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Gastric neuroendocrine neoplasm

MedGen UID:
232548
Concept ID:
C1333783
Neoplastic Process
Synonyms: Gastric NET; Gastric Neuroendocrine Neoplasm; gastric neuroendocrine neoplasm; Gastric neuroendocrine tumor; GNET; NET of stomach; Neuroendocrine neoplasm of stomach; Neuroendocrine Neoplasm of Stomach; neuroendocrine neoplasm of stomach; Neuroendocrine Neoplasm of the Stomach; neuroendocrine neoplasm of the stomach; neuroendocrine tumor of stomach; Neuroendocrine tumor of stomach; neuroendocrine tumor of the stomach; neuroendocrine tumour of stomach; neuroendocrine tumour of the stomach; stomach NET; Stomach Neuroendocrine Neoplasm; stomach neuroendocrine neoplasm; stomach neuroendocrine tumor; stomach neuroendocrine tumor, well differentiated, low or intermediate grade; stomach neuroendocrine tumour
SNOMED CT: Neuroendocrine neoplasm of stomach (721194008); Gastric neuroendocrine neoplasm (721194008)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0003111
Orphanet: ORPHA100075

Definition

A rare subtype of neuroendocrine neoplasm, arising from enterochromaffin-like cells in the stomach, with a variable clinical presentation, disease course and prognosis, depending on the disease type and histological grade. Most patients are asymptomatic, with diagnosis usually occurring incidentally during gastroscopy, however, symptoms of dyspepsia, anemia, pain, weight loss and gastrointestinal bleeding can be observed. Association with Zollinger-Ellison syndrome and multiple endocrine neoplasia type I has been reported. [from ORDO]

Professional guidelines

PubMed

Shah SC, Piazuelo MB, Kuipers EJ, Li D
Gastroenterology 2021 Oct;161(4):1325-1332.e7. Epub 2021 Aug 26 doi: 10.1053/j.gastro.2021.06.078. PMID: 34454714Free PMC Article
Gonzalez RS
Surg Pathol Clin 2020 Sep;13(3):377-397. doi: 10.1016/j.path.2020.04.002. PMID: 32773190
Norton JA, Foster DS, Ito T, Jensen RT
Endocrinol Metab Clin North Am 2018 Sep;47(3):577-601. doi: 10.1016/j.ecl.2018.04.009. PMID: 30098717Free PMC Article

Recent clinical studies

Etiology

Cavalcoli F, Gallo C, Coltro LA, Rausa E, Cantù P, Invernizzi P, Massironi S
Medicina (Kaunas) 2023 Oct 1;59(10) doi: 10.3390/medicina59101757. PMID: 37893475Free PMC Article
Liang W, Xu X, Liu Y, Cui J, Gao Y, Wang C, Zhuang Z, Zhang K, Xi H, Cai A, Wei B, Chen L
World J Surg Oncol 2022 Nov 9;20(1):356. doi: 10.1186/s12957-022-02822-9. PMID: 36348366Free PMC Article
Zhou YJ, Lu XF, Zheng KI, Wang QW, Chen JN, Zhang QW, Yan FR, Li XB
BMC Endocr Disord 2020 Jul 23;20(1):111. doi: 10.1186/s12902-020-00565-w. PMID: 32703291Free PMC Article
Pak LM, Yang T, Wang J
J Gastrointest Surg 2019 Apr;23(4):720-729. Epub 2018 Jun 27 doi: 10.1007/s11605-018-3845-3. PMID: 29951901
Massironi S, Zilli A, Conte D
World J Gastroenterol 2015 Jun 14;21(22):6785-93. doi: 10.3748/wjg.v21.i22.6785. PMID: 26078554Free PMC Article

Diagnosis

Liang W, Xu X, Liu Y, Cui J, Gao Y, Wang C, Zhuang Z, Zhang K, Xi H, Cai A, Wei B, Chen L
World J Surg Oncol 2022 Nov 9;20(1):356. doi: 10.1186/s12957-022-02822-9. PMID: 36348366Free PMC Article
Roseland ME, Francis IR, Shampain KL, Stein EB, Wasnik AP, Millet JD
Abdom Radiol (NY) 2022 Dec;47(12):3993-4004. Epub 2022 Apr 12 doi: 10.1007/s00261-022-03509-1. PMID: 35411433
Abe Y, Hatta W, Asonuma S, Koike T, Abe H, Ogata Y, Saito M, Jin X, Kanno T, Uno K, Asano N, Imatani A, Fujishima F, Sasano H, Masamune A
Intern Med 2022 Aug 15;61(16):2441-2448. Epub 2022 Feb 1 doi: 10.2169/internalmedicine.8253-21. PMID: 35110476Free PMC Article
Zhou YJ, Lu XF, Zheng KI, Wang QW, Chen JN, Zhang QW, Yan FR, Li XB
BMC Endocr Disord 2020 Jul 23;20(1):111. doi: 10.1186/s12902-020-00565-w. PMID: 32703291Free PMC Article
Daskalakis K, Tsoli M, Karapanagioti A, Chrysochoou M, Thomas D, Sougioultzis S, Karoumpalis I, Kaltsas GA, Alexandraki KI
Clin Endocrinol (Oxf) 2019 Oct;91(4):534-543. Epub 2019 Jul 7 doi: 10.1111/cen.14055. PMID: 31254407

Therapy

Massironi S, Zilli A, Conte D
World J Gastroenterol 2015 Jun 14;21(22):6785-93. doi: 10.3748/wjg.v21.i22.6785. PMID: 26078554Free PMC Article

Prognosis

Cavalcoli F, Gallo C, Coltro LA, Rausa E, Cantù P, Invernizzi P, Massironi S
Medicina (Kaunas) 2023 Oct 1;59(10) doi: 10.3390/medicina59101757. PMID: 37893475Free PMC Article
Roseland ME, Francis IR, Shampain KL, Stein EB, Wasnik AP, Millet JD
Abdom Radiol (NY) 2022 Dec;47(12):3993-4004. Epub 2022 Apr 12 doi: 10.1007/s00261-022-03509-1. PMID: 35411433
Daskalakis K, Tsoli M, Karapanagioti A, Chrysochoou M, Thomas D, Sougioultzis S, Karoumpalis I, Kaltsas GA, Alexandraki KI
Clin Endocrinol (Oxf) 2019 Oct;91(4):534-543. Epub 2019 Jul 7 doi: 10.1111/cen.14055. PMID: 31254407
Pak LM, Yang T, Wang J
J Gastrointest Surg 2019 Apr;23(4):720-729. Epub 2018 Jun 27 doi: 10.1007/s11605-018-3845-3. PMID: 29951901
Massironi S, Zilli A, Conte D
World J Gastroenterol 2015 Jun 14;21(22):6785-93. doi: 10.3748/wjg.v21.i22.6785. PMID: 26078554Free PMC Article

Clinical prediction guides

Cavalcoli F, Gallo C, Coltro LA, Rausa E, Cantù P, Invernizzi P, Massironi S
Medicina (Kaunas) 2023 Oct 1;59(10) doi: 10.3390/medicina59101757. PMID: 37893475Free PMC Article
Liang W, Xu X, Liu Y, Cui J, Gao Y, Wang C, Zhuang Z, Zhang K, Xi H, Cai A, Wei B, Chen L
World J Surg Oncol 2022 Nov 9;20(1):356. doi: 10.1186/s12957-022-02822-9. PMID: 36348366Free PMC Article
Zhou YJ, Lu XF, Zheng KI, Wang QW, Chen JN, Zhang QW, Yan FR, Li XB
BMC Endocr Disord 2020 Jul 23;20(1):111. doi: 10.1186/s12902-020-00565-w. PMID: 32703291Free PMC Article
Daskalakis K, Tsoli M, Karapanagioti A, Chrysochoou M, Thomas D, Sougioultzis S, Karoumpalis I, Kaltsas GA, Alexandraki KI
Clin Endocrinol (Oxf) 2019 Oct;91(4):534-543. Epub 2019 Jul 7 doi: 10.1111/cen.14055. PMID: 31254407
Pak LM, Yang T, Wang J
J Gastrointest Surg 2019 Apr;23(4):720-729. Epub 2018 Jun 27 doi: 10.1007/s11605-018-3845-3. PMID: 29951901

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