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Coma due to diabetes mellitus

MedGen UID:
226813
Concept ID:
C1263960
Disease or Syndrome
Synonyms: Coma, Diabetic; Comas, Diabetic; Diabetic Coma; Diabetic Comas
SNOMED CT: Coma due to diabetes mellitus (420662003); Diabetic coma (420662003)

Definition

A state of unconsciousness as a complication of diabetes mellitus. It occurs in cases of extreme HYPERGLYCEMIA or extreme HYPOGLYCEMIA as a complication of INSULIN therapy. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVComa due to diabetes mellitus

Professional guidelines

PubMed

Mustafa OG, Haq M, Dashora U, Castro E, Dhatariya KK; Joint British Diabetes Societies (JBDS) for Inpatient Care Group
Diabet Med 2023 Mar;40(3):e15005. Epub 2022 Dec 21 doi: 10.1111/dme.15005. PMID: 36370077Free PMC Article
Glaser N, Fritsch M, Priyambada L, Rewers A, Cherubini V, Estrada S, Wolfsdorf JI, Codner E
Pediatr Diabetes 2022 Nov;23(7):835-856. doi: 10.1111/pedi.13406. PMID: 36250645
Fayfman M, Pasquel FJ, Umpierrez GE
Med Clin North Am 2017 May;101(3):587-606. doi: 10.1016/j.mcna.2016.12.011. PMID: 28372715Free PMC Article

Recent clinical studies

Etiology

Mustafa OG, Haq M, Dashora U, Castro E, Dhatariya KK; Joint British Diabetes Societies (JBDS) for Inpatient Care Group
Diabet Med 2023 Mar;40(3):e15005. Epub 2022 Dec 21 doi: 10.1111/dme.15005. PMID: 36370077Free PMC Article
Hamud AA, Mudawi K, Shamekh A, Kadri A, Powell C, Abdelgadir I
Arch Dis Child 2022 Nov;107(11):1023-1028. Epub 2022 Jun 23 doi: 10.1136/archdischild-2022-324042. PMID: 35738870
Karslioglu French E, Donihi AC, Korytkowski MT
BMJ 2019 May 29;365:l1114. doi: 10.1136/bmj.l1114. PMID: 31142480
Yazdanpanah S, Rabiee M, Tahriri M, Abdolrahim M, Rajab A, Jazayeri HE, Tayebi L
Crit Rev Clin Lab Sci 2017 Jun;54(4):219-232. Epub 2017 Apr 10 doi: 10.1080/10408363.2017.1299684. PMID: 28393586
Bragg F, Holmes MV, Iona A, Guo Y, Du H, Chen Y, Bian Z, Yang L, Herrington W, Bennett D, Turnbull I, Liu Y, Feng S, Chen J, Clarke R, Collins R, Peto R, Li L, Chen Z; China Kadoorie Biobank Collaborative Group
JAMA 2017 Jan 17;317(3):280-289. doi: 10.1001/jama.2016.19720. PMID: 28114552Free PMC Article

Diagnosis

Glaser N, Fritsch M, Priyambada L, Rewers A, Cherubini V, Estrada S, Wolfsdorf JI, Codner E
Pediatr Diabetes 2022 Nov;23(7):835-856. doi: 10.1111/pedi.13406. PMID: 36250645
Stoner GD
Am Fam Physician 2017 Dec 1;96(11):729-736. PMID: 29431405
Fayfman M, Pasquel FJ, Umpierrez GE
Med Clin North Am 2017 May;101(3):587-606. doi: 10.1016/j.mcna.2016.12.011. PMID: 28372715Free PMC Article
Dhatariya KK, Vellanki P
Curr Diab Rep 2017 May;17(5):33. doi: 10.1007/s11892-017-0857-4. PMID: 28364357Free PMC Article
Umpierrez G, Korytkowski M
Nat Rev Endocrinol 2016 Apr;12(4):222-32. Epub 2016 Feb 19 doi: 10.1038/nrendo.2016.15. PMID: 26893262

Therapy

Mustafa OG, Haq M, Dashora U, Castro E, Dhatariya KK; Joint British Diabetes Societies (JBDS) for Inpatient Care Group
Diabet Med 2023 Mar;40(3):e15005. Epub 2022 Dec 21 doi: 10.1111/dme.15005. PMID: 36370077Free PMC Article
Dingle HE, Slovis C
Emerg Med Pract 2020 Feb;22(2):1-20. Epub 2020 Feb 1 PMID: 31978294
Stoner GD
Am Fam Physician 2017 Dec 1;96(11):729-736. PMID: 29431405
Fayfman M, Pasquel FJ, Umpierrez GE
Med Clin North Am 2017 May;101(3):587-606. doi: 10.1016/j.mcna.2016.12.011. PMID: 28372715Free PMC Article
Umpierrez G, Korytkowski M
Nat Rev Endocrinol 2016 Apr;12(4):222-32. Epub 2016 Feb 19 doi: 10.1038/nrendo.2016.15. PMID: 26893262

Prognosis

von Herrath M, Bain SC, Bode B, Clausen JO, Coppieters K, Gaysina L, Gumprecht J, Hansen TK, Mathieu C, Morales C, Mosenzon O, Segel S, Tsoukas G, Pieber TR; Anti-IL-21–liraglutide Study Group investigators and contributors
Lancet Diabetes Endocrinol 2021 Apr;9(4):212-224. Epub 2021 Mar 1 doi: 10.1016/S2213-8587(21)00019-X. PMID: 33662334
Fayfman M, Pasquel FJ, Umpierrez GE
Med Clin North Am 2017 May;101(3):587-606. doi: 10.1016/j.mcna.2016.12.011. PMID: 28372715Free PMC Article
Bragg F, Holmes MV, Iona A, Guo Y, Du H, Chen Y, Bian Z, Yang L, Herrington W, Bennett D, Turnbull I, Liu Y, Feng S, Chen J, Clarke R, Collins R, Peto R, Li L, Chen Z; China Kadoorie Biobank Collaborative Group
JAMA 2017 Jan 17;317(3):280-289. doi: 10.1001/jama.2016.19720. PMID: 28114552Free PMC Article
Umpierrez G, Korytkowski M
Nat Rev Endocrinol 2016 Apr;12(4):222-32. Epub 2016 Feb 19 doi: 10.1038/nrendo.2016.15. PMID: 26893262
Pasquel FJ, Umpierrez GE
Diabetes Care 2014 Nov;37(11):3124-31. doi: 10.2337/dc14-0984. PMID: 25342831Free PMC Article

Clinical prediction guides

von Herrath M, Bain SC, Bode B, Clausen JO, Coppieters K, Gaysina L, Gumprecht J, Hansen TK, Mathieu C, Morales C, Mosenzon O, Segel S, Tsoukas G, Pieber TR; Anti-IL-21–liraglutide Study Group investigators and contributors
Lancet Diabetes Endocrinol 2021 Apr;9(4):212-224. Epub 2021 Mar 1 doi: 10.1016/S2213-8587(21)00019-X. PMID: 33662334
Pasquel FJ, Tsegka K, Wang H, Cardona S, Galindo RJ, Fayfman M, Davis G, Vellanki P, Migdal A, Gujral U, Narayan KMV, Umpierrez GE
Diabetes Care 2020 Feb;43(2):349-357. Epub 2019 Nov 8 doi: 10.2337/dc19-1168. PMID: 31704689Free PMC Article
Kuppermann N, Ghetti S, Schunk JE, Stoner MJ, Rewers A, McManemy JK, Myers SR, Nigrovic LE, Garro A, Brown KM, Quayle KS, Trainor JL, Tzimenatos L, Bennett JE, DePiero AD, Kwok MY, Perry CS 3rd, Olsen CS, Casper TC, Dean JM, Glaser NS; PECARN DKA FLUID Study Group
N Engl J Med 2018 Jun 14;378(24):2275-2287. doi: 10.1056/NEJMoa1716816. PMID: 29897851Free PMC Article
Leache L, Aquerreta I, Moraza L, Ortega A
Am J Health Syst Pharm 2016 Nov 15;73(22):1840-1843. doi: 10.2146/ajhp151012. PMID: 27821396
Shapiro AM, Lakey JR, Ryan EA, Korbutt GS, Toth E, Warnock GL, Kneteman NM, Rajotte RV
N Engl J Med 2000 Jul 27;343(4):230-8. doi: 10.1056/NEJM200007273430401. PMID: 10911004

Recent systematic reviews

Zhang W, Chen J, Bi J, Ding N, Chen X, Wang Z, Jiao Y
Front Endocrinol (Lausanne) 2022;13:1084441. Epub 2023 Jan 4 doi: 10.3389/fendo.2022.1084441. PMID: 36686495Free PMC Article
Lin C, Li X, Qiu Y, Chen Z, Liu J
Front Public Health 2022;10:885001. Epub 2022 Aug 5 doi: 10.3389/fpubh.2022.885001. PMID: 35991054Free PMC Article
Hamud AA, Mudawi K, Shamekh A, Kadri A, Powell C, Abdelgadir I
Arch Dis Child 2022 Nov;107(11):1023-1028. Epub 2022 Jun 23 doi: 10.1136/archdischild-2022-324042. PMID: 35738870
Søvik S, Isachsen MS, Nordhuus KM, Tveiten CK, Eken T, Sunde K, Brurberg KG, Beitland S
Intensive Care Med 2019 Apr;45(4):407-419. Epub 2019 Feb 6 doi: 10.1007/s00134-019-05535-y. PMID: 30725141
Suri RS, Clark WF, Barrowman N, Mahon JL, Thiessen-Philbrook HR, Rosas-Arellano MP, Zarnke K, Garland JS, Garg AX
Diabetes Care 2005 Oct;28(10):2556-62. doi: 10.2337/diacare.28.10.2556. PMID: 16186301

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