U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Breast extraskeletal osteosarcoma

MedGen UID:
235414
•Concept ID:
C1335149
•
Neoplastic Process
Synonyms: Breast Extraskeletal Osteosarcoma; breast extraskeletal osteosarcoma; Breast Osteosarcoma; breast osteosarcoma; breast osteosarcoma (disease); Osteogenic Breast Sarcoma; osteogenic breast sarcoma; Osteogenic Sarcoma of Breast; osteogenic sarcoma of breast; Osteogenic Sarcoma of the Breast; osteogenic sarcoma of the breast; Osteosarcoma of Breast; osteosarcoma of breast; Osteosarcoma of the Breast; osteosarcoma of the breast
 
Monarch Initiative: MONDO:0004360

Definition

An osteosarcoma arising from the breast tissue. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBreast extraskeletal osteosarcoma

Recent clinical studies

Etiology

Ewing sarcoma: A pictorial review of typical and atypical locations with reference to the updated 2020 WHO classification system.
Sparreboom BD, Trautman J, Yaxley J
J Med Imaging Radiat Oncol 2022 Sep;66(6):812-818. Epub 2022 Jul 16 doi: 10.1111/1754-9485.13456. PMID: 35842789
Increased Prevalence of Malignancies in Fibrous Dysplasia/McCune-Albright Syndrome (FD/MAS): Data from a National Referral Center and the Dutch National Pathology Registry (PALGA).
Hagelstein-Rotman M, Meier ME, Majoor BCJ, Cleven AHG, Dijkstra PDS, Hamdy NAT, van de Sande MAJ, Dekkers OM, Appelman-Dijkstra NM
Calcif Tissue Int 2021 Mar;108(3):346-353. Epub 2020 Nov 23 doi: 10.1007/s00223-020-00780-6. PMID: 33226445
Extraskeletal osteosarcoma: MDM2 and H3K27me3 analysis of 19 cases suggest disease heterogeneity.
Makise N, Sekimizu M, Kubo T, Wakai S, Watanabe SI, Kato T, Kinoshita T, Hiraoka N, Fukayama M, Kawai A, Ichikawa H, Yoshida A
Histopathology 2018 Jul;73(1):147-156. Epub 2018 Apr 19 doi: 10.1111/his.13506. PMID: 29489027
Extraosseous osteosarcoma: single institutional experience in Korea.
Lee S, Lee MR, Lee SJ, Ahn HK, Yi J, Yi SY, Seo SW, Sung KS, Park JO, Lee J
Asia Pac J Clin Oncol 2010 Jun;6(2):126-9. doi: 10.1111/j.1743-7563.2010.01278.x. PMID: 20565425
Whole-body MRI for detecting metastatic bone tumor: diagnostic value of diffusion-weighted images.
Nakanishi K, Kobayashi M, Nakaguchi K, Kyakuno M, Hashimoto N, Onishi H, Maeda N, Nakata S, Kuwabara M, Murakami T, Nakamura H
Magn Reson Med Sci 2007;6(3):147-55. doi: 10.2463/mrms.6.147. PMID: 18037795

Diagnosis

Expression of TRPS1 in phyllodes tumor and sarcoma of the breast.
Wang J, Wang WL, Sun H, Huo L, Wu Y, Chen H, Gan Q, Meis JM, Maloney N, Lazar AJ, Yoon EC, Albarracin CT, Krishnamurthy S, Middleton LP, Resetkova E, Yu W, Tan D, Lu W, Solis Soto LM, Wang S, Wistuba II, Parwani AV, Prieto VG, Sahin AA, Li Z, Ding Q
Hum Pathol 2022 Mar;121:73-80. Epub 2022 Jan 19 doi: 10.1016/j.humpath.2022.01.002. PMID: 35063444
Primary Osteosarcoma of the Breast: Pathophysiology and Imaging Review.
Mujtaba B, Nassar SM, Aslam R, Garg N, Madewell JE, Taher A, Hanafy AK, Whitman G
Curr Probl Diagn Radiol 2020 Mar-Apr;49(2):116-123. Epub 2019 Jan 3 doi: 10.1067/j.cpradiol.2019.01.001. PMID: 30655112
Postradiation Extraskeletal Osteosarcoma Masquerading as an Axillary Artery Pseudoaneurysm.
Wohlauer M, McKenney JK, Park WM
Ann Vasc Surg 2016 Jan;30:157.e7-9. Epub 2015 Aug 17 doi: 10.1016/j.avsg.2015.06.069. PMID: 26291499
Osteosarcoma of breast: a rare case of extraskeletal osteosarcoma.
Kallianpur AA, Gupta R, Muduly DK, Kapali A, Subbarao KC
J Cancer Res Ther 2013 Apr-Jun;9(2):292-4. doi: 10.4103/0973-1482.113392. PMID: 23771379
Extraskeletal osteosarcoma of the breast in an adolescent girl.
Zils K, Ebner F, Ott M, Müller J, Baumhoer D, Greulich M, Rehnitz D, Rempen A, Schaetzle S, Wilhelm M, Bielack S
J Pediatr Hematol Oncol 2012 Aug;34(6):e261-3. doi: 10.1097/MPH.0b013e31823366b4. PMID: 22246152

Therapy

Primary extraskeletal Ewing's sarcoma/primitive neuroectodermal tumour of breast.
Ikhwan SM, Kenneth VK, Seoparjoo A, Zin AA
BMJ Case Rep 2013 Jun 21;2013 doi: 10.1136/bcr-2013-009584. PMID: 23813511Free PMC Article
Osteosarcoma of breast: a rare case of extraskeletal osteosarcoma.
Kallianpur AA, Gupta R, Muduly DK, Kapali A, Subbarao KC
J Cancer Res Ther 2013 Apr-Jun;9(2):292-4. doi: 10.4103/0973-1482.113392. PMID: 23771379
Extraskeletal osteosarcoma of the breast in an adolescent girl.
Zils K, Ebner F, Ott M, Müller J, Baumhoer D, Greulich M, Rehnitz D, Rempen A, Schaetzle S, Wilhelm M, Bielack S
J Pediatr Hematol Oncol 2012 Aug;34(6):e261-3. doi: 10.1097/MPH.0b013e31823366b4. PMID: 22246152
Postradiation soft tissue sarcoma: a multiinstitutional analysis of 14 cases in Japan.
Fang Z, Matsumoto S, Ae K, Kawaguchi N, Yoshikawa H, Ueda T, Ishii T, Araki N, Kito M
J Orthop Sci 2004;9(3):242-6. doi: 10.1007/s00776-004-0768-5. PMID: 15168177
Radiation-induced extraskeletal osteosarcoma.
Alpert LI, Abaci IF, Werthamer S
Cancer 1973 Jun;31(6):1359-63. doi: 10.1002/1097-0142(197306)31:6<1359::aid-cncr2820310609>3.0.co;2-f. PMID: 4350957

Prognosis

Ewing sarcoma: A pictorial review of typical and atypical locations with reference to the updated 2020 WHO classification system.
Sparreboom BD, Trautman J, Yaxley J
J Med Imaging Radiat Oncol 2022 Sep;66(6):812-818. Epub 2022 Jul 16 doi: 10.1111/1754-9485.13456. PMID: 35842789
Extraosseous osteosarcoma: single institutional experience in Korea.
Lee S, Lee MR, Lee SJ, Ahn HK, Yi J, Yi SY, Seo SW, Sung KS, Park JO, Lee J
Asia Pac J Clin Oncol 2010 Jun;6(2):126-9. doi: 10.1111/j.1743-7563.2010.01278.x. PMID: 20565425
Whole-body MRI for detecting metastatic bone tumor: diagnostic value of diffusion-weighted images.
Nakanishi K, Kobayashi M, Nakaguchi K, Kyakuno M, Hashimoto N, Onishi H, Maeda N, Nakata S, Kuwabara M, Murakami T, Nakamura H
Magn Reson Med Sci 2007;6(3):147-55. doi: 10.2463/mrms.6.147. PMID: 18037795
Primary osteosarcoma of the breast.
Momoi H, Wada Y, Sarumaru S, Tamaki N, Gomi T, Kanaya S, Katayama T, Ootoshi M, Fukumoto M
Breast Cancer 2004;11(4):396-400. doi: 10.1007/BF02968048. PMID: 15604996
Postradiation soft tissue sarcoma: a multiinstitutional analysis of 14 cases in Japan.
Fang Z, Matsumoto S, Ae K, Kawaguchi N, Yoshikawa H, Ueda T, Ishii T, Araki N, Kito M
J Orthop Sci 2004;9(3):242-6. doi: 10.1007/s00776-004-0768-5. PMID: 15168177

Clinical prediction guides

Ewing sarcoma: A pictorial review of typical and atypical locations with reference to the updated 2020 WHO classification system.
Sparreboom BD, Trautman J, Yaxley J
J Med Imaging Radiat Oncol 2022 Sep;66(6):812-818. Epub 2022 Jul 16 doi: 10.1111/1754-9485.13456. PMID: 35842789
Increased Prevalence of Malignancies in Fibrous Dysplasia/McCune-Albright Syndrome (FD/MAS): Data from a National Referral Center and the Dutch National Pathology Registry (PALGA).
Hagelstein-Rotman M, Meier ME, Majoor BCJ, Cleven AHG, Dijkstra PDS, Hamdy NAT, van de Sande MAJ, Dekkers OM, Appelman-Dijkstra NM
Calcif Tissue Int 2021 Mar;108(3):346-353. Epub 2020 Nov 23 doi: 10.1007/s00223-020-00780-6. PMID: 33226445
Extraskeletal osteosarcoma: MDM2 and H3K27me3 analysis of 19 cases suggest disease heterogeneity.
Makise N, Sekimizu M, Kubo T, Wakai S, Watanabe SI, Kato T, Kinoshita T, Hiraoka N, Fukayama M, Kawai A, Ichikawa H, Yoshida A
Histopathology 2018 Jul;73(1):147-156. Epub 2018 Apr 19 doi: 10.1111/his.13506. PMID: 29489027
Whole-body MRI for detecting metastatic bone tumor: diagnostic value of diffusion-weighted images.
Nakanishi K, Kobayashi M, Nakaguchi K, Kyakuno M, Hashimoto N, Onishi H, Maeda N, Nakata S, Kuwabara M, Murakami T, Nakamura H
Magn Reson Med Sci 2007;6(3):147-55. doi: 10.2463/mrms.6.147. PMID: 18037795
Primary osteosarcoma of the breast.
Momoi H, Wada Y, Sarumaru S, Tamaki N, Gomi T, Kanaya S, Katayama T, Ootoshi M, Fukumoto M
Breast Cancer 2004;11(4):396-400. doi: 10.1007/BF02968048. PMID: 15604996

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...