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Urinary bladder small cell neuroendocrine carcinoma

MedGen UID:
231950
Concept ID:
C1332564
Neoplastic Process
Synonyms: Bladder Small Cell Carcinoma; bladder small cell neuroendocrine cancer; Bladder Small Cell Neuroendocrine Carcinoma; bladder small cell neuroendocrine carcinoma; Poorly differentiated neuroendocrine carcinoma of the bladder; poorly differentiated neuroendocrine carcinoma of the bladder; SCCB; Small cell bladder cancer; small cell bladder cancer; Small cell bladder carcinoma; small cell bladder carcinoma; small cell carcinoma of the bladder; Small cell carcinoma of the bladder; Small cell carcinoma of the urinary bladder; small cell carcinoma of the urinary bladder; small cell carcinoma of urinary bladder; Small cell neuroendocrine carcinoma of bladder; Small Cell Neuroendocrine Carcinoma of the Urinary Bladder; small cell neuroendocrine carcinoma of the urinary bladder; Small Cell Neuroendocrine Carcinoma of Urinary Bladder; small cell neuroendocrine carcinoma of urinary bladder; small cell/neuroendocrine carcinoma of urinary bladder; urinary bladder small cell carcinoma; urinary bladder small cell neuroendocrine carcinoma
SNOMED CT: Small cell neuroendocrine carcinoma of bladder (718604008)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0004114
Orphanet: ORPHA284400

Definition

Small cell carcinoma of the bladder (SCCB) is a very rare, poorly differentiated neuroendocrine epithelial bladder tumor characterized clinically by hematuria and/or dysuria and a highly aggressive course. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUrinary bladder small cell neuroendocrine carcinoma

Professional guidelines

PubMed

Brown JT, Narayan VM, Joshi SS, Harik L, Jani AB, Bilen MA
Cancer Treat Res Commun 2023;34:100663. Epub 2022 Dec 5 doi: 10.1016/j.ctarc.2022.100663. PMID: 36527979
Bansal P, Dwivedi DK, Hatwal D, Sharma P, Gupta V, Goyal S, Maithani M
Anticancer Agents Med Chem 2021;21(18):2478-2486. doi: 10.2174/1871520621666210121093852. PMID: 33475078
Fahed E, Hansel DE, Raghavan D, Quinn DI, Dorff TB
Semin Oncol 2012 Oct;39(5):615-8. doi: 10.1053/j.seminoncol.2012.08.009. PMID: 23040258

Recent clinical studies

Etiology

Dahm P, Narayan VM
NEJM Evid 2022 Oct;1(10):EVIDe2200194. Epub 2022 Sep 27 doi: 10.1056/EVIDe2200194. PMID: 38319828
Su Z, Monshaugen I, Wilson B, Wang F, Klungland A, Ougland R, Dutta A
Nat Commun 2022 Apr 20;13(1):2165. doi: 10.1038/s41467-022-29790-8. PMID: 35444240Free PMC Article
Hoffman-Censits JH, Lombardo KA, Parimi V, Kamanda S, Choi W, Hahn NM, McConkey DJ, McGuire BM, Bivalacqua TJ, Kates M, Matoso A
Appl Immunohistochem Mol Morphol 2021 Sep 1;29(8):619-625. doi: 10.1097/PAI.0000000000000938. PMID: 33901032Free PMC Article
Jung K, Ghatalia P, Litwin S, Horwitz EM, Uzzo RG, Greenberg RE, Viterbo R, Geynisman DM, Kutikov A, Plimack ER, Smaldone MC, Wong YN, Bilusic M
Clin Genitourin Cancer 2017 Jun;15(3):e337-e343. Epub 2016 Sep 30 doi: 10.1016/j.clgc.2016.09.005. PMID: 27991416Free PMC Article
Gkirlemis K, Miliadou A, Koukourakis G, Sotiropoulou-Lontou A
J BUON 2013 Jan-Mar;18(1):220-6. PMID: 23613409

Diagnosis

Dahm P, Narayan VM
NEJM Evid 2022 Oct;1(10):EVIDe2200194. Epub 2022 Sep 27 doi: 10.1056/EVIDe2200194. PMID: 38319828
Mitra S, Ayyanar P, Kaur G
Int J Surg Pathol 2020 Feb;28(1):4-12. Epub 2019 Aug 13 doi: 10.1177/1066896919868527. PMID: 31409167
Wang Y, Li Q, Wang J, Tong M, Xing H, Xue Y, Pan H, Huang C, Li D
Med Oncol 2019 Oct 29;36(12):98. doi: 10.1007/s12032-019-1321-x. PMID: 31664527
Erdem GU, Özdemir NY, Demirci NS, Şahin S, Bozkaya Y, Zengin N
Curr Med Res Opin 2016 Jun;32(6):1013-21. Epub 2016 Mar 17 doi: 10.1185/03007995.2016.1155982. PMID: 26889739
Lopez-Beltran A, Marques RC, Montironi R, Reymundo C, Fonseca J, Cheng L
Anal Quant Cytopathol Histpathol 2015 Feb;37(1):29-38. PMID: 26072632

Therapy

Spaas M, Sundahl N, Kruse V, Rottey S, De Maeseneer D, Duprez F, Lievens Y, Surmont V, Brochez L, Reynders D, Danckaert W, Goetghebeur E, Van den Begin R, Van Gestel D, Renard V, Dirix P, Ost P
JAMA Oncol 2023 Sep 1;9(9):1205-1213. doi: 10.1001/jamaoncol.2023.2132. PMID: 37410476Free PMC Article
Subbiah V, Iannotti NO, Gutierrez M, Smith DC, Féliz L, Lihou CF, Tian C, Silverman IM, Ji T, Saleh M
Ann Oncol 2022 May;33(5):522-533. Epub 2022 Feb 14 doi: 10.1016/j.annonc.2022.02.001. PMID: 35176457
Banchereau R, Leng N, Zill O, Sokol E, Liu G, Pavlick D, Maund S, Liu LF, Kadel E 3rd, Baldwin N, Jhunjhunwala S, Nickles D, Assaf ZJ, Bower D, Patil N, McCleland M, Shames D, Molinero L, Huseni M, Sanjabi S, Cummings C, Mellman I, Mariathasan S, Hegde P, Powles T
Nat Commun 2021 Jun 25;12(1):3969. doi: 10.1038/s41467-021-24112-w. PMID: 34172722Free PMC Article
Balakrishna P, George S, Hatoum H, Mukherjee S
Int J Mol Sci 2021 Jan 28;22(3) doi: 10.3390/ijms22031268. PMID: 33525332Free PMC Article
Ott PA, Hu-Lieskovan S, Chmielowski B, Govindan R, Naing A, Bhardwaj N, Margolin K, Awad MM, Hellmann MD, Lin JJ, Friedlander T, Bushway ME, Balogh KN, Sciuto TE, Kohler V, Turnbull SJ, Besada R, Curran RR, Trapp B, Scherer J, Poran A, Harjanto D, Barthelme D, Ting YS, Dong JZ, Ware Y, Huang Y, Huang Z, Wanamaker A, Cleary LD, Moles MA, Manson K, Greshock J, Khondker ZS, Fritsch E, Rooney MS, DeMario M, Gaynor RB, Srinivasan L
Cell 2020 Oct 15;183(2):347-362.e24. doi: 10.1016/j.cell.2020.08.053. PMID: 33064988

Prognosis

Lonati C, Simeone C, Suardi N, Briganti A, Montorsi F, Moschini M
Curr Opin Urol 2022 Sep 1;32(5):504-510. Epub 2022 Jul 18 doi: 10.1097/MOU.0000000000001023. PMID: 35855578
Wang Y, Li Q, Wang J, Tong M, Xing H, Xue Y, Pan H, Huang C, Li D
Med Oncol 2019 Oct 29;36(12):98. doi: 10.1007/s12032-019-1321-x. PMID: 31664527
Jung K, Ghatalia P, Litwin S, Horwitz EM, Uzzo RG, Greenberg RE, Viterbo R, Geynisman DM, Kutikov A, Plimack ER, Smaldone MC, Wong YN, Bilusic M
Clin Genitourin Cancer 2017 Jun;15(3):e337-e343. Epub 2016 Sep 30 doi: 10.1016/j.clgc.2016.09.005. PMID: 27991416Free PMC Article
Erdem GU, Özdemir NY, Demirci NS, Şahin S, Bozkaya Y, Zengin N
Curr Med Res Opin 2016 Jun;32(6):1013-21. Epub 2016 Mar 17 doi: 10.1185/03007995.2016.1155982. PMID: 26889739
Shatagopam K, Kaimakliotis HZ, Cheng L, Koch MO
Future Oncol 2015;11(3):479-88. doi: 10.2217/fon.14.277. PMID: 25675127

Clinical prediction guides

Spaas M, Sundahl N, Kruse V, Rottey S, De Maeseneer D, Duprez F, Lievens Y, Surmont V, Brochez L, Reynders D, Danckaert W, Goetghebeur E, Van den Begin R, Van Gestel D, Renard V, Dirix P, Ost P
JAMA Oncol 2023 Sep 1;9(9):1205-1213. doi: 10.1001/jamaoncol.2023.2132. PMID: 37410476Free PMC Article
Banchereau R, Leng N, Zill O, Sokol E, Liu G, Pavlick D, Maund S, Liu LF, Kadel E 3rd, Baldwin N, Jhunjhunwala S, Nickles D, Assaf ZJ, Bower D, Patil N, McCleland M, Shames D, Molinero L, Huseni M, Sanjabi S, Cummings C, Mellman I, Mariathasan S, Hegde P, Powles T
Nat Commun 2021 Jun 25;12(1):3969. doi: 10.1038/s41467-021-24112-w. PMID: 34172722Free PMC Article
Hoffman-Censits JH, Lombardo KA, Parimi V, Kamanda S, Choi W, Hahn NM, McConkey DJ, McGuire BM, Bivalacqua TJ, Kates M, Matoso A
Appl Immunohistochem Mol Morphol 2021 Sep 1;29(8):619-625. doi: 10.1097/PAI.0000000000000938. PMID: 33901032Free PMC Article
Ott PA, Hu-Lieskovan S, Chmielowski B, Govindan R, Naing A, Bhardwaj N, Margolin K, Awad MM, Hellmann MD, Lin JJ, Friedlander T, Bushway ME, Balogh KN, Sciuto TE, Kohler V, Turnbull SJ, Besada R, Curran RR, Trapp B, Scherer J, Poran A, Harjanto D, Barthelme D, Ting YS, Dong JZ, Ware Y, Huang Y, Huang Z, Wanamaker A, Cleary LD, Moles MA, Manson K, Greshock J, Khondker ZS, Fritsch E, Rooney MS, DeMario M, Gaynor RB, Srinivasan L
Cell 2020 Oct 15;183(2):347-362.e24. doi: 10.1016/j.cell.2020.08.053. PMID: 33064988
Robertson AG, Kim J, Al-Ahmadie H, Bellmunt J, Guo G, Cherniack AD, Hinoue T, Laird PW, Hoadley KA, Akbani R, Castro MAA, Gibb EA, Kanchi RS, Gordenin DA, Shukla SA, Sanchez-Vega F, Hansel DE, Czerniak BA, Reuter VE, Su X, de Sa Carvalho B, Chagas VS, Mungall KL, Sadeghi S, Pedamallu CS, Lu Y, Klimczak LJ, Zhang J, Choo C, Ojesina AI, Bullman S, Leraas KM, Lichtenberg TM, Wu CJ, Schultz N, Getz G, Meyerson M, Mills GB, McConkey DJ; TCGA Research Network, Weinstein JN, Kwiatkowski DJ, Lerner SP
Cell 2017 Oct 19;171(3):540-556.e25. Epub 2017 Oct 5 doi: 10.1016/j.cell.2017.09.007. PMID: 28988769Free PMC Article

Recent systematic reviews

Tian BW, Han CL, Wang HC, Yan LJ, Ding ZN, Liu H, Mao XC, Tian JC, Xue JS, Yang LS, Tan SY, Dong ZR, Yan YC, Wang DX, Li T
Clin Exp Metastasis 2023 Aug;40(4):255-287. Epub 2023 Jun 13 doi: 10.1007/s10585-023-10217-7. PMID: 37308706
Lopes S, Pabst L, Dory A, Klotz M, Gourieux B, Michel B, Mascaux C
Front Immunol 2023;14:1070076. Epub 2023 Jan 26 doi: 10.3389/fimmu.2023.1070076. PMID: 36776847Free PMC Article
Zalay O, Yan M, Sigurdson S, Malone S, Vera-Badillo FE, Mahmud A
Curr Oncol 2022 Dec 20;30(1):19-36. doi: 10.3390/curroncol30010002. PMID: 36661651Free PMC Article
Svatek RS, Hollenbeck BK, Holmäng S, Lee R, Kim SP, Stenzl A, Lotan Y
Eur Urol 2014 Aug;66(2):253-62. Epub 2014 Jan 21 doi: 10.1016/j.eururo.2014.01.006. PMID: 24472711
Rai BP, Shelley M, Coles B, Biyani CS, El-Mokadem I, Nabi G
Cochrane Database Syst Rev 2011 Apr 13;(4):CD007349. doi: 10.1002/14651858.CD007349.pub2. PMID: 21491399

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