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Composite hemangioendothelioma

MedGen UID:
220987
Concept ID:
C1304513
Neoplastic Process
Synonyms: Composite Hemangioendothelioma; composite hemangioendothelioma
SNOMED CT: Composite hemangioendothelioma (403984006); Composite hemangioendothelioma (703660008)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0018712
Orphanet: ORPHA458758

Definition

A rare vascular tumor characterized by a poorly circumscribed, infiltrative nodular lesion with vascular differentiation, centered in the dermis and subcutis. The tumor is composed of histologically benign, intermediate, and malignant components. Typical is an admixture of different components which include epithelioid and retiform hemangioendothelioma, spindle cell hemangioma, angiosarcoma-like areas, and benign vascular lesions. Predilection sites are the distal extremities. Many patients have a history of lymphedema. Local recurrence is frequent, while metastasis is rare. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVComposite hemangioendothelioma

Professional guidelines

PubMed

Casiraghi A, Musazzi UM, Rocco P, Franzè S, Minghetti P
Skin Pharmacol Physiol 2016;29(4):210-9. Epub 2016 Aug 18 doi: 10.1159/000447672. PMID: 27532634

Recent clinical studies

Etiology

Folpe AL
Hum Pathol 2024 May;147:114-128. Epub 2024 Feb 13 doi: 10.1016/j.humpath.2024.01.014. PMID: 38360216
Dermawan JK, DiNapoli SE, Sukhadia P, Mullaney KA, Gladdy R, Healey JH, Agaimy A, Cleven AH, Suurmeijer AJH, Dickson BC, Antonescu CR
Genes Chromosomes Cancer 2023 Apr;62(4):191-201. Epub 2023 Jan 2 doi: 10.1002/gcc.23102. PMID: 36344258Free PMC Article
Zhang X, Wang S, Jin M
Heart Surg Forum 2022 Apr 22;25(2):E284-E287. doi: 10.1532/hsf.4587. PMID: 35486043
Dashti NK, Dickson BC, Zhang L, Xie Z, Nielsen GP, Antonescu CR
Genes Chromosomes Cancer 2021 Nov;60(11):762-771. Epub 2021 Aug 6 doi: 10.1002/gcc.22984. PMID: 34310785Free PMC Article
Fasolis M, Iaquinta C, Montesco MC, Garzino-Demo P, Tosco P, Tanteri G, Bonandini E, Ninfo V, Berrone S
Head Neck 2008 Jul;30(7):974-9. doi: 10.1002/hed.20761. PMID: 18286494

Diagnosis

Folpe AL
Hum Pathol 2024 May;147:114-128. Epub 2024 Feb 13 doi: 10.1016/j.humpath.2024.01.014. PMID: 38360216
Papke DJ Jr, Hornick JL
Virchows Arch 2020 Jan;476(1):17-28. Epub 2019 Aug 28 doi: 10.1007/s00428-019-02651-4. PMID: 31463731
Shon W, Billings SD
Adv Anat Pathol 2019 May;26(3):186-197. doi: 10.1097/PAP.0000000000000228. PMID: 30762622
Shang Leen SL, Fisher C, Thway K
Adv Anat Pathol 2015 Jul;22(4):254-9. doi: 10.1097/PAP.0000000000000079. PMID: 26050262
McNab PM, Quigley BC, Glass LF, Jukic DM
Am J Dermatopathol 2013 Jun;35(4):517-22. doi: 10.1097/DAD.0b013e31827a0d37. PMID: 23694827

Therapy

McNab PM, Quigley BC, Glass LF, Jukic DM
Am J Dermatopathol 2013 Jun;35(4):517-22. doi: 10.1097/DAD.0b013e31827a0d37. PMID: 23694827

Prognosis

Dermawan JK, Westra WH, Antonescu CR
Genes Chromosomes Cancer 2022 Apr;61(4):187-193. Epub 2021 Dec 11 doi: 10.1002/gcc.23017. PMID: 34862698Free PMC Article
Shang Leen SL, Fisher C, Thway K
Adv Anat Pathol 2015 Jul;22(4):254-9. doi: 10.1097/PAP.0000000000000079. PMID: 26050262
Leen SL, Clarke PM, Chapman J, Fisher C, Thway K
Head Neck Pathol 2015 Dec;9(4):519-24. Epub 2015 Feb 10 doi: 10.1007/s12105-015-0612-6. PMID: 25666464Free PMC Article
McNab PM, Quigley BC, Glass LF, Jukic DM
Am J Dermatopathol 2013 Jun;35(4):517-22. doi: 10.1097/DAD.0b013e31827a0d37. PMID: 23694827
Fasolis M, Iaquinta C, Montesco MC, Garzino-Demo P, Tosco P, Tanteri G, Bonandini E, Ninfo V, Berrone S
Head Neck 2008 Jul;30(7):974-9. doi: 10.1002/hed.20761. PMID: 18286494

Clinical prediction guides

Nakamura S, Uehara M, Kobayashi S, Hasegawa H, Tanaka A, Takahashi J
BMC Geriatr 2022 Dec 9;22(1):952. doi: 10.1186/s12877-022-03677-1. PMID: 36494779Free PMC Article
Koutlas IG, Oetting WS, Burns GM, Gopalakrishnan R, Antonescu CR
Head Neck Pathol 2022 Sep;16(3):849-856. Epub 2021 Nov 17 doi: 10.1007/s12105-021-01393-7. PMID: 34791601Free PMC Article
McNab PM, Quigley BC, Glass LF, Jukic DM
Am J Dermatopathol 2013 Jun;35(4):517-22. doi: 10.1097/DAD.0b013e31827a0d37. PMID: 23694827
Fukunaga M, Suzuki K, Saegusa N, Folpe AL
Am J Surg Pathol 2007 Oct;31(10):1567-72. doi: 10.1097/PAS.0b013e318038f6b5. PMID: 17895759
Reis-Filho JS, Paiva ME, Lopes JM
J Cutan Pathol 2002 Apr;29(4):226-31. doi: 10.1034/j.1600-0560.2002.290405.x. PMID: 12028155

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