U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Schwannoma of twelfth cranial nerve

MedGen UID:
235581
•Concept ID:
C1335928
•
Neoplastic Process
Synonyms: Hypoglossal Nerve Neurilemmoma; hypoglossal nerve neurilemmoma; Hypoglossal Nerve Schwannoma; hypoglossal nerve schwannoma; Hypoglossal Neurilemmoma; hypoglossal neurilemmoma; Hypoglossal Schwannoma; hypoglossal schwannoma; Neurilemmoma of Hypoglossal Nerve; neurilemmoma of hypoglossal nerve; Neurilemmoma of the Hypoglossal Nerve; neurilemmoma of the hypoglossal nerve; Neurilemmoma of the Twelfth Cranial Nerve; neurilemmoma of the twelfth cranial nerve; Neurilemmoma of Twelfth Cranial Nerve; neurilemmoma of twelfth cranial nerve; Schwannoma of Hypoglossal Nerve; schwannoma of hypoglossal nerve; Schwannoma of the Hypoglossal Nerve; schwannoma of the hypoglossal nerve; Schwannoma of the Twelfth Cranial Nerve; schwannoma of the twelfth cranial nerve; Schwannoma of Twelfth Cranial Nerve; schwannoma of twelfth cranial nerve; Twelfth Cranial Nerve Neurilemmoma; twelfth cranial nerve neurilemmoma; Twelfth Cranial Nerve Schwannoma; twelfth cranial nerve schwannoma
 
Monarch Initiative: MONDO:0002549

Definition

A benign schwannoma occurring in the twelfth cranial nerve. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSchwannoma of twelfth cranial nerve

Professional guidelines

PubMed

Diagnosis and management of hypoglossal nerve-derived schwannoma in the floor of mouth: a case series.
Zhong J, Zhou Z, Hu Y, Zhao T, Yao Y, Zhong L, Zhu D
BMC Oral Health 2022 Jun 29;22(1):265. doi: 10.1186/s12903-022-02302-2. PMID: 35768820Free PMC Article
Management of non-vestibular schwannomas in adult patients: a systematic review and consensus statement on behalf of the EANS skull base section Part III: Lower cranial nerve schwannomas, jugular foramen (CN IX, X, XI) and hypoglossal schwannoma (XII).
Bal J, Bruneau M, Berhouma M, Cornelius JF, Cavallo LM, Daniel RT, Froelich S, Jouanneau E, Meling TR, Messerer M, Roche PH, Schroeder H, Tatagiba M, Zazpe I, Paraskevopoulos D
Acta Neurochir (Wien) 2022 Feb;164(2):321-329. Epub 2021 Dec 2 doi: 10.1007/s00701-021-05072-y. PMID: 34854994
Surgical management and outcome of schwannomas in the craniocervical region.
Cavalcanti DD, Martirosyan NL, Verma K, Safavi-Abbasi S, Porter RW, Theodore N, Sonntag VK, Dickman CA, Spetzler RF
J Neurosurg 2011 May;114(5):1257-67. Epub 2010 Jul 9 doi: 10.3171/2010.5.JNS0966. PMID: 20617880

Recent clinical studies

Etiology

Diagnosis and management of hypoglossal nerve-derived schwannoma in the floor of mouth: a case series.
Zhong J, Zhou Z, Hu Y, Zhao T, Yao Y, Zhong L, Zhu D
BMC Oral Health 2022 Jun 29;22(1):265. doi: 10.1186/s12903-022-02302-2. PMID: 35768820Free PMC Article
Management of facial nerve schwannoma: when is the timing for surgery.
Cho YS, Choi JE, Lim JH, Cho YS
Eur Arch Otorhinolaryngol 2022 Mar;279(3):1243-1249. Epub 2021 Apr 8 doi: 10.1007/s00405-021-06765-x. PMID: 33834275
Carotid Body Tumor - radiological imaging and genetic assessment.
Berger G, Łukasiewicz A, Grinevych V, Tarasów E
Pol Przegl Chir 2020 Nov 6;92(6):39-44. doi: 10.5604/01.3001.0014.4872. PMID: 33408267
Hypoglossal Schwannoma of Neck: Case Report and Review of Literature.
Plitt A, El Ahmadieh TY, Bindal S, Myers L, White J, Gluf W
World Neurosurg 2018 Feb;110:240-243. Epub 2017 Nov 22 doi: 10.1016/j.wneu.2017.11.069. PMID: 29175571
Surgical Management of Intrinsic Tumors of the Facial Nerve.
Prasad SC, Laus M, Dandinarasaiah M, Piccirillo E, Russo A, Taibah A, Sanna M
Neurosurgery 2018 Oct 1;83(4):740-752. doi: 10.1093/neuros/nyx489. PMID: 29029275

Diagnosis

Surgical Management of Craniovertebral Junction Schwannomas: A Systematic Review.
Palmisciano P, Ferini G, Watanabe G, Conching A, Ogasawara C, Scalia G, Bin-Alamer O, Haider AS, Passanisi M, Maugeri R, Hoz SS, Baldoncini M, Campero A, Salvati M, Cohen-Gadol AA, Umana GE
Curr Oncol 2022 Jul 9;29(7):4842-4855. doi: 10.3390/curroncol29070384. PMID: 35877244Free PMC Article
Diagnosis and management of hypoglossal nerve-derived schwannoma in the floor of mouth: a case series.
Zhong J, Zhou Z, Hu Y, Zhao T, Yao Y, Zhong L, Zhu D
BMC Oral Health 2022 Jun 29;22(1):265. doi: 10.1186/s12903-022-02302-2. PMID: 35768820Free PMC Article
A clinical study of submandibular schwannoma.
Park KW, Lee DH, Lee JK, Lim SC
Oral Surg Oral Med Oral Pathol Oral Radiol 2022 Jan;133(1):e6-e9. Epub 2021 Jul 16 doi: 10.1016/j.oooo.2021.07.005. PMID: 34493472
Carotid Body Tumor - radiological imaging and genetic assessment.
Berger G, Łukasiewicz A, Grinevych V, Tarasów E
Pol Przegl Chir 2020 Nov 6;92(6):39-44. doi: 10.5604/01.3001.0014.4872. PMID: 33408267
Diagnostic, Surgical, and Postoperative Challenges of Neuroendocrine Tumors of the Neck: Clinical Experience and Literature Review.
Khan MM, Khan MI, Ali H, Kazmi T, Iqbal H
Ann Vasc Surg 2017 Nov;45:92-97. Epub 2017 Jul 6 doi: 10.1016/j.avsg.2017.06.128. PMID: 28688875

Therapy

Surgical Management of Craniovertebral Junction Schwannomas: A Systematic Review.
Palmisciano P, Ferini G, Watanabe G, Conching A, Ogasawara C, Scalia G, Bin-Alamer O, Haider AS, Passanisi M, Maugeri R, Hoz SS, Baldoncini M, Campero A, Salvati M, Cohen-Gadol AA, Umana GE
Curr Oncol 2022 Jul 9;29(7):4842-4855. doi: 10.3390/curroncol29070384. PMID: 35877244Free PMC Article
Side-to-End Hypoglossal-Facial Neurorrhaphy for Treatment of Complete and Irreversible Facial Paralysis after Vestibular Schwannoma Removal by Means of a Retrosigmoid Approach: A Clinical and Anatomic Study.
González-Darder JM, Capilla-Guasch P, Escartín FP, Quilis-Quesada V
World Neurosurg 2020 Apr;136:e262-e269. Epub 2020 Jan 2 doi: 10.1016/j.wneu.2019.12.149. PMID: 31904436
Comparison of Direct Side-to-End and End-to-End Hypoglossal-Facial Anastomosis for Facial Nerve Repair.
Samii M, Alimohamadi M, Khouzani RK, Rashid MR, Gerganov V
World Neurosurg 2015 Aug;84(2):368-75. Epub 2015 Mar 25 doi: 10.1016/j.wneu.2015.03.029. PMID: 25819525
An algorithm for treating extracranial head and neck schwannomas.
Yafit D, Horowitz G, Vital I, Locketz G, Fliss DM
Eur Arch Otorhinolaryngol 2015 Aug;272(8):2035-8. Epub 2014 Jun 25 doi: 10.1007/s00405-014-3156-6. PMID: 24961439
Facial and lower cranial nerve function preservation in lateral approach for craniocervical schwannomas.
Wang Z, Chen H, Huang Q, Zhang Z, Yang J, Wu H
Eur Arch Otorhinolaryngol 2015 Sep;272(9):2207-12. Epub 2014 Jun 14 doi: 10.1007/s00405-014-3127-y. PMID: 24927829

Prognosis

Hemihypoglossal-facial nerve anastomosis: results and electromyographic characterization.
Fík Z, Kraus J, Čada Z, Chovanec M, Fíková A, Zvěřina E, Betka J, Plzák J
Eur Arch Otorhinolaryngol 2022 Jan;279(1):467-479. Epub 2021 May 25 doi: 10.1007/s00405-021-06893-4. PMID: 34036422
The Experience of a Facial Nerve Unit in the Treatment of Patients With Facial Paralysis Following Skull Base Surgery.
Lassaletta L, Morales-Puebla JM, González-Otero T, Moraleda S, Roda JM, Gavilán J
Otol Neurotol 2020 Dec;41(10):e1340-e1349. doi: 10.1097/MAO.0000000000002902. PMID: 33492811
Hypoglossal Schwannoma of Neck: Case Report and Review of Literature.
Plitt A, El Ahmadieh TY, Bindal S, Myers L, White J, Gluf W
World Neurosurg 2018 Feb;110:240-243. Epub 2017 Nov 22 doi: 10.1016/j.wneu.2017.11.069. PMID: 29175571
Surgical Management of Intrinsic Tumors of the Facial Nerve.
Prasad SC, Laus M, Dandinarasaiah M, Piccirillo E, Russo A, Taibah A, Sanna M
Neurosurgery 2018 Oct 1;83(4):740-752. doi: 10.1093/neuros/nyx489. PMID: 29029275
Diagnostic, Surgical, and Postoperative Challenges of Neuroendocrine Tumors of the Neck: Clinical Experience and Literature Review.
Khan MM, Khan MI, Ali H, Kazmi T, Iqbal H
Ann Vasc Surg 2017 Nov;45:92-97. Epub 2017 Jul 6 doi: 10.1016/j.avsg.2017.06.128. PMID: 28688875

Clinical prediction guides

Hemihypoglossal-facial nerve anastomosis: results and electromyographic characterization.
Fík Z, Kraus J, Čada Z, Chovanec M, Fíková A, Zvěřina E, Betka J, Plzák J
Eur Arch Otorhinolaryngol 2022 Jan;279(1):467-479. Epub 2021 May 25 doi: 10.1007/s00405-021-06893-4. PMID: 34036422
Management of facial nerve schwannoma: when is the timing for surgery.
Cho YS, Choi JE, Lim JH, Cho YS
Eur Arch Otorhinolaryngol 2022 Mar;279(3):1243-1249. Epub 2021 Apr 8 doi: 10.1007/s00405-021-06765-x. PMID: 33834275
Hemihypoglossal-Facial Nerve Anastomosis for Facial Nerve Reanimation: Case Series and Technical Note.
Dziedzic TA, Kunert P, Marchel A
World Neurosurg 2018 Oct;118:e460-e467. Epub 2018 Jul 4 doi: 10.1016/j.wneu.2018.06.217. PMID: 30257299
Diagnostic, Surgical, and Postoperative Challenges of Neuroendocrine Tumors of the Neck: Clinical Experience and Literature Review.
Khan MM, Khan MI, Ali H, Kazmi T, Iqbal H
Ann Vasc Surg 2017 Nov;45:92-97. Epub 2017 Jul 6 doi: 10.1016/j.avsg.2017.06.128. PMID: 28688875
Spontaneous Regression of a Hypoglossal Neurinoma: Case Report and Review of the Literature.
Santander XA, Cotúa CE, Saldaña C
World Neurosurg 2017 Sep;105:1033.e7-1033.e9. Epub 2017 Jun 8 doi: 10.1016/j.wneu.2017.06.004. PMID: 28602924

Recent systematic reviews

Surgical Management of Craniovertebral Junction Schwannomas: A Systematic Review.
Palmisciano P, Ferini G, Watanabe G, Conching A, Ogasawara C, Scalia G, Bin-Alamer O, Haider AS, Passanisi M, Maugeri R, Hoz SS, Baldoncini M, Campero A, Salvati M, Cohen-Gadol AA, Umana GE
Curr Oncol 2022 Jul 9;29(7):4842-4855. doi: 10.3390/curroncol29070384. PMID: 35877244Free PMC Article
Management of non-vestibular schwannomas in adult patients: a systematic review and consensus statement on behalf of the EANS skull base section Part III: Lower cranial nerve schwannomas, jugular foramen (CN IX, X, XI) and hypoglossal schwannoma (XII).
Bal J, Bruneau M, Berhouma M, Cornelius JF, Cavallo LM, Daniel RT, Froelich S, Jouanneau E, Meling TR, Messerer M, Roche PH, Schroeder H, Tatagiba M, Zazpe I, Paraskevopoulos D
Acta Neurochir (Wien) 2022 Feb;164(2):321-329. Epub 2021 Dec 2 doi: 10.1007/s00701-021-05072-y. PMID: 34854994
Anaplastic Hemangiopericytoma of the Jugular Foramen: Case Report and Systematic Review.
Li D, Westfall E, Aasen M, Borys E, Leonetti JP, Anderson DE
World Neurosurg 2021 Sep;153:11-20. Epub 2021 Jun 26 doi: 10.1016/j.wneu.2021.06.094. PMID: 34182175
Hypoglossal schwannomas: A systematic review of the literature.
Bindal S, El Ahmadieh TY, Plitt A, Aoun SG, Neeley OJ, El Tecle NE, Barnett S, Gluf W
J Clin Neurosci 2019 Apr;62:162-173. Epub 2018 Nov 22 doi: 10.1016/j.jocn.2018.11.037. PMID: 30472335

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...