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Expressive aphasia

MedGen UID:
214592
Concept ID:
C0917814
Mental or Behavioral Dysfunction
Synonyms: Aphasia, Expressive; Expressive Aphasia
SNOMED CT: Expressive aphasia (229665008); Expressive dysphasia (229665008); Non-fluent aphasia (229665008); Non-fluent dysphasia (229665008)
 
HPO: HP:0002427

Definition

Impairment of expressive language and relative preservation of receptive language abilities. That is, the patient understands language (speech, writing) but cannot express it. [from HPO]

Term Hierarchy

Conditions with this feature

Charcot-Marie-Tooth disease X-linked dominant 1
MedGen UID:
98290
Concept ID:
C0393808
Disease or Syndrome
GJB1 disorders are typically characterized by peripheral motor and sensory neuropathy with or without fixed CNS abnormalities and/or acute, self-limited episodes of transient neurologic dysfunction (especially weakness and dysarthria). Peripheral neuropathy typically manifests in affected males between ages five and 25 years. Although both men and women are affected, manifestations tend to be less severe in women, some of whom may remain asymptomatic. Less commonly, initial manifestations in some affected individuals are stroke-like episodes (acute fulminant episodes of reversible CNS dysfunction).
Hereditary spastic paraplegia 16
MedGen UID:
375796
Concept ID:
C1846046
Disease or Syndrome
Spastic paraplegias (SPGs) are a genetically heterogeneous group of neurologic disorders characterized by progressive weakness and spasticity of the legs. Complicated SPGs are accompanied by additional neurologic symptoms such as cerebellar ataxia, sensory loss, mental retardation, nystagmus, and optic atrophy (summary by Steinmuller et al., 1997). A locus for spastic paraplegia-16 has been mapped to Xq11.2-q23 (Steinmuller et al., 1997). For a discussion of genetic heterogeneity of X-linked spastic paraplegia, see 303350.

Professional guidelines

PubMed

Watanabe K, MacLeod R
Neurol Med Chir (Tokyo) 2005 Dec;45(12):657-9. doi: 10.2176/nmc.45.657. PMID: 16377957
Chan TA, Weingart JD, Parisi M, Hughes MA, Olivi A, Borzillary S, Alahakone D, Detorie NA, Wharam MD, Kleinberg L
Int J Radiat Oncol Biol Phys 2005 Jul 15;62(4):1133-9. doi: 10.1016/j.ijrobp.2004.12.032. PMID: 15990019
Erkan D, Yazici Y, Sobel R, Lockshin MD
J Rheumatol 2000 Dec;27(12):2817-21. PMID: 11128669

Recent clinical studies

Etiology

Preetha UM, Perumal RC
Neurol India 2022 May-Jun;70(3):1125-1130. doi: 10.4103/0028-3886.349635. PMID: 35864649
Oh S, Chung J, Baek S, Park YJ
J Int Med Res 2020 Aug;48(8):300060520948751. doi: 10.1177/0300060520948751. PMID: 32851907Free PMC Article
Salahuddin H, Sheikh AA, Hussaini S, Verghese C, Tietjen GE
Am J Med Sci 2018 Oct;356(4):399-403. Epub 2018 Mar 29 doi: 10.1016/j.amjms.2018.03.021. PMID: 29980285
Nakai Y, Jeong JW, Brown EC, Rothermel R, Kojima K, Kambara T, Shah A, Mittal S, Sood S, Asano E
Brain 2017 May 1;140(5):1351-1370. doi: 10.1093/brain/awx051. PMID: 28334963Free PMC Article
Croquelois A, Bogousslavsky J
Cerebrovasc Dis 2011;31(4):392-9. Epub 2011 Feb 22 doi: 10.1159/000323217. PMID: 21346340

Diagnosis

Mullholand JB, Tolman N, De Obaldia A, Hennrikus E
BMJ Case Rep 2021 Dec 8;14(12) doi: 10.1136/bcr-2021-243665. PMID: 34880034Free PMC Article
Salahuddin H, Sheikh AA, Hussaini S, Verghese C, Tietjen GE
Am J Med Sci 2018 Oct;356(4):399-403. Epub 2018 Mar 29 doi: 10.1016/j.amjms.2018.03.021. PMID: 29980285
Koutrolou-Sotiropoulou P, Singh A, Leeman-Markowski M, Rashba EJ
Acute Card Care 2016 Mar;18(1):31-34. Epub 2016 Nov 21 doi: 10.1080/17482941.2016.1234056. PMID: 27869560
Molloy A, Forde D, De Gascun C, Fanning N, Wyse G, O'Toole O
BMJ Case Rep 2011 Mar 25;2011 doi: 10.1136/bcr.11.2010.3481. PMID: 22700078Free PMC Article
Freeman JM
Pediatr Neurol 2005 May;32(5):295-9. doi: 10.1016/j.pediatrneurol.2004.12.002. PMID: 15866428

Therapy

Mullholand JB, Tolman N, De Obaldia A, Hennrikus E
BMJ Case Rep 2021 Dec 8;14(12) doi: 10.1136/bcr-2021-243665. PMID: 34880034Free PMC Article
Salahuddin H, Sheikh AA, Hussaini S, Verghese C, Tietjen GE
Am J Med Sci 2018 Oct;356(4):399-403. Epub 2018 Mar 29 doi: 10.1016/j.amjms.2018.03.021. PMID: 29980285
Koutrolou-Sotiropoulou P, Singh A, Leeman-Markowski M, Rashba EJ
Acute Card Care 2016 Mar;18(1):31-34. Epub 2016 Nov 21 doi: 10.1080/17482941.2016.1234056. PMID: 27869560
Donovan NJ, Kendall DL, Heaton SC, Kwon S, Velozo CA, Duncan PW
Neurorehabil Neural Repair 2008 Mar-Apr;22(2):122-35. Epub 2007 Aug 30 doi: 10.1177/1545968307306239. PMID: 17761809
Nunnink L
Emerg Med (Fremantle) 2002 Dec;14(4):412-21. doi: 10.1046/j.1442-2026.2002.00348.x. PMID: 12534485

Prognosis

Sandweiss AJ, Kannan V, Desai NK, Kralik SF, Muscal E, Fisher KS
Neurol Neuroimmunol Neuroinflamm 2023 Jul;10(4) Epub 2023 Apr 24 doi: 10.1212/NXI.0000000000200119. PMID: 37094999Free PMC Article
Nakai Y, Jeong JW, Brown EC, Rothermel R, Kojima K, Kambara T, Shah A, Mittal S, Sood S, Asano E
Brain 2017 May 1;140(5):1351-1370. doi: 10.1093/brain/awx051. PMID: 28334963Free PMC Article
Riley JP, Boucher AB, Kim DS, Barrow DL, Reynolds MR
World Neurosurg 2017 Jan;97:761.e5-761.e10. Epub 2016 Sep 28 doi: 10.1016/j.wneu.2016.09.083. PMID: 27693768
Denvir J, Neitch S, Fan J, Niles RM, Boskovic G, Schreurs BG, Primerano DA, Alkon DL
J Alzheimers Dis 2015;46(2):483-90. doi: 10.3233/JAD-150051. PMID: 25812849Free PMC Article
Salvucci A, Devine IM, Hammond D, Sheth RD
Pediatr Neurol 2014 May;50(5):507-10. Epub 2014 Jan 6 doi: 10.1016/j.pediatrneurol.2014.01.012. PMID: 24656207

Clinical prediction guides

Preetha UM, Perumal RC
Neurol India 2022 May-Jun;70(3):1125-1130. doi: 10.4103/0028-3886.349635. PMID: 35864649
Ghannam M, Zakarna L, Alawneh I, Al-Chalabi M, Kenney-Jung D
Am J Case Rep 2021 Jan 5;22:e926529. doi: 10.12659/AJCR.926529. PMID: 33397839Free PMC Article
Nakai Y, Jeong JW, Brown EC, Rothermel R, Kojima K, Kambara T, Shah A, Mittal S, Sood S, Asano E
Brain 2017 May 1;140(5):1351-1370. doi: 10.1093/brain/awx051. PMID: 28334963Free PMC Article
Denvir J, Neitch S, Fan J, Niles RM, Boskovic G, Schreurs BG, Primerano DA, Alkon DL
J Alzheimers Dis 2015;46(2):483-90. doi: 10.3233/JAD-150051. PMID: 25812849Free PMC Article
Croquelois A, Bogousslavsky J
Cerebrovasc Dis 2011;31(4):392-9. Epub 2011 Feb 22 doi: 10.1159/000323217. PMID: 21346340

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