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Giant cell arteritis(GCA)

MedGen UID:
21478
Concept ID:
C0039483
Disease or Syndrome
Synonyms: Arteritides, Giant Cell; Arteritis, Giant Cell; Arteritis, Giant Cell, Horton; Arteritis, Giant Cell, Horton's; Giant Cell Arteritides; Giant Cell Arteritis; Giant Cell Arteritis, Horton; Horton Disease; Horton Giant Cell Arteritis; Horton's Disease; Horton's Giant Cell Arteritis; Hortons Disease
SNOMED CT: Horton's disease (400130008); Giant cell arteritis (400130008)
 
OMIM®: 187360

Definition

A systemic autoimmune disorder that typically affects medium and large ARTERIES, usually leading to occlusive granulomatous vasculitis with transmural infiltrate containing multinucleated GIANT CELLS. The TEMPORAL ARTERY is commonly involved. This disorder appears primarily in people over the age of 50. Symptoms include FEVER; FATIGUE; HEADACHE; visual impairment; pain in the jaw and tongue; and aggravation of pain by cold temperatures. (From Adams et al., Principles of Neurology, 6th ed) [from MeSH]

Term Hierarchy

Professional guidelines

PubMed

Kermani TA, Warrington KJ, Dua AB
Rheum Dis Clin North Am 2022 Aug;48(3):705-724. Epub 2022 Jul 5 doi: 10.1016/j.rdc.2022.03.006. PMID: 35953232
Maz M, Chung SA, Abril A, Langford CA, Gorelik M, Guyatt G, Archer AM, Conn DL, Full KA, Grayson PC, Ibarra MF, Imundo LF, Kim S, Merkel PA, Rhee RL, Seo P, Stone JH, Sule S, Sundel RP, Vitobaldi OI, Warner A, Byram K, Dua AB, Husainat N, James KE, Kalot MA, Lin YC, Springer JM, Turgunbaev M, Villa-Forte A, Turner AS, Mustafa RA
Arthritis Rheumatol 2021 Aug;73(8):1349-1365. Epub 2021 Jul 8 doi: 10.1002/art.41774. PMID: 34235884
Ciofalo A, Gulotta G, Iannella G, Pasquariello B, Manno A, Angeletti D, Pace A, Greco A, Altissimi G, de Vincentiis M, Magliulo G
Curr Rheumatol Rev 2019;15(4):259-268. doi: 10.2174/1573397115666190227194014. PMID: 30827250

Recent clinical studies

Etiology

Golenbiewski J, Burden S, Wolfe RM
Best Pract Res Clin Rheumatol 2023 Mar;37(1):101833. Epub 2023 May 30 doi: 10.1016/j.berh.2023.101833. PMID: 37263808
Camellino D, Giusti A, Girasole G, Bianchi G, Dejaco C
Drugs Aging 2019 Nov;36(11):1015-1026. doi: 10.1007/s40266-019-00705-5. PMID: 31493201
Cho HJ, Bloomberg J, Nichols J
Dis Mon 2017 Mar;63(3):88-91. Epub 2016 Dec 29 doi: 10.1016/j.disamonth.2016.10.006. PMID: 28041616
Hoffman GS
Ann Intern Med 2016 Nov 1;165(9):ITC65-ITC80. doi: 10.7326/AITC201611010. PMID: 27802475
Ninan J, Lester S, Hill C
Best Pract Res Clin Rheumatol 2016 Feb;30(1):169-88. Epub 2016 Jun 20 doi: 10.1016/j.berh.2016.05.001. PMID: 27421223

Diagnosis

Pepper K
Postgrad Med 2023 Jan;135(sup1):22-32. Epub 2023 Apr 6 doi: 10.1080/00325481.2023.2190288. PMID: 37021621
Rebello A, Joshi P
N Engl J Med 2022 Oct 13;387(15):e36. Epub 2022 Oct 8 doi: 10.1056/NEJMicm2202567. PMID: 36214594
Ling ML, Yosar J, Lee BW, Shah SA, Jiang IW, Finniss A, Allende A, Francis IC
Clin Exp Optom 2020 Sep;103(5):572-582. Epub 2019 Oct 29 doi: 10.1111/cxo.12975. PMID: 31663193
Younger DS
Neurol Clin 2019 May;37(2):335-344. Epub 2019 Mar 16 doi: 10.1016/j.ncl.2019.01.008. PMID: 30952412
Ciofalo A, Gulotta G, Iannella G, Pasquariello B, Manno A, Angeletti D, Pace A, Greco A, Altissimi G, de Vincentiis M, Magliulo G
Curr Rheumatol Rev 2019;15(4):259-268. doi: 10.2174/1573397115666190227194014. PMID: 30827250

Therapy

Pepper K
Postgrad Med 2023 Jan;135(sup1):22-32. Epub 2023 Apr 6 doi: 10.1080/00325481.2023.2190288. PMID: 37021621
Hellmich B, Agueda A, Monti S, Buttgereit F, de Boysson H, Brouwer E, Cassie R, Cid MC, Dasgupta B, Dejaco C, Hatemi G, Hollinger N, Mahr A, Mollan SP, Mukhtyar C, Ponte C, Salvarani C, Sivakumar R, Tian X, Tomasson G, Turesson C, Schmidt W, Villiger PM, Watts R, Young C, Luqmani RA
Ann Rheum Dis 2020 Jan;79(1):19-30. Epub 2019 Jul 3 doi: 10.1136/annrheumdis-2019-215672. PMID: 31270110
Ciofalo A, Gulotta G, Iannella G, Pasquariello B, Manno A, Angeletti D, Pace A, Greco A, Altissimi G, de Vincentiis M, Magliulo G
Curr Rheumatol Rev 2019;15(4):259-268. doi: 10.2174/1573397115666190227194014. PMID: 30827250
Stone JH, Tuckwell K, Dimonaco S, Klearman M, Aringer M, Blockmans D, Brouwer E, Cid MC, Dasgupta B, Rech J, Salvarani C, Schett G, Schulze-Koops H, Spiera R, Unizony SH, Collinson N
N Engl J Med 2017 Jul 27;377(4):317-328. doi: 10.1056/NEJMoa1613849. PMID: 28745999
Buttgereit F, Dejaco C, Matteson EL, Dasgupta B
JAMA 2016 Jun 14;315(22):2442-58. doi: 10.1001/jama.2016.5444. PMID: 27299619

Prognosis

Colombo MG, Wetzel AJ, Haumann H, Dally S, Kirtschig G, Joos S
Dtsch Arztebl Int 2022 Jun 17;119(24):411-417. doi: 10.3238/arztebl.m2022.0218. PMID: 35635433Free PMC Article
Rosenberg H, Halman S, Yadav K
CMAJ 2021 Nov 22;193(46):E1770. doi: 10.1503/cmaj.210541. PMID: 34810164Free PMC Article
Erdogan M
Curr Opin Rheumatol 2021 Jan;33(1):34-40. doi: 10.1097/BOR.0000000000000762. PMID: 33186247
Salvarani C, Cantini F, Hunder GG
Lancet 2008 Jul 19;372(9634):234-45. doi: 10.1016/S0140-6736(08)61077-6. PMID: 18640460
Nordborg E, Nordborg C, Malmvall BE, Andersson R, Bengtsson BA
Rheum Dis Clin North Am 1995 Nov;21(4):1013-26. PMID: 8592734

Clinical prediction guides

Dejaco C, Ponte C, Monti S, Rozza D, Scirè CA, Terslev L, Bruyn GAW, Boumans D, Hartung W, Hočevar A, Milchert M, Døhn UM, Mukhtyar CB, Aschwanden M, Bosch P, Camellino D, Chrysidis S, Ciancio G, D'Agostino MA, Daikeler T, Dasgupta B, De Miguel E, Diamantopoulos AP, Duftner C, Agueda A, Fredberg U, Hanova P, Hansen IT, Hauge EM, Iagnocco A, Inanc N, Juche A, Karalilova R, Kawamoto T, Keller KK, Keen HI, Kermani TA, Kohler MJ, Koster M, Luqmani RA, Macchioni P, Mackie SL, Naredo E, Nielsen BD, Ogasawara M, Pineda C, Schäfer VS, Seitz L, Tomelleri A, Torralba KD, van der Geest KSM, Warrington KJ, Schmidt WA
Ann Rheum Dis 2023 Apr;82(4):556-564. Epub 2022 Dec 12 doi: 10.1136/ard-2022-223367. PMID: 36600183
Ponte C, Grayson PC, Robson JC, Suppiah R, Gribbons KB, Judge A, Craven A, Khalid S, Hutchings A, Watts RA, Merkel PA, Luqmani RA; DCVAS Study Group
Ann Rheum Dis 2022 Dec;81(12):1647-1653. Epub 2022 Nov 9 doi: 10.1136/ard-2022-223480. PMID: 36351706
Lundberg IE, Sharma A, Turesson C, Mohammad AJ
J Intern Med 2022 Nov;292(5):717-732. Epub 2022 Jun 11 doi: 10.1111/joim.13525. PMID: 35612524Free PMC Article
Younger DS
Neurol Clin 2019 May;37(2):335-344. Epub 2019 Mar 16 doi: 10.1016/j.ncl.2019.01.008. PMID: 30952412
Gasparyan AY, Ayvazyan L, Mukanova U, Yessirkepov M, Kitas GD
Ann Lab Med 2019 Jul;39(4):345-357. doi: 10.3343/alm.2019.39.4.345. PMID: 30809980Free PMC Article

Recent systematic reviews

Dejaco C, Kerschbaumer A, Aletaha D, Bond M, Hysa E, Camellino D, Ehlers L, Abril A, Appenzeller S, Cid MC, Dasgupta B, Duftner C, Grayson PC, Hellmich B, Hočevar A, Kermani TA, Matteson EL, Mollan SP, Neill L, Ponte C, Salvarani C, Sattui SE, Schmidt WA, Seo P, Smolen JS, Thiel J, Toro-Gutiérrez CE, Whitlock M, Buttgereit F
Ann Rheum Dis 2024 Jan 2;83(1):48-57. doi: 10.1136/ard-2022-223429. PMID: 36828585Free PMC Article
Maz M, Chung SA, Abril A, Langford CA, Gorelik M, Guyatt G, Archer AM, Conn DL, Full KA, Grayson PC, Ibarra MF, Imundo LF, Kim S, Merkel PA, Rhee RL, Seo P, Stone JH, Sule S, Sundel RP, Vitobaldi OI, Warner A, Byram K, Dua AB, Husainat N, James KE, Kalot MA, Lin YC, Springer JM, Turgunbaev M, Villa-Forte A, Turner AS, Mustafa RA
Arthritis Rheumatol 2021 Aug;73(8):1349-1365. Epub 2021 Jul 8 doi: 10.1002/art.41774. PMID: 34235884
Torp CK, Brüner M, Keller KK, Brouwer E, Hauge EM, McGonagle D, Kragstrup TW
Autoimmun Rev 2021 Jun;20(6):102829. Epub 2021 Apr 16 doi: 10.1016/j.autrev.2021.102829. PMID: 33872767
Dejaco C, Ramiro S, Duftner C, Besson FL, Bley TA, Blockmans D, Brouwer E, Cimmino MA, Clark E, Dasgupta B, Diamantopoulos AP, Direskeneli H, Iagnocco A, Klink T, Neill L, Ponte C, Salvarani C, Slart RHJA, Whitlock M, Schmidt WA
Ann Rheum Dis 2018 May;77(5):636-643. Epub 2018 Jan 22 doi: 10.1136/annrheumdis-2017-212649. PMID: 29358285
Buttgereit F, Dejaco C, Matteson EL, Dasgupta B
JAMA 2016 Jun 14;315(22):2442-58. doi: 10.1001/jama.2016.5444. PMID: 27299619

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