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Minor Salivary Gland Intraductal Papillary Neoplasm

MedGen UID:
1793127
•Concept ID:
C5556686
•
Neoplastic Process
Synonym: Minor Salivary Gland Intraductal Papillary-Cystic Neoplasm

Definition

A rare papillary neoplasm that grows within and is limited to the duct system of the minor salivary glands. This category includes papillary cystadenoma, ductal papilloma (including the intraductal and inverted variants), sialadenoma papilliferum, and intraductal papillary mucinous neoplasm. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMinor Salivary Gland Intraductal Papillary Neoplasm

Professional guidelines

PubMed

Histopathological evaluation of minor salivary gland papillary-cystic tumours: focus on genetic alterations in sialadenoma papilliferum and intraductal papillary mucinous neoplasm.
Nakaguro M, Urano M, Ogawa I, Hirai H, Yamamoto Y, Yamaguchi H, Tanigawa M, Matsubayashi J, Hirano H, Shibahara J, Tada Y, Tsuzuki T, Okada Y, Sato Y, Ikeda K, Sukeda A, Honda Y, Mikami Y, Nagao T
Histopathology 2020 Feb;76(3):411-422. Epub 2019 Dec 1 doi: 10.1111/his.13990. PMID: 31505033

Recent clinical studies

Etiology

Ductal papillomas of salivary gland origin: A report of 19 cases and a review of the literature.
Brannon RB, Sciubba JJ, Giulani M
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2001 Jul;92(1):68-77. doi: 10.1067/moe.2001.115978. PMID: 11458248
Salivary duct carcinoma in major and minor salivary glands. A clinicopathological analysis of four cases.
Zohar Y, Shem-Tov Y, Gal R
J Craniomaxillofac Surg 1988 Oct;16(7):320-3. doi: 10.1016/s1010-5182(88)80071-4. PMID: 2848871
Tumors of minor salivary origin. A clinicopathologic study of 492 cases.
Spiro RH, Koss LG, Hajdu SI, Strong EW
Cancer 1973 Jan;31(1):117-29. doi: 10.1002/1097-0142(197301)31:1<117::aid-cncr2820310116>3.0.co;2-7. PMID: 4345606

Diagnosis

Intraductal Papilloma Arising From the Minor Salivary Glands of the Larynx: A Case Report.
Hara S, Ohba S, Arakawa A, Matsumoto F, Ito S, Fujimaki M, Kojima M, Ikeda K
Ear Nose Throat J 2022 Feb;101(2):NP73-NP77. Epub 2020 Aug 3 doi: 10.1177/0145561320944638. PMID: 32744904
Histopathological evaluation of minor salivary gland papillary-cystic tumours: focus on genetic alterations in sialadenoma papilliferum and intraductal papillary mucinous neoplasm.
Nakaguro M, Urano M, Ogawa I, Hirai H, Yamamoto Y, Yamaguchi H, Tanigawa M, Matsubayashi J, Hirano H, Shibahara J, Tada Y, Tsuzuki T, Okada Y, Sato Y, Ikeda K, Sukeda A, Honda Y, Mikami Y, Nagao T
Histopathology 2020 Feb;76(3):411-422. Epub 2019 Dec 1 doi: 10.1111/his.13990. PMID: 31505033
Intraductal papilloma arising from the accessory parotid gland: A case report and literature review.
Sun S, Wang P, Wang Y, Su W, Wang F, Yang H
Medicine (Baltimore) 2018 May;97(20):e10761. doi: 10.1097/MD.0000000000010761. PMID: 29768362Free PMC Article
Intraductal Papillary Mucinous Neoplasms of Minor Salivary Glands With AKT1 p.Glu17Lys Mutation.
Agaimy A, Mueller SK, Bumm K, Iro H, Moskalev EA, Hartmann A, Stoehr R, Haller F
Am J Surg Pathol 2018 Aug;42(8):1076-1082. doi: 10.1097/PAS.0000000000001080. PMID: 29738361
Ductal papillomas of salivary gland origin: A report of 19 cases and a review of the literature.
Brannon RB, Sciubba JJ, Giulani M
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2001 Jul;92(1):68-77. doi: 10.1067/moe.2001.115978. PMID: 11458248

Prognosis

Low-Grade Intraductal Carcinoma of the Parotid Gland: A Case Report and Literature Review.
Russo D, Di Crescenzo RM, Varricchio S, Broggi G, Bizzoca ME, Troise S, Salzano G, Ilardi G, Merolla F
Head Neck Pathol 2021 Dec;15(4):1359-1371. Epub 2021 Jan 27 doi: 10.1007/s12105-021-01290-z. PMID: 33501556Free PMC Article
Ductal papillomas of salivary gland origin: A report of 19 cases and a review of the literature.
Brannon RB, Sciubba JJ, Giulani M
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2001 Jul;92(1):68-77. doi: 10.1067/moe.2001.115978. PMID: 11458248
Salivary duct carcinoma in major and minor salivary glands. A clinicopathological analysis of four cases.
Zohar Y, Shem-Tov Y, Gal R
J Craniomaxillofac Surg 1988 Oct;16(7):320-3. doi: 10.1016/s1010-5182(88)80071-4. PMID: 2848871
Tumors of minor salivary origin. A clinicopathologic study of 492 cases.
Spiro RH, Koss LG, Hajdu SI, Strong EW
Cancer 1973 Jan;31(1):117-29. doi: 10.1002/1097-0142(197301)31:1<117::aid-cncr2820310116>3.0.co;2-7. PMID: 4345606

Clinical prediction guides

NKX3.1 Expression in Salivary Gland "Intraductal" Papillary Mucinous Neoplasm: A Low-Grade Subtype of Salivary Gland Mucinous Adenocarcinoma.
Nakaguro M, Sadow PM, Hu R, Hattori H, Kuwabara K, Tsuzuki T, Urano M, Nagao T, Faquin WC
Head Neck Pathol 2022 Dec;16(4):1114-1123. Epub 2022 Jul 14 doi: 10.1007/s12105-022-01471-4. PMID: 35834096Free PMC Article
Intraductal Papillary Mucinous Neoplasms of Minor Salivary Glands With AKT1 p.Glu17Lys Mutation.
Agaimy A, Mueller SK, Bumm K, Iro H, Moskalev EA, Hartmann A, Stoehr R, Haller F
Am J Surg Pathol 2018 Aug;42(8):1076-1082. doi: 10.1097/PAS.0000000000001080. PMID: 29738361
Intraductal papilloma arising from sublingual minor salivary gland: case report and immunohistochemical study.
Aikawa T, Kishino M, Masuda T, Isomura ET, Tanaka S, Namikawa M, Iida S
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009 May;107(5):e34-7. doi: 10.1016/j.tripleo.2009.01.019. PMID: 19426904

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