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Cervical carcinosarcoma

MedGen UID:
232338
•Concept ID:
C1332917
•
Neoplastic Process
Synonyms: Carcinosarcoma of cervix uteri; carcinosarcoma of the cervix uteri; Carcinosarcoma of the cervix uteri; Cervical Carcinosarcoma; cervical carcinosarcoma; Cervical Malignant Mixed Mesodermal (Mullerian) Tumor; cervical malignant mixed mesodermal (Mullerian) tumor; cervical malignant mixed mesodermal (Mullerian) tumour; Cervical Malignant Mixed Mesodermal (Müllerian) Tumor; cervical malignant mixed mesodermal (Müllerian) tumor; cervical malignant mixed mesodermal (Müllerian) tumour; cervical malignant mixed mesodermal mullerian tumor; cervical malignant mixed mesodermal mullerian tumour; cervical malignant mixed Mullerian tumor; cervical malignant mixed Mullerian tumour; cervical malignant Mullerian mixed tumor; cervical malignant Mullerian mixed tumour; cervical malignant Müllerian mixed tumor; Cervical malignant Müllerian mixed tumor; cervical malignant Müllerian mixed tumour; cervical mixed epithelial and mesenchymal neoplasm; malignant Mullerian mixed tumor of the cervix uteri; malignant Mullerian mixed tumour of the cervix uteri; Malignant Müllerian mixed neoplasm of cervix uteri; Malignant Müllerian mixed tumor of cervix uteri; Malignant Müllerian mixed tumor of the cervix uteri; malignant Müllerian mixed tumor of the cervix uteri; malignant Müllerian mixed tumour of the cervix uteri; uterine cervix carcinosarcoma
SNOMED CT: Cervical carcinosarcoma (764951002); Carcinosarcoma of cervix uteri (764951002); Malignant Müllerian mixed tumor of cervix uteri (764951002); Malignant Müllerian mixed neoplasm of cervix uteri (764951002)
 
Monarch Initiative: MONDO:0002877
Orphanet: ORPHA213787

Definition

Carcinosarcoma of the cervix uteri is a rare, malignant, mixed epithelial and mesenchymal tumor, located in the cervix uteri, composed of an admixture of carcinomatous and sarcomatous elements. It usually presents with abnormal vaginal bleeding and a round, well-defined, grey to yellowish-white, pedunculated polypoid mass protruding through the cervical canal. Association with HPV infection (especially serotype 16) has been frequently reported. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCervical carcinosarcoma

Professional guidelines

PubMed

APOBEC3C is a novel target for the immune treatment of lower-grade gliomas.
Zhao S, Li Y, Xu J, Shen L
Neurol Res 2024 Mar;46(3):227-242. Epub 2024 Jan 22 doi: 10.1080/01616412.2023.2287340. PMID: 38007705
DICER1-associated Tumors in the Female Genital Tract: Molecular Basis, Clinicopathologic Features, and Differential Diagnosis.
Han LM, Weiel JJ, Longacre TA, Folkins AK
Adv Anat Pathol 2022 Sep 1;29(5):297-308. Epub 2022 Jul 1 doi: 10.1097/PAP.0000000000000351. PMID: 35778792
Primary cutaneous carcinosarcoma: clinical, histological, and immunohistochemical analysis of eight cases.
García-Souto F, Pereyra-Rodriguez JJ, Cabrera-Perez R, Durán-Romero AJ, Escudero-Ordoñez J, Conejo-Mir J
Int J Dermatol 2021 Jan;60(1):93-98. Epub 2020 Jun 12 doi: 10.1111/ijd.14996. PMID: 32530054

Recent clinical studies

Etiology

Small Cell and Other Rare Histologic Types of Cervical Cancer.
Marchocki Z, Swift B, Covens A
Curr Oncol Rep 2022 Nov;24(11):1531-1539. Epub 2022 Aug 10 doi: 10.1007/s11912-022-01316-x. PMID: 35947285
Therapy Modalities, Prognostic Factors, and Outcome of the Primary Cervical Carcinosarcoma: Meta-analysis of Extremely Rare Tumor of Cervix.
Kimyon Comert G, Turkmen O, Karalok A, Basaran D, Bulbul D, Turan T
Int J Gynecol Cancer 2017 Nov;27(9):1957-1969. doi: 10.1097/IGC.0000000000001086. PMID: 28708788
Mesonephric carcinosarcoma of the uterine cervix: a case report.
Lopez-Chardi L, González-Bosquet E, Rovira Zurriaga C, Laïlla Vicens JM
Eur J Gynaecol Oncol 2013;34(4):336-8. PMID: 24020142
High expressions of bcl-2 and survivin, and decreased apoptosis in uterine cervical carcinosarcoma compared to cervical squamous cell carcinoma.
Gan XL, Li JK, Yu TH, Zhang Y, Hu LN
Arch Gynecol Obstet 2011 Jul;284(1):175-81. Epub 2010 Jul 29 doi: 10.1007/s00404-010-1610-2. PMID: 20668868
Cervical carcinosarcoma occurring after subtotal hysterectomy, a case report.
Farley JH, Taylor RR
Gynecol Oncol 1997 Dec;67(3):322-4. doi: 10.1006/gyno.1997.4872. PMID: 9441782

Diagnosis

Cervical carcinosarcoma, report of some cases and a literature review.
Mariño-Noya A, Magallanes-Peláez N, Puga-González N, Conde-Ferreirós M, Vieitez-Villaverde MD, López-Ramón Y Cajal CN
Int J Gynaecol Obstet 2024 Feb;164(2):795-796. Epub 2023 Oct 30 doi: 10.1002/ijgo.15202. PMID: 37899741
Cervical carcinosarcoma presented in advanced stage after high grade cervical displasia.
Karataşlı V, Erkılınç S, Can B, Çakır İ, Temel O, Gökçü M, Sancı M
J Exp Ther Oncol 2019 Dec;13(2):165-167. PMID: 31881134
Synchronous carcinosarcoma of the uterine cervix with adenoid basal carcinoma and cervical intraepithelial neoplasia III: A case report and literature review.
Lin Y, Chen H, Ye Z, Ding L, Cao Q, Xue L
Pathol Res Pract 2017 May;213(5):570-573. Epub 2017 Feb 7 doi: 10.1016/j.prp.2017.02.006. PMID: 28214205
Mesonephric adenocarcinoma with a sarcomatous component, a notable subtype of cervical carcinosarcoma: a case report and review of the literature.
Meguro S, Yasuda M, Shimizu M, Kurosaki A, Fujiwara K
Diagn Pathol 2013 May 7;8:74. doi: 10.1186/1746-1596-8-74. PMID: 23651629Free PMC Article
Uterine cervical carcinosarcoma with heterologous mesenchymal component: a case report and review of the literature.
Kadota K, Haba R, Ishikawa M, Kushida Y, Katsuki N, Hayashi T, Miyai Y, Bando K, Shiota A, Hata T
Arch Gynecol Obstet 2009 Nov;280(5):839-43. Epub 2009 Mar 5 doi: 10.1007/s00404-009-1017-0. PMID: 19263060

Therapy

Exceptional Response of Cryoablation Followed by Pembrolizumab in a Patient with Metastatic Cervical Carcinosarcoma with High Tumor Mutational Burden: A Case Report.
Zhu B, Liu Y, Li J, Diao L, Shao L, Han-Zhang H, Zhang L, Kang Q, Yang W
Oncologist 2020 Jan;25(1):15-18. Epub 2019 Dec 17 doi: 10.1634/theoncologist.2019-0739. PMID: 31848313Free PMC Article
A case of uterine cervical carcinosarcoma recurrence who obtained a clinically complete response by ifosfamide, doxorubicin and cisplatin.
Xu C, Nishi H, Isaka K
Eur J Gynaecol Oncol 2011;32(1):119-21. PMID: 21446343

Prognosis

Cervical carcinosarcoma presented in advanced stage after high grade cervical displasia.
Karataşlı V, Erkılınç S, Can B, Çakır İ, Temel O, Gökçü M, Sancı M
J Exp Ther Oncol 2019 Dec;13(2):165-167. PMID: 31881134
Therapy Modalities, Prognostic Factors, and Outcome of the Primary Cervical Carcinosarcoma: Meta-analysis of Extremely Rare Tumor of Cervix.
Kimyon Comert G, Turkmen O, Karalok A, Basaran D, Bulbul D, Turan T
Int J Gynecol Cancer 2017 Nov;27(9):1957-1969. doi: 10.1097/IGC.0000000000001086. PMID: 28708788
Coexistence of homologous-type cervical carcinosarcoma with endometrioid-type G1 endometrial cancer: a case report with an immunohistochemical study.
Semczuk A, Colas E, Walczyna B, Joźwik M, Pyra A, Semczuk-Sikora A, Rechberger T
Int J Clin Exp Pathol 2014;7(10):7191-5. Epub 2014 Sep 15 PMID: 25400816Free PMC Article
Cervical carcinosarcoma: a case report.
Abidi A, Menn K, Sherman A, Konia T, Azodi M
J Reprod Med 2008 Feb;53(2):138-40. PMID: 18357808
Case of uterine cervical carcinosarcoma.
Iida T, Yasuda M, Kajiwara H, Minematsu T, Osamura RY, Itoh J, Inomo A, Hirasawa T, Muramatsu T, Murakami M
J Obstet Gynaecol Res 2005 Oct;31(5):404-8. doi: 10.1111/j.1447-0756.2005.00310.x. PMID: 16176508

Clinical prediction guides

Exceptional Response of Cryoablation Followed by Pembrolizumab in a Patient with Metastatic Cervical Carcinosarcoma with High Tumor Mutational Burden: A Case Report.
Zhu B, Liu Y, Li J, Diao L, Shao L, Han-Zhang H, Zhang L, Kang Q, Yang W
Oncologist 2020 Jan;25(1):15-18. Epub 2019 Dec 17 doi: 10.1634/theoncologist.2019-0739. PMID: 31848313Free PMC Article
Coexistence of homologous-type cervical carcinosarcoma with endometrioid-type G1 endometrial cancer: a case report with an immunohistochemical study.
Semczuk A, Colas E, Walczyna B, Joźwik M, Pyra A, Semczuk-Sikora A, Rechberger T
Int J Clin Exp Pathol 2014;7(10):7191-5. Epub 2014 Sep 15 PMID: 25400816Free PMC Article
High expressions of bcl-2 and survivin, and decreased apoptosis in uterine cervical carcinosarcoma compared to cervical squamous cell carcinoma.
Gan XL, Li JK, Yu TH, Zhang Y, Hu LN
Arch Gynecol Obstet 2011 Jul;284(1):175-81. Epub 2010 Jul 29 doi: 10.1007/s00404-010-1610-2. PMID: 20668868

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