U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Tolosa-Hunt syndrome

MedGen UID:
21197
Concept ID:
C0040381
Disease or Syndrome
Synonyms: Nonspecific inflammation of the cavernous sinus or superior orbital fissure; Ophthalmoplegia, painful
SNOMED CT: Tolosa-Hunt syndrome (95794005)
 
Monarch Initiative: MONDO:0018983
Orphanet: ORPHA64686

Definition

An ophthalmoplegic syndrome, affecting all age groups, with characteristics of acute attacks (lasting a few days to a few weeks) of periorbital pain, ipsilateral ocular motor nerve palsies, ptosis, disordered eye movements and blurred vision usually caused by a non-specific inflammatory process in the cavernous sinus and superior orbital fissure. It has an unpredictable course with spontaneous remission occurring in some and recurrence of attacks in others. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTolosa-Hunt syndrome

Professional guidelines

PubMed

Mullen E, Green M, Hersh E, Iloreta AM, Bederson J, Shrivastava R
Cephalalgia 2018 Sep;38(10):1696-1700. Epub 2017 Nov 23 doi: 10.1177/0333102417745271. PMID: 29169256
La Mantia L, Curone M, Rapoport AM, Bussone G; International Headache Society
Cephalalgia 2006 Jul;26(7):772-81. doi: 10.1111/j.1468-2982.2006.01115.x. PMID: 16776691
Hunt WE, Brightman RP
Acta Neurochir Suppl (Wien) 1988;42:248-52. doi: 10.1007/978-3-7091-8975-7_48. PMID: 3055832

Recent clinical studies

Etiology

Kim HJ, Lee SU, Lee ES, Choi JY, Kim JS
J Neurol 2024 Feb;271(2):935-943. Epub 2023 Oct 19 doi: 10.1007/s00415-023-12044-y. PMID: 37853245
Yang Q, Lai C, Meng C, Chang Q, Wang J
Eur Neurol 2022;85(4):265-272. Epub 2022 Mar 9 doi: 10.1159/000522187. PMID: 35263741
Kim H, Oh SY
BMC Ophthalmol 2021 May 27;21(1):237. doi: 10.1186/s12886-021-02007-0. PMID: 34044807Free PMC Article
Lutt JR, Lim LL, Phal PM, Rosenbaum JT
Semin Arthritis Rheum 2008 Feb;37(4):207-22. Epub 2007 Sep 4 doi: 10.1016/j.semarthrit.2007.06.003. PMID: 17765951
Palacios E, Valvassori G, Bresler M
Ear Nose Throat J 1999 Mar;78(3):150. PMID: 10188349

Diagnosis

Kmeid M, Medrea I
Curr Pain Headache Rep 2023 Dec;27(12):843-849. Epub 2023 Nov 30 doi: 10.1007/s11916-023-01193-4. PMID: 38032539
Munawar K, Nayak G, Fatterpekar GM, Sen C, Zagzag D, Zan E, Hagiwara M
Clin Imaging 2020 Dec;68:71-89. Epub 2020 Jun 18 doi: 10.1016/j.clinimag.2020.06.029. PMID: 32574933
Friedman DI
Continuum (Minneap Minn) 2015 Aug;21(4 Headache):1109-17. doi: 10.1212/CON.0000000000000204. PMID: 26252594
Lutt JR, Lim LL, Phal PM, Rosenbaum JT
Semin Arthritis Rheum 2008 Feb;37(4):207-22. Epub 2007 Sep 4 doi: 10.1016/j.semarthrit.2007.06.003. PMID: 17765951
Aron-Rosa D, Doyon D, Salamon G, Michotey P
Ann Ophthalmol 1978 Sep;10(9):1161-8. PMID: 736403

Therapy

Kim HJ, Lee SU, Lee ES, Choi JY, Kim JS
J Neurol 2024 Feb;271(2):935-943. Epub 2023 Oct 19 doi: 10.1007/s00415-023-12044-y. PMID: 37853245
Tsirigotaki M, Ntoulios G, Lioumpas M, Voutoufianakis S, Vorgia P
Pediatr Neurol 2019 Oct;99:60-63. Epub 2019 Feb 20 doi: 10.1016/j.pediatrneurol.2019.02.013. PMID: 30982655
Yeung MC, Kwong KL, Wong YC, Wong SN
J Paediatr Child Health 2004 Jul;40(7):410-3. doi: 10.1111/j.1440-1754.2004.00414.x. PMID: 15228576
Kline LB, Hoyt WF
J Neurol Neurosurg Psychiatry 2001 Nov;71(5):577-82. doi: 10.1136/jnnp.71.5.577. PMID: 11606665Free PMC Article
Hannerz J
Cephalalgia 1992 Feb;12(1):45-51. doi: 10.1046/j.1468-2982.1992.1201045.x. PMID: 1559257

Prognosis

Kim HJ, Lee SU, Lee ES, Choi JY, Kim JS
J Neurol 2024 Feb;271(2):935-943. Epub 2023 Oct 19 doi: 10.1007/s00415-023-12044-y. PMID: 37853245
Jagiasi K, Barvalia PP
Neurol India 2022 Nov-Dec;70(6):2422-2426. doi: 10.4103/0028-3886.364052. PMID: 36537427
Sim NK, Liew SY, Warren DJ, Hassan A
BMJ Case Rep 2022 Mar 1;15(3) doi: 10.1136/bcr-2021-246519. PMID: 35232735Free PMC Article
Pérez CA, Evangelista M
Pediatr Neurol 2016 Sep;62:18-26. Epub 2016 Jun 25 doi: 10.1016/j.pediatrneurol.2016.06.017. PMID: 27473647
Palacios E, Valvassori G, Bresler M
Ear Nose Throat J 1999 Mar;78(3):150. PMID: 10188349

Clinical prediction guides

Kim HJ, Lee SU, Lee ES, Choi JY, Kim JS
J Neurol 2024 Feb;271(2):935-943. Epub 2023 Oct 19 doi: 10.1007/s00415-023-12044-y. PMID: 37853245
Ang T, Tong JY, Patel S, Khong JJ, Selva D
Int Ophthalmol 2023 Sep;43(9):3391-3401. Epub 2023 May 17 doi: 10.1007/s10792-023-02747-6. PMID: 37198501Free PMC Article
Jagiasi K, Barvalia PP
Neurol India 2022 Nov-Dec;70(6):2422-2426. doi: 10.4103/0028-3886.364052. PMID: 36537427
Lee KP, Sung PS, Lee WA
Acta Neurol Taiwan 2021 Mar;30(1):39-42. PMID: 34549400
Pérez CA, Evangelista M
Pediatr Neurol 2016 Sep;62:18-26. Epub 2016 Jun 25 doi: 10.1016/j.pediatrneurol.2016.06.017. PMID: 27473647

Recent systematic reviews

Tayebi A, Samimisedeh P, Jafari Afshar E, Mahmoudnia S, Milan N, Ayati A, Madady A, Rastad H
BMC Neurol 2023 Dec 11;23(1):437. doi: 10.1186/s12883-023-03486-y. PMID: 38082244Free PMC Article
Falsaperla R, Presti S, Lo Bianco M, Catanzaro S, Marino S, Ruggieri M
Ital J Pediatr 2022 Jun 3;48(1):82. doi: 10.1186/s13052-022-01274-x. PMID: 35659705Free PMC Article
Lotan I, Lydston M, Levy M
J Neuroophthalmol 2022 Jun 1;42(2):154-162. Epub 2022 Mar 25 doi: 10.1097/WNO.0000000000001537. PMID: 35427282
Gama BP, Silva-Néto RP
Neuropediatrics 2021 Feb;52(1):1-5. Epub 2020 Sep 6 doi: 10.1055/s-0040-1715632. PMID: 32892335
Lubomski M, Dalgliesh J, Lee K, Damodaran O, McKew G, Reddel S
Pract Neurol 2018 Oct;18(5):373-377. Epub 2018 Apr 12 doi: 10.1136/practneurol-2017-001844. PMID: 29650638

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...