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Advanced HER2-Positive Breast Carcinoma

MedGen UID:
1793162
Concept ID:
C5556721
Neoplastic Process
Synonym: Advanced HER2 Positive Breast Carcinoma

Definition

HER2-positive breast carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdvanced HER2-Positive Breast Carcinoma

Professional guidelines

PubMed

Karpel HC, Slomovitz B, Coleman RL, Pothuri B
Curr Opin Obstet Gynecol 2023 Jun 1;35(3):270-278. Epub 2023 Mar 20 doi: 10.1097/GCO.0000000000000855. PMID: 36943683
Najjar MK, Manore SG, Regua AT, Lo HW
Genes (Basel) 2022 Nov 8;13(11) doi: 10.3390/genes13112065. PMID: 36360302Free PMC Article
Maximiano S, Magalhães P, Guerreiro MP, Morgado M
BioDrugs 2016 Apr;30(2):75-86. doi: 10.1007/s40259-016-0162-9. PMID: 26892619

Recent clinical studies

Etiology

Hurvitz SA, Hegg R, Chung WP, Im SA, Jacot W, Ganju V, Chiu JWY, Xu B, Hamilton E, Madhusudan S, Iwata H, Altintas S, Henning JW, Curigliano G, Perez-Garcia JM, Kim SB, Petry V, Huang CS, Li W, Frenel JS, Antolin S, Yeo W, Bianchini G, Loi S, Tsurutani J, Egorov A, Liu Y, Cathcart J, Ashfaque S, Cortés J
Lancet 2023 Jan 14;401(10371):105-117. Epub 2022 Dec 7 doi: 10.1016/S0140-6736(22)02420-5. PMID: 36495879
Najjar S, Allison KH
Virchows Arch 2022 Jan;480(1):163-176. Epub 2022 Jan 14 doi: 10.1007/s00428-022-03267-x. PMID: 35029776
Aebi S, Karlsson P, Wapnir IL
Breast 2022 Mar;62 Suppl 1(Suppl 1):S58-S62. Epub 2021 Dec 15 doi: 10.1016/j.breast.2021.12.011. PMID: 34930650Free PMC Article
Modi S, Saura C, Yamashita T, Park YH, Kim SB, Tamura K, Andre F, Iwata H, Ito Y, Tsurutani J, Sohn J, Denduluri N, Perrin C, Aogi K, Tokunaga E, Im SA, Lee KS, Hurvitz SA, Cortes J, Lee C, Chen S, Zhang L, Shahidi J, Yver A, Krop I; DESTINY-Breast01 Investigators
N Engl J Med 2020 Feb 13;382(7):610-621. Epub 2019 Dec 11 doi: 10.1056/NEJMoa1914510. PMID: 31825192Free PMC Article
Verma S, Miles D, Gianni L, Krop IE, Welslau M, Baselga J, Pegram M, Oh DY, Diéras V, Guardino E, Fang L, Lu MW, Olsen S, Blackwell K; EMILIA Study Group
N Engl J Med 2012 Nov 8;367(19):1783-91. Epub 2012 Oct 1 doi: 10.1056/NEJMoa1209124. PMID: 23020162Free PMC Article

Diagnosis

Swain SM, Shastry M, Hamilton E
Nat Rev Drug Discov 2023 Feb;22(2):101-126. Epub 2022 Nov 7 doi: 10.1038/s41573-022-00579-0. PMID: 36344672Free PMC Article
Ren S, Wang J, Ying J, Mitsudomi T, Lee DH, Wang Z, Chu Q, Mack PC, Cheng Y, Duan J, Fan Y, Han B, Hui Z, Liu A, Liu J, Lu Y, Ma Z, Shi M, Shu Y, Song Q, Song X, Song Y, Wang C, Wang X, Wang Z, Xu Y, Yao Y, Zhang L, Zhao M, Zhu B, Zhang J, Zhou C, Hirsch FR
ESMO Open 2022 Feb;7(1):100395. Epub 2022 Feb 8 doi: 10.1016/j.esmoop.2022.100395. PMID: 35149428Free PMC Article
Najjar S, Allison KH
Virchows Arch 2022 Jan;480(1):163-176. Epub 2022 Jan 14 doi: 10.1007/s00428-022-03267-x. PMID: 35029776
Zimmer AS, Van Swearingen AED, Anders CK
Cancer Rep (Hoboken) 2022 Apr;5(4):e1274. Epub 2020 Sep 3 doi: 10.1002/cnr2.1274. PMID: 32881421Free PMC Article
Tan Y, Sun R, Liu L, Yang D, Xiang Q, Li L, Tang J, Qiu Z, Peng W, Wang Y, Ye L, Ren G, Xiang T
Theranostics 2021;11(11):5214-5231. Epub 2021 Mar 5 doi: 10.7150/thno.58322. PMID: 33859743Free PMC Article

Therapy

Aebi S, Karlsson P, Wapnir IL
Breast 2022 Mar;62 Suppl 1(Suppl 1):S58-S62. Epub 2021 Dec 15 doi: 10.1016/j.breast.2021.12.011. PMID: 34930650Free PMC Article
Tan AR, Im SA, Mattar A, Colomer R, Stroyakovskii D, Nowecki Z, De Laurentiis M, Pierga JY, Jung KH, Schem C, Hogea A, Badovinac Crnjevic T, Heeson S, Shivhare M, Kirschbrown WP, Restuccia E, Jackisch C; FeDeriCa study group
Lancet Oncol 2021 Jan;22(1):85-97. Epub 2020 Dec 21 doi: 10.1016/S1470-2045(20)30536-2. PMID: 33357420
Modi S, Saura C, Yamashita T, Park YH, Kim SB, Tamura K, Andre F, Iwata H, Ito Y, Tsurutani J, Sohn J, Denduluri N, Perrin C, Aogi K, Tokunaga E, Im SA, Lee KS, Hurvitz SA, Cortes J, Lee C, Chen S, Zhang L, Shahidi J, Yver A, Krop I; DESTINY-Breast01 Investigators
N Engl J Med 2020 Feb 13;382(7):610-621. Epub 2019 Dec 11 doi: 10.1056/NEJMoa1914510. PMID: 31825192Free PMC Article
Rinnerthaler G, Gampenrieder SP, Greil R
Int J Mol Sci 2019 Mar 5;20(5) doi: 10.3390/ijms20051115. PMID: 30841523Free PMC Article
Verma S, Miles D, Gianni L, Krop IE, Welslau M, Baselga J, Pegram M, Oh DY, Diéras V, Guardino E, Fang L, Lu MW, Olsen S, Blackwell K; EMILIA Study Group
N Engl J Med 2012 Nov 8;367(19):1783-91. Epub 2012 Oct 1 doi: 10.1056/NEJMoa1209124. PMID: 23020162Free PMC Article

Prognosis

Roy M, Fowler AM, Ulaner GA, Mahajan A
PET Clin 2023 Oct;18(4):441-458. Epub 2023 May 31 doi: 10.1016/j.cpet.2023.04.002. PMID: 37268505
Najjar MK, Manore SG, Regua AT, Lo HW
Genes (Basel) 2022 Nov 8;13(11) doi: 10.3390/genes13112065. PMID: 36360302Free PMC Article
Najjar S, Allison KH
Virchows Arch 2022 Jan;480(1):163-176. Epub 2022 Jan 14 doi: 10.1007/s00428-022-03267-x. PMID: 35029776
Gianni L, Pienkowski T, Im YH, Tseng LM, Liu MC, Lluch A, Starosławska E, de la Haba-Rodriguez J, Im SA, Pedrini JL, Poirier B, Morandi P, Semiglazov V, Srimuninnimit V, Bianchi GV, Magazzù D, McNally V, Douthwaite H, Ross G, Valagussa P
Lancet Oncol 2016 Jun;17(6):791-800. Epub 2016 May 11 doi: 10.1016/S1470-2045(16)00163-7. PMID: 27179402
Verma S, Miles D, Gianni L, Krop IE, Welslau M, Baselga J, Pegram M, Oh DY, Diéras V, Guardino E, Fang L, Lu MW, Olsen S, Blackwell K; EMILIA Study Group
N Engl J Med 2012 Nov 8;367(19):1783-91. Epub 2012 Oct 1 doi: 10.1056/NEJMoa1209124. PMID: 23020162Free PMC Article

Clinical prediction guides

Roy M, Fowler AM, Ulaner GA, Mahajan A
PET Clin 2023 Oct;18(4):441-458. Epub 2023 May 31 doi: 10.1016/j.cpet.2023.04.002. PMID: 37268505
Najjar S, Allison KH
Virchows Arch 2022 Jan;480(1):163-176. Epub 2022 Jan 14 doi: 10.1007/s00428-022-03267-x. PMID: 35029776
Dieci MV, Miglietta F, Guarneri V
Cells 2021 Jan 23;10(2) doi: 10.3390/cells10020223. PMID: 33498711Free PMC Article
Tsurutani J, Iwata H, Krop I, Jänne PA, Doi T, Takahashi S, Park H, Redfern C, Tamura K, Wise-Draper TM, Saito K, Sugihara M, Singh J, Jikoh T, Gallant G, Li BT
Cancer Discov 2020 May;10(5):688-701. Epub 2020 Mar 25 doi: 10.1158/2159-8290.CD-19-1014. PMID: 32213540Free PMC Article
Modi S, Saura C, Yamashita T, Park YH, Kim SB, Tamura K, Andre F, Iwata H, Ito Y, Tsurutani J, Sohn J, Denduluri N, Perrin C, Aogi K, Tokunaga E, Im SA, Lee KS, Hurvitz SA, Cortes J, Lee C, Chen S, Zhang L, Shahidi J, Yver A, Krop I; DESTINY-Breast01 Investigators
N Engl J Med 2020 Feb 13;382(7):610-621. Epub 2019 Dec 11 doi: 10.1056/NEJMoa1914510. PMID: 31825192Free PMC Article

Recent systematic reviews

Wang Y, Xu H, Han Y, Wu Y, Sa Q, Wang J
ESMO Open 2023 Jun;8(3):101216. Epub 2023 Apr 20 doi: 10.1016/j.esmoop.2023.101216. PMID: 37084609Free PMC Article
Giordano SH, Franzoi MAB, Temin S, Anders CK, Chandarlapaty S, Crews JR, Kirshner JJ, Krop IE, Lin NU, Morikawa A, Patt DA, Perlmutter J, Ramakrishna N, Davidson NE
J Clin Oncol 2022 Aug 10;40(23):2612-2635. Epub 2022 May 31 doi: 10.1200/JCO.22.00519. PMID: 35640077
Ramakrishna N, Anders CK, Lin NU, Morikawa A, Temin S, Chandarlapaty S, Crews JR, Davidson NE, Franzoi MAB, Kirshner JJ, Krop IE, Patt DA, Perlmutter J, Giordano SH
J Clin Oncol 2022 Aug 10;40(23):2636-2655. Epub 2022 May 31 doi: 10.1200/JCO.22.00520. PMID: 35640075
Martin AP, Downing J, Cochrane M, Collins B, Francis B, Haycox A, Alfirevic A, Pirmohamed M
Crit Rev Oncol Hematol 2018 Oct;130:92-107. Epub 2018 Aug 3 doi: 10.1016/j.critrevonc.2018.07.012. PMID: 30196916
Kümler I, Tuxen MK, Nielsen DL
Cancer Treat Rev 2014 Mar;40(2):259-70. Epub 2013 Sep 11 doi: 10.1016/j.ctrv.2013.09.002. PMID: 24080156

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