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Non-Neoplastic Cardiovascular Disorder

MedGen UID:
233232
•Concept ID:
C1334999
•
Disease or Syndrome
Synonym: Non-Neoplastic Cardiovascular Disease

Definition

A non-neoplastic disorder that affects the heart and/or vessels. Representative examples include myocardial infarction, endocarditis, arteriosclerosis, thrombosis, and lymphedema. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNon-Neoplastic Cardiovascular Disorder

Professional guidelines

PubMed

A Clinico-Pathologic Approach to the Differential Diagnosis of Pericardial Tumors.
Krywanczyk AR, Tan CD, Rodriguez ER
Curr Cardiol Rep 2021 Jul 16;23(9):119. doi: 10.1007/s11886-021-01548-6. PMID: 34269901
Current knowledge and management of portal vein thrombosis in cirrhosis.
Senzolo M, Garcia-Tsao G, García-Pagán JC
J Hepatol 2021 Aug;75(2):442-453. Epub 2021 Apr 27 doi: 10.1016/j.jhep.2021.04.029. PMID: 33930474
Cardiac Tumors: Diagnosis, Prognosis, and Treatment.
Bussani R, Castrichini M, Restivo L, Fabris E, Porcari A, Ferro F, Pivetta A, Korcova R, Cappelletto C, Manca P, Nuzzi V, Bessi R, Pagura L, Massa L, Sinagra G
Curr Cardiol Rep 2020 Oct 10;22(12):169. doi: 10.1007/s11886-020-01420-z. PMID: 33040219Free PMC Article

Recent clinical studies

Etiology

The association between genetically elevated polyunsaturated fatty acids and risk of cancer.
Haycock PC, Borges MC, Burrows K, Lemaitre RN, Burgess S, Khankari NK, Tsilidis KK, Gaunt TR, Hemani G, Zheng J, Truong T, Birmann BM, OMara T, Spurdle AB, Iles MM, Law MH, Slager SL, Saberi Hosnijeh F, Mariosa D, Cotterchio M, Cerhan JR, Peters U, Enroth S, Gharahkhani P, Le Marchand L, Williams AC, Block RC; ACCC; CCFR-CORECT-GECCO; EPITHYR; InterLymph; MMAC; ECAC; ILCCO; PRACTICAL Consortium; PanScan; PanC4, Amos CI, Hung RJ, Zheng W, Gunter MJ, Smith GD, Relton C, Martin RM; Fatty Acids in Cancer Mendelian Randomization Collaboration
EBioMedicine 2023 May;91:104510. Epub 2023 Apr 20 doi: 10.1016/j.ebiom.2023.104510. PMID: 37086649Free PMC Article
CYAD-01, an autologous NKG2D-based CAR T-cell therapy, in relapsed or refractory acute myeloid leukaemia and myelodysplastic syndromes or multiple myeloma (THINK): haematological cohorts of the dose escalation segment of a phase 1 trial.
Sallman DA, Kerre T, Havelange V, Poiré X, Lewalle P, Wang ES, Brayer JB, Davila ML, Moors I, Machiels JP, Awada A, Alcantar-Orozco EM, Borissova R, Braun N, Dheur MS, Gilham DE, Lonez C, Lehmann FF, Flament A
Lancet Haematol 2023 Mar;10(3):e191-e202. Epub 2023 Feb 7 doi: 10.1016/S2352-3026(22)00378-7. PMID: 36764323
Current knowledge and management of portal vein thrombosis in cirrhosis.
Senzolo M, Garcia-Tsao G, García-Pagán JC
J Hepatol 2021 Aug;75(2):442-453. Epub 2021 Apr 27 doi: 10.1016/j.jhep.2021.04.029. PMID: 33930474
The Importance of Nephropathology in Kidney Cancer.
Henriksen KJ, Chang A
Semin Nephrol 2020 Jan;40(1):69-75. doi: 10.1016/j.semnephrol.2019.12.008. PMID: 32130968
Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases: A Mendelian Randomization Study.
Telomeres Mendelian Randomization Collaboration, Haycock PC, Burgess S, Nounu A, Zheng J, Okoli GN, Bowden J, Wade KH, Timpson NJ, Evans DM, Willeit P, Aviv A, Gaunt TR, Hemani G, Mangino M, Ellis HP, Kurian KM, Pooley KA, Eeles RA, Lee JE, Fang S, Chen WV, Law MH, Bowdler LM, Iles MM, Yang Q, Worrall BB, Markus HS, Hung RJ, Amos CI, Spurdle AB, Thompson DJ, O'Mara TA, Wolpin B, Amundadottir L, Stolzenberg-Solomon R, Trichopoulou A, Onland-Moret NC, Lund E, Duell EJ, Canzian F, Severi G, Overvad K, Gunter MJ, Tumino R, Svenson U, van Rij A, Baas AF, Bown MJ, Samani NJ, van t'Hof FNG, Tromp G, Jones GT, Kuivaniemi H, Elmore JR, Johansson M, Mckay J, Scelo G, Carreras-Torres R, Gaborieau V, Brennan P, Bracci PM, Neale RE, Olson SH, Gallinger S, Li D, Petersen GM, Risch HA, Klein AP, Han J, Abnet CC, Freedman ND, Taylor PR, Maris JM, Aben KK, Kiemeney LA, Vermeulen SH, Wiencke JK, Walsh KM, Wrensch M, Rice T, Turnbull C, Litchfield K, Paternoster L, Standl M, Abecasis GR, SanGiovanni JP, Li Y, Mijatovic V, Sapkota Y, Low SK, Zondervan KT, Montgomery GW, Nyholt DR, van Heel DA, Hunt K, Arking DE, Ashar FN, Sotoodehnia N, Woo D, Rosand J, Comeau ME, Brown WM, Silverman EK, Hokanson JE, Cho MH, Hui J, Ferreira MA, Thompson PJ, Morrison AC, Felix JF, Smith NL, Christiano AM, Petukhova L, Betz RC, Fan X, Zhang X, Zhu C, Langefeld CD, Thompson SD, Wang F, Lin X, Schwartz DA, Fingerlin T, Rotter JI, Cotch MF, Jensen RA, Munz M, Dommisch H, Schaefer AS, Han F, Ollila HM, Hillary RP, Albagha O, Ralston SH, Zeng C, Zheng W, Shu XO, Reis A, Uebe S, Hüffmeier U, Kawamura Y, Otowa T, Sasaki T, Hibberd ML, Davila S, Xie G, Siminovitch K, Bei JX, Zeng YX, Försti A, Chen B, Landi S, Franke A, Fischer A, Ellinghaus D, Flores C, Noth I, Ma SF, Foo JN, Liu J, Kim JW, Cox DG, Delattre O, Mirabeau O, Skibola CF, Tang CS, Garcia-Barcelo M, Chang KP, Su WH, Chang YS, Martin NG, Gordon S, Wade TD, Lee C, Kubo M, Cha PC, Nakamura Y, Levy D, Kimura M, Hwang SJ, Hunt S, Spector T, Soranzo N, Manichaikul AW, Barr RG, Kahali B, Speliotes E, Yerges-Armstrong LM, Cheng CY, Jonas JB, Wong TY, Fogh I, Lin K, Powell JF, Rice K, Relton CL, Martin RM, Davey Smith G
JAMA Oncol 2017 May 1;3(5):636-651. doi: 10.1001/jamaoncol.2016.5945. PMID: 28241208Free PMC Article

Diagnosis

The association between genetically elevated polyunsaturated fatty acids and risk of cancer.
Haycock PC, Borges MC, Burrows K, Lemaitre RN, Burgess S, Khankari NK, Tsilidis KK, Gaunt TR, Hemani G, Zheng J, Truong T, Birmann BM, OMara T, Spurdle AB, Iles MM, Law MH, Slager SL, Saberi Hosnijeh F, Mariosa D, Cotterchio M, Cerhan JR, Peters U, Enroth S, Gharahkhani P, Le Marchand L, Williams AC, Block RC; ACCC; CCFR-CORECT-GECCO; EPITHYR; InterLymph; MMAC; ECAC; ILCCO; PRACTICAL Consortium; PanScan; PanC4, Amos CI, Hung RJ, Zheng W, Gunter MJ, Smith GD, Relton C, Martin RM; Fatty Acids in Cancer Mendelian Randomization Collaboration
EBioMedicine 2023 May;91:104510. Epub 2023 Apr 20 doi: 10.1016/j.ebiom.2023.104510. PMID: 37086649Free PMC Article
Current knowledge and management of portal vein thrombosis in cirrhosis.
Senzolo M, Garcia-Tsao G, García-Pagán JC
J Hepatol 2021 Aug;75(2):442-453. Epub 2021 Apr 27 doi: 10.1016/j.jhep.2021.04.029. PMID: 33930474
Vascular neoplasms and non-neoplastic vascular lesions of the spleen.
Sangiorgio VFI, Arber DA
Semin Diagn Pathol 2021 Mar;38(2):154-158. Epub 2020 Jul 8 doi: 10.1053/j.semdp.2020.07.001. PMID: 32674844
Cardiac Tumors: Diagnosis, Prognosis, and Treatment.
Bussani R, Castrichini M, Restivo L, Fabris E, Porcari A, Ferro F, Pivetta A, Korcova R, Cappelletto C, Manca P, Nuzzi V, Bessi R, Pagura L, Massa L, Sinagra G
Curr Cardiol Rep 2020 Oct 10;22(12):169. doi: 10.1007/s11886-020-01420-z. PMID: 33040219Free PMC Article
The Importance of Nephropathology in Kidney Cancer.
Henriksen KJ, Chang A
Semin Nephrol 2020 Jan;40(1):69-75. doi: 10.1016/j.semnephrol.2019.12.008. PMID: 32130968

Therapy

The association between genetically elevated polyunsaturated fatty acids and risk of cancer.
Haycock PC, Borges MC, Burrows K, Lemaitre RN, Burgess S, Khankari NK, Tsilidis KK, Gaunt TR, Hemani G, Zheng J, Truong T, Birmann BM, OMara T, Spurdle AB, Iles MM, Law MH, Slager SL, Saberi Hosnijeh F, Mariosa D, Cotterchio M, Cerhan JR, Peters U, Enroth S, Gharahkhani P, Le Marchand L, Williams AC, Block RC; ACCC; CCFR-CORECT-GECCO; EPITHYR; InterLymph; MMAC; ECAC; ILCCO; PRACTICAL Consortium; PanScan; PanC4, Amos CI, Hung RJ, Zheng W, Gunter MJ, Smith GD, Relton C, Martin RM; Fatty Acids in Cancer Mendelian Randomization Collaboration
EBioMedicine 2023 May;91:104510. Epub 2023 Apr 20 doi: 10.1016/j.ebiom.2023.104510. PMID: 37086649Free PMC Article
CYAD-01, an autologous NKG2D-based CAR T-cell therapy, in relapsed or refractory acute myeloid leukaemia and myelodysplastic syndromes or multiple myeloma (THINK): haematological cohorts of the dose escalation segment of a phase 1 trial.
Sallman DA, Kerre T, Havelange V, Poiré X, Lewalle P, Wang ES, Brayer JB, Davila ML, Moors I, Machiels JP, Awada A, Alcantar-Orozco EM, Borissova R, Braun N, Dheur MS, Gilham DE, Lonez C, Lehmann FF, Flament A
Lancet Haematol 2023 Mar;10(3):e191-e202. Epub 2023 Feb 7 doi: 10.1016/S2352-3026(22)00378-7. PMID: 36764323
Targeting Angiogenesis via Resolution of Inflammation.
Kelly AG, Panigrahy D
Cold Spring Harb Perspect Med 2023 Mar 1;13(3) doi: 10.1101/cshperspect.a041172. PMID: 35817542Free PMC Article
Snus: a compelling harm reduction alternative to cigarettes.
Clarke E, Thompson K, Weaver S, Thompson J, O'Connell G
Harm Reduct J 2019 Nov 27;16(1):62. doi: 10.1186/s12954-019-0335-1. PMID: 31775744Free PMC Article
Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases: A Mendelian Randomization Study.
Telomeres Mendelian Randomization Collaboration, Haycock PC, Burgess S, Nounu A, Zheng J, Okoli GN, Bowden J, Wade KH, Timpson NJ, Evans DM, Willeit P, Aviv A, Gaunt TR, Hemani G, Mangino M, Ellis HP, Kurian KM, Pooley KA, Eeles RA, Lee JE, Fang S, Chen WV, Law MH, Bowdler LM, Iles MM, Yang Q, Worrall BB, Markus HS, Hung RJ, Amos CI, Spurdle AB, Thompson DJ, O'Mara TA, Wolpin B, Amundadottir L, Stolzenberg-Solomon R, Trichopoulou A, Onland-Moret NC, Lund E, Duell EJ, Canzian F, Severi G, Overvad K, Gunter MJ, Tumino R, Svenson U, van Rij A, Baas AF, Bown MJ, Samani NJ, van t'Hof FNG, Tromp G, Jones GT, Kuivaniemi H, Elmore JR, Johansson M, Mckay J, Scelo G, Carreras-Torres R, Gaborieau V, Brennan P, Bracci PM, Neale RE, Olson SH, Gallinger S, Li D, Petersen GM, Risch HA, Klein AP, Han J, Abnet CC, Freedman ND, Taylor PR, Maris JM, Aben KK, Kiemeney LA, Vermeulen SH, Wiencke JK, Walsh KM, Wrensch M, Rice T, Turnbull C, Litchfield K, Paternoster L, Standl M, Abecasis GR, SanGiovanni JP, Li Y, Mijatovic V, Sapkota Y, Low SK, Zondervan KT, Montgomery GW, Nyholt DR, van Heel DA, Hunt K, Arking DE, Ashar FN, Sotoodehnia N, Woo D, Rosand J, Comeau ME, Brown WM, Silverman EK, Hokanson JE, Cho MH, Hui J, Ferreira MA, Thompson PJ, Morrison AC, Felix JF, Smith NL, Christiano AM, Petukhova L, Betz RC, Fan X, Zhang X, Zhu C, Langefeld CD, Thompson SD, Wang F, Lin X, Schwartz DA, Fingerlin T, Rotter JI, Cotch MF, Jensen RA, Munz M, Dommisch H, Schaefer AS, Han F, Ollila HM, Hillary RP, Albagha O, Ralston SH, Zeng C, Zheng W, Shu XO, Reis A, Uebe S, Hüffmeier U, Kawamura Y, Otowa T, Sasaki T, Hibberd ML, Davila S, Xie G, Siminovitch K, Bei JX, Zeng YX, Försti A, Chen B, Landi S, Franke A, Fischer A, Ellinghaus D, Flores C, Noth I, Ma SF, Foo JN, Liu J, Kim JW, Cox DG, Delattre O, Mirabeau O, Skibola CF, Tang CS, Garcia-Barcelo M, Chang KP, Su WH, Chang YS, Martin NG, Gordon S, Wade TD, Lee C, Kubo M, Cha PC, Nakamura Y, Levy D, Kimura M, Hwang SJ, Hunt S, Spector T, Soranzo N, Manichaikul AW, Barr RG, Kahali B, Speliotes E, Yerges-Armstrong LM, Cheng CY, Jonas JB, Wong TY, Fogh I, Lin K, Powell JF, Rice K, Relton CL, Martin RM, Davey Smith G
JAMA Oncol 2017 May 1;3(5):636-651. doi: 10.1001/jamaoncol.2016.5945. PMID: 28241208Free PMC Article

Prognosis

A Clinico-Pathologic Approach to the Differential Diagnosis of Pericardial Tumors.
Krywanczyk AR, Tan CD, Rodriguez ER
Curr Cardiol Rep 2021 Jul 16;23(9):119. doi: 10.1007/s11886-021-01548-6. PMID: 34269901
Current knowledge and management of portal vein thrombosis in cirrhosis.
Senzolo M, Garcia-Tsao G, García-Pagán JC
J Hepatol 2021 Aug;75(2):442-453. Epub 2021 Apr 27 doi: 10.1016/j.jhep.2021.04.029. PMID: 33930474
Vascular neoplasms and non-neoplastic vascular lesions of the spleen.
Sangiorgio VFI, Arber DA
Semin Diagn Pathol 2021 Mar;38(2):154-158. Epub 2020 Jul 8 doi: 10.1053/j.semdp.2020.07.001. PMID: 32674844
Cardiac Tumors: Diagnosis, Prognosis, and Treatment.
Bussani R, Castrichini M, Restivo L, Fabris E, Porcari A, Ferro F, Pivetta A, Korcova R, Cappelletto C, Manca P, Nuzzi V, Bessi R, Pagura L, Massa L, Sinagra G
Curr Cardiol Rep 2020 Oct 10;22(12):169. doi: 10.1007/s11886-020-01420-z. PMID: 33040219Free PMC Article
Contrast - in cardiac magnetic resonance imaging.
Patel N, Kolakalapudi P, Arora G
Echocardiography 2018 Mar;35(3):401-409. Epub 2018 Feb 23 doi: 10.1111/echo.13845. PMID: 29474744Free PMC Article

Clinical prediction guides

Clinical outcomes and prognostic factors in non-cirrhotic non-neoplastic patients with portal vein thrombosis: A single-centre experience.
Gioia S, Riggio O, Nardelli S, Ridola L, Marzano C
Dig Liver Dis 2023 Nov;55(11):1487-1495. Epub 2023 May 23 doi: 10.1016/j.dld.2023.05.007. PMID: 37230857
Neoplastic and Non-Neoplastic Causes of Acute Intracerebral Hemorrhage on CT : The Diagnostic Value of Perihematomal Edema.
Nawabi J, Hanning U, Broocks G, Schön G, Schneider T, Fiehler J, Thaler C, Gellissen S
Clin Neuroradiol 2020 Jun;30(2):271-278. Epub 2019 Mar 21 doi: 10.1007/s00062-019-00774-4. PMID: 30899965
Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases: A Mendelian Randomization Study.
Telomeres Mendelian Randomization Collaboration, Haycock PC, Burgess S, Nounu A, Zheng J, Okoli GN, Bowden J, Wade KH, Timpson NJ, Evans DM, Willeit P, Aviv A, Gaunt TR, Hemani G, Mangino M, Ellis HP, Kurian KM, Pooley KA, Eeles RA, Lee JE, Fang S, Chen WV, Law MH, Bowdler LM, Iles MM, Yang Q, Worrall BB, Markus HS, Hung RJ, Amos CI, Spurdle AB, Thompson DJ, O'Mara TA, Wolpin B, Amundadottir L, Stolzenberg-Solomon R, Trichopoulou A, Onland-Moret NC, Lund E, Duell EJ, Canzian F, Severi G, Overvad K, Gunter MJ, Tumino R, Svenson U, van Rij A, Baas AF, Bown MJ, Samani NJ, van t'Hof FNG, Tromp G, Jones GT, Kuivaniemi H, Elmore JR, Johansson M, Mckay J, Scelo G, Carreras-Torres R, Gaborieau V, Brennan P, Bracci PM, Neale RE, Olson SH, Gallinger S, Li D, Petersen GM, Risch HA, Klein AP, Han J, Abnet CC, Freedman ND, Taylor PR, Maris JM, Aben KK, Kiemeney LA, Vermeulen SH, Wiencke JK, Walsh KM, Wrensch M, Rice T, Turnbull C, Litchfield K, Paternoster L, Standl M, Abecasis GR, SanGiovanni JP, Li Y, Mijatovic V, Sapkota Y, Low SK, Zondervan KT, Montgomery GW, Nyholt DR, van Heel DA, Hunt K, Arking DE, Ashar FN, Sotoodehnia N, Woo D, Rosand J, Comeau ME, Brown WM, Silverman EK, Hokanson JE, Cho MH, Hui J, Ferreira MA, Thompson PJ, Morrison AC, Felix JF, Smith NL, Christiano AM, Petukhova L, Betz RC, Fan X, Zhang X, Zhu C, Langefeld CD, Thompson SD, Wang F, Lin X, Schwartz DA, Fingerlin T, Rotter JI, Cotch MF, Jensen RA, Munz M, Dommisch H, Schaefer AS, Han F, Ollila HM, Hillary RP, Albagha O, Ralston SH, Zeng C, Zheng W, Shu XO, Reis A, Uebe S, Hüffmeier U, Kawamura Y, Otowa T, Sasaki T, Hibberd ML, Davila S, Xie G, Siminovitch K, Bei JX, Zeng YX, Försti A, Chen B, Landi S, Franke A, Fischer A, Ellinghaus D, Flores C, Noth I, Ma SF, Foo JN, Liu J, Kim JW, Cox DG, Delattre O, Mirabeau O, Skibola CF, Tang CS, Garcia-Barcelo M, Chang KP, Su WH, Chang YS, Martin NG, Gordon S, Wade TD, Lee C, Kubo M, Cha PC, Nakamura Y, Levy D, Kimura M, Hwang SJ, Hunt S, Spector T, Soranzo N, Manichaikul AW, Barr RG, Kahali B, Speliotes E, Yerges-Armstrong LM, Cheng CY, Jonas JB, Wong TY, Fogh I, Lin K, Powell JF, Rice K, Relton CL, Martin RM, Davey Smith G
JAMA Oncol 2017 May 1;3(5):636-651. doi: 10.1001/jamaoncol.2016.5945. PMID: 28241208Free PMC Article
Long-term complications of lymphoma and its treatment.
Ng AK, LaCasce A, Travis LB
J Clin Oncol 2011 May 10;29(14):1885-92. Epub 2011 Apr 11 doi: 10.1200/JCO.2010.32.8427. PMID: 21483015
The non-neoplastic kidney in tumor nephrectomy specimens: what can it show and what is important?
Bonsib SM, Pei Y
Adv Anat Pathol 2010 Jul;17(4):235-50. doi: 10.1097/PAP.0b013e3181e3c02d. PMID: 20574169

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