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Neurohypophysis granular cell tumor

MedGen UID:
232255
•Concept ID:
C1333873
•
Neoplastic Process
Synonyms: Granular cell tumor of neurohypophysis; Granular Cell Tumor of Neurohypophysis; granular cell tumor of Neurohypophysis; granular cell tumor of neurohypophysis; Granular cell tumor of posterior pituitary; Granular Cell Tumor of the Neurohypophysis; granular cell tumor of the neurohypophysis; Granular Cell Tumor of the Neurohypophysis (WHO Grade 1); Granular Cell Tumor of the Neurohypophysis (WHO Grade I); granular cell tumor of the Neurohypophysis (WHO grade I); Granular Cell Tumor of the Posterior Pituitary Gland; granular cell tumor of the posterior pituitary gland; Granular Cell Tumor of the Sellar Region; granular cell tumour of neurohypophysis; granular cell tumour of Neurohypophysis; granular cell tumour of the neurohypophysis; granular cell tumour of the Neurohypophysis (WHO grade I); granular cell tumour of the posterior pituitary gland; Granular Cell Tumour of the Sellar Region/Granular Cell Pituicytoma; neurohypophysis granular cell tumor
SNOMED CT: Granular cell tumor of neurohypophysis (699331002); Granular cell tumor of posterior pituitary (699331002)
 
Monarch Initiative: MONDO:0003256

Definition

A generally benign intrasellar and/or suprasellar mass arising from the neurohypophysis or infundibulum. It is composed of nests of large cells with granular, eosinophilic cytoplasm due to abundant intracytoplasmic lysosomes. It generally has a slow progression and lacks invasive growth. (Adapted from WHO) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeurohypophysis granular cell tumor

Professional guidelines

PubMed

Granular Cell Tumor and Spindle Cell Oncocytoma of the Pituitary Gland: Imaging and Intraoperative Cytology Diagnostic Dilemmas and Management Challenges.
Kandregula S, Shashidhar A, Rao S, Beniwal M, Shukla D, Srinivas D, Saini J, Mahadevan A, Santosh V, Arimappamagan A
J Neurol Surg A Cent Eur Neurosurg 2022 Sep;83(5):442-450. Epub 2021 Dec 15 doi: 10.1055/s-0041-1740264. PMID: 34911085

Recent clinical studies

Etiology

Overview of the 2022 WHO Classification of Pituitary Tumors.
Asa SL, Mete O, Perry A, Osamura RY
Endocr Pathol 2022 Mar;33(1):6-26. Epub 2022 Mar 15 doi: 10.1007/s12022-022-09703-7. PMID: 35291028
Granular Cell Tumor and Spindle Cell Oncocytoma of the Pituitary Gland: Imaging and Intraoperative Cytology Diagnostic Dilemmas and Management Challenges.
Kandregula S, Shashidhar A, Rao S, Beniwal M, Shukla D, Srinivas D, Saini J, Mahadevan A, Santosh V, Arimappamagan A
J Neurol Surg A Cent Eur Neurosurg 2022 Sep;83(5):442-450. Epub 2021 Dec 15 doi: 10.1055/s-0041-1740264. PMID: 34911085
Clinical and imaging features of granular cell tumor of the neurohypophysis: A retrospective analysis.
Han F, Gao L, Wang Y, Jin Y, Lv Y, Yao Z, Zhang J
Medicine (Baltimore) 2018 Mar;97(9):e9745. doi: 10.1097/MD.0000000000009745. PMID: 29489677Free PMC Article
The 2017 World Health Organization classification of tumors of the pituitary gland: a summary.
Lopes MBS
Acta Neuropathol 2017 Oct;134(4):521-535. Epub 2017 Aug 18 doi: 10.1007/s00401-017-1769-8. PMID: 28821944
Overview of the 2017 WHO Classification of Pituitary Tumors.
Mete O, Lopes MB
Endocr Pathol 2017 Sep;28(3):228-243. doi: 10.1007/s12022-017-9498-z. PMID: 28766057

Diagnosis

Overview of the 2022 WHO Classification of Pituitary Tumors.
Asa SL, Mete O, Perry A, Osamura RY
Endocr Pathol 2022 Mar;33(1):6-26. Epub 2022 Mar 15 doi: 10.1007/s12022-022-09703-7. PMID: 35291028
Neuropathology of Pituitary Adenomas and Sellar Lesions.
Kobalka PJ, Huntoon K, Becker AP
Neurosurgery 2021 Apr 15;88(5):900-918. doi: 10.1093/neuros/nyaa548. PMID: 33476394
Primary tumors of the posterior pituitary: A systematic review.
Guerrero-Pérez F, Marengo AP, Vidal N, Iglesias P, Villabona C
Rev Endocr Metab Disord 2019 Jun;20(2):219-238. doi: 10.1007/s11154-019-09484-1. PMID: 30864049
Histological features of pituitary adenomas and sellar region masses.
Kleinschmidt-DeMasters BK
Curr Opin Endocrinol Diabetes Obes 2016 Dec;23(6):476-484. doi: 10.1097/MED.0000000000000293. PMID: 27763894
Pituicytoma: case report.
Wolfe SQ, Bruce J, Morcos JJ
Neurosurgery 2008 Jul;63(1):E173-4; discussion E174. doi: 10.1227/01.NEU.0000335084.93093.C8. PMID: 18728556

Therapy

Posterior pituitary tumours: the spectrum of a unique entity. A clinical and histological study of a large case series.
Guerrero-Pérez F, Vidal N, Marengo AP, Pozo CD, Blanco C, Rivero-Celada D, Díez JJ, Iglesias P, Picó A, Villabona C
Endocrine 2019 Jan;63(1):36-43. Epub 2018 Oct 1 doi: 10.1007/s12020-018-1774-2. PMID: 30276594

Prognosis

Tumors of the Neurohypophysis: One Unit's Experience and Literature Review.
Borg A, Jaunmuktane Z, Dorward N
World Neurosurg 2020 Feb;134:e968-e978. Epub 2019 Nov 14 doi: 10.1016/j.wneu.2019.11.043. PMID: 31734425
The 2017 World Health Organization classification of tumors of the pituitary gland: a summary.
Lopes MBS
Acta Neuropathol 2017 Oct;134(4):521-535. Epub 2017 Aug 18 doi: 10.1007/s00401-017-1769-8. PMID: 28821944
Granular cell tumor of the neurohypophysis with optic tract edema.
Shizukuishi T, Abe O, Haradome H, Fukushima T, Katayama Y, Sugitani M
Jpn J Radiol 2014 Mar;32(3):179-82. Epub 2014 Jan 11 doi: 10.1007/s11604-013-0279-4. PMID: 24414885
Spindle cell oncocytomas and granular cell tumors of the pituitary are variants of pituicytoma.
Mete O, Lopes MB, Asa SL
Am J Surg Pathol 2013 Nov;37(11):1694-9. doi: 10.1097/PAS.0b013e31829723e7. PMID: 23887161
Symptomatic granular cell tumor of the pituitary gland: case report and review of the literature.
Schaller B, Kirsch E, Tolnay M, Mindermann T
Neurosurgery 1998 Jan;42(1):166-70; discussion 170-1. doi: 10.1097/00006123-199801000-00036. PMID: 9442519

Clinical prediction guides

Genetic and epigenetic characterization of posterior pituitary tumors.
Schmid S, Solomon DA, Perez E, Thieme A, Kleinschmidt-DeMasters BK, Giannini C, Reinhardt A, Asa SL, Mete O, Stichel D, Siewert C, Dittmayer C, Hasselblatt M, Paulus W, Nagel C, Harter PN, Schittenhelm J, Honegger J, Rushing E, Coras R, Pfister SM, Buslei R, Koch A, Perry A, Jones DTW, von Deimling A, Capper D, Lopes MB
Acta Neuropathol 2021 Dec;142(6):1025-1043. Epub 2021 Oct 18 doi: 10.1007/s00401-021-02377-1. PMID: 34661724Free PMC Article
Co-occurrence of Pituitary Neuroendocrine Tumors (PitNETs) and Tumors of the Neurohypophysis.
Saeger W, von Schöning J, Flitsch J, Jautzke G, Bergmann M, Hagel C, Knappe UJ
Endocr Pathol 2021 Dec;32(4):473-479. Epub 2021 Jun 15 doi: 10.1007/s12022-021-09677-y. PMID: 34129177
Granular Cell Tumor of the Pituitary Presenting with Major Intraventricular Hemorrhage.
Maenhoudt W, Van Dorpe J, Vanhauwaert D
World Neurosurg 2020 Aug;140:60-62. Epub 2020 May 11 doi: 10.1016/j.wneu.2020.05.027. PMID: 32407921
Non-adenomatous pituitary tumours mimicking functioning pituitary adenomas.
Feng Z, Mao Z, Wang Z, Liao B, Zhu Y, Wang H
Br J Neurosurg 2020 Oct;34(5):487-491. Epub 2018 Apr 18 doi: 10.1080/02688697.2018.1464121. PMID: 29667493
Spindle cell oncocytomas and granular cell tumors of the pituitary are variants of pituicytoma.
Mete O, Lopes MB, Asa SL
Am J Surg Pathol 2013 Nov;37(11):1694-9. doi: 10.1097/PAS.0b013e31829723e7. PMID: 23887161

Recent systematic reviews

Primary Tumors of the Posterior Pituitary Gland: A Systematic Review of the Literature in Light of the New 2017 World Health Organization Classification of Pituitary Tumors.
Whipple SG, Savardekar AR, Rao S, Mahadevan A, Guthikonda B, Kosty JA
World Neurosurg 2021 Jan;145:148-158. Epub 2020 Sep 8 doi: 10.1016/j.wneu.2020.09.023. PMID: 32916355
Primary tumors of the posterior pituitary: A systematic review.
Guerrero-Pérez F, Marengo AP, Vidal N, Iglesias P, Villabona C
Rev Endocr Metab Disord 2019 Jun;20(2):219-238. doi: 10.1007/s11154-019-09484-1. PMID: 30864049
Granular cell tumor of the infundibulum: a systematic review of MR-radiography, pathology, and clinical findings.
Polasek JB, Laviv Y, Nigim F, Rojas R, Anderson M, Varma H, Kasper EM
J Neurooncol 2018 Nov;140(2):181-198. Epub 2018 Aug 23 doi: 10.1007/s11060-018-2986-2. PMID: 30141059
Granular Cell Tumor of the Neurohypophysis: 3 Cases and a Systematic Literature Review of 98 Cases.
Zhang Y, Teng Y, Zhu H, Lu L, Deng K, Pan H, Yao Y
World Neurosurg 2018 Oct;118:e621-e630. Epub 2018 Jul 11 doi: 10.1016/j.wneu.2018.07.004. PMID: 30017767

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