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Alexia

MedGen UID:
1809
Concept ID:
C0002018
Finding; Mental or Behavioral Dysfunction
Synonym: Alexias
SNOMED CT: Alexia (9236007); Optical alexia (9236007); Visual amnesia (9236007); Aphemesthesia (9236007)
 
HPO: HP:0010523
Monarch Initiative: MONDO:0001712

Definition

An acquired type of sensory aphasia where damage to the brain leads to the loss of the ability to read. [from HPO]

Professional guidelines

PubMed

Steverson T, Marsden J, Blake J
Clin Rehabil 2024 Jul;38(7):944-954. Epub 2024 Mar 5 doi: 10.1177/02692155241236602. PMID: 38439657Free PMC Article
Ross K, Johnson JP, Kiran S
Neuropsychol Rehabil 2019 May;29(4):565-604. Epub 2017 Apr 19 doi: 10.1080/09602011.2017.1311796. PMID: 28421910
Burns MS
Top Stroke Rehabil 2004 Winter;11(1):1-9. doi: 10.1310/N13K-YKYQ-3XX1-NFAV. PMID: 14872395

Recent clinical studies

Etiology

Leff A, Barton JJS
Handb Clin Neurol 2021;178:361-386. doi: 10.1016/B978-0-12-821377-3.00015-5. PMID: 33832686
Peña AS, Witchel SF, Hoeger KM, Oberfield SE, Vogiatzi MG, Misso M, Garad R, Dabadghao P, Teede H
BMC Med 2020 Mar 24;18(1):72. doi: 10.1186/s12916-020-01516-x. PMID: 32204714Free PMC Article
Haque S, Vaphiades MS, Lueck CJ
J Neuroophthalmol 2018 Sep;38(3):379-392. doi: 10.1097/WNO.0000000000000556. PMID: 28945627
Ardila A, Rosselli M
Int J Neurosci 1994 Oct;78(3-4):177-84. doi: 10.3109/00207459408986056. PMID: 7883454
Ardila A, Rosselli M
Brain Cogn 1993 Jul;22(2):137-47. doi: 10.1006/brcg.1993.1029. PMID: 8373568

Diagnosis

Gonzalez R, Rojas M, Ardila A
Int J Lang Commun Disord 2020 Nov;55(6):875-883. Epub 2020 Jul 31 doi: 10.1111/1460-6984.12566. PMID: 32735061
Peña AS, Witchel SF, Hoeger KM, Oberfield SE, Vogiatzi MG, Misso M, Garad R, Dabadghao P, Teede H
BMC Med 2020 Mar 24;18(1):72. doi: 10.1186/s12916-020-01516-x. PMID: 32204714Free PMC Article
Henderson VW
Front Neurol Neurosci 2019;44:39-52. Epub 2019 Apr 30 doi: 10.1159/000494951. PMID: 31220840
Berlucchi G, Vallar G
Handb Clin Neurol 2018;151:3-30. doi: 10.1016/B978-0-444-63622-5.00001-2. PMID: 29519464
Haque S, Vaphiades MS, Lueck CJ
J Neuroophthalmol 2018 Sep;38(3):379-392. doi: 10.1097/WNO.0000000000000556. PMID: 28945627

Therapy

Zivanovic O, Chi DS, Zhou Q, Iasonos A, Konner JA, Makker V, Grisham RN, Brown AK, Nerenstone S, Diaz JP, Schroeder ED, Langstraat CL, Paroder V, Lakhman Y, Soldan K, Su K, Gardner GJ, Andikyan V, Guo J, Jewell EL, Long Roche K, Troso-Sandoval T, Lichtman SM, Moukarzel LA, Dessources K, Abu-Rustum NR, Aghajanian C, Tew WP, Beumer J, Sonoda Y, O'Cearbhaill RE
J Clin Oncol 2021 Aug 10;39(23):2594-2604. Epub 2021 May 21 doi: 10.1200/JCO.21.00605. PMID: 34019431Free PMC Article
Lee JI, Jansen A, Samadzadeh S, Kahlen U, Moll M, Ringelstein M, Soncin G, Bigalke H, Aktas O, Moldovan AS, Waskoenig J, Jander S, Gliem M, Schnitzler A, Hartung HP, Hefter H, Albrecht P
Ann Clin Transl Neurol 2021 Jan;8(1):15-28. Epub 2020 Dec 1 doi: 10.1002/acn3.51225. PMID: 33259153Free PMC Article
Knapp P, Campbell Burton CA, Holmes J, Murray J, Gillespie D, Lightbody CE, Watkins CL, Chun HY, Lewis SR
Cochrane Database Syst Rev 2017 May 23;5(5):CD008860. doi: 10.1002/14651858.CD008860.pub3. PMID: 28535332Free PMC Article
Cunanan KM, Gonen M, Shen R, Hyman DM, Riely GJ, Begg CB, Iasonos A
J Clin Oncol 2017 Jan 20;35(3):271-273. Epub 2016 Nov 28 doi: 10.1200/JCO.2016.69.9751. PMID: 27893325Free PMC Article
Ahmed N, Brawley VS, Hegde M, Robertson C, Ghazi A, Gerken C, Liu E, Dakhova O, Ashoori A, Corder A, Gray T, Wu MF, Liu H, Hicks J, Rainusso N, Dotti G, Mei Z, Grilley B, Gee A, Rooney CM, Brenner MK, Heslop HE, Wels WS, Wang LL, Anderson P, Gottschalk S
J Clin Oncol 2015 May 20;33(15):1688-96. Epub 2015 Mar 23 doi: 10.1200/JCO.2014.58.0225. PMID: 25800760Free PMC Article

Prognosis

Ioannou A, Patel RK, Martinez-Naharro A, Razvi Y, Porcari A, Rauf MU, Bolhuis RE, Fernando-Sayers J, Virsinskaite R, Bandera F, Kotecha T, Venneri L, Knight D, Manisty C, Moon J, Lachmann H, Whelan C, Kellman P, Hawkins PN, Gillmore JD, Wechalekar A, Fontana M
JAMA Cardiol 2023 Sep 1;8(9):848-852. doi: 10.1001/jamacardio.2023.2010. PMID: 37466990Free PMC Article
Leblanc R
J Hist Neurosci 2022 Jan-Mar;31(1):1-19. Epub 2021 Jun 11 doi: 10.1080/0964704X.2021.1898909. PMID: 34115961
Sinanović O, Mrkonjić Z, Zukić S, Vidović M, Imamović K
Acta Clin Croat 2011 Mar;50(1):79-94. PMID: 22034787
Ferro JM
J Neurol 2001 Oct;248(10):841-9. doi: 10.1007/s004150170067. PMID: 11697519
Caselli RJ
Semin Neurol 2000;20(1):139-44. doi: 10.1055/s-2000-6839. PMID: 10874783

Clinical prediction guides

Starrfelt R, Woodhead Z
Handb Clin Neurol 2021;178:213-232. doi: 10.1016/B978-0-12-821377-3.00010-6. PMID: 33832678
Gonzalez R, Rojas M, Ardila A
Int J Lang Commun Disord 2020 Nov;55(6):875-883. Epub 2020 Jul 31 doi: 10.1111/1460-6984.12566. PMID: 32735061
Ardila A, Rosselli M
Behav Neurol 2019;2019:3151092. Epub 2019 Apr 4 doi: 10.1155/2019/3151092. PMID: 31093301Free PMC Article
Starrfelt R, Behrmann M
Neuropsychologia 2011 Jul;49(9):2283-98. Epub 2011 May 4 doi: 10.1016/j.neuropsychologia.2011.04.028. PMID: 21554892
Ardila A, Rosselli M
Brain Cogn 1993 Jul;22(2):137-47. doi: 10.1006/brcg.1993.1029. PMID: 8373568

Recent systematic reviews

Cochrane A, Chen C, Stephen J, Rønning OM, Anderson CS, Hankey GJ, Al-Shahi Salman R
Cochrane Database Syst Rev 2023 Jan 26;1(1):CD012144. doi: 10.1002/14651858.CD012144.pub3. PMID: 36700520Free PMC Article
Cistola G, Farrús M, van der Meulen I
Int J Lang Commun Disord 2021 Jan;56(1):161-173. Epub 2020 Sep 12 doi: 10.1111/1460-6984.12569. PMID: 32918536
Rohde A, Worrall L, Godecke E, O'Halloran R, Farrell A, Massey M
PLoS One 2018;13(3):e0194143. Epub 2018 Mar 22 doi: 10.1371/journal.pone.0194143. PMID: 29566043Free PMC Article
Knapp P, Campbell Burton CA, Holmes J, Murray J, Gillespie D, Lightbody CE, Watkins CL, Chun HY, Lewis SR
Cochrane Database Syst Rev 2017 May 23;5(5):CD008860. doi: 10.1002/14651858.CD008860.pub3. PMID: 28535332Free PMC Article
Starrfelt R, Behrmann M
Neuropsychologia 2011 Jul;49(9):2283-98. Epub 2011 May 4 doi: 10.1016/j.neuropsychologia.2011.04.028. PMID: 21554892

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