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Low Grade Esophageal Squamous Intraepithelial Neoplasia

MedGen UID:
232470
•Concept ID:
C1333458
•
Neoplastic Process
Synonyms: Esophageal Low Grade Squamous Intraepithelial Neoplasia; Low Grade Esophageal Squamous Dysplasia

Definition

A lesion in which the architectural and cytologic abnormalities are confined to the lower half of the esophageal squamous epithelium. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLow Grade Esophageal Squamous Intraepithelial Neoplasia

Professional guidelines

PubMed

Histological criteria for "intraepithelial squamous cell carcinoma" of the esophagus: continued dialogue between Ukrainian and Japanese pathologists.
Shcherbynina M, Itabashi M, Soloviova N
Exp Oncol 2020 Dec;42(4):314-317. doi: 10.32471/exp-oncology.2312-8852.vol-42-no-4.15437. PMID: 33355864
Endoscopic screening using esophageal iodine staining and genotypes of ADH1B and ALDH2 in Japanese alcohol-dependent women.
Yokoyama A, Yokoyama T, Omori T, Maesato H, Takimura T, Iwahara C, Kimura M, Matsui T, Mizukami T, Maruyama K
PLoS One 2019;14(1):e0210546. Epub 2019 Jan 10 doi: 10.1371/journal.pone.0210546. PMID: 30629674Free PMC Article
A review of the current understanding and clinical utility of miRNAs in esophageal cancer.
Sakai NS, Samia-Aly E, Barbera M, Fitzgerald RC
Semin Cancer Biol 2013 Dec;23(6 Pt B):512-21. Epub 2013 Sep 3 doi: 10.1016/j.semcancer.2013.08.005. PMID: 24013023

Recent clinical studies

Etiology

Squamous Neoplastic Precursor Lesions of the Esophagus.
Arai T, Ono S, Takubo K
Gastroenterol Clin North Am 2024 Mar;53(1):25-38. Epub 2023 Oct 23 doi: 10.1016/j.gtc.2023.09.004. PMID: 38280749
Spatial transcriptomics analysis of esophageal squamous precancerous lesions and their progression to esophageal cancer.
Liu X, Zhao S, Wang K, Zhou L, Jiang M, Gao Y, Yang R, Yan S, Zhang W, Lu B, Liu F, Zhao R, Liu W, Zhang Z, Liu K, Li X, Dong Z
Nat Commun 2023 Aug 8;14(1):4779. doi: 10.1038/s41467-023-40343-5. PMID: 37553345Free PMC Article
Machine learning-based automated sponge cytology for screening of oesophageal squamous cell carcinoma and adenocarcinoma of the oesophagogastric junction: a nationwide, multicohort, prospective study.
Gao Y, Xin L, Lin H, Yao B, Zhang T, Zhou AJ, Huang S, Wang JH, Feng YD, Yao SH, Guo Y, Dang T, Meng XM, Yang ZZ, Jia WQ, Pang HF, Tian XJ, Deng B, Wang JP, Fan WC, Wang J, Shi LH, Yang GY, Sun C, Wang W, Zang JC, Li SY, Shi RH, Li ZS, Wang LW
Lancet Gastroenterol Hepatol 2023 May;8(5):432-445. Epub 2023 Mar 14 doi: 10.1016/S2468-1253(23)00004-3. PMID: 36931287
Long-term Incidence Rates of Esophageal Squamous Cell Carcinoma in Chinese Patients With Low-grade Intraepithelial Neoplasia and Association of Surveillance Endoscopy With Incidence.
Li H, Wu H, Cao M, Yu Y, Zhou J, Zhang S, Tong F, Gong J, Wang H, Yang F, He S, Yan X, Zhang S, Luo P, Ma H, Liang L, Xia C, Chen W
JAMA Netw Open 2022 Dec 1;5(12):e2247415. doi: 10.1001/jamanetworkopen.2022.47415. PMID: 36534402Free PMC Article
Endoscopic detection of esophageal low-grade squamous dysplasia: How to predict pathologic upgrades before treatment?
Chen H, Zhou XY, Li S, Jiang LQ, Hua J, Si XM, Zhang GX
J Dig Dis 2022 Apr;23(4):209-219. doi: 10.1111/1751-2980.13095. PMID: 35373467

Diagnosis

Squamous Neoplastic Precursor Lesions of the Esophagus.
Arai T, Ono S, Takubo K
Gastroenterol Clin North Am 2024 Mar;53(1):25-38. Epub 2023 Oct 23 doi: 10.1016/j.gtc.2023.09.004. PMID: 38280749
Machine learning-based automated sponge cytology for screening of oesophageal squamous cell carcinoma and adenocarcinoma of the oesophagogastric junction: a nationwide, multicohort, prospective study.
Gao Y, Xin L, Lin H, Yao B, Zhang T, Zhou AJ, Huang S, Wang JH, Feng YD, Yao SH, Guo Y, Dang T, Meng XM, Yang ZZ, Jia WQ, Pang HF, Tian XJ, Deng B, Wang JP, Fan WC, Wang J, Shi LH, Yang GY, Sun C, Wang W, Zang JC, Li SY, Shi RH, Li ZS, Wang LW
Lancet Gastroenterol Hepatol 2023 May;8(5):432-445. Epub 2023 Mar 14 doi: 10.1016/S2468-1253(23)00004-3. PMID: 36931287
Long-term Incidence Rates of Esophageal Squamous Cell Carcinoma in Chinese Patients With Low-grade Intraepithelial Neoplasia and Association of Surveillance Endoscopy With Incidence.
Li H, Wu H, Cao M, Yu Y, Zhou J, Zhang S, Tong F, Gong J, Wang H, Yang F, He S, Yan X, Zhang S, Luo P, Ma H, Liang L, Xia C, Chen W
JAMA Netw Open 2022 Dec 1;5(12):e2247415. doi: 10.1001/jamanetworkopen.2022.47415. PMID: 36534402Free PMC Article
Risk factors for esophageal squamous cell carcinoma and its histological precursor lesions in China: a multicenter cross-sectional study.
Niu C, Liu Y, Wang J, Liu Y, Zhang S, Zhang Y, Zhang L, Zhao D, Liu F, Chao L, Wang X, Zhang C, Song G, Zhang Z, Li Y, Yan Z, Wen Y, Ge Y, Zang Z, Feng W, Zhang H, Tao L, Nakyeyune R, Shen Y, Shao Y, Guo X, Miles T, Yang A, Liu F, Wang G
BMC Cancer 2021 Sep 16;21(1):1034. doi: 10.1186/s12885-021-08764-x. PMID: 34530751Free PMC Article
Squamous intraepithelial neoplasia of the esophagus: past, present, and future.
Shimizu M, Nagata K, Yamaguchi H, Kita H
J Gastroenterol 2009;44(2):103-12. Epub 2009 Feb 13 doi: 10.1007/s00535-008-2298-y. PMID: 19214671

Therapy

Risk factors for esophageal squamous cell carcinoma and its histological precursor lesions in China: a multicenter cross-sectional study.
Niu C, Liu Y, Wang J, Liu Y, Zhang S, Zhang Y, Zhang L, Zhao D, Liu F, Chao L, Wang X, Zhang C, Song G, Zhang Z, Li Y, Yan Z, Wen Y, Ge Y, Zang Z, Feng W, Zhang H, Tao L, Nakyeyune R, Shen Y, Shao Y, Guo X, Miles T, Yang A, Liu F, Wang G
BMC Cancer 2021 Sep 16;21(1):1034. doi: 10.1186/s12885-021-08764-x. PMID: 34530751Free PMC Article
Expression and significance of ASPP2 in squamous carcinoma of esophagus.
Liu B, Yang L, Li XJ, Li R, Sun W, Chen XY, Liu JC
Kaohsiung J Med Sci 2018 Jun;34(6):321-329. Epub 2018 Jan 19 doi: 10.1016/j.kjms.2017.12.011. PMID: 29747775
Nitrous oxide cryotherapy for treatment of esophageal squamous cell neoplasia: initial multicenter international experience with a novel portable cryoballoon ablation system (with video).
Canto MI, Abrams JA, Künzli HT, Weusten B, Komatsu Y, Jobe BA, Lightdale CJ
Gastrointest Endosc 2018 Feb;87(2):574-581. Epub 2017 Jul 16 doi: 10.1016/j.gie.2017.07.013. PMID: 28720474
Effects of endoscopic mucosal resection in patients with low-grade intraepithelial dysplasia of esophageal squamous cells.
Li H, Cheng JL, Dong NN, Cui CY, Diao TY, Zhou XR
Dig Surg 2013;30(4-6):302-8. Epub 2013 Sep 17 doi: 10.1159/000354577. PMID: 24051496
Endoscopic and surgical resection of T1a/T1b esophageal neoplasms: a systematic review.
Sgourakis G, Gockel I, Lang H
World J Gastroenterol 2013 Mar 7;19(9):1424-37. doi: 10.3748/wjg.v19.i9.1424. PMID: 23539431Free PMC Article

Prognosis

Spatial transcriptomics analysis of esophageal squamous precancerous lesions and their progression to esophageal cancer.
Liu X, Zhao S, Wang K, Zhou L, Jiang M, Gao Y, Yang R, Yan S, Zhang W, Lu B, Liu F, Zhao R, Liu W, Zhang Z, Liu K, Li X, Dong Z
Nat Commun 2023 Aug 8;14(1):4779. doi: 10.1038/s41467-023-40343-5. PMID: 37553345Free PMC Article
Machine learning-based automated sponge cytology for screening of oesophageal squamous cell carcinoma and adenocarcinoma of the oesophagogastric junction: a nationwide, multicohort, prospective study.
Gao Y, Xin L, Lin H, Yao B, Zhang T, Zhou AJ, Huang S, Wang JH, Feng YD, Yao SH, Guo Y, Dang T, Meng XM, Yang ZZ, Jia WQ, Pang HF, Tian XJ, Deng B, Wang JP, Fan WC, Wang J, Shi LH, Yang GY, Sun C, Wang W, Zang JC, Li SY, Shi RH, Li ZS, Wang LW
Lancet Gastroenterol Hepatol 2023 May;8(5):432-445. Epub 2023 Mar 14 doi: 10.1016/S2468-1253(23)00004-3. PMID: 36931287
Long-term Incidence Rates of Esophageal Squamous Cell Carcinoma in Chinese Patients With Low-grade Intraepithelial Neoplasia and Association of Surveillance Endoscopy With Incidence.
Li H, Wu H, Cao M, Yu Y, Zhou J, Zhang S, Tong F, Gong J, Wang H, Yang F, He S, Yan X, Zhang S, Luo P, Ma H, Liang L, Xia C, Chen W
JAMA Netw Open 2022 Dec 1;5(12):e2247415. doi: 10.1001/jamanetworkopen.2022.47415. PMID: 36534402Free PMC Article
Endoscopic detection of esophageal low-grade squamous dysplasia: How to predict pathologic upgrades before treatment?
Chen H, Zhou XY, Li S, Jiang LQ, Hua J, Si XM, Zhang GX
J Dig Dis 2022 Apr;23(4):209-219. doi: 10.1111/1751-2980.13095. PMID: 35373467
Endoscopic and surgical resection of T1a/T1b esophageal neoplasms: a systematic review.
Sgourakis G, Gockel I, Lang H
World J Gastroenterol 2013 Mar 7;19(9):1424-37. doi: 10.3748/wjg.v19.i9.1424. PMID: 23539431Free PMC Article

Clinical prediction guides

Spatial transcriptomics analysis of esophageal squamous precancerous lesions and their progression to esophageal cancer.
Liu X, Zhao S, Wang K, Zhou L, Jiang M, Gao Y, Yang R, Yan S, Zhang W, Lu B, Liu F, Zhao R, Liu W, Zhang Z, Liu K, Li X, Dong Z
Nat Commun 2023 Aug 8;14(1):4779. doi: 10.1038/s41467-023-40343-5. PMID: 37553345Free PMC Article
Machine learning-based automated sponge cytology for screening of oesophageal squamous cell carcinoma and adenocarcinoma of the oesophagogastric junction: a nationwide, multicohort, prospective study.
Gao Y, Xin L, Lin H, Yao B, Zhang T, Zhou AJ, Huang S, Wang JH, Feng YD, Yao SH, Guo Y, Dang T, Meng XM, Yang ZZ, Jia WQ, Pang HF, Tian XJ, Deng B, Wang JP, Fan WC, Wang J, Shi LH, Yang GY, Sun C, Wang W, Zang JC, Li SY, Shi RH, Li ZS, Wang LW
Lancet Gastroenterol Hepatol 2023 May;8(5):432-445. Epub 2023 Mar 14 doi: 10.1016/S2468-1253(23)00004-3. PMID: 36931287
Long-term Incidence Rates of Esophageal Squamous Cell Carcinoma in Chinese Patients With Low-grade Intraepithelial Neoplasia and Association of Surveillance Endoscopy With Incidence.
Li H, Wu H, Cao M, Yu Y, Zhou J, Zhang S, Tong F, Gong J, Wang H, Yang F, He S, Yan X, Zhang S, Luo P, Ma H, Liang L, Xia C, Chen W
JAMA Netw Open 2022 Dec 1;5(12):e2247415. doi: 10.1001/jamanetworkopen.2022.47415. PMID: 36534402Free PMC Article
Endoscopic detection of esophageal low-grade squamous dysplasia: How to predict pathologic upgrades before treatment?
Chen H, Zhou XY, Li S, Jiang LQ, Hua J, Si XM, Zhang GX
J Dig Dis 2022 Apr;23(4):209-219. doi: 10.1111/1751-2980.13095. PMID: 35373467
A review of the current understanding and clinical utility of miRNAs in esophageal cancer.
Sakai NS, Samia-Aly E, Barbera M, Fitzgerald RC
Semin Cancer Biol 2013 Dec;23(6 Pt B):512-21. Epub 2013 Sep 3 doi: 10.1016/j.semcancer.2013.08.005. PMID: 24013023

Recent systematic reviews

Endoscopic and surgical resection of T1a/T1b esophageal neoplasms: a systematic review.
Sgourakis G, Gockel I, Lang H
World J Gastroenterol 2013 Mar 7;19(9):1424-37. doi: 10.3748/wjg.v19.i9.1424. PMID: 23539431Free PMC Article

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