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Ovarian Granulosa-Stromal Cell Tumor

MedGen UID:
233274
•Concept ID:
C1335162
•
Neoplastic Process

Definition

A group of sex cord-stromal tumors that arise from the ovary. These tumors are characterized by the presence of granulosa cells, stromal cells, and/or theca cells. This group includes granulosa cell tumor and tumors of the thecoma/fibroma group. [from NCI]

Recent clinical studies

Etiology

Trisomy 8 as sole karyotypic aberration in an ovarian metastasizing Sertoli-Leydig cell tumor.
Manegold E, Tietze L, Günther K, Fleischer A, Amo-Takyi BK, Schröder W, Handt S
Hum Pathol 2001 May;32(5):559-62. doi: 10.1053/hupa.2001.24316. PMID: 11381376
Ovarian granulosa-stromal cell tumors are characterized by trisomy 12.
Fletcher JA, Gibas Z, Donovan K, Perez-Atayde A, Genest D, Morton CC, Lage JM
Am J Pathol 1991 Mar;138(3):515-20. PMID: 2000932Free PMC Article

Prognosis

Trisomy 8 as sole karyotypic aberration in an ovarian metastasizing Sertoli-Leydig cell tumor.
Manegold E, Tietze L, Günther K, Fleischer A, Amo-Takyi BK, Schröder W, Handt S
Hum Pathol 2001 May;32(5):559-62. doi: 10.1053/hupa.2001.24316. PMID: 11381376

Clinical prediction guides

Nuclear localization of E-cadherin but not beta-catenin in human ovarian granulosa cell tumours and normal ovarian follicles and ovarian stroma.
Ohishi Y, Oda Y, Kurihara S, Kaku T, Kobayashi H, Wake N, Tsuneyoshi M
Histopathology 2011 Feb;58(3):423-32. Epub 2011 Feb 7 doi: 10.1111/j.1365-2559.2011.03761.x. PMID: 21299609
Human ovarian tumors express gamma-glutamyl transpeptidase.
Hanigan MH, Frierson HF Jr, Brown JE, Lovell MA, Taylor PT
Cancer Res 1994 Jan 1;54(1):286-90. PMID: 7903206
Trisomy 12 in pediatric granulosa-stromal cell tumors. Demonstration by a modified method of fluorescence in situ hybridization on paraffin-embedded material.
Schofield DE, Fletcher JA
Am J Pathol 1992 Dec;141(6):1265-9. PMID: 1466394Free PMC Article

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