. PMID: 35872032
Modi S, Jacot W, Yamashita T, Sohn J, Vidal M, Tokunaga E, Tsurutani J, Ueno NT, Prat A, Chae YS, Lee KS, Niikura N, Park YH, Xu B, Wang X, Gil-Gil M, Li W, Pierga JY, Im SA, Moore HCF, Rugo HS, Yerushalmi R, Zagouri F, Gombos A, Kim SB, Liu Q, Luo T, Saura C, Schmid P, Sun T, Gambhire D, Yung L, Wang Y, Singh J, Vitazka P, Meinhardt G, Harbeck N, Cameron DA; DESTINY-Breast04 Trial Investigators
N Engl J Med 2022 Jul 7;387(1):9-20. Epub 2022 Jun 5 doi: 10.1056/NEJMoa2203690. PMID: 35665782Free PMC Article
Tarantino P, Gandini S, Nicolò E, Trillo P, Giugliano F, Zagami P, Vivanet G, Bellerba F, Trapani D, Marra A, Esposito A, Criscitiello C, Viale G, Curigliano G
Eur J Cancer 2022 Mar;163:35-43. Epub 2022 Jan 13 doi: 10.1016/j.ejca.2021.12.022. PMID: 35032815
Najjar S, Allison KH
Virchows Arch 2022 Jan;480(1):163-176. Epub 2022 Jan 14 doi: 10.1007/s00428-022-03267-x. PMID: 35029776
Zhang H, Katerji H, Turner BM, Hicks DG
Am J Clin Pathol 2022 Mar 3;157(3):328-336. doi: 10.1093/ajcp/aqab117. PMID: 34519765

Recent systematic reviews

Molinelli C, Jacobs F, Agostinetto E, Nader-Marta G, Ceppi M, Bruzzone M, Blondeaux E, Schettini F, Prat A, Viale G, Del Mastro L, Lambertini M, de Azambuja E
ESMO Open 2023 Aug;8(4):101592. Epub 2023 Jul 4 doi: 10.1016/j.esmoop.2023.101592. PMID: 37413762Free PMC Article
Schettini F, Venturini S, Giuliano M, Lambertini M, Pinato DJ, Onesti CE, De Placido P, Harbeck N, Lüftner D, Denys H, Van Dam P, Arpino G, Zaman K, Mustacchi G, Gligorov J, Awada A, Campone M, Wildiers H, Gennari A, Tjan-Heijnen V, Bartsch R, Cortes J, Paris I, Martín M, De Placido S, Del Mastro L, Jerusalem G, Curigliano G, Prat A, Generali D
Cancer Treat Rev 2022 Dec;111:102468. Epub 2022 Sep 28 doi: 10.1016/j.ctrv.2022.102468. PMID: 36202026

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