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Squamous Cell Carcinoma In Situ of the Nipple

MedGen UID:
236845
•Concept ID:
C1336080
•
Neoplastic Process
Synonyms: Intraepidermal Squamous Carcinoma of Nipple; Intraepidermal Squamous Carcinoma of the Nipple; Nipple Intraepidermal Squamous Carcinoma; Squamous Cell Carcinoma In Situ of Nipple

Definition

An intraepidermal squamous cell carcinoma involving the area of the nipple. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSquamous Cell Carcinoma In Situ of the Nipple

Professional guidelines

PubMed

'Eczematous' dermatitis of the nipple: clinical and histopathological differential diagnosis of Paget disease.
Zengin HB, Tan PH, Liu R, Smoller BR
Pathology 2024 Apr;56(3):300-312. Epub 2024 Jan 6 doi: 10.1016/j.pathol.2023.10.018. PMID: 38307774
Application of Mohs micrographic surgery appropriate-use criteria to skin cancers at a university health system.
Blechman AB, Patterson JW, Russell MA
J Am Acad Dermatol 2014 Jul;71(1):29-35. Epub 2014 May 9 doi: 10.1016/j.jaad.2014.02.025. PMID: 24813300

Recent clinical studies

Etiology

Paget's disease of the male breast in the 21st century: A systematic review.
Adams SJ, Kanthan R
Breast 2016 Oct;29:14-23. Epub 2016 Jul 6 doi: 10.1016/j.breast.2016.06.015. PMID: 27394005
Clinico-epidemiological profile of breast cancer patients and the retrospective application of Gail model 2: An Indian perspective.
Thomas S, Desai G, Pathania OP, Jain M, Aggarwal L, Ali S, Sharma K, Tudu SK
Breast Dis 2016 Jan 27;36(1):15-22. doi: 10.3233/BD-150203. PMID: 27177339
Bowen's disease of the nipple in a young man with AIDS: a case report.
Sharma R, Iyer M
Clin Breast Cancer 2009 Feb;9(1):53-5. doi: 10.3816/CBC.2009.n.010. PMID: 19299242
Pagetoid dyskeratosis of the nipple epidermis: an incidental finding mimicking Paget's disease of the nipple.
Garijo MF, Val D, Val-Bernal JF
APMIS 2008 Feb;116(2):139-46. doi: 10.1111/j.1600-0463.2008.00826.x. PMID: 18321365
Metaplastic spindle cell breast tumors arising within papillomas, complex sclerosing lesions, and nipple adenomas.
Gobbi H, Simpson JF, Jensen RA, Olson SJ, Page DL
Mod Pathol 2003 Sep;16(9):893-901. doi: 10.1097/01.MP.0000085027.75201.B5. PMID: 13679453

Diagnosis

'Eczematous' dermatitis of the nipple: clinical and histopathological differential diagnosis of Paget disease.
Zengin HB, Tan PH, Liu R, Smoller BR
Pathology 2024 Apr;56(3):300-312. Epub 2024 Jan 6 doi: 10.1016/j.pathol.2023.10.018. PMID: 38307774
A rare case of Bowen's disease of the nipple: Literature review and management pathway.
Liang DG, Soliman B, Cha J
Breast J 2020 Jun;26(6):1234-1238. Epub 2020 Mar 24 doi: 10.1111/tbj.13824. PMID: 32212188
Clinico-epidemiological profile of breast cancer patients and the retrospective application of Gail model 2: An Indian perspective.
Thomas S, Desai G, Pathania OP, Jain M, Aggarwal L, Ali S, Sharma K, Tudu SK
Breast Dis 2016 Jan 27;36(1):15-22. doi: 10.3233/BD-150203. PMID: 27177339
Primary basaloid carcinoma of the nipple with associated squamous cell carcinoma in situ.
Chen CH, Rowlands C, Sengupta SK, George RL, Parulekar W, Thain K, O'Malley F, Isotalo PA
Breast J 2009 Jul-Aug;15(4):409-13. doi: 10.1111/j.1524-4741.2009.00746.x. PMID: 19601946
Acantholytic anaplastic Paget's disease.
Mobini N
J Cutan Pathol 2009 Mar;36(3):374-80. doi: 10.1111/j.1600-0560.2008.01053.x. PMID: 19220635

Therapy

Primary basaloid carcinoma of the nipple with associated squamous cell carcinoma in situ.
Chen CH, Rowlands C, Sengupta SK, George RL, Parulekar W, Thain K, O'Malley F, Isotalo PA
Breast J 2009 Jul-Aug;15(4):409-13. doi: 10.1111/j.1524-4741.2009.00746.x. PMID: 19601946

Prognosis

Paget's disease of the male breast in the 21st century: A systematic review.
Adams SJ, Kanthan R
Breast 2016 Oct;29:14-23. Epub 2016 Jul 6 doi: 10.1016/j.breast.2016.06.015. PMID: 27394005
Clinico-epidemiological profile of breast cancer patients and the retrospective application of Gail model 2: An Indian perspective.
Thomas S, Desai G, Pathania OP, Jain M, Aggarwal L, Ali S, Sharma K, Tudu SK
Breast Dis 2016 Jan 27;36(1):15-22. doi: 10.3233/BD-150203. PMID: 27177339
Primary basaloid carcinoma of the nipple with associated squamous cell carcinoma in situ.
Chen CH, Rowlands C, Sengupta SK, George RL, Parulekar W, Thain K, O'Malley F, Isotalo PA
Breast J 2009 Jul-Aug;15(4):409-13. doi: 10.1111/j.1524-4741.2009.00746.x. PMID: 19601946
Bowen's disease of the nipple in a young man with AIDS: a case report.
Sharma R, Iyer M
Clin Breast Cancer 2009 Feb;9(1):53-5. doi: 10.3816/CBC.2009.n.010. PMID: 19299242

Clinical prediction guides

Clinico-epidemiological profile of breast cancer patients and the retrospective application of Gail model 2: An Indian perspective.
Thomas S, Desai G, Pathania OP, Jain M, Aggarwal L, Ali S, Sharma K, Tudu SK
Breast Dis 2016 Jan 27;36(1):15-22. doi: 10.3233/BD-150203. PMID: 27177339
Bowen's disease of the nipple-a new method of treatment.
Brookes PT, Jhawar S, Hinton CP, Murdoch S, Usman T
Breast 2005 Feb;14(1):65-7. doi: 10.1016/j.breast.2004.05.001. PMID: 15695084

Recent systematic reviews

Paget's disease of the male breast in the 21st century: A systematic review.
Adams SJ, Kanthan R
Breast 2016 Oct;29:14-23. Epub 2016 Jul 6 doi: 10.1016/j.breast.2016.06.015. PMID: 27394005

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