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Endometrial squamous cell carcinoma

MedGen UID:
234217
•Concept ID:
C1333396
•
Neoplastic Process
Synonyms: Endometrial Squamous Cell Carcinoma; endometrial squamous cell carcinoma; endometrium squamous cell carcinoma; Primary squamous cell carcinoma of endometrium; Squamous Cell Carcinoma of Endometrium; squamous cell carcinoma of endometrium; Squamous Cell Carcinoma of the Endometrium; squamous cell carcinoma of the endometrium
SNOMED CT: Endometrial squamous cell carcinoma (733359005); Primary squamous cell carcinoma of endometrium (733359005)
 
Monarch Initiative: MONDO:0006198

Definition

A primary carcinoma of the endometrium characterized by the presence of malignant squamous cells. [from NCI]

Professional guidelines

PubMed

Molecular Analysis of HPV-independent Primary Endometrial Squamous Cell Carcinoma Reveals TP53 and CDKN2A Comutations : A Clinicopathologic Analysis With Re-evaluation of Diagnostic Criteria.
Hopkins MR, Palsgrove DN, Ronnett BM, Vang R, Lin J, Murdock TA
Am J Surg Pathol 2022 Dec 1;46(12):1611-1622. Epub 2022 Sep 5 doi: 10.1097/PAS.0000000000001970. PMID: 36069815

Recent clinical studies

Etiology

Molecular Analysis of HPV-independent Primary Endometrial Squamous Cell Carcinoma Reveals TP53 and CDKN2A Comutations : A Clinicopathologic Analysis With Re-evaluation of Diagnostic Criteria.
Hopkins MR, Palsgrove DN, Ronnett BM, Vang R, Lin J, Murdock TA
Am J Surg Pathol 2022 Dec 1;46(12):1611-1622. Epub 2022 Sep 5 doi: 10.1097/PAS.0000000000001970. PMID: 36069815
Low grade uterine stromal sarcoma and squamous cell carcinoma associated with an IUD: a report of 2 cases.
Valente PT, Ahmad MM
J Reprod Med 2004 Apr;49(4):324-8. PMID: 15134161
Primary squamous cell carcinoma of the endometrium: a case report and a suggestion of new histogenesis.
Yamamoto Y, Izumi K, Otsuka H, Kishi Y, Mimura T, Okitsu O
Int J Gynecol Pathol 1995 Jan;14(1):75-80. doi: 10.1097/00004347-199501000-00013. PMID: 7883431
Primary endometrial squamous cell carcinoma with long-term survival.
Dalrymple JC, Russell P
Aust N Z J Obstet Gynaecol 1993 Aug;33(3):330-2. doi: 10.1111/j.1479-828x.1993.tb02102.x. PMID: 7508224

Diagnosis

Endometrial serous carcinoma with extensive squamous differentiation mimicking primary endometrial squamous cell carcinoma: Clinicopathological and molecular analysis of a case with literature review.
Santoro A, Travaglino A, Arciuolo D, Fulgione C, Pasquini S, Minucci A, Raffone A, Inzani F, Zannoni GF
Pathol Res Pract 2022 Dec;240:154209. Epub 2022 Nov 9 doi: 10.1016/j.prp.2022.154209. PMID: 36423403
Molecular Analysis of HPV-independent Primary Endometrial Squamous Cell Carcinoma Reveals TP53 and CDKN2A Comutations : A Clinicopathologic Analysis With Re-evaluation of Diagnostic Criteria.
Hopkins MR, Palsgrove DN, Ronnett BM, Vang R, Lin J, Murdock TA
Am J Surg Pathol 2022 Dec 1;46(12):1611-1622. Epub 2022 Sep 5 doi: 10.1097/PAS.0000000000001970. PMID: 36069815
PAX8 Positivity, Abnormal p53 Expression, and p16 Negativity in a Primary Endometrial Squamous Cell Carcinoma: A Case Report and Review of the Literature.
Fanni D, Peiretti M, Mais V, Massa E, Gerosa C, Ledda F, Fais ML, Faa G, Angioni S
Int J Gynecol Pathol 2022 Jul 1;41(4):431-435. Epub 2021 Aug 23 doi: 10.1097/PGP.0000000000000820. PMID: 34420026
Primary endometrial squamous cell carcinoma.
Thomakos N, Galaal K, Godfrey KA, Hemming D, Naik R, Hatem MH, Lopes A
Arch Gynecol Obstet 2008 Aug;278(2):177-80. Epub 2008 Jan 31 doi: 10.1007/s00404-008-0567-x. PMID: 18236059
Squamous cell carcinoma of the endometrium: a report of eight cases and a review of the literature.
Goodman A, Zukerberg LR, Rice LW, Fuller AF, Young RH, Scully RE
Gynecol Oncol 1996 Apr;61(1):54-60. doi: 10.1006/gyno.1996.0096. PMID: 8626118

Therapy

Low grade uterine stromal sarcoma and squamous cell carcinoma associated with an IUD: a report of 2 cases.
Valente PT, Ahmad MM
J Reprod Med 2004 Apr;49(4):324-8. PMID: 15134161
Endometrial squamous cell carcinoma following whole pelvic radiation therapy: response to carboplatin.
Sorosky JI, Kaminski PF, Kreider J, Podczaski ES, Olt GJ, Zaino R
Gynecol Oncol 1995 Jun;57(3):426-9. doi: 10.1006/gyno.1995.1167. PMID: 7774850
Primary endometrial squamous cell carcinoma with long-term survival.
Dalrymple JC, Russell P
Aust N Z J Obstet Gynaecol 1993 Aug;33(3):330-2. doi: 10.1111/j.1479-828x.1993.tb02102.x. PMID: 7508224

Prognosis

Primary squamous cell carcinoma of the endometrium in a woman of perimenopausal age: A case report.
Zhang C, Zhang H, Yang L, Wang Y, Li X, Guo J, Xu J
Medicine (Baltimore) 2018 Nov;97(48):e13418. doi: 10.1097/MD.0000000000013418. PMID: 30508948Free PMC Article
p16, p14, p53, cyclin D1, and steroid hormone receptor expression and human papillomaviruses analysis in primary squamous cell carcinoma of the endometrium.
Horn LC, Richter CE, Einenkel J, Tannapfel A, Liebert UG, Leo C
Ann Diagn Pathol 2006 Aug;10(4):193-6. doi: 10.1016/j.anndiagpath.2005.09.001. PMID: 16844559
Five-year survival of a patient with primary endometrial squamous cell carcinoma: a case report and review of the literature.
Varras M, Kioses E
Eur J Gynaecol Oncol 2002;23(4):327-9. PMID: 12214735
Primary squamous cell carcinoma of the endometrium: a case report and a suggestion of new histogenesis.
Yamamoto Y, Izumi K, Otsuka H, Kishi Y, Mimura T, Okitsu O
Int J Gynecol Pathol 1995 Jan;14(1):75-80. doi: 10.1097/00004347-199501000-00013. PMID: 7883431

Clinical prediction guides

Endometrial serous carcinoma with extensive squamous differentiation mimicking primary endometrial squamous cell carcinoma: Clinicopathological and molecular analysis of a case with literature review.
Santoro A, Travaglino A, Arciuolo D, Fulgione C, Pasquini S, Minucci A, Raffone A, Inzani F, Zannoni GF
Pathol Res Pract 2022 Dec;240:154209. Epub 2022 Nov 9 doi: 10.1016/j.prp.2022.154209. PMID: 36423403

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