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Anaplastic Lesion

MedGen UID:
1903
•Concept ID:
C0002793
•
Neoplastic Process
Synonyms: Anaplasia; Anaplasias
SNOMED CT: Dedifferentiation (89945005); Anaplasia (89945005)

Definition

A morphologic finding indicating the presence of a malignant cellular infiltrate characterized by the presence of large pleomorphic cells, necrosis, and high mitotic activity in a tissue sample. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAnaplastic Lesion

Professional guidelines

PubMed

SEOM clinical guideline for management of adult medulloblastoma (2020).
Luque R, Benavides M, Del Barco S, Egaña L, García-Gómez J, Martínez-García M, Pérez-Segura P, Pineda E, Sepúlveda JM, Vieito M
Clin Transl Oncol 2021 May;23(5):940-947. Epub 2021 Apr 1 doi: 10.1007/s12094-021-02581-1. PMID: 33792841Free PMC Article
Novel, emerging and provisional renal entities: The Genitourinary Pathology Society (GUPS) update on renal neoplasia.
Trpkov K, Williamson SR, Gill AJ, Adeniran AJ, Agaimy A, Alaghehbandan R, Amin MB, Argani P, Chen YB, Cheng L, Epstein JI, Cheville JC, Comperat E, da Cunha IW, Gordetsky JB, Gupta S, He H, Hirsch MS, Humphrey PA, Kapur P, Kojima F, Lopez JI, Maclean F, Magi-Galluzzi C, McKenney JK, Mehra R, Menon S, Netto GJ, Przybycin CG, Rao P, Rao Q, Reuter VE, Saleeb RM, Shah RB, Smith SC, Tickoo S, Tretiakova MS, True L, Verkarre V, Wobker SE, Zhou M, Hes O
Mod Pathol 2021 Jun;34(6):1167-1184. Epub 2021 Feb 1 doi: 10.1038/s41379-021-00737-6. PMID: 33526874
Cannabinoids for Symptom Management and Cancer Therapy: The Evidence.
Davis MP
J Natl Compr Canc Netw 2016 Jul;14(7):915-22. doi: 10.6004/jnccn.2016.0094. PMID: 27407130

Recent clinical studies

Etiology

Do long-standing nodular goitres result in malignancies?
Mathai V, Idikula J, Fenn AS, Nair A
Aust N Z J Surg 1994 Mar;64(3):180-2. doi: 10.1111/j.1445-2197.1994.tb02173.x. PMID: 8117195
Pancreatic carcinoma in childhood: case report of long survival and review of the literature.
Tersigni R, Arena L, Alessandroni L, Bufalini G, Bochicchio O, Gallo P, Stipa S
Surgery 1984 Sep;96(3):560-6. PMID: 6474362

Diagnosis

TERTp Mutation Detection in Plasma by Droplet-Digital Polymerase Chain Reaction in Spinal Myxopapillary Ependymoma with Lung Metastases.
Deniel A, Marguet F, Beaussire L, Tobenas-Dujardin AC, Peillon C, Gambirasio MA, Veresezan O, Magne N, Di Fiore F, Laquerrière A, Sarafan-Vasseur N, Fontanilles M
World Neurosurg 2019 Oct;130:405-409. Epub 2019 Jul 19 doi: 10.1016/j.wneu.2019.07.111. PMID: 31330336
Pigmented papillary epithelial neoplasm of the pituitary fossa: a distinct lesion of uncertain histogenesis.
Fuller CE, Smith M, Miller DC, Schelper R
Arch Pathol Lab Med 2001 Sep;125(9):1242-5. doi: 10.5858/2001-125-1242-PPENOT. PMID: 11520283
PCV for oligodendroglial tumors: in search of prognostic factors for response and survival.
Fortin D, Macdonald DR, Stitt L, Cairncross JG
Can J Neurol Sci 2001 Aug;28(3):215-23. doi: 10.1017/s0317167100001359. PMID: 11513339

Therapy

PCV for oligodendroglial tumors: in search of prognostic factors for response and survival.
Fortin D, Macdonald DR, Stitt L, Cairncross JG
Can J Neurol Sci 2001 Aug;28(3):215-23. doi: 10.1017/s0317167100001359. PMID: 11513339

Prognosis

TERTp Mutation Detection in Plasma by Droplet-Digital Polymerase Chain Reaction in Spinal Myxopapillary Ependymoma with Lung Metastases.
Deniel A, Marguet F, Beaussire L, Tobenas-Dujardin AC, Peillon C, Gambirasio MA, Veresezan O, Magne N, Di Fiore F, Laquerrière A, Sarafan-Vasseur N, Fontanilles M
World Neurosurg 2019 Oct;130:405-409. Epub 2019 Jul 19 doi: 10.1016/j.wneu.2019.07.111. PMID: 31330336
PCV for oligodendroglial tumors: in search of prognostic factors for response and survival.
Fortin D, Macdonald DR, Stitt L, Cairncross JG
Can J Neurol Sci 2001 Aug;28(3):215-23. doi: 10.1017/s0317167100001359. PMID: 11513339
Malignant cerebellar astrocytomas in childhood. Experience with four cases.
Bristot R, Raco A, Vangelista T, Delfini R
Childs Nerv Syst 1998 Oct;14(10):532-6. doi: 10.1007/s003810050268. PMID: 9840375
Pancreatic carcinoma in childhood: case report of long survival and review of the literature.
Tersigni R, Arena L, Alessandroni L, Bufalini G, Bochicchio O, Gallo P, Stipa S
Surgery 1984 Sep;96(3):560-6. PMID: 6474362

Clinical prediction guides

Multistep carcinogenesis in anaplastic thyroid carcinoma: a case report.
Asakawa H, Kobayashi T
Pathology 2002 Feb;34(1):94-7. doi: 10.1080/00313020120105732. PMID: 11902457
PCV for oligodendroglial tumors: in search of prognostic factors for response and survival.
Fortin D, Macdonald DR, Stitt L, Cairncross JG
Can J Neurol Sci 2001 Aug;28(3):215-23. doi: 10.1017/s0317167100001359. PMID: 11513339
Pancreatic carcinoma in childhood: case report of long survival and review of the literature.
Tersigni R, Arena L, Alessandroni L, Bufalini G, Bochicchio O, Gallo P, Stipa S
Surgery 1984 Sep;96(3):560-6. PMID: 6474362

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