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Cavernous hemangioma of the face

MedGen UID:
Concept ID:
Neoplastic Process
Synonyms: Cavernous Hemangioma of Face; cavernous hemangioma of face; Cavernous Hemangioma of the Face; cavernous hemangioma of the Face; face cavernous hemangioma
HPO: HP:0007486
Monarch Initiative: MONDO:0003645


A cavernous hemangioma arising from the face. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCavernous hemangioma of the face

Conditions with this feature

Roberts-SC phocomelia syndrome
MedGen UID:
Concept ID:
Disease or Syndrome
ESCO2 spectrum disorder is characterized by mild-to-severe prenatal growth restriction, limb malformations (which can include bilateral symmetric tetraphocomelia or hypomelia caused by mesomelic shortening), hand anomalies (including oligodactyly, thumb aplasia or hypoplasia, and syndactyly), elbow and knee flexion contractures (involving elbows, wrists, knees, ankles, and feet [talipes equinovarus]), and craniofacial abnormalities (which can include bilateral cleft lip and/or cleft palate, micrognathia, widely spaced eyes, exophthalmos, downslanted palpebral fissures, malar flattening, and underdeveloped ala nasi), ear malformation, and corneal opacities. Intellectual disability (ranging from mild to severe) is common. Early mortality is common among severely affected pregnancies and newborns; mildly affected individuals may survive to adulthood.
Cavernous hemangiomas of face-supraumbilical midline raphe syndrome
MedGen UID:
Concept ID:
Neoplastic Process
PHACE syndrome
MedGen UID:
Concept ID:
Disease or Syndrome
PHACE is an acronym for a neurocutaneous syndrome encompassing the following features: posterior fossa brain malformations, hemangiomas of the face (large or complex), arterial anomalies, cardiac anomalies, and eye abnormalities. The association is referred to as PHACES when ventral developmental defects, such as sternal clefting or supraumbilical raphe, are present (summary by Bracken et al., 2011).

Professional guidelines


Muntianu LAS, Mihai G, Bodnar T
J Craniofac Surg 2022 Jul-Aug 01;33(5):e470-e472. Epub 2022 Jun 27 doi: 10.1097/SCS.0000000000008365. PMID: 35758425
Hoque S, Das BK
Pediatr Surg Int 2011 May;27(5):527-31. doi: 10.1007/s00383-010-2824-x. PMID: 21290138
Niechajev IA, Clodius L
Ann Plast Surg 1993 Jul;31(1):32-41. PMID: 8357218

Recent clinical studies


Gass JD
Trans Am Ophthalmol Soc 1996;94:227-37; discussion 237-9. PMID: 8981698Free PMC Article
Itoh K, Nishimura K, Togashi K, Fujisawa I, Nakano Y, Itoh H, Torizuka K
J Comput Assist Tomogr 1986 Sep-Oct;10(5):831-5. doi: 10.1097/00004728-198609000-00024. PMID: 3745555

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