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Decreased dendritic spine number

MedGen UID:
1814113
•Concept ID:
C5558378
•
Finding
HPO: HP:0034005

Definition

An abnormal reduction in the amount of spines on a given dendrite. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased dendritic spine number

Professional guidelines

PubMed

Preservation of dendritic spine morphology and postsynaptic signaling markers after treatment with solid lipid curcumin particles in the 5xFAD mouse model of Alzheimer's amyloidosis.
Maiti P, Bowers Z, Bourcier-Schultz A, Morse J, Dunbar GL
Alzheimers Res Ther 2021 Feb 8;13(1):37. doi: 10.1186/s13195-021-00769-9. PMID: 33557949Free PMC Article
PLA2G4E, a candidate gene for resilience in Alzheimer´s disease and a new target for dementia treatment.
Pérez-González M, Mendioroz M, Badesso S, Sucunza D, Roldan M, Espelosín M, Ursua S, Luján R, Cuadrado-Tejedor M, Garcia-Osta A
Prog Neurobiol 2020 Aug;191:101818. Epub 2020 May 5 doi: 10.1016/j.pneurobio.2020.101818. PMID: 32380223
Levodopa treatment and dendritic spine pathology.
Nishijima H, Ueno T, Funamizu Y, Ueno S, Tomiyama M
Mov Disord 2018 Jul;33(6):877-888. Epub 2017 Sep 7 doi: 10.1002/mds.27172. PMID: 28880414Free PMC Article

Recent clinical studies

Etiology

Endogenous PTEN-Induced Kinase 1 Regulates Dendritic Architecture and Spinogenesis.
Otero PA, Fricklas G, Nigam A, Lizama BN, Wills ZP, Johnson JW, Chu CT
J Neurosci 2022 Oct 12;42(41):7848-7860. Epub 2022 Sep 7 doi: 10.1523/JNEUROSCI.0785-22.2022. PMID: 36414008Free PMC Article
C9orf72 hexanucleotide repeat expansion leads to altered neuronal and dendritic spine morphology and synaptic dysfunction.
Huber N, Hoffmann D, Giniatullina R, Rostalski H, Leskelä S, Takalo M, Natunen T, Solje E, Remes AM, Giniatullin R, Hiltunen M, Haapasalo A
Neurobiol Dis 2022 Jan;162:105584. Epub 2021 Dec 14 doi: 10.1016/j.nbd.2021.105584. PMID: 34915153
Alpha-amylase 1A copy number variants and the association with memory performance and Alzheimer's dementia.
Byman E, Nägga K, Gustavsson AM; Netherlands Brain Bank, Andersson-Assarsson J, Hansson O, Sonestedt E, Wennström M
Alzheimers Res Ther 2020 Nov 21;12(1):158. doi: 10.1186/s13195-020-00726-y. PMID: 33220711Free PMC Article
Autism spectrum disorder: neuropathology and animal models.
Varghese M, Keshav N, Jacot-Descombes S, Warda T, Wicinski B, Dickstein DL, Harony-Nicolas H, De Rubeis S, Drapeau E, Buxbaum JD, Hof PR
Acta Neuropathol 2017 Oct;134(4):537-566. Epub 2017 Jun 5 doi: 10.1007/s00401-017-1736-4. PMID: 28584888Free PMC Article
When cortical development goes wrong: schizophrenia as a neurodevelopmental disease of microcircuits.
Garey L
J Anat 2010 Oct;217(4):324-33. doi: 10.1111/j.1469-7580.2010.01231.x. PMID: 20408906Free PMC Article

Diagnosis

Alpha-amylase 1A copy number variants and the association with memory performance and Alzheimer's dementia.
Byman E, Nägga K, Gustavsson AM; Netherlands Brain Bank, Andersson-Assarsson J, Hansson O, Sonestedt E, Wennström M
Alzheimers Res Ther 2020 Nov 21;12(1):158. doi: 10.1186/s13195-020-00726-y. PMID: 33220711Free PMC Article
Autism spectrum disorder: neuropathology and animal models.
Varghese M, Keshav N, Jacot-Descombes S, Warda T, Wicinski B, Dickstein DL, Harony-Nicolas H, De Rubeis S, Drapeau E, Buxbaum JD, Hof PR
Acta Neuropathol 2017 Oct;134(4):537-566. Epub 2017 Jun 5 doi: 10.1007/s00401-017-1736-4. PMID: 28584888Free PMC Article
When cortical development goes wrong: schizophrenia as a neurodevelopmental disease of microcircuits.
Garey L
J Anat 2010 Oct;217(4):324-33. doi: 10.1111/j.1469-7580.2010.01231.x. PMID: 20408906Free PMC Article
Neurons and their dendrites in frontotemporal dementia.
Ferrer I
Dement Geriatr Cogn Disord 1999;10 Suppl 1:55-60. doi: 10.1159/000051214. PMID: 10436342
The integrative properties of spiny distal dendrites.
Jaslove SW
Neuroscience 1992;47(3):495-519. doi: 10.1016/0306-4522(92)90161-t. PMID: 1584406

Therapy

Lithium rescues dendritic abnormalities in Ank3 deficiency models through the synergic effects of GSK3β and cyclic AMP signaling pathways.
Piguel NH, Yoon S, Gao R, Horan KE, Garza JC, Petryshen TL, Smith KR, Penzes P
Neuropsychopharmacology 2023 Jun;48(7):1000-1010. Epub 2022 Nov 14 doi: 10.1038/s41386-022-01502-2. PMID: 36376465Free PMC Article
Impact of Pharmacological and Non-Pharmacological Modulators on Dendritic Spines Structure and Functions in Brain.
Mahalakshmi AM, Ray B, Tuladhar S, Hediyal TA, Raj P, Rathipriya AG, Qoronfleh MW, Essa MM, Chidambaram SB
Cells 2021 Dec 2;10(12) doi: 10.3390/cells10123405. PMID: 34943913Free PMC Article
Mutant APP and amyloid beta-induced defective autophagy, mitophagy, mitochondrial structural and functional changes and synaptic damage in hippocampal neurons from Alzheimer's disease.
Reddy PH, Yin X, Manczak M, Kumar S, Pradeepkiran JA, Vijayan M, Reddy AP
Hum Mol Genet 2018 Jul 15;27(14):2502-2516. doi: 10.1093/hmg/ddy154. PMID: 29701781Free PMC Article
Levodopa treatment and dendritic spine pathology.
Nishijima H, Ueno T, Funamizu Y, Ueno S, Tomiyama M
Mov Disord 2018 Jul;33(6):877-888. Epub 2017 Sep 7 doi: 10.1002/mds.27172. PMID: 28880414Free PMC Article
The heterozygote reeler mouse as a model for the development of a new generation of antipsychotics.
Costa E, Davis J, Pesold C, Tueting P, Guidotti A
Curr Opin Pharmacol 2002 Feb;2(1):56-62. doi: 10.1016/s1471-4892(01)00121-7. PMID: 11786309

Prognosis

Excess Neuronal Branching Allows for Local Innervation of Specific Dendritic Compartments in Mature Cortex.
Bird AD, Deters LH, Cuntz H
Cereb Cortex 2021 Jan 5;31(2):1008-1031. doi: 10.1093/cercor/bhaa271. PMID: 33078188
Stress induced neural reorganization: A conceptual framework linking depression and Alzheimer's disease.
Ross JA, Gliebus G, Van Bockstaele EJ
Prog Neuropsychopharmacol Biol Psychiatry 2018 Jul 13;85:136-151. Epub 2017 Aug 10 doi: 10.1016/j.pnpbp.2017.08.004. PMID: 28803923Free PMC Article
Molecular profiles of pyramidal neurons in the superior temporal cortex in schizophrenia.
Pietersen CY, Mauney SA, Kim SS, Lim MP, Rooney RJ, Goldstein JM, Petryshen TL, Seidman LJ, Shenton ME, McCarley RW, Sonntag KC, Woo TU
J Neurogenet 2014 Mar-Jun;28(1-2):53-69. Epub 2014 Apr 10 doi: 10.3109/01677063.2014.882918. PMID: 24702465Free PMC Article
Stereologic estimates of total spinophilin-immunoreactive spine number in area 9 and the CA1 field: relationship with the progression of Alzheimer's disease.
Akram A, Christoffel D, Rocher AB, Bouras C, Kövari E, Perl DP, Morrison JH, Herrmann FR, Haroutunian V, Giannakopoulos P, Hof PR
Neurobiol Aging 2008 Sep;29(9):1296-307. Epub 2007 Apr 8 doi: 10.1016/j.neurobiolaging.2007.03.007. PMID: 17420070Free PMC Article
Different dendrite and dendritic spine alterations in basal and apical arbors in mutant human amyloid precursor protein transgenic mice.
Alpár A, Ueberham U, Brückner MK, Seeger G, Arendt T, Gärtner U
Brain Res 2006 Jul 12;1099(1):189-98. Epub 2006 Jun 15 doi: 10.1016/j.brainres.2006.04.109. PMID: 16781686

Clinical prediction guides

Lithium rescues dendritic abnormalities in Ank3 deficiency models through the synergic effects of GSK3β and cyclic AMP signaling pathways.
Piguel NH, Yoon S, Gao R, Horan KE, Garza JC, Petryshen TL, Smith KR, Penzes P
Neuropsychopharmacology 2023 Jun;48(7):1000-1010. Epub 2022 Nov 14 doi: 10.1038/s41386-022-01502-2. PMID: 36376465Free PMC Article
Endogenous PTEN-Induced Kinase 1 Regulates Dendritic Architecture and Spinogenesis.
Otero PA, Fricklas G, Nigam A, Lizama BN, Wills ZP, Johnson JW, Chu CT
J Neurosci 2022 Oct 12;42(41):7848-7860. Epub 2022 Sep 7 doi: 10.1523/JNEUROSCI.0785-22.2022. PMID: 36414008Free PMC Article
Synapse impairment associated with enhanced apoptosis in post-traumatic stress disorder.
Chen X, Jiang Y, Wang J, Liu Y, Xiao M, Song C, Bai Y, Yinuo Han N, Han F
Synapse 2020 Feb;74(2):e22134. Epub 2019 Sep 30 doi: 10.1002/syn.22134. PMID: 31562782
Mutant APP and amyloid beta-induced defective autophagy, mitophagy, mitochondrial structural and functional changes and synaptic damage in hippocampal neurons from Alzheimer's disease.
Reddy PH, Yin X, Manczak M, Kumar S, Pradeepkiran JA, Vijayan M, Reddy AP
Hum Mol Genet 2018 Jul 15;27(14):2502-2516. doi: 10.1093/hmg/ddy154. PMID: 29701781Free PMC Article
Neuropathology of Rett syndrome.
Armstrong DD
J Child Neurol 2005 Sep;20(9):747-53. doi: 10.1177/08830738050200090901. PMID: 16225830

Recent systematic reviews

Synapse Pathology in Schizophrenia: A Meta-analysis of Postsynaptic Elements in Postmortem Brain Studies.
Berdenis van Berlekom A, Muflihah CH, Snijders GJLJ, MacGillavry HD, Middeldorp J, Hol EM, Kahn RS, de Witte LD
Schizophr Bull 2020 Feb 26;46(2):374-386. doi: 10.1093/schbul/sbz060. PMID: 31192350Free PMC Article
Use of human amniotic epithelial cells in mouse models of bleomycin-induced lung fibrosis: A systematic review and meta-analysis.
He F, Zhou A, Feng S
PLoS One 2018;13(5):e0197658. Epub 2018 May 17 doi: 10.1371/journal.pone.0197658. PMID: 29772024Free PMC Article

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