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Scurvy(SCURVY)

MedGen UID:
20684
•Concept ID:
C0036474
•
Disease or Syndrome
Synonyms: Deficiency of vitamin C; Hypoascorbemia; Scorbutus; SCURVY; VITAMIN C, INABILITY TO SYNTHESIZE
SNOMED CT: Scurvy (76169001)
 
Monarch Initiative: MONDO:0009412
OMIM®: 240400

Definition

Abnormally low concentrations of vitamin C in the blood. [from NCI]

Clinical features

From HPO
Abnormality of metabolism/homeostasis
MedGen UID:
867398
•Concept ID:
C4021768
•
Finding
See: Feature record | Search on this feature

Professional guidelines

PubMed

Technical note: The use and misuse of threshold diagnostic criteria in paleopathology.
Vlok M
Am J Biol Anthropol 2023 Jun;181(2):326-335. Epub 2023 Mar 3 doi: 10.1002/ajpa.24721. PMID: 36866523
A review of the effectiveness of hibiscus for treatment of metabolic syndrome.
Jeffery TD, Richardson ML
J Ethnopharmacol 2021 Apr 24;270:113762. Epub 2020 Dec 28 doi: 10.1016/j.jep.2020.113762. PMID: 33383111
The role of vitamin C in the treatment of pain: new insights.
Carr AC, McCall C
J Transl Med 2017 Apr 14;15(1):77. doi: 10.1186/s12967-017-1179-7. PMID: 28410599Free PMC Article

Recent clinical studies

Etiology

A Review of Micronutrients and the Immune System-Working in Harmony to Reduce the Risk of Infection.
Gombart AF, Pierre A, Maggini S
Nutrients 2020 Jan 16;12(1) doi: 10.3390/nu12010236. PMID: 31963293Free PMC Article
Chapter 6: Vitamins and Oral Health.
Gutierrez Gossweiler A, Martinez-Mier EA
Monogr Oral Sci 2020;28:59-67. Epub 2019 Nov 7 doi: 10.1159/000455372. PMID: 31940621
Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.
Chapple ILC, Mealey BL, Van Dyke TE, Bartold PM, Dommisch H, Eickholz P, Geisinger ML, Genco RJ, Glogauer M, Goldstein M, Griffin TJ, Holmstrup P, Johnson GK, Kapila Y, Lang NP, Meyle J, Murakami S, Plemons J, Romito GA, Shapira L, Tatakis DN, Teughels W, Trombelli L, Walter C, Wimmer G, Xenoudi P, Yoshie H
J Periodontol 2018 Jun;89 Suppl 1:S74-S84. doi: 10.1002/JPER.17-0719. PMID: 29926944
Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.
Chapple ILC, Mealey BL, Van Dyke TE, Bartold PM, Dommisch H, Eickholz P, Geisinger ML, Genco RJ, Glogauer M, Goldstein M, Griffin TJ, Holmstrup P, Johnson GK, Kapila Y, Lang NP, Meyle J, Murakami S, Plemons J, Romito GA, Shapira L, Tatakis DN, Teughels W, Trombelli L, Walter C, Wimmer G, Xenoudi P, Yoshie H
J Clin Periodontol 2018 Jun;45 Suppl 20:S68-S77. doi: 10.1111/jcpe.12940. PMID: 29926499
Pharmacology of vitamin C.
Sauberlich HE
Annu Rev Nutr 1994;14:371-91. doi: 10.1146/annurev.nu.14.070194.002103. PMID: 7946525

Diagnosis

Scurvy.
Krečak I, Babić G, Skelin M
Acta Dermatovenerol Croat 2022 Jul;30(1):59-60. PMID: 36153722
Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.
Chapple ILC, Mealey BL, Van Dyke TE, Bartold PM, Dommisch H, Eickholz P, Geisinger ML, Genco RJ, Glogauer M, Goldstein M, Griffin TJ, Holmstrup P, Johnson GK, Kapila Y, Lang NP, Meyle J, Murakami S, Plemons J, Romito GA, Shapira L, Tatakis DN, Teughels W, Trombelli L, Walter C, Wimmer G, Xenoudi P, Yoshie H
J Periodontol 2018 Jun;89 Suppl 1:S74-S84. doi: 10.1002/JPER.17-0719. PMID: 29926944
Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.
Chapple ILC, Mealey BL, Van Dyke TE, Bartold PM, Dommisch H, Eickholz P, Geisinger ML, Genco RJ, Glogauer M, Goldstein M, Griffin TJ, Holmstrup P, Johnson GK, Kapila Y, Lang NP, Meyle J, Murakami S, Plemons J, Romito GA, Shapira L, Tatakis DN, Teughels W, Trombelli L, Walter C, Wimmer G, Xenoudi P, Yoshie H
J Clin Periodontol 2018 Jun;45 Suppl 20:S68-S77. doi: 10.1111/jcpe.12940. PMID: 29926499
Neuropsychiatric scurvy.
Brown TM
Psychosomatics 2015 Jan-Feb;56(1):12-20. Epub 2014 Jun 2 doi: 10.1016/j.psym.2014.05.010. PMID: 25619670
Cutaneous pseudovasculitis.
Carlson JA, Chen KR
Am J Dermatopathol 2007 Feb;29(1):44-55. doi: 10.1097/01.dad.0000245195.35106.3c. PMID: 17284961

Therapy

Scurvy.
Krečak I, Babić G, Skelin M
Acta Dermatovenerol Croat 2022 Jul;30(1):59-60. PMID: 36153722
Scurvy.
Ishizuka K, Ohira Y
QJM 2022 Jul 9;115(7):475. doi: 10.1093/qjmed/hcac122. PMID: 35575388
A Review of Micronutrients and the Immune System-Working in Harmony to Reduce the Risk of Infection.
Gombart AF, Pierre A, Maggini S
Nutrients 2020 Jan 16;12(1) doi: 10.3390/nu12010236. PMID: 31963293Free PMC Article
Scurvy and embryo culture.
Barnhart KT
Fertil Steril 2018 Jun;109(6):988. doi: 10.1016/j.fertnstert.2018.04.015. PMID: 29935658
Pharmacology of vitamin C.
Sauberlich HE
Annu Rev Nutr 1994;14:371-91. doi: 10.1146/annurev.nu.14.070194.002103. PMID: 7946525

Prognosis

Introduction: Scientific rigor in paleopathology.
Buikstra JE, Cook DC, Bolhofner KL
Int J Paleopathol 2017 Dec;19:80-87. Epub 2017 Oct 13 doi: 10.1016/j.ijpp.2017.08.005. PMID: 29198402
A Case of Scurvy-Uncommon Disease-Presenting as Panniculitis, Purpura, and Oligoarthritis.
Mintsoulis D, Milman N, Fahim S
J Cutan Med Surg 2016 Nov;20(6):592-595. Epub 2016 Jul 14 doi: 10.1177/1203475416660311. PMID: 27416817
Scurvy: a disease almost forgotten.
Olmedo JM, Yiannias JA, Windgassen EB, Gornet MK
Int J Dermatol 2006 Aug;45(8):909-13. doi: 10.1111/j.1365-4632.2006.02844.x. PMID: 16911372
In search of the cause of gastric cancer.
Kodama M, Kodama T
In Vivo 2000 Jan-Feb;14(1):125-38. PMID: 10757069
The dawn of Darwinian medicine.
Williams GC, Nesse RM
Q Rev Biol 1991 Mar;66(1):1-22. doi: 10.1086/417048. PMID: 2052670

Clinical prediction guides

Clinical therapeutic trials.
Buchanan WW, Kean CA, Rainsford KD, Kean WF
Inflammopharmacology 2024 Feb;32(1):61-71. Epub 2023 Aug 3 doi: 10.1007/s10787-023-01303-z. PMID: 37535211
Scurvy: old disease, new lessons.
Kinlin LM, Weinstein M
Paediatr Int Child Health 2023 Nov;43(4):83-94. Epub 2023 Dec 29 doi: 10.1080/20469047.2023.2262787. PMID: 37795755
Unwinding the potentials of vitamin C in COVID-19 and other diseases: An updated review.
Mehta N, Pokharna P, Shetty SR
Nutr Health 2023 Sep;29(3):415-433. Epub 2022 Nov 29 doi: 10.1177/02601060221139628. PMID: 36445072Free PMC Article
Dietary Vitamin C in Human Health.
Granger M, Eck P
Adv Food Nutr Res 2018;83:281-310. Epub 2018 Feb 16 doi: 10.1016/bs.afnr.2017.11.006. PMID: 29477224
Scurvy: past, present and future.
Magiorkinis E, Beloukas A, Diamantis A
Eur J Intern Med 2011 Apr;22(2):147-52. Epub 2010 Nov 16 doi: 10.1016/j.ejim.2010.10.006. PMID: 21402244

Recent systematic reviews

Bleeding tendency and ascorbic acid requirements: systematic review and meta-analysis of clinical trials.
Hujoel PP, Kato T, Hujoel IA, Hujoel MLA
Nutr Rev 2021 Aug 9;79(9):964-975. doi: 10.1093/nutrit/nuaa115. PMID: 33517432
Nutritional Deficiency Disease Secondary to ARFID Symptoms Associated with Autism and the Broad Autism Phenotype: A Qualitative Systematic Review of Case Reports and Case Series.
Yule S, Wanik J, Holm EM, Bruder MB, Shanley E, Sherman CQ, Fitterman M, Lerner J, Marcello M, Parenchuck N, Roman-White C, Ziff M
J Acad Nutr Diet 2021 Mar;121(3):467-492. Epub 2020 Nov 19 doi: 10.1016/j.jand.2020.10.017. PMID: 33221247
The neuropsychiatric effects of vitamin C deficiency: a systematic review.
Plevin D, Galletly C
BMC Psychiatry 2020 Jun 18;20(1):315. doi: 10.1186/s12888-020-02730-w. PMID: 32552785Free PMC Article
Scurvy as a Sequela of Avoidant-Restrictive Food Intake Disorder in Autism: A Systematic Review.
Sharp WG, Berry RC, Burrell L, Scahill L, McElhanon BO
J Dev Behav Pediatr 2020 Jun/Jul;41(5):397-405. doi: 10.1097/DBP.0000000000000782. PMID: 32044868
Treating nerves: from anecdote to systematic review.
Hughes RA
J R Soc Med 2003 Sep;96(9):432-5. doi: 10.1177/014107680309600904. PMID: 12949197Free PMC Article

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