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Pseudogout

MedGen UID:
19539
•Concept ID:
C0033802
•
Disease or Syndrome
Synonym: Chondrocalcinosis

Definition

An acute episode of pain, swelling, and redness, sometimes associated with fever. It is caused by the deposition of calcium pyrophosphate crystals in the joints. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPseudogout

Professional guidelines

PubMed

An Update on the Diagnosis and Management of Calcium Crystal Disease.
Flood R, Stack J, McCarthy G
Curr Rheumatol Rep 2023 Aug;25(8):145-151. Epub 2023 May 30 doi: 10.1007/s11926-023-01106-9. PMID: 37249830Free PMC Article
Management of calcium pyrophosphate crystal deposition disease: A systematic review.
Parperis K, Papachristodoulou E, Kakoullis L, Rosenthal AK
Semin Arthritis Rheum 2021 Feb;51(1):84-94. Epub 2020 Dec 21 doi: 10.1016/j.semarthrit.2020.10.005. PMID: 33360232
Diagnosis and Treatment of Gout and Pseudogout for Everyday Practice.
Sidari A, Hill E
Prim Care 2018 Jun;45(2):213-236. doi: 10.1016/j.pop.2018.02.004. PMID: 29759121

Recent clinical studies

Etiology

An Update on the Diagnosis and Management of Calcium Crystal Disease.
Flood R, Stack J, McCarthy G
Curr Rheumatol Rep 2023 Aug;25(8):145-151. Epub 2023 May 30 doi: 10.1007/s11926-023-01106-9. PMID: 37249830Free PMC Article
Knee Arthrocentesis in Adults.
Tieng A, Franchin G
J Vis Exp 2022 Feb 25;(180) doi: 10.3791/63135. PMID: 35285829
Issues in CPPD Nomenclature and Classification.
Tedeschi SK
Curr Rheumatol Rep 2019 Jul 25;21(9):49. doi: 10.1007/s11926-019-0847-4. PMID: 31346795
Diagnosis and Treatment of Gout and Pseudogout for Everyday Practice.
Sidari A, Hill E
Prim Care 2018 Jun;45(2):213-236. doi: 10.1016/j.pop.2018.02.004. PMID: 29759121
HFE-related hemochromatosis: an update for the rheumatologist.
Husar-Memmer E, Stadlmayr A, Datz C, Zwerina J
Curr Rheumatol Rep 2014 Jan;16(1):393. doi: 10.1007/s11926-013-0393-4. PMID: 24264720

Diagnosis

An Update on the Diagnosis and Management of Calcium Crystal Disease.
Flood R, Stack J, McCarthy G
Curr Rheumatol Rep 2023 Aug;25(8):145-151. Epub 2023 May 30 doi: 10.1007/s11926-023-01106-9. PMID: 37249830Free PMC Article
Hand Infections.
Teo WZW, Chung KC
Clin Plast Surg 2019 Jul;46(3):371-381. doi: 10.1016/j.cps.2019.03.003. PMID: 31103082
Cartilage diseases.
Krishnan Y, Grodzinsky AJ
Matrix Biol 2018 Oct;71-72:51-69. Epub 2018 May 24 doi: 10.1016/j.matbio.2018.05.005. PMID: 29803938Free PMC Article
Diagnosis and Treatment of Gout and Pseudogout for Everyday Practice.
Sidari A, Hill E
Prim Care 2018 Jun;45(2):213-236. doi: 10.1016/j.pop.2018.02.004. PMID: 29759121
Crystal-associated arthritis.
Agudelo CA, Wise CM
Clin Geriatr Med 1998 Aug;14(3):495-513. PMID: 9664104

Therapy

Management of calcium pyrophosphate crystal deposition disease: A systematic review.
Parperis K, Papachristodoulou E, Kakoullis L, Rosenthal AK
Semin Arthritis Rheum 2021 Feb;51(1):84-94. Epub 2020 Dec 21 doi: 10.1016/j.semarthrit.2020.10.005. PMID: 33360232
Hand Infections.
Teo WZW, Chung KC
Clin Plast Surg 2019 Jul;46(3):371-381. doi: 10.1016/j.cps.2019.03.003. PMID: 31103082
Emergent nanotherapies in microcrystal-induced arthritis.
Zamudio-Cuevas Y, Fernández-Torres J, Martínez-Nava GA, Martínez-Flores K, López-Reyes A
Int Immunopharmacol 2018 Aug;61:197-203. Epub 2018 Jun 8 doi: 10.1016/j.intimp.2018.06.007. PMID: 29890413
Diagnosis and Treatment of Gout and Pseudogout for Everyday Practice.
Sidari A, Hill E
Prim Care 2018 Jun;45(2):213-236. doi: 10.1016/j.pop.2018.02.004. PMID: 29759121
Gout and pseudogout.
Higgins PA
JAAPA 2016 Mar;29(3):50-2. doi: 10.1097/01.JAA.0000475472.40251.58. PMID: 26914781

Prognosis

Classifying Pseudogout Using Machine Learning Approaches With Electronic Health Record Data.
Tedeschi SK, Cai T, He Z, Ahuja Y, Hong C, Yates KA, Dahal K, Xu C, Lyu H, Yoshida K, Solomon DH, Cai T, Liao KP
Arthritis Care Res (Hoboken) 2021 Mar;73(3):442-448. doi: 10.1002/acr.24132. PMID: 31910317Free PMC Article
Hand Infections.
Teo WZW, Chung KC
Clin Plast Surg 2019 Jul;46(3):371-381. doi: 10.1016/j.cps.2019.03.003. PMID: 31103082
Calcium pyrophosphate deposition disease: a review of epidemiologic findings.
Abhishek A
Curr Opin Rheumatol 2016 Mar;28(2):133-9. doi: 10.1097/BOR.0000000000000246. PMID: 26626724
Crystal-associated arthritis.
Agudelo CA, Wise CM
Clin Geriatr Med 1998 Aug;14(3):495-513. PMID: 9664104
Pyrophosphate arthropathy.
Bjelle A
Scand J Rheumatol 1979;8(3):145-53. doi: 10.3109/03009747909114447. PMID: 227047

Clinical prediction guides

Patient-Reported Outcomes in Calcium Pyrophosphate Deposition Disease Compared to Gout and Osteoarthritis.
Whelan MG, Hayashi K, Altwies H, Tedeschi SK
J Rheumatol 2023 Aug;50(8):1058-1062. Epub 2023 Apr 15 doi: 10.3899/jrheum.2023-0031. PMID: 37061233Free PMC Article
Gout and pseudo-gout-related crystals promote GLUT1-mediated glycolysis that governs NLRP3 and interleukin-1β activation on macrophages.
Renaudin F, Orliaguet L, Castelli F, Fenaille F, Prignon A, Alzaid F, Combes C, Delvaux A, Adimy Y, Cohen-Solal M, Richette P, Bardin T, Riveline JP, Venteclef N, Lioté F, Campillo-Gimenez L, Ea HK
Ann Rheum Dis 2020 Nov;79(11):1506-1514. Epub 2020 Jul 22 doi: 10.1136/annrheumdis-2020-217342. PMID: 32699039
Imaging in rheumatoid arthritis: the role of magnetic resonance imaging and computed tomography.
Østergaard M, Boesen M
Radiol Med 2019 Nov;124(11):1128-1141. Epub 2019 Mar 18 doi: 10.1007/s11547-019-01014-y. PMID: 30880357
Neutrophil Extracellular Traps and Microcrystals.
Rada B
J Immunol Res 2017;2017:2896380. Epub 2017 Mar 7 doi: 10.1155/2017/2896380. PMID: 28373994Free PMC Article
Clinical and roentgenographic aspects of pseudogout: a study of 50 cases and a review.
Fam AG, Topp JR, Stein HB, Little AH
Can Med Assoc J 1981 Mar 1;124(5):545-51. PMID: 7008926Free PMC Article

Recent systematic reviews

Distinguishing Periprosthetic Crystalline Arthropathy from Infection in Total Knee Arthroplasty: A Systematic Review.
Bradley AT, King CA, Lin Y, Sculco P, Balach T, Landy DC
J Knee Surg 2022 May;35(6):668-675. Epub 2020 Sep 17 doi: 10.1055/s-0040-1716507. PMID: 32942331
Management of calcium pyrophosphate crystal deposition disease: A systematic review.
Parperis K, Papachristodoulou E, Kakoullis L, Rosenthal AK
Semin Arthritis Rheum 2021 Feb;51(1):84-94. Epub 2020 Dec 21 doi: 10.1016/j.semarthrit.2020.10.005. PMID: 33360232
Systematic Overview of Solid Particles and Their Host Responses.
Shu F, Shi Y
Front Immunol 2018;9:1157. Epub 2018 May 28 doi: 10.3389/fimmu.2018.01157. PMID: 29892295Free PMC Article
Rheumatic diseases presenting as sports-related injuries.
Jennings F, Lambert E, Fredericson M
Sports Med 2008;38(11):917-30. doi: 10.2165/00007256-200838110-00003. PMID: 18937522

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