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Granulomatous dermatitis

MedGen UID:
196647
•Concept ID:
C0743086
•
Disease or Syndrome
Synonyms: Granulomatous Dermatitis; granulomatous dermatitis
 
Monarch Initiative: MONDO:0006555

Definition

An inflammatory reaction of the skin to various organic and inorganic antigens. It is characterized by tumor-like masses or nodules of granulomatous tissue comprised of activated histiocytes, epitheliod cells, and multinucleated giant cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGranulomatous dermatitis

Professional guidelines

PubMed

Tofacitinib, a suppressor of NOD2 expression, is a potential treatment for Blau syndrome.
Ueki Y, Takimoto-Ito R, Saito MK, Tanizaki H, Kambe N
Front Immunol 2023;14:1211240. Epub 2023 Jun 21 doi: 10.3389/fimmu.2023.1211240. PMID: 37415984Free PMC Article
Treatment of granuloma annulare and related granulomatous diseases with sulphasalazine: a series of 16 cases.
Yang YW, Lehrer MD, Mangold AR, Yiannias JA, Nelson SA, Pittelkow MR
J Eur Acad Dermatol Venereol 2021 Jan;35(1):211-215. Epub 2020 Jul 21 doi: 10.1111/jdv.16356. PMID: 32216136
The role of biologics in the treatment of chronic granuloma annulare.
Chen A, Truong AK, Worswick S
Int J Dermatol 2019 May;58(5):622-626. Epub 2019 Jan 7 doi: 10.1111/ijd.14350. PMID: 30618205

Recent clinical studies

Etiology

Palisaded Neutrophilic Granulomatous Dermatitis, Bowel-Associated Dermatosis-Arthritis Syndrome, and Rheumatoid Neutrophilic Dermatitis.
Yamanaka-Takaichi M, Alavi A
Dermatol Clin 2024 Apr;42(2):297-305. Epub 2023 Sep 9 doi: 10.1016/j.det.2023.08.008. PMID: 38423688
Clinical and histopathological features of hypereosinophilic syndrome with cutaneous involvement: The Mayo Clinic Experience.
Zayas J, Peters MS, Butterfield JH, Pongdee T, Sokumbi O
J Cutan Pathol 2023 May;50(5):455-465. Epub 2023 Mar 3 doi: 10.1111/cup.14410. PMID: 36790036
Underlying Systemic Diseases in Interstitial Granulomatous Dermatitis and Palisaded Neutrophilic Granulomatous Dermatitis: A Systematic Review.
Yang C, Tang S, Li S, Ying S, Zhu D, Liu T, Chu Y, Fang H, Qiao J
Dermatology 2023;239(2):287-298. Epub 2022 Dec 7 doi: 10.1159/000527461. PMID: 36476409
Cutaneous Granulomatosis: a Comprehensive Review.
Terziroli Beretta-Piccoli B, Mainetti C, Peeters MA, Laffitte E
Clin Rev Allergy Immunol 2018 Feb;54(1):131-146. doi: 10.1007/s12016-017-8666-8. PMID: 29352388
Granulomatous & histiocytic dermatitides.
Wick MR
Semin Diagn Pathol 2017 May;34(3):301-311. Epub 2016 Dec 14 doi: 10.1053/j.semdp.2016.12.003. PMID: 28094163

Diagnosis

Unexpected Granulomatous Dermatitis.
Murray DW 3rd, Fagan KK, Eikenberg JD, Grider DJ
Am J Dermatopathol 2023 May 1;45(5):348-349. doi: 10.1097/DAD.0000000000002389. PMID: 37074014
Skin manifestations of rheumatoid arthritis.
Lora V, Cerroni L, Cota C
G Ital Dermatol Venereol 2018 Apr;153(2):243-255. Epub 2018 Jan 24 doi: 10.23736/S0392-0488.18.05872-8. PMID: 29368864
Cutaneous Granulomatosis: a Comprehensive Review.
Terziroli Beretta-Piccoli B, Mainetti C, Peeters MA, Laffitte E
Clin Rev Allergy Immunol 2018 Feb;54(1):131-146. doi: 10.1007/s12016-017-8666-8. PMID: 29352388
Reactive Granulomatous Dermatitis: A Review of Palisaded Neutrophilic and Granulomatous Dermatitis, Interstitial Granulomatous Dermatitis, Interstitial Granulomatous Drug Reaction, and a Proposed Reclassification.
Rosenbach M, English JC 3rd
Dermatol Clin 2015 Jul;33(3):373-87. Epub 2015 Jun 5 doi: 10.1016/j.det.2015.03.005. PMID: 26143420
Coccidioidomycosis.
DiCaudo DJ
Semin Cutan Med Surg 2014 Sep;33(3):140-5. doi: 10.12788/j.sder.0111. PMID: 25577855

Therapy

Tofacitinib, a suppressor of NOD2 expression, is a potential treatment for Blau syndrome.
Ueki Y, Takimoto-Ito R, Saito MK, Tanizaki H, Kambe N
Front Immunol 2023;14:1211240. Epub 2023 Jun 21 doi: 10.3389/fimmu.2023.1211240. PMID: 37415984Free PMC Article
Interstitial granulomatous dermatitis following tocilizumab, a paradoxical reaction?
Altemir A, Iglesias-Sancho M, Sola-Casas MLÁ, Novoa-Lamazares L, Fernández-Figueras M, Salleras-Redonnet M
Dermatol Ther 2020 Nov;33(6):e14207. Epub 2020 Sep 7 doi: 10.1111/dth.14207. PMID: 32816393
Immune checkpoint inhibitors and the development of granulomatous reactions.
Cornejo CM, Haun P, English J 3rd, Rosenbach M
J Am Acad Dermatol 2019 Nov;81(5):1165-1175. Epub 2018 Aug 6 doi: 10.1016/j.jaad.2018.07.051. PMID: 30092327
Talimogene laherparepvec: First in class oncolytic virotherapy.
Conry RM, Westbrook B, McKee S, Norwood TG
Hum Vaccin Immunother 2018 Apr 3;14(4):839-846. Epub 2018 Feb 22 doi: 10.1080/21645515.2017.1412896. PMID: 29420123Free PMC Article
Skin manifestations of rheumatoid arthritis.
Lora V, Cerroni L, Cota C
G Ital Dermatol Venereol 2018 Apr;153(2):243-255. Epub 2018 Jan 24 doi: 10.23736/S0392-0488.18.05872-8. PMID: 29368864

Prognosis

Case Report: Methotrexate and hydroxychloroquine in combination for the treatment of NOD2-mutation-associated Blau syndrome.
Jensen ME, Harrell K, McBride JD
Front Immunol 2023;14:1279329. Epub 2023 Oct 5 doi: 10.3389/fimmu.2023.1279329. PMID: 37868966Free PMC Article
Reactive granulomatous dermatitis as a clinically relevant and unifying term: a retrospective review of clinical features, associated systemic diseases, histopathology and treatment for a series of 65 patients at Mayo Clinic.
Bangalore Kumar A, Lehman JS, Johnson EF, Cantwell HM, Sartori Valinotti JC, Sokumbi O, Davis MDP, Wetter DA
J Eur Acad Dermatol Venereol 2022 Dec;36(12):2443-2450. Epub 2022 May 26 doi: 10.1111/jdv.18203. PMID: 35535506Free PMC Article
Histopathological Spectrum and Immunophenotypic Characterization of Symmetrical Drug-Related Intertriginous and Flexural Exanthema.
Muresan AM, Metze D, Böer-Auer A, Braun SA
Am J Dermatopathol 2021 Feb 1;43(2):103-111. doi: 10.1097/DAD.0000000000001722. PMID: 32618703
Clinical and histologic presentation of pediatric reactive granulomatous dermatitis.
Akinshemoyin Vaughn OL, Siegel DH, Chiu YE, DeBord LC, Hogeling M, Hunt RD, Nguyen C, Sokumbi O, Verbsky JW, Arkin LM
Pediatr Dermatol 2020 May;37(3):498-503. Epub 2020 Mar 1 doi: 10.1111/pde.14137. PMID: 32115758
Non-infectious granulomatous diseases of the skin and their associated systemic diseases: an evidence-based update to important clinical questions.
Hawryluk EB, Izikson L, English JC 3rd
Am J Clin Dermatol 2010;11(3):171-81. doi: 10.2165/11530080-000000000-00000. PMID: 20184390

Clinical prediction guides

Reactive granulomatous dermatitis as a clinically relevant and unifying term: a retrospective review of clinical features, associated systemic diseases, histopathology and treatment for a series of 65 patients at Mayo Clinic.
Bangalore Kumar A, Lehman JS, Johnson EF, Cantwell HM, Sartori Valinotti JC, Sokumbi O, Davis MDP, Wetter DA
J Eur Acad Dermatol Venereol 2022 Dec;36(12):2443-2450. Epub 2022 May 26 doi: 10.1111/jdv.18203. PMID: 35535506Free PMC Article
Histopathological Spectrum and Immunophenotypic Characterization of Symmetrical Drug-Related Intertriginous and Flexural Exanthema.
Muresan AM, Metze D, Böer-Auer A, Braun SA
Am J Dermatopathol 2021 Feb 1;43(2):103-111. doi: 10.1097/DAD.0000000000001722. PMID: 32618703
Histopathologic Characterization of Mogamulizumab-associated Rash.
Wang JY, Hirotsu KE, Neal TM, Raghavan SS, Kwong BY, Khodadoust MS, Brown RA, Novoa RA, Kim YH, Rieger KE
Am J Surg Pathol 2020 Dec;44(12):1666-1676. doi: 10.1097/PAS.0000000000001587. PMID: 32976123
Interstitial Granulomatous Dermatitis: A Clinicopathological Study.
Coutinho I, Pereira N, Gouveia M, Cardoso JC, Tellechea O
Am J Dermatopathol 2015 Aug;37(8):614-9. doi: 10.1097/DAD.0000000000000288. PMID: 25830722
Interstitial granulomatous dermatitis: a distinct entity with characteristic histological and clinical pattern.
Peroni A, Colato C, Schena D, Gisondi P, Girolomoni G
Br J Dermatol 2012 Apr;166(4):775-83. doi: 10.1111/j.1365-2133.2011.10727.x. PMID: 22059717

Recent systematic reviews

Underlying Systemic Diseases in Interstitial Granulomatous Dermatitis and Palisaded Neutrophilic Granulomatous Dermatitis: A Systematic Review.
Yang C, Tang S, Li S, Ying S, Zhu D, Liu T, Chu Y, Fang H, Qiao J
Dermatology 2023;239(2):287-298. Epub 2022 Dec 7 doi: 10.1159/000527461. PMID: 36476409
Health risks for body pierced community: a systematic review.
Sindoni A, Valeriani F, Protano C, Liguori G, Romano Spica V, Vitali M, Gallè F
Public Health 2022 Apr;205:202-215. Epub 2022 Mar 24 doi: 10.1016/j.puhe.2022.01.035. PMID: 35339940
The role of biologics in the treatment of chronic granuloma annulare.
Chen A, Truong AK, Worswick S
Int J Dermatol 2019 May;58(5):622-626. Epub 2019 Jan 7 doi: 10.1111/ijd.14350. PMID: 30618205

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