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Neoplasm, Uncertain Whether Benign or Malignant

MedGen UID:
195599
•Concept ID:
C0677041
•
Neoplastic Process
Synonyms: Neoplasm, uncertain whether benign or malignant; Tumor, borderline malignancy; Tumor, uncertain whether benign or malignant; Unclassified tumor, borderline malignancy
SNOMED CT: Tumor, uncertain whether benign or malignant (86251006); Neoplasm, uncertain whether benign or malignant (86251006); Unclassified tumor, borderline malignancy (86251006); Tumor, borderline malignancy (86251006)

Definition

A neoplasm which, on morphologic grounds, can not be classified with certainty as benign or malignant. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeoplasm, Uncertain Whether Benign or Malignant

Professional guidelines

PubMed

Metastatic colorectal cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up.
Cervantes A, Adam R, Roselló S, Arnold D, Normanno N, Taïeb J, Seligmann J, De Baere T, Osterlund P, Yoshino T, Martinelli E; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Ann Oncol 2023 Jan;34(1):10-32. Epub 2022 Oct 25 doi: 10.1016/j.annonc.2022.10.003. PMID: 36307056
Gastric cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up.
Lordick F, Carneiro F, Cascinu S, Fleitas T, Haustermans K, Piessen G, Vogel A, Smyth EC; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Ann Oncol 2022 Oct;33(10):1005-1020. Epub 2022 Jul 29 doi: 10.1016/j.annonc.2022.07.004. PMID: 35914639
Updated International Tuberous Sclerosis Complex Diagnostic Criteria and Surveillance and Management Recommendations.
Northrup H, Aronow ME, Bebin EM, Bissler J, Darling TN, de Vries PJ, Frost MD, Fuchs Z, Gosnell ES, Gupta N, Jansen AC, Jóźwiak S, Kingswood JC, Knilans TK, McCormack FX, Pounders A, Roberds SL, Rodriguez-Buritica DF, Roth J, Sampson JR, Sparagana S, Thiele EA, Weiner HL, Wheless JW, Towbin AJ, Krueger DA; International Tuberous Sclerosis Complex Consensus Group
Pediatr Neurol 2021 Oct;123:50-66. Epub 2021 Jul 24 doi: 10.1016/j.pediatrneurol.2021.07.011. PMID: 34399110

Recent clinical studies

Etiology

Pediatric primary salivary gland tumors.
Jesberg P, Monzon A, Gitomer SA, Herrmann BW
Am J Otolaryngol 2023 Sep-Oct;44(5):103948. Epub 2023 Jun 8 doi: 10.1016/j.amjoto.2023.103948. PMID: 37352681
Histopathology of Parasellar Neoplasms.
Manojlovic-Gacic E, Rostami E, Karavitaki N, Casar-Borota O
Neuroendocrinology 2020;110(9-10):740-752. Epub 2020 Mar 11 doi: 10.1159/000507084. PMID: 32155632Free PMC Article
Surgical treatment of fibroids for subfertility.
Metwally M, Raybould G, Cheong YC, Horne AW
Cochrane Database Syst Rev 2020 Jan 29;1(1):CD003857. doi: 10.1002/14651858.CD003857.pub4. PMID: 31995657Free PMC Article
Ollier disease.
Silve C, Jüppner H
Orphanet J Rare Dis 2006 Sep 22;1:37. doi: 10.1186/1750-1172-1-37. PMID: 16995932Free PMC Article
Mechanisms of metastasis.
Nguyen TH
Clin Dermatol 2004 May-Jun;22(3):209-16. doi: 10.1016/j.clindermatol.2003.12.007. PMID: 15262306

Diagnosis

Contemporary diagnostic approach to atypical vascular lesion and angiosarcoma.
Rutland CD, Bean GR, Charville GW
Semin Diagn Pathol 2023 Jul;40(4):284-294. Epub 2023 Apr 25 doi: 10.1053/j.semdp.2023.04.017. PMID: 37121782
Cholangiocarcinoma.
Khan AS, Dageforde LA
Surg Clin North Am 2019 Apr;99(2):315-335. Epub 2019 Feb 10 doi: 10.1016/j.suc.2018.12.004. PMID: 30846037
Urologic malignancies in kidney transplantation.
Hickman LA, Sawinski D, Guzzo T, Locke JE
Am J Transplant 2018 Jan;18(1):13-22. Epub 2017 Dec 1 doi: 10.1111/ajt.14533. PMID: 28985026
Malignant pericardial effusion.
Burazor I, Imazio M, Markel G, Adler Y
Cardiology 2013;124(4):224-32. Epub 2013 Apr 5 doi: 10.1159/000348559. PMID: 23571453
Ollier disease.
Silve C, Jüppner H
Orphanet J Rare Dis 2006 Sep 22;1:37. doi: 10.1186/1750-1172-1-37. PMID: 16995932Free PMC Article

Therapy

Clinical Trials in the Genomic Era.
Joffe E, Iasonos A, Younes A
J Clin Oncol 2017 Mar 20;35(9):1011-1017. Epub 2017 Feb 13 doi: 10.1200/JCO.2016.70.8891. PMID: 28297622Free PMC Article
Clinical trials.
Giacinti L, Lopez M, Giordano A
Front Biosci 2006 Sep 1;11:2918-23. doi: 10.2741/2020. PMID: 16720363
Laparoscopy and malignancy.
Are C, Talamini MA
J Laparoendosc Adv Surg Tech A 2005 Feb;15(1):38-47. doi: 10.1089/lap.2005.15.38. PMID: 15772475
Therapeutic studies.
Rubinstein LV
Hematol Oncol Clin North Am 2000 Aug;14(4):849-76, ix. doi: 10.1016/s0889-8588(05)70315-4. PMID: 10949777
Clinical trials.
Blichert-Toft M, Mouridsen H, Andersen KW
Semin Surg Oncol 1996 Jan-Feb;12(1):32-8. doi: 10.1002/(SICI)1098-2388(199601/02)12:1<32::AID-SSU5>3.0.CO;2-7. PMID: 8821407

Prognosis

Cancer Statistics, 2021.
Siegel RL, Miller KD, Fuchs HE, Jemal A
CA Cancer J Clin 2021 Jan;71(1):7-33. Epub 2021 Jan 12 doi: 10.3322/caac.21654. PMID: 33433946
Progress in cancer mortality, incidence, and survival: a global overview.
Santucci C, Carioli G, Bertuccio P, Malvezzi M, Pastorino U, Boffetta P, Negri E, Bosetti C, La Vecchia C
Eur J Cancer Prev 2020 Sep;29(5):367-381. doi: 10.1097/CEJ.0000000000000594. PMID: 32740162
CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2012-2016.
Ostrom QT, Cioffi G, Gittleman H, Patil N, Waite K, Kruchko C, Barnholtz-Sloan JS
Neuro Oncol 2019 Nov 1;21(Suppl 5):v1-v100. doi: 10.1093/neuonc/noz150. PMID: 31675094Free PMC Article
Global Cancer Incidence and Mortality Rates and Trends--An Update.
Torre LA, Siegel RL, Ward EM, Jemal A
Cancer Epidemiol Biomarkers Prev 2016 Jan;25(1):16-27. Epub 2015 Dec 14 doi: 10.1158/1055-9965.EPI-15-0578. PMID: 26667886
Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012.
Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray F
Int J Cancer 2015 Mar 1;136(5):E359-86. Epub 2014 Oct 9 doi: 10.1002/ijc.29210. PMID: 25220842

Clinical prediction guides

Interobserver Variability and Diagnostic Performance in Predicting Malignancy of Pancreatic Intraductal Papillary Mucinous Neoplasm with MRI.
Choi SY, Min JH, Kim JH, Park HJ, Kim YY, Han YE, Bae SH, Lee JH, Choi YH, Moon JE
Radiology 2023 Jul;308(1):e222463. doi: 10.1148/radiol.222463. PMID: 37489989
Clinical outcomes of follicular tumor of uncertain malignant potential of the thyroid: real-world data.
Ito Y, Hirokawa M, Hayashi T, Kihara M, Onoda N, Miya A, Miyauchi A
Endocr J 2022 Jul 28;69(7):757-761. Epub 2022 Jan 26 doi: 10.1507/endocrj.EJ21-0723. PMID: 35082189
The Frontiers of Appendiceal Controversies: Mucinous Neoplasms and Pseudomyxoma Peritonei.
Hissong E, Yantiss RK
Am J Surg Pathol 2022 Jan 1;46(1):e27-e42. doi: 10.1097/PAS.0000000000001662. PMID: 33417324
Cancer taxonomy: pathology beyond pathology.
Salto-Tellez M, Cree IA
Eur J Cancer 2019 Jul;115:57-60. Epub 2019 May 17 doi: 10.1016/j.ejca.2019.03.026. PMID: 31108243
Update in adrenocortical carcinoma.
Fassnacht M, Kroiss M, Allolio B
J Clin Endocrinol Metab 2013 Dec;98(12):4551-64. Epub 2013 Sep 30 doi: 10.1210/jc.2013-3020. PMID: 24081734

Recent systematic reviews

Late relapse after CAR-T cell therapy for adult patients with hematologic malignancies: A definite evidence from systematic review and meta-analysis on individual data.
Zinzi A, Gaio M, Liguori V, Cagnotta C, Paolino D, Paolisso G, Castaldo G, Nicoletti GF, Rossi F, Capuano A, Rafaniello C
Pharmacol Res 2023 Apr;190:106742. Epub 2023 Mar 22 doi: 10.1016/j.phrs.2023.106742. PMID: 36963592
Diagnosis and management of parathyroid carcinoma: a state-of-the-art review.
Roser P, Leca BM, Coelho C, Schulte KM, Gilbert J, Drakou EE, Kosmas C, Ling Chuah L, Wassati H, Miras AD, Crane J, Aylwin SJB, Grossman AB, Dimitriadis GK
Endocr Relat Cancer 2023 Apr 1;30(4) Epub 2023 Mar 22 doi: 10.1530/ERC-22-0287. PMID: 36621911
Primary Sjögren's syndrome is associated with increased risk of malignancies besides lymphoma: A systematic review and meta-analysis.
Zhong H, Liu S, Wang Y, Xu D, Li M, Zhao Y, Zeng X
Autoimmun Rev 2022 May;21(5):103084. Epub 2022 Mar 24 doi: 10.1016/j.autrev.2022.103084. PMID: 35341972
Surgical treatment of fibroids for subfertility.
Metwally M, Raybould G, Cheong YC, Horne AW
Cochrane Database Syst Rev 2020 Jan 29;1(1):CD003857. doi: 10.1002/14651858.CD003857.pub4. PMID: 31995657Free PMC Article
Oral potentially malignant disorders: A comprehensive review on clinical aspects and management.
Warnakulasuriya S
Oral Oncol 2020 Mar;102:104550. Epub 2020 Jan 22 doi: 10.1016/j.oraloncology.2019.104550. PMID: 31981993

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