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Congenital rubella syndrome

MedGen UID:
19841
•Concept ID:
C0035921
•
Disease or Syndrome
Synonym: Rubella congenital
SNOMED CT: Congenital rubella syndrome (1857005); Gestational rubella syndrome (1857005); Gregg's syndrome (1857005); Congenital rubella (1857005)
 
Monarch Initiative: MONDO:0017361

Definition

A condition, whose clinical manifestations include intrauterine growth restriction, petechial rash, jaundice, generalized lymphadenopathy, hepatosplenomegaly, peripheral pulmonary stenosis, cataracts, and sensorineural deafness, that is caused by fetal exposure to the rubella virus during the first trimester of pregnancy. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCongenital rubella syndrome
Follow this link to review classifications for Congenital rubella syndrome in Orphanet.

Professional guidelines

PubMed

No. 368-RUBELLA IN PREGNANCY.
Boucoiran I, Castillo E
J Obstet Gynaecol Can 2018 Dec;40(12):1646-1656. doi: 10.1016/j.jogc.2018.07.003. PMID: 30527073
No. 203-Rubella in Pregnancy.
Dontigny L, Arsenault MY, Martel MJ
J Obstet Gynaecol Can 2018 Aug;40(8):e615-e621. doi: 10.1016/j.jogc.2018.05.009. PMID: 30103885
Rubella and pregnancy: diagnosis, management and outcomes.
Bouthry E, Picone O, Hamdi G, Grangeot-Keros L, Ayoubi JM, Vauloup-Fellous C
Prenat Diagn 2014 Dec;34(13):1246-53. Epub 2014 Sep 16 doi: 10.1002/pd.4467. PMID: 25066688

Recent clinical studies

Etiology

Rubella Virus Infection, the Congenital Rubella Syndrome, and the Link to Autism.
Mawson AR, Croft AM
Int J Environ Res Public Health 2019 Sep 22;16(19) doi: 10.3390/ijerph16193543. PMID: 31546693Free PMC Article
Congenital and perinatal infections.
Ostrander B, Bale JF
Handb Clin Neurol 2019;162:133-153. doi: 10.1016/B978-0-444-64029-1.00006-0. PMID: 31324308
Congenital rubella syndrome: progress and future challenges.
Morice A, Ulloa-Gutierrez R, Avila-Agüero ML
Expert Rev Vaccines 2009 Mar;8(3):323-31. doi: 10.1586/14760584.8.3.323. PMID: 19249974
Rubella and rubeola.
Rosa C
Semin Perinatol 1998 Aug;22(4):318-22. doi: 10.1016/s0146-0005(98)80020-7. PMID: 9738996
Rubella.
Boniuk V
Int Ophthalmol Clin 1975 Winter;15(4):229-41. doi: 10.1097/00004397-197501540-00019. PMID: 773881

Diagnosis

Rubella.
Winter AK, Moss WJ
Lancet 2022 Apr 2;399(10332):1336-1346. doi: 10.1016/S0140-6736(21)02691-X. PMID: 35367004
Rubella Virus Infection, the Congenital Rubella Syndrome, and the Link to Autism.
Mawson AR, Croft AM
Int J Environ Res Public Health 2019 Sep 22;16(19) doi: 10.3390/ijerph16193543. PMID: 31546693Free PMC Article
Congenital and perinatal infections.
Ostrander B, Bale JF
Handb Clin Neurol 2019;162:133-153. doi: 10.1016/B978-0-444-64029-1.00006-0. PMID: 31324308
Measles.
Moss WJ
Lancet 2017 Dec 2;390(10111):2490-2502. Epub 2017 Jun 30 doi: 10.1016/S0140-6736(17)31463-0. PMID: 28673424
Rubella.
Lambert N, Strebel P, Orenstein W, Icenogle J, Poland GA
Lancet 2015 Jun 6;385(9984):2297-307. Epub 2015 Jan 8 doi: 10.1016/S0140-6736(14)60539-0. PMID: 25576992Free PMC Article

Therapy

Measles.
Moss WJ
Lancet 2017 Dec 2;390(10111):2490-2502. Epub 2017 Jun 30 doi: 10.1016/S0140-6736(17)31463-0. PMID: 28673424
Epidemiology of rubella and congenital rubella syndrome in Japan before 1989.
Ueda K
Vaccine 2016 Apr 7;34(16):1971-4. Epub 2015 Oct 23 doi: 10.1016/j.vaccine.2015.10.010. PMID: 26469722
TORCH infections.
Neu N, Duchon J, Zachariah P
Clin Perinatol 2015 Mar;42(1):77-103, viii. Epub 2014 Dec 20 doi: 10.1016/j.clp.2014.11.001. PMID: 25677998
Rubella.
Lambert N, Strebel P, Orenstein W, Icenogle J, Poland GA
Lancet 2015 Jun 6;385(9984):2297-307. Epub 2015 Jan 8 doi: 10.1016/S0140-6736(14)60539-0. PMID: 25576992Free PMC Article
Rubella.
Banatvala JE, Brown DW
Lancet 2004 Apr 3;363(9415):1127-37. doi: 10.1016/S0140-6736(04)15897-2. PMID: 15064032

Prognosis

Rubella in Poland in 2020.
Bogusz J, Augustynowicz E, Paradowska-Stankiewicz I
Przegl Epidemiol 2022;76(4):554-560. doi: 10.32394/pe.76.50. PMID: 37017447
Rubella (German measles) revisited.
Leung AKC, Hon KL, Leong KF
Hong Kong Med J 2019 Apr;25(2):134-141. Epub 2019 Apr 10 doi: 10.12809/hkmj187785. PMID: 30967519
Clinical manifestations of congenital rubella syndrome: A review of our experience in Vietnam.
Toizumi M, Vo HM, Dang DA, Moriuchi H, Yoshida LM
Vaccine 2019 Jan 3;37(1):202-209. Epub 2018 Nov 30 doi: 10.1016/j.vaccine.2018.11.046. PMID: 30503658
Epidemiology of rubella and congenital rubella syndrome in Japan before 1989.
Ueda K
Vaccine 2016 Apr 7;34(16):1971-4. Epub 2015 Oct 23 doi: 10.1016/j.vaccine.2015.10.010. PMID: 26469722
Rubella and rubeola.
Rosa C
Semin Perinatol 1998 Aug;22(4):318-22. doi: 10.1016/s0146-0005(98)80020-7. PMID: 9738996

Clinical prediction guides

Facial dysmorphism in congenital rubella syndrome.
Chattannavar G, Bansal A, Kekunnaya R
J AAPOS 2024 Feb;28(1):103791. Epub 2023 Nov 7 doi: 10.1016/j.jaapos.2023.08.020. PMID: 37939916
Congenital Rubella syndrome: A short report and literature review.
Gudeloglu E, Akillioglu M, Bedir Demirdag T, Unal NA, Tapisiz AA
Trop Doct 2023 Jan;53(1):171-175. Epub 2022 Nov 1 doi: 10.1177/00494755221134327. PMID: 36321169
Rubella in Poland in 2020.
Bogusz J, Augustynowicz E, Paradowska-Stankiewicz I
Przegl Epidemiol 2022;76(4):554-560. doi: 10.32394/pe.76.50. PMID: 37017447
Perinatal viral infections.
Ueda K, Tokugawa K, Kusuhara K
Early Hum Dev 1992 Jun-Jul;29(1-3):131-5. doi: 10.1016/0378-3782(92)90127-3. PMID: 1396225
Rubella.
Boniuk V
Int Ophthalmol Clin 1975 Winter;15(4):229-41. doi: 10.1097/00004397-197501540-00019. PMID: 773881

Recent systematic reviews

The end of measles and congenital rubella: an achievable dream?
Adamo G, Sturabotti G, D'Andrea E, Baccolini V, Romano F, Iannazzo S, Marzuillo C, Villari P
Ann Ig 2017 Jan-Feb;29(1):1-26. doi: 10.7416/ai.2017.2128. PMID: 28067934
Systematic Review of Measles and Rubella Serology Studies.
Thompson KM, Odahowski CL
Risk Anal 2016 Jul;36(7):1459-86. Epub 2015 Jun 16 doi: 10.1111/risa.12430. PMID: 26077609
Systematic Review of Health Economic Analyses of Measles and Rubella Immunization Interventions.
Thompson KM, Odahowski CL
Risk Anal 2016 Jul;36(7):1297-314. Epub 2014 Dec 24 doi: 10.1111/risa.12331. PMID: 25545778
Post-exposure passive immunisation for preventing rubella and congenital rubella syndrome.
Young MK, Cripps AW, Nimmo GR, van Driel ML
Cochrane Database Syst Rev 2015 Sep 9;2015(9):CD010586. doi: 10.1002/14651858.CD010586.pub2. PMID: 26350479Free PMC Article
Burden of Congenital Rubella Syndrome (CRS) in India: a systematic review.
Dewan P, Gupta P
Indian Pediatr 2012 May;49(5):377-99. doi: 10.1007/s13312-012-0087-4. PMID: 22700664

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