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Esophageal Neuroendocrine Tumor G1

MedGen UID:
232157
•Concept ID:
C1333444
•
Neoplastic Process
Synonyms: Carcinoid Tumor of Esophagus; Carcinoid Tumor of the Esophagus; Esophageal Carcinoid Tumor; Esophageal NET G1; Esophageal NET G1 (Carcinoid); Esophageal Neuroendocrine Tumor G1 (Carcinoid)

Definition

A rare, well differentiated, low grade neoplasm with neuroendocrine differentiation that arises from the esophagus. The mitotic count is less than 2 per 10 HPF and/or the Ki67 index is equal to or less than 2 percent. The majority of cases have a polypoid appearance, are small lesions, and found incidentally. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEsophageal Neuroendocrine Tumor G1

Recent clinical studies

Etiology

Safety and efficacy of the FLOT regimen in the Polish population - an analysis of the prospective trial.
Marcisz-Grzanka K, Winiarek M, Pałucki J, Wieszczy P, Olesiński T, Jóźwiak M, Samsel R, Sułkowska U, Kolasińska-Ćwikła A, Wyrwicz LS
Neoplasma 2022 Dec;69(6):1445-1450. Epub 2022 Nov 11 doi: 10.4149/neo_2022_220720N734. PMID: 36353936
Nationwide registry for patients with neuroendocrine neoplasm of pancreas, gastrointestinal tract, lungs, bronchi, or thymus in Japan.
Masui T, Ito T, Komoto I, Kojima S, Kasai Y, Tanabe M, Hara K, Hirano S, Okusaka T, Ichikawa Y, Kinugasa Y, Kokudo N, Kudo A, Sakurai A, Sugihara K, Date H, Haruma K, Hijioka S, Hirata K, Yamano H, Sakamine M, Kikuchi T, Fukushima M, Imamura M, Uemoto S
Int J Clin Oncol 2022 May;27(5):840-849. Epub 2022 Feb 18 doi: 10.1007/s10147-022-02130-y. PMID: 35178624Free PMC Article
Digestive Neuroendocrine Tumor Distribution and Characteristics According to the 2010 WHO Classification: a Single Institution Experience in Lebanon.
Kourie HR, Ghorra C, Rassy M, Kesserouani C, Kattan J
Asian Pac J Cancer Prev 2016;17(5):2679-81. PMID: 27268650

Diagnosis

Nationwide registry for patients with neuroendocrine neoplasm of pancreas, gastrointestinal tract, lungs, bronchi, or thymus in Japan.
Masui T, Ito T, Komoto I, Kojima S, Kasai Y, Tanabe M, Hara K, Hirano S, Okusaka T, Ichikawa Y, Kinugasa Y, Kokudo N, Kudo A, Sakurai A, Sugihara K, Date H, Haruma K, Hijioka S, Hirata K, Yamano H, Sakamine M, Kikuchi T, Fukushima M, Imamura M, Uemoto S
Int J Clin Oncol 2022 May;27(5):840-849. Epub 2022 Feb 18 doi: 10.1007/s10147-022-02130-y. PMID: 35178624Free PMC Article
A Case of Pedunculated Esophageal Neuroendocrine Tumor G1.
Aoki H, Omori Y, Katanuma A
Clin Gastroenterol Hepatol 2022 Apr;20(4):e651-e652. Epub 2021 Mar 1 doi: 10.1016/j.cgh.2021.02.039. PMID: 33662595
Digestive Neuroendocrine Tumor Distribution and Characteristics According to the 2010 WHO Classification: a Single Institution Experience in Lebanon.
Kourie HR, Ghorra C, Rassy M, Kesserouani C, Kattan J
Asian Pac J Cancer Prev 2016;17(5):2679-81. PMID: 27268650
Endoscopic submucosal dissection for foregut neuroendocrine tumors: an initial study.
Li QL, Zhang YQ, Chen WF, Xu MD, Zhong YS, Ma LL, Qin WZ, Hu JW, Cai MY, Yao LQ, Zhou PH
World J Gastroenterol 2012 Oct 28;18(40):5799-806. doi: 10.3748/wjg.v18.i40.5799. PMID: 23155323Free PMC Article
Use of the succinate dehydrogenase inhibition test in assessing the heat sensitivity of tumor cells.
Kohnoe S, Maehara Y, Takahashi I, Yoshida M, Emi Y, Kusumoto T, Sugimachi K
Oncology 1993 Nov-Dec;50(6):500-4. doi: 10.1159/000227236. PMID: 8233294

Therapy

Safety and efficacy of the FLOT regimen in the Polish population - an analysis of the prospective trial.
Marcisz-Grzanka K, Winiarek M, Pałucki J, Wieszczy P, Olesiński T, Jóźwiak M, Samsel R, Sułkowska U, Kolasińska-Ćwikła A, Wyrwicz LS
Neoplasma 2022 Dec;69(6):1445-1450. Epub 2022 Nov 11 doi: 10.4149/neo_2022_220720N734. PMID: 36353936
Digestive Neuroendocrine Tumor Distribution and Characteristics According to the 2010 WHO Classification: a Single Institution Experience in Lebanon.
Kourie HR, Ghorra C, Rassy M, Kesserouani C, Kattan J
Asian Pac J Cancer Prev 2016;17(5):2679-81. PMID: 27268650
The immunomodulator PSK induces in vitro cytotoxic activity in tumour cell lines via arrest of cell cycle and induction of apoptosis.
Jiménez-Medina E, Berruguilla E, Romero I, Algarra I, Collado A, Garrido F, Garcia-Lora A
BMC Cancer 2008 Mar 24;8:78. doi: 10.1186/1471-2407-8-78. PMID: 18366723Free PMC Article

Prognosis

Safety and efficacy of the FLOT regimen in the Polish population - an analysis of the prospective trial.
Marcisz-Grzanka K, Winiarek M, Pałucki J, Wieszczy P, Olesiński T, Jóźwiak M, Samsel R, Sułkowska U, Kolasińska-Ćwikła A, Wyrwicz LS
Neoplasma 2022 Dec;69(6):1445-1450. Epub 2022 Nov 11 doi: 10.4149/neo_2022_220720N734. PMID: 36353936
Nationwide registry for patients with neuroendocrine neoplasm of pancreas, gastrointestinal tract, lungs, bronchi, or thymus in Japan.
Masui T, Ito T, Komoto I, Kojima S, Kasai Y, Tanabe M, Hara K, Hirano S, Okusaka T, Ichikawa Y, Kinugasa Y, Kokudo N, Kudo A, Sakurai A, Sugihara K, Date H, Haruma K, Hijioka S, Hirata K, Yamano H, Sakamine M, Kikuchi T, Fukushima M, Imamura M, Uemoto S
Int J Clin Oncol 2022 May;27(5):840-849. Epub 2022 Feb 18 doi: 10.1007/s10147-022-02130-y. PMID: 35178624Free PMC Article
Digestive Neuroendocrine Tumor Distribution and Characteristics According to the 2010 WHO Classification: a Single Institution Experience in Lebanon.
Kourie HR, Ghorra C, Rassy M, Kesserouani C, Kattan J
Asian Pac J Cancer Prev 2016;17(5):2679-81. PMID: 27268650

Clinical prediction guides

Endoscopic submucosal dissection for foregut neuroendocrine tumors: an initial study.
Li QL, Zhang YQ, Chen WF, Xu MD, Zhong YS, Ma LL, Qin WZ, Hu JW, Cai MY, Yao LQ, Zhou PH
World J Gastroenterol 2012 Oct 28;18(40):5799-806. doi: 10.3748/wjg.v18.i40.5799. PMID: 23155323Free PMC Article

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