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Uveitis-glaucoma-hyphema syndrome

MedGen UID:
226870
•Concept ID:
C1271448
•
Disease or Syndrome
Synonyms: UGH syndrome; Uveitis Glaucoma and Hyphema Syndrome; Uveitis-hyphema-glaucoma syndrome
SNOMED CT: Uveitis-hyphema-glaucoma syndrome (392029006); UGH syndrome (392029006); Uveitis-glaucoma-hyphema syndrome (392029006)

Definition

Clinical triad of uveitis, glaucoma, and hyphema (UGH), especially associated with the early anterior chamber intraocular lens (IOL). Glaucoma is believed to be caused by movement of the IOL against the iris causing release of inflammatory and red blood cell debris, which obstruct the trabecular meshwork. The haptic also may cause direct damage to the trabecular meshwork contributing to the glaucoma. Incidence of UGH is dependent on both surgical methodology applied in the cataract population and type of IOL used. UGH is particularly common if metal clip lenses have been used. Components of the condition may be reversed if the offending IOL is removed before permanent damage has occurred. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUveitis-glaucoma-hyphema syndrome

Professional guidelines

PubMed

Uveitis-Glaucoma-Hyphema Syndrome: Clinical Features and Differential Diagnosis.
Accorinti M, Saturno MC, Paroli MP, De Geronimo D, Gilardi M
Ocul Immunol Inflamm 2022 Aug;30(6):1408-1413. Epub 2021 Apr 1 doi: 10.1080/09273948.2021.1881563. PMID: 33793379

Recent clinical studies

Etiology

The role of anterior segment optical coherence tomography in uveitis-glaucoma-hyphema syndrome.
Lippera M, Nicolosi C, Vannozzi L, Bacherini D, Vicini G, Rizzo S, Virgili G, Giansanti F
Eur J Ophthalmol 2022 Jul;32(4):2211-2218. Epub 2021 Nov 29 doi: 10.1177/11206721211063738. PMID: 34841924
Uveitis-Glaucoma-Hyphema Syndrome: Clinical Features and Differential Diagnosis.
Accorinti M, Saturno MC, Paroli MP, De Geronimo D, Gilardi M
Ocul Immunol Inflamm 2022 Aug;30(6):1408-1413. Epub 2021 Apr 1 doi: 10.1080/09273948.2021.1881563. PMID: 33793379
Size Matters for Interplicata Diameter: A Case-Control Study of Plateau Iris.
Garza PS, Man X, Queen JH, Ayres BM, McClendon T, Parrish EA, Reed DM, Moroi SE
Ophthalmol Glaucoma 2020 Nov-Dec;3(6):475-480. Epub 2020 Jul 2 doi: 10.1016/j.ogla.2020.06.007. PMID: 32771455
Late-onset uveitis-glaucoma-hyphema syndrome caused by Soemmering ring cataract.
Cheung AY, Price JM, Hart JC Jr
Can J Ophthalmol 2019 Aug;54(4):445-450. Epub 2018 Nov 26 doi: 10.1016/j.jcjo.2018.09.001. PMID: 31358142
Ultrasound biomicroscopy in uveitis-glaucoma-hyphema syndrome.
Piette S, Canlas OA, Tran HV, Ishikawa H, Liebmann JM, Ritch R
Am J Ophthalmol 2002 Jun;133(6):839-41. doi: 10.1016/s0002-9394(02)01386-7. PMID: 12036685

Diagnosis

Current Concepts of the Uveitis-Glaucoma-Hyphema (UGH) Syndrome.
Ramakrishnan MS, Wald KJ
Curr Eye Res 2023 Jun;48(6):529-535. Epub 2023 Jan 4 doi: 10.1080/02713683.2022.2156547. PMID: 36476057
Lens-in-the-Bag Uveitis-Glaucoma-Hyphema Syndrome Diagnosed by Endoscopy.
Kogachi K, Edmunds B, Sun L
Ophthalmol Glaucoma 2022 Nov-Dec;5(6):671. Epub 2022 Sep 29 doi: 10.1016/j.ogla.2022.08.005. PMID: 36184482
Uveitis-Glaucoma-Hyphema Syndrome: Clinical Features and Differential Diagnosis.
Accorinti M, Saturno MC, Paroli MP, De Geronimo D, Gilardi M
Ocul Immunol Inflamm 2022 Aug;30(6):1408-1413. Epub 2021 Apr 1 doi: 10.1080/09273948.2021.1881563. PMID: 33793379
Intraocular Lens Complications: Decentration, Uveitis-Glaucoma-Hyphema Syndrome, Opacification, and Refractive Surprises.
Durr GM, Ahmed IIK
Ophthalmology 2021 Nov;128(11):e186-e194. Epub 2020 Jul 8 doi: 10.1016/j.ophtha.2020.07.004. PMID: 32652203
Late-onset uveitis-glaucoma-hyphema syndrome caused by Soemmering ring cataract.
Cheung AY, Price JM, Hart JC Jr
Can J Ophthalmol 2019 Aug;54(4):445-450. Epub 2018 Nov 26 doi: 10.1016/j.jcjo.2018.09.001. PMID: 31358142

Therapy

Current Concepts of the Uveitis-Glaucoma-Hyphema (UGH) Syndrome.
Ramakrishnan MS, Wald KJ
Curr Eye Res 2023 Jun;48(6):529-535. Epub 2023 Jan 4 doi: 10.1080/02713683.2022.2156547. PMID: 36476057
Endoscopic Visualization for Atypical Uveitis Glaucoma Hyphema Syndrome Management.
Francis BA, Dentone P, Heilweil G, Chopra V, Nassiri N
J Glaucoma 2023 Feb 1;32(2):e3-e10. Epub 2022 Aug 29 doi: 10.1097/IJG.0000000000002117. PMID: 36222877
Intraocular Lens Complications: Decentration, Uveitis-Glaucoma-Hyphema Syndrome, Opacification, and Refractive Surprises.
Durr GM, Ahmed IIK
Ophthalmology 2021 Nov;128(11):e186-e194. Epub 2020 Jul 8 doi: 10.1016/j.ophtha.2020.07.004. PMID: 32652203
Late-onset uveitis-glaucoma-hyphema syndrome caused by Soemmering ring cataract.
Cheung AY, Price JM, Hart JC Jr
Can J Ophthalmol 2019 Aug;54(4):445-450. Epub 2018 Nov 26 doi: 10.1016/j.jcjo.2018.09.001. PMID: 31358142
Novel microsurgical management of uveitis-glaucoma-hyphema syndrome.
Jasinskas V, Vaiciuliene R, Varoniukaite A, Speckauskas M
Int Ophthalmol 2019 Jul;39(7):1607-1612. Epub 2018 Jun 26 doi: 10.1007/s10792-018-0972-5. PMID: 29943072

Prognosis

A novel approach for scleral fixation using Carlevale lens.
Fiore T, Messina M, Muzi A, Lupidi M, Reibaldi M, Giansanti F, Cagini C
Eur J Ophthalmol 2021 Nov;31(6):2947-2954. Epub 2021 Jan 30 doi: 10.1177/1120672121991358. PMID: 33517768
Size Matters for Interplicata Diameter: A Case-Control Study of Plateau Iris.
Garza PS, Man X, Queen JH, Ayres BM, McClendon T, Parrish EA, Reed DM, Moroi SE
Ophthalmol Glaucoma 2020 Nov-Dec;3(6):475-480. Epub 2020 Jul 2 doi: 10.1016/j.ogla.2020.06.007. PMID: 32771455
Late-onset uveitis-glaucoma-hyphema syndrome caused by Soemmering ring cataract.
Cheung AY, Price JM, Hart JC Jr
Can J Ophthalmol 2019 Aug;54(4):445-450. Epub 2018 Nov 26 doi: 10.1016/j.jcjo.2018.09.001. PMID: 31358142
Population-based Incidence of Intraocular Lens Exchange in Olmsted County, Minnesota.
Bothun ED, Cavalcante LCB, Hodge DO, Patel SV
Am J Ophthalmol 2018 Mar;187:80-86. Epub 2018 Jan 2 doi: 10.1016/j.ajo.2017.12.016. PMID: 29305312Free PMC Article
Ultrasound biomicroscopy in uveitis-glaucoma-hyphema syndrome.
Piette S, Canlas OA, Tran HV, Ishikawa H, Liebmann JM, Ritch R
Am J Ophthalmol 2002 Jun;133(6):839-41. doi: 10.1016/s0002-9394(02)01386-7. PMID: 12036685

Clinical prediction guides

Comparison of two different scleral fixation techniques of posterior chamber Carlevale lens.
Fiore T, Messina M, Muzi A, Tosi G, Lupidi M, Casini G, Marruso V, Cagini C
Medicine (Baltimore) 2021 Aug 13;100(32):e26728. doi: 10.1097/MD.0000000000026728. PMID: 34397876Free PMC Article
A novel approach for scleral fixation using Carlevale lens.
Fiore T, Messina M, Muzi A, Lupidi M, Reibaldi M, Giansanti F, Cagini C
Eur J Ophthalmol 2021 Nov;31(6):2947-2954. Epub 2021 Jan 30 doi: 10.1177/1120672121991358. PMID: 33517768
Novel microsurgical management of uveitis-glaucoma-hyphema syndrome.
Jasinskas V, Vaiciuliene R, Varoniukaite A, Speckauskas M
Int Ophthalmol 2019 Jul;39(7):1607-1612. Epub 2018 Jun 26 doi: 10.1007/s10792-018-0972-5. PMID: 29943072
Mechanisms for in-the-bag uveitis-glaucoma-hyphema syndrome.
Zhang L, Hood CT, Vrabec JP, Cullen AL, Parrish EA, Moroi SE
J Cataract Refract Surg 2014 Mar;40(3):490-2. Epub 2014 Jan 11 doi: 10.1016/j.jcrs.2013.12.002. PMID: 24417893
The uveitis-glaucoma-hyphema syndrome associated with the Mark VIII anterior chamber lens implant.
Ellingson FT
J Am Intraocul Implant Soc 1978 Apr;4(2):50-3. doi: 10.1016/s0146-2776(78)80054-8. PMID: 701165

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