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Decreased CSF copper concentration

MedGen UID:
1842043
•Concept ID:
C5826684
•
Finding
Synonym: Copper low in cerebrospinal fluid
 
HPO: HP:0034823

Definition

Concentration of copper in the cerebrospinal fluid (CSF) below the lower limit of normal. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased CSF copper concentration

Conditions with this feature

Neurodegeneration and seizures due to copper transport defect
MedGen UID:
1841021
•Concept ID:
C5830385
•
Disease or Syndrome
Neurodegeneration and seizures due to copper transport defect (NSCT) is an autosomal recessive disorder of copper transport characterized by hypotonia, global developmental delay, seizures, and rapid brain atrophy (summary by Dame et al., 2023).
See: Condition Record
Neurodegeneration and seizures due to copper transport defect

Professional guidelines

PubMed

CSF copper concentrations, blood-brain barrier function, and coeruloplasmin synthesis during the treatment of Wilson's disease.
Stuerenburg HJ
J Neural Transm (Vienna) 2000;107(3):321-9. doi: 10.1007/s007020050026. PMID: 10821440

Recent clinical studies

Etiology

Selenium and Other Trace Elements in the Etiology of Parkinson's Disease: A Systematic Review and Meta-Analysis of Case-Control Studies.
Adani G, Filippini T, Michalke B, Vinceti M
Neuroepidemiology 2020;54(1):1-23. Epub 2019 Aug 27 doi: 10.1159/000502357. PMID: 31454800
Copper and ceruloplasmin dyshomeostasis in serum and cerebrospinal fluid of multiple sclerosis subjects.
De Riccardis L, Buccolieri A, Muci M, Pitotti E, De Robertis F, Trianni G, Manno D, Maffia M
Biochim Biophys Acta Mol Basis Dis 2018 May;1864(5 Pt A):1828-1838. Epub 2018 Mar 8 doi: 10.1016/j.bbadis.2018.03.007. PMID: 29524632
Concentration of calcium and magnesium and trace elements (zinc, copper, iron and manganese) in cerebrospinal fluid: a try of a pathophysiological classification.
Romarís EM, Cervantes II, López JM, Marcén JF
J Trace Elem Med Biol 2011 Jan;25 Suppl 1:S45-9. Epub 2010 Dec 13 doi: 10.1016/j.jtemb.2010.10.009. PMID: 21146970
Cerebrospinal fluid levels of transition metals in patients with Parkinson's disease.
Jiménez-Jiménez FJ, Molina JA, Aguilar MV, Meseguer I, Mateos-Vega CJ, González-Muñoz MJ, de Bustos F, Martínez-Salio A, Ortí-Pareja M, Zurdo M, Martínez-Para MC
J Neural Transm (Vienna) 1998;105(4-5):497-505. doi: 10.1007/s007020050073. PMID: 9720977
Zinc, copper and magnesium concentration in serum and CSF of patients with neurological disorders.
Kapaki E, Segditsa J, Papageorgiou C
Acta Neurol Scand 1989 May;79(5):373-8. doi: 10.1111/j.1600-0404.1989.tb03803.x. PMID: 2545071

Diagnosis

BSA nanoclusters-based sensor for detection of dopamine in schizophrenia from biofluids.
Khanolkar B, Shende P
Drug Dev Ind Pharm 2024 Apr;50(4):341-353. Epub 2024 Mar 21 doi: 10.1080/03639045.2024.2328722. PMID: 38470160
Oxidative stress in children with neurocysticercosis.
Prasad R, Anil, Mishra OP, Mishra SP, Upadhyay RS, Singh TB
Pediatr Infect Dis J 2012 Oct;31(10):1012-5. doi: 10.1097/INF.0b013e31825cf1d7. PMID: 22572748
CSF copper concentration: a new parameter for diagnosis and monitoring therapy of Wilson's disease with cerebral manifestation.
Weisner B, Hartard C, Dieu C
J Neurol Sci 1987 Jun;79(1-2):229-37. doi: 10.1016/0022-510x(87)90275-9. PMID: 3612170

Therapy

Copper and ceruloplasmin dyshomeostasis in serum and cerebrospinal fluid of multiple sclerosis subjects.
De Riccardis L, Buccolieri A, Muci M, Pitotti E, De Robertis F, Trianni G, Manno D, Maffia M
Biochim Biophys Acta Mol Basis Dis 2018 May;1864(5 Pt A):1828-1838. Epub 2018 Mar 8 doi: 10.1016/j.bbadis.2018.03.007. PMID: 29524632
Antioxidative enzymes activity and malondialdehyde concentration during mitoxantrone therapy in multiple sclerosis patients.
Adamczyk-Sowa M, Sowa P, Pierzchala K, Polaniak R, Labuz-Roszak B
J Physiol Pharmacol 2012 Dec;63(6):683-90. PMID: 23388485
CSF copper concentrations, blood-brain barrier function, and coeruloplasmin synthesis during the treatment of Wilson's disease.
Stuerenburg HJ
J Neural Transm (Vienna) 2000;107(3):321-9. doi: 10.1007/s007020050026. PMID: 10821440
Wilson's disease with cerebral manifestation: monitoring therapy by CSF copper concentration.
Hartard C, Weisner B, Dieu C, Kunze K
J Neurol 1993 Dec;241(2):101-7. doi: 10.1007/BF00869772. PMID: 8138824
CSF copper concentration: a new parameter for diagnosis and monitoring therapy of Wilson's disease with cerebral manifestation.
Weisner B, Hartard C, Dieu C
J Neurol Sci 1987 Jun;79(1-2):229-37. doi: 10.1016/0022-510x(87)90275-9. PMID: 3612170

Prognosis

CSF copper concentrations, blood-brain barrier function, and coeruloplasmin synthesis during the treatment of Wilson's disease.
Stuerenburg HJ
J Neural Transm (Vienna) 2000;107(3):321-9. doi: 10.1007/s007020050026. PMID: 10821440
Wilson's disease with cerebral manifestation: monitoring therapy by CSF copper concentration.
Hartard C, Weisner B, Dieu C, Kunze K
J Neurol 1993 Dec;241(2):101-7. doi: 10.1007/BF00869772. PMID: 8138824
CSF copper concentration: a new parameter for diagnosis and monitoring therapy of Wilson's disease with cerebral manifestation.
Weisner B, Hartard C, Dieu C
J Neurol Sci 1987 Jun;79(1-2):229-37. doi: 10.1016/0022-510x(87)90275-9. PMID: 3612170

Clinical prediction guides

BSA nanoclusters-based sensor for detection of dopamine in schizophrenia from biofluids.
Khanolkar B, Shende P
Drug Dev Ind Pharm 2024 Apr;50(4):341-353. Epub 2024 Mar 21 doi: 10.1080/03639045.2024.2328722. PMID: 38470160
Nutrients and amyloid β status in the brain: A narrative review.
Díaz G, Lengele L, Sourdet S, Soriano G, de Souto Barreto P
Ageing Res Rev 2022 Nov;81:101728. Epub 2022 Aug 30 doi: 10.1016/j.arr.2022.101728. PMID: 36049590
Oxidative stress in children with neurocysticercosis.
Prasad R, Anil, Mishra OP, Mishra SP, Upadhyay RS, Singh TB
Pediatr Infect Dis J 2012 Oct;31(10):1012-5. doi: 10.1097/INF.0b013e31825cf1d7. PMID: 22572748
Concentration of calcium and magnesium and trace elements (zinc, copper, iron and manganese) in cerebrospinal fluid: a try of a pathophysiological classification.
Romarís EM, Cervantes II, López JM, Marcén JF
J Trace Elem Med Biol 2011 Jan;25 Suppl 1:S45-9. Epub 2010 Dec 13 doi: 10.1016/j.jtemb.2010.10.009. PMID: 21146970
Cerebrospinal fluid levels of transition metals in patients with Parkinson's disease.
Jiménez-Jiménez FJ, Molina JA, Aguilar MV, Meseguer I, Mateos-Vega CJ, González-Muñoz MJ, de Bustos F, Martínez-Salio A, Ortí-Pareja M, Zurdo M, Martínez-Para MC
J Neural Transm (Vienna) 1998;105(4-5):497-505. doi: 10.1007/s007020050073. PMID: 9720977

Recent systematic reviews

Selenium and Other Trace Elements in the Etiology of Parkinson's Disease: A Systematic Review and Meta-Analysis of Case-Control Studies.
Adani G, Filippini T, Michalke B, Vinceti M
Neuroepidemiology 2020;54(1):1-23. Epub 2019 Aug 27 doi: 10.1159/000502357. PMID: 31454800

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