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Endometrial endometrioid adenocarcinoma

MedGen UID:
234467
•Concept ID:
C1336905
•
Neoplastic Process
Synonyms: Endometrial Endometrioid Adenocarcinoma; endometrial endometrioid adenocarcinoma; Endometrial Endometrioid Carcinoma; Endometrioid Adenocarcinoma of Endometrium; endometrioid adenocarcinoma of endometrium; Endometrioid Adenocarcinoma of the Endometrium; endometrioid adenocarcinoma of the endometrium; Endometrioid carcinoma of endometrium; Endometrioid Carcinoma of Endometrium; endometrioid carcinoma of endometrium; Endometrioid Carcinoma of the Endometrium; endometrioid carcinoma of the endometrium; endometrioid endomet. adenocar.; endometrioid endometrial adenocarcinoma; Uterine Corpus Endometrioid Adenocarcinoma; uterine corpus endometrioid adenocarcinoma; Uterine Corpus Endometrioid Carcinoma; uterine corpus endometrioid carcinoma; uterine endometrioid carcinoma
SNOMED CT: Endometrial endometrioid adenocarcinoma (1260086007); Endometrioid carcinoma of endometrium (1260086007)
 
Monarch Initiative: MONDO:0006192

Definition

A primary endometrial adenocarcinoma composed of neoplastic cells that form complex glandular patterns associated with budding and branching of the neoplastic glands. The neoplastic glands resemble those of the normal endometrium and may or may not be associated with sheet-like proliferation of malignant cells. Endometrioid adenocarcinoma is the most commonly seen morphologic variant of endometrial adenocarcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEndometrial endometrioid adenocarcinoma

Professional guidelines

PubMed

Adjuvant treatment and outcomes for patients with stage IIIA grade 1 endometrioid endometrial cancer.
Montes de Oca MK, Albright BB, Secord AA, Havrilesky LJ, Moss HA
Int J Gynecol Cancer 2021 Dec;31(12):1549-1556. Epub 2021 Nov 1 doi: 10.1136/ijgc-2021-002884. PMID: 34725205
Fertility-Sparing Treatment for Atypical Endometrial Hyperplasia and Endometrial Cancer: A Cochrane Systematic Review Protocol.
Fernandez-Montoli ME, Sabadell J, Contreras-Perez NA
Adv Ther 2021 May;38(5):2717-2731. Epub 2021 Apr 8 doi: 10.1007/s12325-021-01693-y. PMID: 33830463
Racial disparities in treatment of high-grade endometrial cancer in the Medicare population.
Rauh-Hain JA, Buskwofie A, Clemmer J, Boruta DM, Schorge JO, Del Carmen MG
Obstet Gynecol 2015 Apr;125(4):843-851. doi: 10.1097/AOG.0000000000000605. PMID: 25751197

Recent clinical studies

Etiology

Two Distinct Tumorigenic Processes in Endometrial Endometrioid Adenocarcinoma.
Sugiyama Y, Gotoh O, Fukui N, Tanaka N, Hasumi K, Takazawa Y, Noda T, Mori S
Am J Pathol 2020 Jan;190(1):234-251. Epub 2019 Nov 13 doi: 10.1016/j.ajpath.2019.09.022. PMID: 31733184
BMI and Odds of Endometrial Adenocarcinoma in Czech Women - a Case Control Study.
Tichý M, Ptáčková H, Plančíková D, Majdan M, Chodacká M
Klin Onkol 2019 Summer;32(4):281-287. doi: 10.14735/amko2019281. PMID: 31426644
Endometrium and steroids, a pathologic overview.
Plaza-Parrochia F, Romero C, Valladares L, Vega M
Steroids 2017 Oct;126:85-91. Epub 2017 Aug 18 doi: 10.1016/j.steroids.2017.08.007. PMID: 28827068
Morphological, imaging and surgical aspects in endometrial endometrioid adenocarcinoma.
Berceanu C, Stepan AE, MehedinŢu C, Cîrstoiu MM, Ciortea R, Berceanu S, Gheonea IA, Brătilă E
Rom J Morphol Embryol 2016;57(3):995-1002. PMID: 28002515
Food intake and the risk of endometrial endometrioid adenocarcinoma in Japanese women.
Takayama S, Monma Y, Tsubota-Utsugi M, Nagase S, Tsubono Y, Numata T, Toyoshima M, Utsunomiya H, Sugawara J, Yaegashi N
Nutr Cancer 2013;65(7):954-60. Epub 2013 Sep 20 doi: 10.1080/01635581.2013.818158. PMID: 24053697

Diagnosis

Low grade endometrial endometrioid adenocarcinoma: A review and update with emphasis on morphologic variants, mimics, immunohistochemical and molecular features.
Lucas E, Carrick KS
Semin Diagn Pathol 2022 May;39(3):159-175. Epub 2022 Feb 11 doi: 10.1053/j.semdp.2022.02.002. PMID: 35397943
RRBP1 overexpression is associated with progression and prognosis in endometrial endometrioid adenocarcinoma.
Liu S, Lin M, Ji H, Ding J, Zhu J, Ma R, Meng F
Diagn Pathol 2019 Jan 26;14(1):7. doi: 10.1186/s13000-019-0784-6. PMID: 30684972Free PMC Article
Endometrium and steroids, a pathologic overview.
Plaza-Parrochia F, Romero C, Valladares L, Vega M
Steroids 2017 Oct;126:85-91. Epub 2017 Aug 18 doi: 10.1016/j.steroids.2017.08.007. PMID: 28827068
Morphological, imaging and surgical aspects in endometrial endometrioid adenocarcinoma.
Berceanu C, Stepan AE, MehedinŢu C, Cîrstoiu MM, Ciortea R, Berceanu S, Gheonea IA, Brătilă E
Rom J Morphol Embryol 2016;57(3):995-1002. PMID: 28002515
Undifferentiated endometrial carcinoma: a diagnosis frequently overlooked.
Al-Loh S, Al-Hussaini M
Arch Pathol Lab Med 2013 Mar;137(3):438-42. doi: 10.5858/arpa.2011-0461-RS. PMID: 23451754

Therapy

The role of prolonged progestin treatment and factors predicting successful fertility-sparing treatment for early endometrial endometrioid adenocarcinoma.
Ou YC, Fu HC, Lan J, Wu CH, Kung FT, Lan KC, Tsai YC, Lin H
Eur J Obstet Gynecol Reprod Biol 2021 Dec;267:99-104. Epub 2021 Oct 29 doi: 10.1016/j.ejogrb.2021.10.026. PMID: 34739876
Expression Patterns of the Wnt Pathway Inhibitors Dickkopf3 and Secreted Frizzled-Related Proteins 1 and 4 in Endometrial Endometrioid Adenocarcinoma: An NRG Oncology/Gynecologic Oncology Group Study.
Eskander RN, Ali S, Dellinger T, Lankes HA, Randall LM, Ramirez NC, Monk BJ, Walker JL, Eisenhauer E, Hoang BH
Int J Gynecol Cancer 2016 Jan;26(1):125-32. doi: 10.1097/IGC.0000000000000563. PMID: 26397159Free PMC Article
Circulating microRNAs as a fingerprint for endometrial endometrioid adenocarcinoma.
Wang L, Chen YJ, Xu K, Xu H, Shen XZ, Tu RQ
PLoS One 2014;9(10):e110767. Epub 2014 Oct 20 doi: 10.1371/journal.pone.0110767. PMID: 25329674Free PMC Article
Case-control study of coffee consumption and the risk of endometrial endometrioid adenocarcinoma.
Koizumi T, Nakaya N, Okamura C, Sato Y, Shimazu T, Nagase S, Niikura H, Kuriyama S, Tase T, Ito K, Tsubono Y, Okamura K, Yaegashi N, Tsuji I
Eur J Cancer Prev 2008 Aug;17(4):358-63. doi: 10.1097/CEJ.0b013e3282f0c02c. PMID: 18562962
Dipeptidyl peptidase IV expression in endometrial endometrioid adenocarcinoma and its inverse correlation with tumor grade.
Khin EE, Kikkawa F, Ino K, Kajiyama H, Suzuki T, Shibata K, Tamakoshi K, Nagasaka T, Mizutani S
Am J Obstet Gynecol 2003 Mar;188(3):670-6. doi: 10.1067/mob.2003.169. PMID: 12634639

Prognosis

Two Distinct Tumorigenic Processes in Endometrial Endometrioid Adenocarcinoma.
Sugiyama Y, Gotoh O, Fukui N, Tanaka N, Hasumi K, Takazawa Y, Noda T, Mori S
Am J Pathol 2020 Jan;190(1):234-251. Epub 2019 Nov 13 doi: 10.1016/j.ajpath.2019.09.022. PMID: 31733184
RRBP1 overexpression is associated with progression and prognosis in endometrial endometrioid adenocarcinoma.
Liu S, Lin M, Ji H, Ding J, Zhu J, Ma R, Meng F
Diagn Pathol 2019 Jan 26;14(1):7. doi: 10.1186/s13000-019-0784-6. PMID: 30684972Free PMC Article
Cyclins A, B, E and p27 in Endometrial Endometrioid Adenocarcinoma.
Santala S, Talvensaari-Mattila A, Soini Y, Kuvaja P, Santala M
Anticancer Res 2016 Dec;36(12):6467-6473. doi: 10.21873/anticanres.11245. PMID: 27919969
Patterns of myoinvasion in endometrial adenocarcinoma: recognition and implications.
Cole AJ, Quick CM
Adv Anat Pathol 2013 May;20(3):141-7. doi: 10.1097/PAP.0b013e31828d17cc. PMID: 23574770
Small-cell carcinoma of the endometrium. A clinicopathological study of sixteen cases.
Huntsman DG, Clement PB, Gilks CB, Scully RE
Am J Surg Pathol 1994 Apr;18(4):364-75. doi: 10.1097/00000478-199404000-00005. PMID: 7511354

Clinical prediction guides

The role of prolonged progestin treatment and factors predicting successful fertility-sparing treatment for early endometrial endometrioid adenocarcinoma.
Ou YC, Fu HC, Lan J, Wu CH, Kung FT, Lan KC, Tsai YC, Lin H
Eur J Obstet Gynecol Reprod Biol 2021 Dec;267:99-104. Epub 2021 Oct 29 doi: 10.1016/j.ejogrb.2021.10.026. PMID: 34739876
Construction and validation of nomograms for predicting the prognosis of grade 3 endometrial endometrioid adenocarcinoma cancers: a SEER-based study.
Liu X, Zhao J, Sun Z, Wang G
Bioengineered 2021 Dec;12(1):1752-1765. doi: 10.1080/21655979.2021.1922247. PMID: 33975518Free PMC Article
RRBP1 overexpression is associated with progression and prognosis in endometrial endometrioid adenocarcinoma.
Liu S, Lin M, Ji H, Ding J, Zhu J, Ma R, Meng F
Diagn Pathol 2019 Jan 26;14(1):7. doi: 10.1186/s13000-019-0784-6. PMID: 30684972Free PMC Article
Biomarkers and microsatellite instability analysis of curettings can predict the behavior of FIGO stage I endometrial endometrioid adenocarcinoma.
Steinbakk A, Malpica A, Slewa A, Skaland I, Gudlaugsson E, Janssen EA, Løvslett K, Fiane B, Kruse AJ, Feng W, Yinhua Y, Baak JP
Mod Pathol 2011 Sep;24(9):1262-71. Epub 2011 May 6 doi: 10.1038/modpathol.2011.75. PMID: 21552210
IMP3 distinguishes uterine serous carcinoma from endometrial endometrioid adenocarcinoma.
Mhawech-Fauceglia P, Herrmann FR, Rai H, Tchabo N, Lele S, Izevbaye I, Odunsi K, Cheney RT
Am J Clin Pathol 2010 Jun;133(6):899-908. doi: 10.1309/AJCPQDQXJ4FNRFQB. PMID: 20472848

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