U.S. flag

An official website of the United States government


Send to:

Choose Destination

Temporal lobe calcification

MedGen UID:
Concept ID:
HPO: HP:0034293


The presence of calcium deposition within the temporal lobe of the brain. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTemporal lobe calcification

Conditions with this feature

Lipid proteinosis
MedGen UID:
Concept ID:
Disease or Syndrome
Lipoid proteinosis (LP) is characterized by deposition of hyaline-like material in various tissues resulting in a hoarse voice from early infancy, vesicles and hemorrhagic crusts in the mouth and on the face and extremities, verrucous and keratotic cutaneous lesions on extensor surfaces (especially the elbows), and moniliform blepharosis (multiple beaded papules along the eyelid margins and inner canthus). Extracutaneous manifestations may include epilepsy, neuropsychiatric disorders, spontaneous CNS hemorrhage, and asymptomatic multiple yellowish nodules throughout the gastrointestinal tract. Generally, the disease course is chronic and fluctuating. Males and females are affected equally. Affected individuals have a normal life span unless they experience laryngeal obstruction.

Professional guidelines


Salge-Arrieta FJ, Carrasco-Moro R, Rodríguez-Berrocal V, Vior-Fernández C, Lee P, Pián H, Martínez-San Millán JS, Ley-Urzáiz L
World Neurosurg 2021 May;149:e651-e663. Epub 2021 Feb 4 doi: 10.1016/j.wneu.2021.01.119. PMID: 33548530
Honavar M, Janota I, Polkey CE
Histopathology 1999 Apr;34(4):342-56. doi: 10.1046/j.1365-2559.1999.00576.x. PMID: 10231402

Recent clinical studies

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...