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Vulvar adenocarcinoma

MedGen UID:
234480
•Concept ID:
C1336975
•
Neoplastic Process
Synonyms: Adenocarcinoma of the Vulva; Adenocarcinoma of the vulva; adenocarcinoma of the vulva; Adenocarcinoma of Vulva; adenocarcinoma of vulva; mammalian vulva adenocarcinoma; vulva adenocarcinoma; Vulvar Adenocarcinoma; vulvar adenocarcinoma
 
HPO: HP:0030420
Monarch Initiative: MONDO:0024336
Orphanet: ORPHA494454

Definition

An adenocarcinoma arising in the vulva. [from HPO]

Professional guidelines

PubMed

Extramammary Paget's Disease: Diagnosis, Pathogenesis, and Treatment with Focus on Recent Developments.
Ishizuki S, Nakamura Y
Curr Oncol 2021 Aug 5;28(4):2969-2986. doi: 10.3390/curroncol28040260. PMID: 34436026Free PMC Article
Vulvar Intraepithelial Neoplasia: A Review of the Disease and Current Management.
Dockery LE, Soper JT
Obstet Gynecol Surv 2021 Jan;76(1):55-62. doi: 10.1097/OGX.0000000000000857. PMID: 33506879
Diagnosis and management of vulvar cancer: A review.
Tan A, Bieber AK, Stein JA, Pomeranz MK
J Am Acad Dermatol 2019 Dec;81(6):1387-1396. Epub 2019 Jul 23 doi: 10.1016/j.jaad.2019.07.055. PMID: 31349045

Recent clinical studies

Etiology

Vulvar Adenocarcinoma of Intestinal Type: A Case Report of an Uncommon Entity.
Moscoso O, Reques A, Saco A, Castellví J, Gómez-Hidalgo NR, Ramón Y Cajal S, García Á
Int J Gynecol Pathol 2022 Jan 1;41(1):98-103. doi: 10.1097/PGP.0000000000000784. PMID: 33782341
Primary Bartholin Adenocarcinoma: a Rare Case and Radiotherapy as Definitive Treatment.
Lubis LD, Dina S, Khaidirman DK
Folia Med (Plovdiv) 2021 Dec 31;63(6):985-989. doi: 10.3897/folmed.63.e57633. PMID: 35851231
Characteristics and outcomes of women with adenocarcinoma versus squamous cell carcinoma of the vulva: A Japanese Gynecologic Oncology Group study.
Nishio S, Matsuo K, Matsuzaki S, Kato T, Kamiura S, Adachi H, Okadome M, Nakamura T, Mikami M, Enomoto T
Eur J Surg Oncol 2021 Dec;47(12):3188-3193. Epub 2021 Jul 9 doi: 10.1016/j.ejso.2021.07.002. PMID: 34256962
Primary adenocarcinomas of the vulva and related structures: An enigmatic and diverse group of tumors(✰).
Desouki MM, Fadare O
Semin Diagn Pathol 2021 Jan;38(1):71-84. Epub 2020 Sep 25 doi: 10.1053/j.semdp.2020.09.011. PMID: 33032903
Paget's disease of the vulva: prevalence of associated vulvar adenocarcinoma, invasive Paget's disease, and recurrence after surgical excision.
Fanning J, Lambert HC, Hale TM, Morris PC, Schuerch C
Am J Obstet Gynecol 1999 Jan;180(1 Pt 1):24-7. doi: 10.1016/s0002-9378(99)70143-2. PMID: 9914572

Diagnosis

Case report: Primary vulvar adenocarcinoma of mammary gland type-its genetic characteristics by focused next-generation sequencing.
Hu L, Tiesinga J
Pathol Oncol Res 2024;30:1611376. Epub 2024 Mar 20 doi: 10.3389/pore.2024.1611376. PMID: 38572338Free PMC Article
Diagnosis and management of primary vulvar adenocarcinoma of mammary gland type: report of two distinct cases.
Morais M, Vaz Silva J, Tavares MV
BMJ Case Rep 2022 Jun 7;15(6) doi: 10.1136/bcr-2021-245580. PMID: 35672058Free PMC Article
Vulvar Adenocarcinoma of Intestinal Type: A Case Report of an Uncommon Entity.
Moscoso O, Reques A, Saco A, Castellví J, Gómez-Hidalgo NR, Ramón Y Cajal S, García Á
Int J Gynecol Pathol 2022 Jan 1;41(1):98-103. doi: 10.1097/PGP.0000000000000784. PMID: 33782341
Characteristics and outcomes of women with adenocarcinoma versus squamous cell carcinoma of the vulva: A Japanese Gynecologic Oncology Group study.
Nishio S, Matsuo K, Matsuzaki S, Kato T, Kamiura S, Adachi H, Okadome M, Nakamura T, Mikami M, Enomoto T
Eur J Surg Oncol 2021 Dec;47(12):3188-3193. Epub 2021 Jul 9 doi: 10.1016/j.ejso.2021.07.002. PMID: 34256962
Extramammary Paget's disease: Summary of current knowledge.
Lam C, Funaro D
Dermatol Clin 2010 Oct;28(4):807-26. doi: 10.1016/j.det.2010.08.002. PMID: 20883922

Therapy

Vulvar adenocarcinoma: visual resemblance to a vulvar abscess.
Pandey KC, Revannasiddaiah S, Nautiyal V, Pant NK
BMJ Case Rep 2013 Jun 10;2013 doi: 10.1136/bcr-2013-010365. PMID: 23761517Free PMC Article
Liposomal doxorubicin for treatment of metastatic chemorefractory vulvar adenocarcinoma.
Huang GS, Juretzka M, Ciaravino G, Kohler S, Teng NN
Gynecol Oncol 2002 Dec;87(3):313-8. doi: 10.1006/gyno.2002.6830. PMID: 12468332

Prognosis

Primary vulvar adenocarcinoma of intestinal type: Report of two cases showing molecular similarity with colorectal adenocarcinoma.
Mateoiu C, Palicelli A, Maloberti T, De Biase D, De Leo A, Lindh M, Bohlin KS, Stolnicu S
Pathol Res Pract 2024 Mar;255:155181. Epub 2024 Feb 1 doi: 10.1016/j.prp.2024.155181. PMID: 38340583
Vulvar Adenocarcinoma of Intestinal Type: A Case Report of an Uncommon Entity.
Moscoso O, Reques A, Saco A, Castellví J, Gómez-Hidalgo NR, Ramón Y Cajal S, García Á
Int J Gynecol Pathol 2022 Jan 1;41(1):98-103. doi: 10.1097/PGP.0000000000000784. PMID: 33782341
Characteristics and outcomes of women with adenocarcinoma versus squamous cell carcinoma of the vulva: A Japanese Gynecologic Oncology Group study.
Nishio S, Matsuo K, Matsuzaki S, Kato T, Kamiura S, Adachi H, Okadome M, Nakamura T, Mikami M, Enomoto T
Eur J Surg Oncol 2021 Dec;47(12):3188-3193. Epub 2021 Jul 9 doi: 10.1016/j.ejso.2021.07.002. PMID: 34256962
Vulvar adenocarcinoma: visual resemblance to a vulvar abscess.
Pandey KC, Revannasiddaiah S, Nautiyal V, Pant NK
BMJ Case Rep 2013 Jun 10;2013 doi: 10.1136/bcr-2013-010365. PMID: 23761517Free PMC Article
Extramammary Paget's disease: Summary of current knowledge.
Lam C, Funaro D
Dermatol Clin 2010 Oct;28(4):807-26. doi: 10.1016/j.det.2010.08.002. PMID: 20883922

Clinical prediction guides

Characteristics and outcomes of women with adenocarcinoma versus squamous cell carcinoma of the vulva: A Japanese Gynecologic Oncology Group study.
Nishio S, Matsuo K, Matsuzaki S, Kato T, Kamiura S, Adachi H, Okadome M, Nakamura T, Mikami M, Enomoto T
Eur J Surg Oncol 2021 Dec;47(12):3188-3193. Epub 2021 Jul 9 doi: 10.1016/j.ejso.2021.07.002. PMID: 34256962
Primary Clear Cell Adenocarcinoma of the Vulva: A Case Study With Mutation Analysis and Literature Review.
Kojima N, Yoshida H, Uehara T, Ushigusa T, Asami Y, Shiraishi K, Kato T
Int J Surg Pathol 2019 Oct;27(7):792-797. Epub 2019 May 20 doi: 10.1177/1066896919848823. PMID: 31104528
Liposomal doxorubicin for treatment of metastatic chemorefractory vulvar adenocarcinoma.
Huang GS, Juretzka M, Ciaravino G, Kohler S, Teng NN
Gynecol Oncol 2002 Dec;87(3):313-8. doi: 10.1006/gyno.2002.6830. PMID: 12468332

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