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Endometrial Adenocarcinoma

MedGen UID:
218862
•Concept ID:
C1153706
•
Neoplastic Process
Synonyms: Endometrial adenocarcinoma; Uterine adenocarcinoma
SNOMED CT: Adenocarcinoma of endometrium (123845008); Endometrial adenocarcinoma (123845008); Adenocarcinoma of uterus (309245001)

Definition

An adenocarcinoma arising from the uterine body cavity. This is the most frequent malignant tumor affecting the uterine body, and is linked to estrogen therapy. Most patients present with uterine bleeding and are over age 40 at the time of diagnosis. The prognosis depends on the stage of the tumor, the depth of the uterine wall invasion, and the histologic subtype. Endometrioid adenocarcinoma is the most frequently seen morphologic variant of endometrial adenocarcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEndometrial Adenocarcinoma

Professional guidelines

PubMed

Challenges and controversies in the conservative management of uterine and ovarian cancer.
Janda M, McGrath S, Obermair A
Best Pract Res Clin Obstet Gynaecol 2019 Feb;55:93-108. Epub 2018 Aug 31 doi: 10.1016/j.bpobgyn.2018.08.004. PMID: 30243603
Uterine Carcinosarcomas - Diagnosis and Management.
Denschlag D, Ulrich UA
Oncol Res Treat 2018;41(11):675-679. Epub 2018 Oct 13 doi: 10.1159/000494335. PMID: 30317231
Incretin-based therapies in the treatment of type 2 diabetes--more than meets the eye?
Labuzek K, Kozłowski M, Szkudłapski D, Sikorska P, Kozłowska M, Okopień B
Eur J Intern Med 2013 Apr;24(3):207-12. Epub 2013 Jan 31 doi: 10.1016/j.ejim.2013.01.009. PMID: 23375875

Recent clinical studies

Etiology

Endometrial intraepithelial neoplasia.
Jarboe EA, Mutter GL
Semin Diagn Pathol 2010 Nov;27(4):215-25. doi: 10.1053/j.semdp.2010.09.007. PMID: 21309257
Endometrial adenocarcinoma: beliefs and scepticism.
Sivridis E, Giatromanolaki A
Int J Surg Pathol 2004 Apr;12(2):99-105. doi: 10.1177/106689690401200202. PMID: 15173914
A phase III trial of surgery with or without adjunctive external pelvic radiation therapy in intermediate risk endometrial adenocarcinoma: a Gynecologic Oncology Group study.
Keys HM, Roberts JA, Brunetto VL, Zaino RJ, Spirtos NM, Bloss JD, Pearlman A, Maiman MA, Bell JG; Gynecologic Oncology Group
Gynecol Oncol 2004 Mar;92(3):744-51. doi: 10.1016/j.ygyno.2003.11.048. PMID: 14984936
Endometrial adenocarcinoma.
Noumoff JS, Faruqi S
Microsc Res Tech 1993 Jun 15;25(3):246-54. doi: 10.1002/jemt.1070250306. PMID: 8400424
The menopause.
Gambrell RD Jr
Invest Radiol 1986 Apr;21(4):369-78. doi: 10.1097/00004424-198604000-00017. PMID: 3516923

Diagnosis

Uterine Mesenchymal Tumors: Hereditary Aspects.
Joehlin-Price AS, Garg K
Adv Anat Pathol 2018 Mar;25(2):96-105. doi: 10.1097/PAP.0000000000000175. PMID: 28945610
Endometrial intraepithelial neoplasia.
Jarboe EA, Mutter GL
Semin Diagn Pathol 2010 Nov;27(4):215-25. doi: 10.1053/j.semdp.2010.09.007. PMID: 21309257
Endometrial adenocarcinoma: prevention and early diagnosis.
Jiménez-Ayala M, Jiménez-Ayala Portillo B, Iglesias E, Vallejo MR
Monogr Clin Cytol 2008;17:1-91. doi: 10.1159/000117465. PMID: 18401182
Endometrial adenocarcinoma: beliefs and scepticism.
Sivridis E, Giatromanolaki A
Int J Surg Pathol 2004 Apr;12(2):99-105. doi: 10.1177/106689690401200202. PMID: 15173914
Pathophysiology of adenomyosis.
Ferenczy A
Hum Reprod Update 1998 Jul-Aug;4(4):312-22. doi: 10.1093/humupd/4.4.312. PMID: 9825847

Therapy

Endometrial changes during ulipristal acetate use: A systematic review.
De Milliano I, Van Hattum D, Ket JCF, Huirne JAF, Hehenkamp WJK
Eur J Obstet Gynecol Reprod Biol 2017 Jul;214:56-64. Epub 2017 Apr 28 doi: 10.1016/j.ejogrb.2017.04.042. PMID: 28482329
IMMUNOHISTOCHEMISTRY IN ENDOMETRIAL HYPERPLASIA AND ENDOMETRIAL ADENOCARCINOMA.
Socolov D, Socolov R, Lupascu IA, Rugina V, Gabia O, Garauleanu DM, Carauleanu A
Rev Med Chir Soc Med Nat Iasi 2016 Apr-Jun;120(2):355-62. PMID: 27483717
Life-style and metformin for the prevention of endometrial pathology in postmenopausal women.
Campagnoli C, Abbà C, Ambroggio S, Brucato T, Pasanisi P
Gynecol Endocrinol 2013 Feb;29(2):119-24. Epub 2012 Sep 5 doi: 10.3109/09513590.2012.706671. PMID: 22946682
A phase III trial of surgery with or without adjunctive external pelvic radiation therapy in intermediate risk endometrial adenocarcinoma: a Gynecologic Oncology Group study.
Keys HM, Roberts JA, Brunetto VL, Zaino RJ, Spirtos NM, Bloss JD, Pearlman A, Maiman MA, Bell JG; Gynecologic Oncology Group
Gynecol Oncol 2004 Mar;92(3):744-51. doi: 10.1016/j.ygyno.2003.11.048. PMID: 14984936
The menopause.
Gambrell RD Jr
Invest Radiol 1986 Apr;21(4):369-78. doi: 10.1097/00004424-198604000-00017. PMID: 3516923

Prognosis

Expression and clinical significance of CXCL17 and GPR35 in endometrial carcinoma.
Hao J, Gao X, Wang YP, Liu Q, Zhu H, Zhao SJ, Qin QH, Meng J, Li LL, Lin SC, Song Z, Li H
Anticancer Drugs 2022 Jun 1;33(5):467-477. doi: 10.1097/CAD.0000000000001280. PMID: 35276691
Uterine Carcinosarcomas - Diagnosis and Management.
Denschlag D, Ulrich UA
Oncol Res Treat 2018;41(11):675-679. Epub 2018 Oct 13 doi: 10.1159/000494335. PMID: 30317231
Endometrial intraepithelial neoplasia.
Jarboe EA, Mutter GL
Semin Diagn Pathol 2010 Nov;27(4):215-25. doi: 10.1053/j.semdp.2010.09.007. PMID: 21309257
Imaging of endometrial adenocarcinoma.
Barwick TD, Rockall AG, Barton DP, Sohaib SA
Clin Radiol 2006 Jul;61(7):545-55. doi: 10.1016/j.crad.2006.03.011. PMID: 16784939
Endometrial adenocarcinoma: beliefs and scepticism.
Sivridis E, Giatromanolaki A
Int J Surg Pathol 2004 Apr;12(2):99-105. doi: 10.1177/106689690401200202. PMID: 15173914

Clinical prediction guides

Expression and clinical significance of CXCL17 and GPR35 in endometrial carcinoma.
Hao J, Gao X, Wang YP, Liu Q, Zhu H, Zhao SJ, Qin QH, Meng J, Li LL, Lin SC, Song Z, Li H
Anticancer Drugs 2022 Jun 1;33(5):467-477. doi: 10.1097/CAD.0000000000001280. PMID: 35276691
Metabolic profile of patients with endometrial adenocarcinoma and association with tumor grade.
Andrade Fernandes JP, da Camara AO, Frajacomo FT, Chaves CBP, Fernandes Pereira A, Chaves GV
Int J Gynecol Cancer 2022 May 3;32(5):626-632. doi: 10.1136/ijgc-2021-003245. PMID: 35173052
Endometrial intraepithelial neoplasia.
Jarboe EA, Mutter GL
Semin Diagn Pathol 2010 Nov;27(4):215-25. doi: 10.1053/j.semdp.2010.09.007. PMID: 21309257
From endometrial hyperplasia to endometrial cancer: insight into the biology and possible medical preventive measures.
Boruban MC, Altundag K, Kilic GS, Blankstein J
Eur J Cancer Prev 2008 Apr;17(2):133-8. doi: 10.1097/CEJ.0b013e32811080ce. PMID: 18287870
The menopause.
Gambrell RD Jr
Invest Radiol 1986 Apr;21(4):369-78. doi: 10.1097/00004424-198604000-00017. PMID: 3516923

Recent systematic reviews

Endometrial changes during ulipristal acetate use: A systematic review.
De Milliano I, Van Hattum D, Ket JCF, Huirne JAF, Hehenkamp WJK
Eur J Obstet Gynecol Reprod Biol 2017 Jul;214:56-64. Epub 2017 Apr 28 doi: 10.1016/j.ejogrb.2017.04.042. PMID: 28482329
Effectiveness of aromatase inhibitors in the treatment of advanced endometrial adenocarcinoma.
Bogliolo S, Gardella B, Dominoni M, Musacchi V, Cassani C, Zanellini F, De Silvestri A, Gaggero CR, Babilonti L, Spinillo A
Arch Gynecol Obstet 2016 Apr;293(4):701-8. Epub 2015 Dec 15 doi: 10.1007/s00404-015-3974-9. PMID: 26671487
Chemotherapy for advanced, recurrent or metastatic endometrial carcinoma.
Vale CL, Tierney J, Bull SJ, Symonds PR
Cochrane Database Syst Rev 2012 Aug 15;2012(8):CD003915. doi: 10.1002/14651858.CD003915.pub4. PMID: 22895938Free PMC Article
Efficacy of oral or intrauterine device-delivered progestin in patients with complex endometrial hyperplasia with atypia or early endometrial adenocarcinoma: a meta-analysis and systematic review of the literature.
Baker J, Obermair A, Gebski V, Janda M
Gynecol Oncol 2012 Apr;125(1):263-70. Epub 2011 Dec 3 doi: 10.1016/j.ygyno.2011.11.043. PMID: 22196499
Endometrial cancer after endometrial ablation: systematic review of medical literature.
AlHilli MM, Hopkins MR, Famuyide AO
J Minim Invasive Gynecol 2011 May-Jun;18(3):393-400. doi: 10.1016/j.jmig.2011.02.004. PMID: 21545966

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